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What is the classification of Hydralazine?
What is the classification of Hydralazine?
- Diuretic
- Antibiotic
- Anti-hypertensive (correct)
- Analgesic
What are the alternative names for Hydralazine?
What are the alternative names for Hydralazine?
- Apresoline
- Novo-Hylazin
- Both A and B (correct)
- None of the above
What are the indications for using Hydralazine?
What are the indications for using Hydralazine?
To reduce blood pressure in hypertensive crisis and pre-eclampsia.
What is the mechanism of action (MOA) of Hydralazine?
What is the mechanism of action (MOA) of Hydralazine?
Which of the following are contraindications for Hydralazine?
Which of the following are contraindications for Hydralazine?
What are common interactions with Hydralazine?
What are common interactions with Hydralazine?
What are the adverse effects of Hydralazine?
What are the adverse effects of Hydralazine?
The adult dose of Hydralazine is _____ mg IM or IV.
The adult dose of Hydralazine is _____ mg IM or IV.
For pediatric patients, the dose of Hydralazine is _____ mg/kg/dose.
For pediatric patients, the dose of Hydralazine is _____ mg/kg/dose.
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Study Notes
Hydralazine Overview
- Hydralazine is classified as an anti-hypertensive medication.
- Common brand names include Apresoline and Novo-Hylazin.
Indications
- Primarily used to reduce blood pressure during hypertensive crises and in cases of pre-eclampsia.
Mechanism of Action
- Functions by directly causing vasodilation of vascular smooth muscle.
- Results in reduced preload and increased cardiac output, enhancing renal and cerebral blood flow.
Contraindications
- Not recommended for patients with coronary artery disease, myocardial infarction (MI), tachycardia, systemic lupus erythematosus (SLE), or mitral valvular rheumatic heart disease.
Drug Interactions
- May interact with beta-blockers and other anti-hypertensive medications, necessitating cautious co-administration.
Adverse Effects
- Potential side effects include tachycardia, palpitations, and angina.
Dosage Guidelines
- Adult Dose: Administer 10-40 mg IM or IV slowly (over 1-2 minutes); repeat in 10 minutes as needed. Infusion can be set at 20 mg in 250 ml normal saline, titrated at 5-20 mg/hr based on effect.
- Pediatric Dose: Use 0.1 - 0.2 mg/kg per dose every 4-6 hours IM or IV, with repeat doses as needed. Maximum allowable dosage is 20 mg per day, up to 0.75 - 3.0 mg/kg every 6-12 hours.
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