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Questions and Answers
Where do B cells primarily reside after maturation?
Where do B cells primarily reside after maturation?
- Thymus
- Liver
- Bone marrow
- Lymph nodes and spleen (correct)
What is the primary function of B cells?
What is the primary function of B cells?
- Directly killing infected cells
- Activating T cells
- Regulating inflammatory responses
- Producing antibodies against foreign antigens (correct)
Which type of immune response is mainly mediated by B cells?
Which type of immune response is mainly mediated by B cells?
- Humoral (correct)
- Cell-mediated
- Autoimmune
- Innate
What is typically required for an antibody response by B cells?
What is typically required for an antibody response by B cells?
What process does the activation of B cells by foreign antigens primarily lead to?
What process does the activation of B cells by foreign antigens primarily lead to?
What is the main role of memory B cells?
What is the main role of memory B cells?
Where on the cell membrane do memory B cells continue to display antigen-binding antibodies?
Where on the cell membrane do memory B cells continue to display antigen-binding antibodies?
What is the function of plasma cells?
What is the function of plasma cells?
What unique property do the antibodies secreted by plasma cells possess?
What unique property do the antibodies secreted by plasma cells possess?
What determines the specific antigen that an antibody will bind to?
What determines the specific antigen that an antibody will bind to?
What is the term for when antibodies bind to antigens, marking them for destruction?
What is the term for when antibodies bind to antigens, marking them for destruction?
What is the outcome of antibodies binding to antigens?
What is the outcome of antibodies binding to antigens?
Which of the following is a mechanism by which antibodies act?
Which of the following is a mechanism by which antibodies act?
What is a characteristic of plasma cells?
What is a characteristic of plasma cells?
What ultimately happens to plasma cells after a foreign agent has been destroyed?
What ultimately happens to plasma cells after a foreign agent has been destroyed?
How do B cells recognize antigens differently from T cells?
How do B cells recognize antigens differently from T cells?
What is the primary characteristic of the secondary immune response mediated by memory B cells, compared to the primary response?
What is the primary characteristic of the secondary immune response mediated by memory B cells, compared to the primary response?
Which of the following best describes the actions of antibodies in neutralization?
Which of the following best describes the actions of antibodies in neutralization?
What event is initiated when antibodies activate the complement system?
What event is initiated when antibodies activate the complement system?
How do antibodies contribute to the process of immobilization of antigens?
How do antibodies contribute to the process of immobilization of antigens?
Flashcards
B Cell Development
B Cell Development
B cells develop in bone marrow and after maturation, they reside in the lymph nodes and spleen.
B Cell Antigen Recognition
B Cell Antigen Recognition
B cells recognize antigens directly, unlike T cells which require Antigen Presenting Cells.
B Cell Main Function
B Cell Main Function
The main function of B cells is to produce antibodies against foreign antigens.
B Cell Role in Immune Response
B Cell Role in Immune Response
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B Cell Activation
B Cell Activation
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Memory B Cells
Memory B Cells
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B Cell Secondary Response
B Cell Secondary Response
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Plasma Cells
Plasma Cells
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Antibody Circulation
Antibody Circulation
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Antibody Action
Antibody Action
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Antibody Mechanisms
Antibody Mechanisms
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Plasma Cell Lifespan
Plasma Cell Lifespan
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Plasma Cell Fate
Plasma Cell Fate
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Study Notes
- B cells mature and reside in lymph nodes and the spleen after developing in bone marrow.
- B cells directly recognize free antigens, unlike T cells which require antigen-presenting cells.
- B cells produce antibodies against foreign antigens.
- The major role is in the humoral/antibody-mediated immune response.
- Antibody response depends on T-cell help
- Foreign antigens activate B cells, leading to proliferation and differentiation into plasma cells or memory B cells.
- Memory cells are survivors of previous infections.
- Memory cells remain long-term:
- Memory cells continue to express unique antigen-binding receptors at the tips of the antibody on their cell membrane.
- Memory cells are involved with the secondary immune response.
- Memory cells respond to re-exposure of specific antigens to eliminate them.
- Plasma cells or effector cells secrete millions of antibodies.
- Antibodies have unique antigen-binding properties like receptor molecules on the original B cell's surface.
- Antibodies bind to the antigen that originally activated the B cell,
- Antibodies circulate in the body humors (blood, bile, or phlegm).
- Antibodies lead to phagocytosis of the antigen through:
- Agglutination
- Neutralization
- Immobilization
- Activation of the complement system.
- Plasma cells are generally short-lived and do not express antigen-binding receptors.
- Plasma cells undergo apoptosis, or cell death, once the foreign agent is destroyed.
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