Lecture 21E

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What is the primary function of B cells in humoral immunity?

Produce antibodies that bind to antigens

Where do B cells undergo development?

Bone marrow

What happens to B cells that react to self-antigens?

Undergo apoptosis

Which class of immunoglobulins is responsible for immediate hypersensitivity reactions?

IgE

What is the function of memory antibodies?

Provide long-term protection

How do genetic recombination and somatic hypermutation contribute to humoral immunity?

Generate diverse antibody genes to recognize antigens

Which blood group has the most abundant antibodies in the ABO blood group system?

Group AB

What is the primary function of plasma cells in humoral immunity?

Secrete antibodies at a high rate

What determines the action of immunoglobulins in humoral immunity?

Constant region

Which type of immunity involves B cells producing antibodies that tag antigens for destruction?

Humoral immunity

What is the fate of B cells that react to self-antigens in the body?

They undergo apoptosis

Which region of immunoglobulins is responsible for being antigen-specific?

Variable region

In humoral immunity, what is the function of memory antibodies?

Produce antibodies in case of future exposure

What is the process through which genetic recombination produces different antibody genes in B cells?

Somatic recombination

Which class of immunoglobulins is primarily responsible for immediate hypersensitivity reactions?

IgE

What is the primary function of plasma cells in humoral immunity?

Secrete antibodies to mark antigens for destruction

How do self-tolerant B cells differ from other B cells during development?

They undergo apoptosis if they react to self-antigens

What is the main characteristic of immunoglobulins within the same class?

They have identical variable regions.

What is the function of antibodies produced by B cells in humoral immunity?

Tag antigens for destruction by other means

What is the role of plasma cells in humoral immunity?

Produce antibodies at a rapid rate to combat infections

How do self-tolerant B cells differ from other B cells during development?

They undergo apoptosis if they react to self-antigens

Which process leads to the production of endless combinations of antibody genes in B cells?

Somatic recombination

In humoral immunity, what is the primary function of immunoglobulins?

Bind to specific antigens for immune recognition

Which class of immunoglobulins is found in blood plasma, tissue fluids, and secretions?

IgA

What is the primary role of memory antibodies in the immune system?

Provide immediate protection upon re-exposure to antigens

How do genetic recombination and somatic hypermutation contribute to antibody diversity in B cells?

Generate numerous variations in antibody genes for immune response

What is the main characteristic of the constant region of immunoglobulins within the same class?

It remains constant within each class of immunoglobulins.

What is the main role of B cells in humoral immunity?

Producing antibodies

Which process leads to the formation of immunocompetent clones in B cells?

Genetic recombination

What is the primary function of plasma cells in humoral immunity?

Producing antibodies

What is a characteristic of the variable region of immunoglobulins?

It is responsible for being antigen-specific

What is the primary responsibility of memory antibodies in the immune system?

Mounting a faster and stronger response upon re-exposure to the same antigen

What happens to B cells that react to self-antigens during development?

They undergo apoptosis

Which class of immunoglobulins is responsible for immediate hypersensitivity reactions?

IgE

B cells produce antibodies that bind to antigens and tag them for destruction by other means. B Lymphocytes (B Cells) develop in the ________.

bone marrow

Plasma cells are larger, have more RER, and live 4-5 days. They secrete 2,000 molecules/sec as part of B Cell ________.

activation

Immunoglobulins, also known as Igs, are Y-shaped molecules with variable and constant regions. The variable region is ________ specific.

antigen

Genetic recombination in B cells produces endless combinations of antibody genes through a process called ________ recombination.

somatic

Antibodies are responsible for Type I natural passive immunity to the newborn via ________ milk.

breast

The Rh mother and fetus may experience incompatibilities due to antibodies in the ________ blood system.

ABO

Hemolytic disease of the newborn is primarily caused by antibodies in the ________ system.

ABO

Memory antibodies play a crucial role in forming the ________ immune response.

primary

B cells that react to self-antigens undergo apoptosis during a process known as B cell ________.

selection

B cells produce antibodies that bind to antigens and tag them for destruction by other means. B Lymphocytes (B Cells) develop in the ________

bone marrow

Plasma cells are larger, have more RER, and live 4-5 days. They secrete 2,000 molecules/sec as part of B Cell ________

activation

Antibodies are responsible for Type I natural passive immunity to the newborn via ________ milk

breast

Genetic recombination in B cells produces endless combinations of antibody genes through a process called ________ recombination

somatic

Memory antibodies play a crucial role in forming the ________ immune response

secondary

The Rh mother and fetus may experience incompatibilities due to antibodies in the ________ blood system

blood

Hemolytic disease of the newborn is primarily caused by antibodies in the ________ system

ABO

B cells that react to self-antigens undergo apoptosis during a process known as B cell ________

selection

B cells in the lymph nodules undergo ________ hypermutation

somatic

Plasma cells secrete 1,000 molecules/sec as part of B Cell Activation.

False

Memory antibodies play a minimal role in forming the primary immune response.

False

B cells that react to self-antigens do not undergo apoptosis during development.

False

Immunoglobulins have a constant region that varies within each class.

False

Antibodies responsible for Type I natural passive immunity are transferred to the newborn via formula milk.

False

Somatic recombination is the process that produces endless combinations of antibody genes in B cells.

True

Genetic recombination in B cells does not contribute to antibody diversity.

False

Hemolytic disease of the newborn is mainly caused by antibodies in the ABO blood group system.

False

Self-tolerant B cells divide slowly and do not produce immunocompetent clones.

False

Plasma cells secreting 2,000 molecules/sec as part of B Cell Activation live for 7-8 days.

False

Antibodies produced by B cells in humoral immunity bind to antigens and protect the body by directly destroying pathogens.

False

Memory antibodies have a minimal role in forming the primary immune response.

False

Self-tolerant B cells divide rapidly and produce immunocompetent clones.

True

Antibodies are primarily responsible for immediate hypersensitivity reactions.

False

The main role of plasma cells in humoral immunity is to produce genetic recombination.

False

B Lymphocytes (B Cells) do not develop in the bone marrow.

False

Genetic recombination in B cells leads to a limited number of combinations of antibody genes.

False

Immunoglobulins have a constant region that varies within each class and determines their action.

False

This quiz covers the basics of humoral immunity, focusing on how B cells produce antibodies to target antigens for destruction. Topics include B cell development in the bone marrow and the selection process for self-tolerant B cells. Test your knowledge on this indirect defense mechanism!

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