Podcast
Questions and Answers
What stimulates the conversion of 25-hydroxyvitamin D to its active form?
What stimulates the conversion of 25-hydroxyvitamin D to its active form?
- Parathyroid Hormone (PTH) (correct)
- Insulin
- Calcitonin
- Melatonin
Which organ plays a key role in the reabsorption of calcium?
Which organ plays a key role in the reabsorption of calcium?
- Pancreas
- Intestines
- Kidneys (correct)
- Liver
How does calcitonin impact blood calcium levels?
How does calcitonin impact blood calcium levels?
- Has no effect on blood calcium levels
- Decreases calcium by inhibiting renal excretion
- Reduces calcium by promoting bone deposition (correct)
- Increases calcium by promoting bone resorption
What defines the master clock in the human body?
What defines the master clock in the human body?
What does the term 'zeitgeber' refer to in circadian rhythm regulation?
What does the term 'zeitgeber' refer to in circadian rhythm regulation?
Which structure carries light signals from the retina to the master clock?
Which structure carries light signals from the retina to the master clock?
Which of the following is a physiological consequence of circadian rhythm disruption?
Which of the following is a physiological consequence of circadian rhythm disruption?
What type of light is particularly effective in resetting the circadian clock?
What type of light is particularly effective in resetting the circadian clock?
What is the primary function of the GnRH released by the hypothalamus?
What is the primary function of the GnRH released by the hypothalamus?
During which phase does positive feedback occur in the female reproductive cycle?
During which phase does positive feedback occur in the female reproductive cycle?
What characterizes continuous production in males compared to females?
What characterizes continuous production in males compared to females?
What primarily determines biological sex during embryonic development?
What primarily determines biological sex during embryonic development?
What is a characteristic of the process of oogenesis?
What is a characteristic of the process of oogenesis?
How does androgen insensitivity syndrome (AIS) affect individuals with XY chromosomes?
How does androgen insensitivity syndrome (AIS) affect individuals with XY chromosomes?
What role does FSH play in male reproduction?
What role does FSH play in male reproduction?
Which aspect of gender is distinct from biological sex?
Which aspect of gender is distinct from biological sex?
What is the primary role of calcitonin in calcium homeostasis?
What is the primary role of calcitonin in calcium homeostasis?
Where is the majority of the body's calcium stored?
Where is the majority of the body's calcium stored?
Which of the following actions is directly stimulated by parathyroid hormone (PTH)?
Which of the following actions is directly stimulated by parathyroid hormone (PTH)?
Which of these cells are responsible for the absorption of dietary calcium and phosphate in the small intestine?
Which of these cells are responsible for the absorption of dietary calcium and phosphate in the small intestine?
What is the effect of rising blood calcium levels on PTH secretion?
What is the effect of rising blood calcium levels on PTH secretion?
Which vitamin is synthesized in response to UV light exposure?
Which vitamin is synthesized in response to UV light exposure?
What effect does PTH have on the kidneys regarding calcium handling?
What effect does PTH have on the kidneys regarding calcium handling?
Which of the following is NOT a role of osteoclasts?
Which of the following is NOT a role of osteoclasts?
What is the role of progesterone during the secretory phase of the menstrual cycle?
What is the role of progesterone during the secretory phase of the menstrual cycle?
What is the first stage of parturition?
What is the first stage of parturition?
Which hormone contributes to the amplification of uterine contractions during childbirth?
Which hormone contributes to the amplification of uterine contractions during childbirth?
What is the function of prolactin in lactation?
What is the function of prolactin in lactation?
What hormonal change occurs during menopause?
What hormonal change occurs during menopause?
How does suckling affect ovulation during lactation?
How does suckling affect ovulation during lactation?
What is the significance of the post-reproductive lifespan in evolutionary terms?
What is the significance of the post-reproductive lifespan in evolutionary terms?
Which hormone is primarily responsible for initiating labor?
Which hormone is primarily responsible for initiating labor?
What is the arrangement of pancreatic islets in teleosts compared to mammals?
What is the arrangement of pancreatic islets in teleosts compared to mammals?
What is a key difference in the ratio of A-cells and B-cells in the pancreatic islets of teleosts compared to mammals?
What is a key difference in the ratio of A-cells and B-cells in the pancreatic islets of teleosts compared to mammals?
Which hormone plays a less significant role in carbohydrate metabolism in teleosts compared to mammals?
Which hormone plays a less significant role in carbohydrate metabolism in teleosts compared to mammals?
What can high phosphate levels do to calcium availability in the body?
What can high phosphate levels do to calcium availability in the body?
What are the primary functions of the circadian clock?
What are the primary functions of the circadian clock?
Which of the following hormones is primarily responsible for increasing blood calcium levels?
