16 Questions
What is the recommended timing for starting malaria prophylaxis with chloroquine or hydroxychloroquine?
1-2 weeks before travel
Which of the following is a reported side effect of chloroquine and hydroxychloroquine?
Dizziness
When should travelers stop taking chloroquine or hydroxychloroquine after leaving malaria-endemic areas?
4 weeks after leaving
What is a serious side effect associated with high doses of chloroquine?
Retinopathy
What is one way to potentially improve tolerance of chloroquine for individuals experiencing uncomfortable side effects?
Take it with meals
In what condition can chloroquine and related compounds reportedly exacerbate?
Psoriasis
What is the recommended timing for starting doxycycline prophylaxis before travel to malaria-endemic areas?
1-2 days before travel
How often should doxycycline be taken during travel in malaria-endemic areas?
Once a day
What should people on a long-term regimen of minocycline do if they need malaria prophylaxis?
Stop taking minocycline 1-2 days before travel and start doxycycline
What is a potential side effect of doxycycline related to sun exposure?
Increased risk of sunburn
How can the risk of gastrointestinal side effects of doxycycline be minimized?
Taking the drug with a meal
Who should avoid taking doxycycline as a malaria prophylaxis?
Pregnant individuals
What is advised to reduce the risk for esophagitis when taking doxycycline?
Swallowing the medicine with sufficient fluids
Which medication is associated with an increased frequency of vaginal yeast infections?
Doxycycline
What should be done if someone on a long-term regimen of minocycline needs malaria prophylaxis?
Stop taking minocycline 1-2 days before travel and start doxycycline instead
What should be done to minimize the risk of photosensitivity caused by doxycycline?
Avoiding prolonged, direct exposure to the sun and using sunscreen
Study Notes
Malaria Prophylaxis with Chloroquine and Hydroxychloroquine
- Prophylaxis with chloroquine or hydroxychloroquine should be started 1-2 weeks before traveling to malaria-endemic areas.
- Reported side effects of chloroquine and hydroxychloroquine include gastrointestinal disturbances, headaches, and dizziness.
- Travelers should stop taking chloroquine or hydroxychloroquine 4 weeks after leaving malaria-endemic areas.
- High doses of chloroquine can cause a serious side effect: retinopathy.
- Taking chloroquine with food can potentially improve tolerance for individuals experiencing uncomfortable side effects.
- Chloroquine and related compounds can exacerbate psoriasis.
Malaria Prophylaxis with Doxycycline
- Prophylaxis with doxycycline should be started 1-2 days before traveling to malaria-endemic areas.
- Doxycycline should be taken daily during travel in malaria-endemic areas.
- People on a long-term regimen of minocycline who need malaria prophylaxis should stop taking minocycline and start taking doxycycline instead.
- Doxycycline can cause photosensitivity, especially in fair-skinned individuals.
- The risk of gastrointestinal side effects of doxycycline can be minimized by taking it with food and plenty of fluids.
- Pregnant or breastfeeding women, and children under 8 years old, should avoid taking doxycycline as a malaria prophylaxis.
- To reduce the risk for esophagitis, doxycycline should be taken with a full glass of water and while standing or sitting upright.
- Doxycycline is associated with an increased frequency of vaginal yeast infections.
- To minimize the risk of photosensitivity caused by doxycycline, wear protective clothing, use sunscreen, and avoid prolonged exposure to direct sunlight.
This quiz covers the usage of chloroquine phosphate and hydroxychloroquine sulfate (Plaquenil) for preventing malaria in non-chloroquine-resistant areas. It includes information on when to start prophylaxis and the dosing schedule during travel to malaria-endemic regions.
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