Lecture 21E
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Questions and Answers

What is the primary function of B cells in humoral immunity?

  • Produce antibodies that bind to antigens (correct)
  • Assist in phagocytosis
  • Directly attack pathogens
  • Activate T cells

    • Where do B cells undergo development?

  • Lymph nodes
  • Spleen
  • Bone marrow (correct)
  • Thymus

    • What happens to B cells that react to self-antigens?

  • Multiply rapidly
  • Transform into memory cells
  • Undergo apoptosis (correct)
  • Produce antibodies

    • Which class of immunoglobulins is responsible for immediate hypersensitivity reactions?

    <p>IgE</p> Signup and view all the answers

    What is the function of memory antibodies?

    <p>Provide long-term protection</p> Signup and view all the answers

    How do genetic recombination and somatic hypermutation contribute to humoral immunity?

    <p>Generate diverse antibody genes to recognize antigens</p> Signup and view all the answers

    Which blood group has the most abundant antibodies in the ABO blood group system?

    <p>Group AB</p> Signup and view all the answers

    What is the primary function of plasma cells in humoral immunity?

    <p>Secrete antibodies at a high rate</p> Signup and view all the answers

    What determines the action of immunoglobulins in humoral immunity?

    <p>Constant region</p> Signup and view all the answers

    Which type of immunity involves B cells producing antibodies that tag antigens for destruction?

    <p>Humoral immunity</p> Signup and view all the answers

    What is the fate of B cells that react to self-antigens in the body?

    <p>They undergo apoptosis</p> Signup and view all the answers

    Which region of immunoglobulins is responsible for being antigen-specific?

    <p>Variable region</p> Signup and view all the answers

    In humoral immunity, what is the function of memory antibodies?

    <p>Produce antibodies in case of future exposure</p> Signup and view all the answers

    What is the process through which genetic recombination produces different antibody genes in B cells?

    <p>Somatic recombination</p> Signup and view all the answers

    Which class of immunoglobulins is primarily responsible for immediate hypersensitivity reactions?

    <p>IgE</p> Signup and view all the answers

    What is the primary function of plasma cells in humoral immunity?

    <p>Secrete antibodies to mark antigens for destruction</p> Signup and view all the answers

    How do self-tolerant B cells differ from other B cells during development?

    <p>They undergo apoptosis if they react to self-antigens</p> Signup and view all the answers

    What is the main characteristic of immunoglobulins within the same class?

    <p>They have identical variable regions.</p> Signup and view all the answers

    What is the function of antibodies produced by B cells in humoral immunity?

    <p>Tag antigens for destruction by other means</p> Signup and view all the answers

    What is the role of plasma cells in humoral immunity?

    <p>Produce antibodies at a rapid rate to combat infections</p> Signup and view all the answers

    How do self-tolerant B cells differ from other B cells during development?

    <p>They undergo apoptosis if they react to self-antigens</p> Signup and view all the answers

    Which process leads to the production of endless combinations of antibody genes in B cells?

    <p>Somatic recombination</p> Signup and view all the answers

    In humoral immunity, what is the primary function of immunoglobulins?

    <p>Bind to specific antigens for immune recognition</p> Signup and view all the answers

    Which class of immunoglobulins is found in blood plasma, tissue fluids, and secretions?

    <p>IgA</p> Signup and view all the answers

    What is the primary role of memory antibodies in the immune system?

    <p>Provide immediate protection upon re-exposure to antigens</p> Signup and view all the answers

    How do genetic recombination and somatic hypermutation contribute to antibody diversity in B cells?

    <p>Generate numerous variations in antibody genes for immune response</p> Signup and view all the answers

    What is the main characteristic of the constant region of immunoglobulins within the same class?

    <p>It remains constant within each class of immunoglobulins.</p> Signup and view all the answers

    What is the main role of B cells in humoral immunity?

    <p>Producing antibodies</p> Signup and view all the answers

    Which process leads to the formation of immunocompetent clones in B cells?

    <p>Genetic recombination</p> Signup and view all the answers

    What is the primary function of plasma cells in humoral immunity?

    <p>Producing antibodies</p> Signup and view all the answers

    What is a characteristic of the variable region of immunoglobulins?

    <p>It is responsible for being antigen-specific</p> Signup and view all the answers

    What is the primary responsibility of memory antibodies in the immune system?

    <p>Mounting a faster and stronger response upon re-exposure to the same antigen</p> Signup and view all the answers

    What happens to B cells that react to self-antigens during development?

    <p>They undergo apoptosis</p> Signup and view all the answers

    Which class of immunoglobulins is responsible for immediate hypersensitivity reactions?

    <p>IgE</p> Signup and view all the answers

    B cells produce antibodies that bind to antigens and tag them for destruction by other means. B Lymphocytes (B Cells) develop in the ________.

