Podcast
Questions and Answers
What is the mechanism of action of hydroxychloroquine?
What is the mechanism of action of hydroxychloroquine?
Relieves severe inflammation of arthritis and lupus; for patients who have not responded well to other anti-inflammatory drugs; also used for prophylaxis and treatment of malaria.
What is the therapeutic class of hydroxychloroquine?
What is the therapeutic class of hydroxychloroquine?
Antirheumatic drug; antimalarial.
What is the pharmacologic class of hydroxychloroquine?
What is the pharmacologic class of hydroxychloroquine?
Disease-modifying anti-rheumatic drug.
What should hydroxychloroquine administration alerts include? It should be taken at the same time every day and administered with _____ to decrease GI upset.
What should hydroxychloroquine administration alerts include? It should be taken at the same time every day and administered with _____ to decrease GI upset.
Signup and view all the answers
What is the onset time for hydroxychloroquine's antirheumatic response?
What is the onset time for hydroxychloroquine's antirheumatic response?
Signup and view all the answers
What are some adverse effects of hydroxychloroquine?
What are some adverse effects of hydroxychloroquine?
Signup and view all the answers
Who should not receive hydroxychloroquine?
Who should not receive hydroxychloroquine?
Signup and view all the answers
What can prevent the absorption of hydroxychloroquine?
What can prevent the absorption of hydroxychloroquine?
Signup and view all the answers
What is the treatment for hydroxychloroquine overdose?
What is the treatment for hydroxychloroquine overdose?
Signup and view all the answers
What is the trade name for hydroxychloroquine?
What is the trade name for hydroxychloroquine?
Signup and view all the answers
Study Notes
Hydroxychloroquine Overview
- Used to relieve severe inflammation caused by conditions like arthritis and lupus.
- Effective as prophylaxis and treatment for malaria, particularly in patients unresponsive to other anti-inflammatory drugs.
Therapeutic and Pharmacologic Class
- Classified as an antirheumatic drug and an antimalarial.
- Falls under the category of disease-modifying anti-rheumatic drugs (DMARDs).
Administration Alerts
- Take hydroxychloroquine at the same time daily to maintain consistent levels in the body.
- Recommended to be taken with milk to minimize gastrointestinal (GI) upset.
- Store safely to prevent accidental toxicity, especially in children.
- Classified as pregnancy category C, indicating potential risks.
Pharmacokinetics
- Onset of therapeutic effects for rheumatic conditions typically occurs within 4-6 weeks.
- Peak blood concentration reached in 1-2 hours after administration.
- Duration of action remains unknown.
Adverse Effects
- Common side effects include anorexia, GI disturbances, and hair loss.
- Possible adverse ocular effects, headaches, and mood or mental changes.
- Risk of irreversible retinal changes in patients on high doses or prolonged therapy.
Contraindications
- Not suitable for individuals hypersensitive to hydroxychloroquine or those with retinal changes linked to quinoline drugs.
Drug-Drug Interactions
- Antacids containing aluminum or magnesium may hinder absorption of hydroxychloroquine.
- Increases liver toxicity risk when used with hepatotoxic drugs.
- Alcohol should be avoided.
- May elevate digoxin levels and interfere with rabies vaccine efficacy.
Treatment of Overdose
- Overdose poses life-threatening risks, particularly in children.
- Management may require anticonvulsants, vasopressors, and antidysrhythmics to alleviate critical symptoms.
Trade Name
- Marketed under the trade name Plaquenil.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on hydroxychloroquine, also known as Plaquenil, with these flashcards. This quiz covers its mechanism of action, therapeutic and pharmacologic classes, and clinical applications. Ideal for students and professionals in the field of medicine and pharmacology.
