Human Physiology: Respiratory and Renin-Angiotensin Systems
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Questions and Answers

What provides an extensive area for gas exchange between air and circulating blood?

  • The trachea
  • The diaphragm
  • The lungs (correct)
  • The alveoli
  • What are the two main functions of the respiratory system?

  • Moving air to and from the exchange surfaces of the lung and protecting respiratory surfaces from dehydration, temperature changes, or other environmental variations
  • Maintaining oxygen levels in the blood and removing carbon dioxide from the body
  • Providing olfactory sensations to the CNS and producing chemical mediators
  • All of the above (correct)
  • The larynx is also known as the voice box.

    True (A)

    What is the structure that prevents food from entering the trachea during swallowing?

    <p>Epiglottis</p> Signup and view all the answers

    What is the primary function of the alveoli?

    <p>To exchange gases between the air and the blood (C)</p> Signup and view all the answers

    What is the name of the thin membrane that separates the alveoli from the capillaries?

    <p>Respiratory membrane</p> Signup and view all the answers

    What are the two types of cells found in the alveoli?

    <p>Type I and Type II (D)</p> Signup and view all the answers

    What is the name of the process by which oxygen and carbon dioxide are exchanged between the atmosphere and body cells?

    <p>Respiration</p> Signup and view all the answers

    What are the three distinct phases of respiration?

    <p>Pulmonary ventilation, external respiration, and internal respiration (A)</p> Signup and view all the answers

    What is Boyle's Law?

    <p>Pressure (P) x Volume (V) = 1</p> Signup and view all the answers

    What is the function of the diaphragm during inspiration?

    <p>It contracts and moves downward, increasing the volume of the thoracic cavity (D)</p> Signup and view all the answers

    The diaphragm is a dome-shaped muscle. The diaphragm is the primary muscle of respiration.

    <p>True (A)</p> Signup and view all the answers

    What is the name of the volume of air that is inhaled or exhaled in one breath?

    <p>Tidal volume (B)</p> Signup and view all the answers

    Which of the following is NOT a function of the nervous system in the control of respiration?

    <p>To create the surfactant that keeps the alveoli from collapsing (C)</p> Signup and view all the answers

    Which of the following is located in the pons?

    <p>Both B and C (B)</p> Signup and view all the answers

    What is the name of the reflex that triggers expiration when the lungs are stretched to their physical limit?

    <p>Inflation (Hering-Breuer) reflex</p> Signup and view all the answers

    What is the primary function of the central chemoreceptors?

    <p>All of the above (D)</p> Signup and view all the answers

    Where are the peripheral chemoreceptors located?

    <p>In the aortic bodies in the wall of the aortic arch and in the carotid bodies in the walls of the carotid arteries</p> Signup and view all the answers

    The higher the partial pressure of oxygen in the blood, the higher the percentage of hemoglobin saturation.

    <p>True (A)</p> Signup and view all the answers

    An increase in temperature increases the affinity of hemoglobin for oxygen.

    <p>False (B)</p> Signup and view all the answers

    What is the name of the molecule that is formed in red blood cells when glucose is catabolized to ATP?

    <p>2,3-bisphosphoglycerate (2,3-BPG)</p> Signup and view all the answers

    What is the primary way that oxygen is transported in the blood?

    <p>Bound to hemoglobin in red blood cells (A)</p> Signup and view all the answers

    What is the primary way that carbon dioxide is transported in the blood?

    <p>All of the above (D)</p> Signup and view all the answers

    The oxygen-hemoglobin dissociation curve shows the relationship between the partial pressure of oxygen and the percentage of hemoglobin saturation.

    <p>True (A)</p> Signup and view all the answers

    Study Notes

    Respiratory System Functions

    • Provides extensive area for gas exchange between air and blood.
    • Moves air to and from lung exchange surfaces.
    • Protects respiratory surfaces from environmental variations (dehydration, temperature).
    • Defends respiratory system and other tissues from pathogen invasion.

    Non-Respiratory Functions

    • Regulates blood pH by altering carbon dioxide levels.
    • Produces sounds for communication (speaking, singing).
    • Provides olfactory sensations to the central nervous system (CNS).
    • Produces chemical mediators (HSC 113).

    Renin-Angiotensin-Aldosterone System (RAAS)

    • Regulates blood pressure and fluid balance.
    • Activated when blood volume or sodium levels are low, or potassium is high.
    • Kidney releases renin, which converts angiotensinogen to angiotensin I.
    • Angiotensin I is converted to angiotensin II in the lungs by ACE.
    • Angiotensin II constricts blood vessels and increases blood pressure.
    • It also stimulates aldosterone release from adrenal glands.
    • Aldosterone promotes sodium and water retention and potassium excretion.
    • Overactive system leads to high blood pressure.

    Anatomy of the Respiratory System

    • Structurally: Upper and Lower Respiratory Tract.
    • Functionally: Conducting zone (carries gases) and Respiratory zone (exchange of gases).
    • Organs: Nose, Pharynx, Larynx, Trachea, Bronchi, Bronchioles, Lungs, Intercostal muscles, diaphragm.

    Egyptian Hieroglyphs of the Respiratory System

    • Depictions dating back to the 30th century BC show understanding of pulmonary anatomy, including trachea, bronchi, and lungs.
    • Different depictions from various dynasties are documented.