    <p>bone marrow</p> Signup and view all the answers

    Plasma cells are larger, have more RER, and live 4-5 days. They secrete 2,000 molecules/sec as part of B Cell ________.

    <p>activation</p> Signup and view all the answers

    Immunoglobulins, also known as Igs, are Y-shaped molecules with variable and constant regions. The variable region is ________ specific.

    <p>antigen</p> Signup and view all the answers

    Genetic recombination in B cells produces endless combinations of antibody genes through a process called ________ recombination.

    <p>somatic</p> Signup and view all the answers

    Antibodies are responsible for Type I natural passive immunity to the newborn via ________ milk.

    <p>breast</p> Signup and view all the answers

    The Rh mother and fetus may experience incompatibilities due to antibodies in the ________ blood system.

    <p>ABO</p> Signup and view all the answers

    Hemolytic disease of the newborn is primarily caused by antibodies in the ________ system.

    <p>ABO</p> Signup and view all the answers

    Memory antibodies play a crucial role in forming the ________ immune response.

    <p>primary</p> Signup and view all the answers

    B cells that react to self-antigens undergo apoptosis during a process known as B cell ________.

    <p>selection</p> Signup and view all the answers

    B cells produce antibodies that bind to antigens and tag them for destruction by other means. B Lymphocytes (B Cells) develop in the ________

    <p>bone marrow</p> Signup and view all the answers

    Plasma cells are larger, have more RER, and live 4-5 days. They secrete 2,000 molecules/sec as part of B Cell ________

    <p>activation</p> Signup and view all the answers

    Antibodies are responsible for Type I natural passive immunity to the newborn via ________ milk

    <p>breast</p> Signup and view all the answers

    Genetic recombination in B cells produces endless combinations of antibody genes through a process called ________ recombination

    <p>somatic</p> Signup and view all the answers

    Memory antibodies play a crucial role in forming the ________ immune response

    <p>secondary</p> Signup and view all the answers

    The Rh mother and fetus may experience incompatibilities due to antibodies in the ________ blood system

    <p>blood</p> Signup and view all the answers

    Hemolytic disease of the newborn is primarily caused by antibodies in the ________ system

    <p>ABO</p> Signup and view all the answers

    B cells that react to self-antigens undergo apoptosis during a process known as B cell ________

    <p>selection</p> Signup and view all the answers

    B cells in the lymph nodules undergo ________ hypermutation

    <p>somatic</p> Signup and view all the answers

    Plasma cells secrete 1,000 molecules/sec as part of B Cell Activation.

    <p>False</p> Signup and view all the answers

    Memory antibodies play a minimal role in forming the primary immune response.

    <p>False</p> Signup and view all the answers

    B cells that react to self-antigens do not undergo apoptosis during development.

    <p>False</p> Signup and view all the answers

    Immunoglobulins have a constant region that varies within each class.

    <p>False</p> Signup and view all the answers

    Antibodies responsible for Type I natural passive immunity are transferred to the newborn via formula milk.

    <p>False</p> Signup and view all the answers

    Somatic recombination is the process that produces endless combinations of antibody genes in B cells.

    <p>True</p> Signup and view all the answers

    Genetic recombination in B cells does not contribute to antibody diversity.

    <p>False</p> Signup and view all the answers

    Hemolytic disease of the newborn is mainly caused by antibodies in the ABO blood group system.

    <p>False</p> Signup and view all the answers

    Self-tolerant B cells divide slowly and do not produce immunocompetent clones.

    <p>False</p> Signup and view all the answers

    Plasma cells secreting 2,000 molecules/sec as part of B Cell Activation live for 7-8 days.

    <p>False</p> Signup and view all the answers

    Antibodies produced by B cells in humoral immunity bind to antigens and protect the body by directly destroying pathogens.

    <p>False</p> Signup and view all the answers

    Memory antibodies have a minimal role in forming the primary immune response.

    <p>False</p> Signup and view all the answers

    Self-tolerant B cells divide rapidly and produce immunocompetent clones.

    <p>True</p> Signup and view all the answers

    Antibodies are primarily responsible for immediate hypersensitivity reactions.

    <p>False</p> Signup and view all the answers

    The main role of plasma cells in humoral immunity is to produce genetic recombination.

    <p>False</p> Signup and view all the answers

    B Lymphocytes (B Cells) do not develop in the bone marrow.

    <p>False</p> Signup and view all the answers

    Genetic recombination in B cells leads to a limited number of combinations of antibody genes.

    <p>False</p> Signup and view all the answers

    Immunoglobulins have a constant region that varies within each class and determines their action.

    <p>False</p> Signup and view all the answers

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