Chloroquine & Hydroxychloroquine for Malaria Prevention
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Questions and Answers

What is the recommended timing for starting malaria prophylaxis with chloroquine or hydroxychloroquine?

  • 1-2 weeks before travel (correct)
  • Once in the endemic area
  • 1-2 days before travel
  • At least 4 weeks before travel
  • Which of the following is a reported side effect of chloroquine and hydroxychloroquine?

  • Hair loss
  • Muscle pain
  • Dizziness (correct)
  • Weight gain
  • When should travelers stop taking chloroquine or hydroxychloroquine after leaving malaria-endemic areas?

  • Immediately after leaving
  • 4 weeks after leaving (correct)
  • 1 week after leaving
  • 2 weeks after leaving
  • What is a serious side effect associated with high doses of chloroquine?

    <p>Retinopathy</p> Signup and view all the answers

    What is one way to potentially improve tolerance of chloroquine for individuals experiencing uncomfortable side effects?

    <p>Take it with meals</p> Signup and view all the answers

    In what condition can chloroquine and related compounds reportedly exacerbate?

    <p>Psoriasis</p> Signup and view all the answers

    What is the recommended timing for starting doxycycline prophylaxis before travel to malaria-endemic areas?

    <p>1-2 days before travel</p> Signup and view all the answers

    How often should doxycycline be taken during travel in malaria-endemic areas?

    <p>Once a day</p> Signup and view all the answers

    What should people on a long-term regimen of minocycline do if they need malaria prophylaxis?

    <p>Stop taking minocycline 1-2 days before travel and start doxycycline</p> Signup and view all the answers

    What is a potential side effect of doxycycline related to sun exposure?

    <p>Increased risk of sunburn</p> Signup and view all the answers

    How can the risk of gastrointestinal side effects of doxycycline be minimized?

    <p>Taking the drug with a meal</p> Signup and view all the answers

    Who should avoid taking doxycycline as a malaria prophylaxis?

    <p>Pregnant individuals</p> Signup and view all the answers

    What is advised to reduce the risk for esophagitis when taking doxycycline?

    <p>Swallowing the medicine with sufficient fluids</p> Signup and view all the answers

    Which medication is associated with an increased frequency of vaginal yeast infections?

    <p>Doxycycline</p> Signup and view all the answers

    What should be done if someone on a long-term regimen of minocycline needs malaria prophylaxis?

    <p>Stop taking minocycline 1-2 days before travel and start doxycycline instead</p> Signup and view all the answers

    What should be done to minimize the risk of photosensitivity caused by doxycycline?

    <p>Avoiding prolonged, direct exposure to the sun and using sunscreen</p> Signup and view all the answers

    Study Notes

    Malaria Prophylaxis with Chloroquine and Hydroxychloroquine

    • Prophylaxis with chloroquine or hydroxychloroquine should be started 1-2 weeks before traveling to malaria-endemic areas.
    • Reported side effects of chloroquine and hydroxychloroquine include gastrointestinal disturbances, headaches, and dizziness.
    • Travelers should stop taking chloroquine or hydroxychloroquine 4 weeks after leaving malaria-endemic areas.
    • High doses of chloroquine can cause a serious side effect: retinopathy.
    • Taking chloroquine with food can potentially improve tolerance for individuals experiencing uncomfortable side effects.
    • Chloroquine and related compounds can exacerbate psoriasis.

    Malaria Prophylaxis with Doxycycline

    • Prophylaxis with doxycycline should be started 1-2 days before traveling to malaria-endemic areas.
    • Doxycycline should be taken daily during travel in malaria-endemic areas.
    • People on a long-term regimen of minocycline who need malaria prophylaxis should stop taking minocycline and start taking doxycycline instead.
    • Doxycycline can cause photosensitivity, especially in fair-skinned individuals.
    • The risk of gastrointestinal side effects of doxycycline can be minimized by taking it with food and plenty of fluids.
    • Pregnant or breastfeeding women, and children under 8 years old, should avoid taking doxycycline as a malaria prophylaxis.
    • To reduce the risk for esophagitis, doxycycline should be taken with a full glass of water and while standing or sitting upright.
    • Doxycycline is associated with an increased frequency of vaginal yeast infections.
    • To minimize the risk of photosensitivity caused by doxycycline, wear protective clothing, use sunscreen, and avoid prolonged exposure to direct sunlight.

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    Description

    This quiz covers the usage of chloroquine phosphate and hydroxychloroquine sulfate (Plaquenil) for preventing malaria in non-chloroquine-resistant areas. It includes information on when to start prophylaxis and the dosing schedule during travel to malaria-endemic regions.

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