    Upper Respiratory Tract

    • Nose and Nasal Cavity: Includes vestibule, conchae and olfactory region.
    • Pharynx: Divided into nasopharynx (air passages), oropharynx (food and air), and laryngopharynx (food and air).
    • Contains lymphatic tissue, eustachian tubes, and tonsils.
    • Nasopharynx
      • Contains lymphatic tissue and eustachian tubes.
    • Oropharynx
      • Contains tonsils and passage for food and air.
    • Laryngopharynx
      • Part of both respiratory and digestive systems.

    Larynx (Voice Box)

    • A semi-rigid structure made of cartilage.
    • Cartilages and muscles control vocal cord movement for speech.

    Thyroid and Cricoid Cartilage

    • Provide structural support to airways to prevent collapse.
    • Epiglottis is a leaf-shaped cartilage that covers the larynx during swallowing.
    • Glottis is the opening that leads to the larynx.
    • Vocal cords are involved in sound production.

    Adam's Apple

    • Notch at top of thyroid cartilage, more prominent in men due to puberty.
    • Related to larynx enlargement.

    Internal Laryngeal Structure

    • Detailed description of internal structures of the larynx.

    Lower Respiratory Tract

    • Trachea: Tubular structure with cartilaginous rings to prevent collapse.
    • Primary Bronchi: Divides into right and left bronchi, one for each lung, further branching into secondary and tertiary bronchi, bronchioles.
    • Structure
      • Fibrous and elastic outer layer.
      • Cartilage and smooth muscles in the middle layer.
      • Ciliated epithelium and mucus secretion in the innermost lining.
      • Nerve endings present.
    • Function
      • Prevents kinks and obstructions as head and neck move.
      • Allows changing shape due to food bolus (swallowing).
      • Mucus traps inhaled debris.
      • Cilia move mucus towards the pharynx.
    • Bronchial Tree (Trachea and Bronchi Structures):
      • Bronchi branch into smaller structures called bronchioles, ending up with alveoli.
      • Cartilage decreases and smooth muscle increases in smaller bronchioles.
      • Alveoli are the site of gas exchange.
    • Lungs: The lungs have right and left lobes, with fissures separating the lobes.
    • Alveoli:
      • Tiny air sacs (about 150 million in adults) in lungs.
      • Lined by simple squamous epithelium for gas exchange.
      • Type I cells perform gas exchange and Type II cells produce surfactant (reduces surface tension)
    • Large surface area facilitates gas exchange.

    Alveoli Adaptations for Gas Exchange

    • Thin walls for efficient diffusion.
    • Surfactant reduces surface tension to prevent collapse.
    • Rich capillary network for rapid gas exchange.

    Accessory Muscles of Respiration

    • Muscles that aid in breathing, such as sternomastoids, scalenes, intercostals, and abdominal muscles.

    Physiology of the Respiratory System

    • Pulmonary Ventilation: Breathing (inhalation and exhalation).
    • External Respiration: Gas exchange between alveoli and pulmonary capillaries (O2 in, CO2 out).
    • Internal Respiration: Gas exchange between systemic capillaries and tissues (O2 out, CO2 in).

    Respiratory Mechanics

    • Important factors in breathing, such as Boyle's Law and pressures related to the lungs and chest cavity.

    Pressures During Inspiration and Expiration

    • Details on pressures involved in inhalation and exhalation, like atmospheric pressure, intra-alveolar pressure, and intrapleural pressure.

    Mechanism of Breathing

    • Processes of inhalation (diaphragm contracts) and exhalation (diaphragm relaxes).

    Lung Volumes and Lung Capacities

    • Measurement and definition of different lung volumes and capacities (eg. tidal volume, inspiratory reserve volume).

    Control of Respiration

    • The nervous system and chemical factors regulate respiration.
    • Nervous control: Centers in the brain stem (medulla and pons) send signals to breathing muscles.
    • Central chemoreceptors detect changes in pH of cerebrospinal fluid.
    • Peripheral chemoreceptors (aortic and carotid bodies) monitor blood gases (pO2 and pCO2)
    • Stretch receptors, located in the airways, respond to lung inflation and signal the brain to stop or slow deeper inspiration. (Hering-Breuer reflex).

    Transport of Gases

    • Oxygen transport in blood: bound to hemoglobin (98.5%) or dissolved in plasma (1.5%).
    • Carbon dioxide transport in blood: bicarbonate ions (70%), carbaminohemoglobin (23%), dissolved in plasma (7%).

    Oxygen-Hemoglobin Dissociation Curve

    • Relationship between oxygen partial pressure and hemoglobin saturation.
    • Factors that affect this curve: pH (acidity), temperature, and partial pressure of CO2.

    Factors Affecting Oxygen-Hemoglobin Dissociation Curve

    • Explains how factors like partial pressure of oxygen (pO2), carbon dioxide (pCO2), acidity (pH), and temperature affect the binding of oxygen to hemoglobin

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    Description

    Explore the complex functions of the respiratory system, including gas exchange and non-respiratory roles like sound production and blood pH regulation. Delve into the Renin-Angiotensin-Aldosterone System (RAAS) and its critical role in maintaining blood pressure and fluid balance. This quiz covers key physiological concepts essential for understanding human body functions.

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