Which of the following hormones is primarily responsible for increasing blood calcium levels?
How do core clock genes interact within the circadian clock mechanism?
How do core clock genes interact within the circadian clock mechanism?
What is the role of light in circadian regulation for monarch butterflies?
What is the role of light in circadian regulation for monarch butterflies?
What is the primary function of Vitamin D in relation to calcium and phosphate?
What is the primary function of Vitamin D in relation to calcium and phosphate?
What impact has climate change had on bird migration patterns?
What impact has climate change had on bird migration patterns?
How does the exocrine function of the pancreas in teleosts compare to that of mammals?
How does the exocrine function of the pancreas in teleosts compare to that of mammals?
What role does glucagon play in teleosts compared to mammals?
What role does glucagon play in teleosts compared to mammals?
Which of the following statements correctly describes the function of the endocannabinoid system (ECS)?
Which of the following statements correctly describes the function of the endocannabinoid system (ECS)?
Which of the following genes are considered key in the migratory navigation of monarch butterflies?
Which of the following genes are considered key in the migratory navigation of monarch butterflies?
What physiological effect does disruption of environmental cues have on birds?
What physiological effect does disruption of environmental cues have on birds?
Which molecules are involved in the positive feedback loop of the molecular clock?
Which molecules are involved in the positive feedback loop of the molecular clock?
Flashcards
Calcitriol (1,25-dihydroxyvitamin D)
Calcitriol (1,25-dihydroxyvitamin D)
The active form of vitamin D, produced by the kidneys under the influence of PTH, crucial for calcium absorption and bone health.
Calcitonin
Calcitonin
A hormone produced by the thyroid gland that lowers blood calcium levels by promoting calcium deposition in bones and inhibiting calcium absorption.
Parathyroid Hormone (PTH)
Parathyroid Hormone (PTH)
Hormone produced by the parathyroid glands, primarily involved in increasing blood calcium levels by stimulating bone resorption, enhancing calcium reabsorption in the kidneys, and promoting vitamin D activation.
Hypocalcemia
Hypocalcemia
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Hypercalcemia
Hypercalcemia
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Suprachiasmatic Nucleus (SCN)
Suprachiasmatic Nucleus (SCN)
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Retinohypothalamic Tract (RHT)
Retinohypothalamic Tract (RHT)
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Circadian Rhythms
Circadian Rhythms
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What is the Suprachiasmatic Nucleus (SCN)?
What is the Suprachiasmatic Nucleus (SCN)?
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What are Clock Genes?
What are Clock Genes?
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What role do CLOCK and BMAL1 play in the circadian rhythm?
What role do CLOCK and BMAL1 play in the circadian rhythm?
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What is the role of PER and CRY in the circadian rhythm?
What is the role of PER and CRY in the circadian rhythm?
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How does the circadian rhythm influence monarch butterfly migration?
How does the circadian rhythm influence monarch butterfly migration?
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How does light affect the monarch's circadian rhythm?
How does light affect the monarch's circadian rhythm?
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How does climate change impact bird migration?
How does climate change impact bird migration?
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What is the impact of disrupted environmental cues on bird reproduction?
What is the impact of disrupted environmental cues on bird reproduction?
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Hypothalamus (in HPG Axis)
Hypothalamus (in HPG Axis)
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Pituitary Gland (in HPG Axis)
Pituitary Gland (in HPG Axis)
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Gonads (in HPG Axis)
Gonads (in HPG Axis)
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Hormonal Feedback in HPG Axis
Hormonal Feedback in HPG Axis
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Positive Feedback in Female Reproduction
Positive Feedback in Female Reproduction
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Biological Sex
Biological Sex
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Gender
Gender
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Intersex Variations
Intersex Variations
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Secretory Phase
Secretory Phase
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Luteolysis
Luteolysis
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Parturition
Parturition
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Cervical Dilation
Cervical Dilation
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Delivery of Fetus
Delivery of Fetus
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Delivery of Placenta
Delivery of Placenta
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Lactation
Lactation
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Lactational Amenorrhea
Lactational Amenorrhea
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Teleost Pancreas Structure
Teleost Pancreas Structure
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Glucagon Dominance in Teleosts
Glucagon Dominance in Teleosts
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Teleost Brockmann Bodies
Teleost Brockmann Bodies
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Parathyroid Hormone (PTH) Function
Parathyroid Hormone (PTH) Function
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Vitamin D Function
Vitamin D Function
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Calcium and Phosphate Balance
Calcium and Phosphate Balance
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Phosphate and Calcium Interaction
Phosphate and Calcium Interaction
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Hormonal Control of Minerals
Hormonal Control of Minerals
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What is calcitonin?
What is calcitonin?
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How does bone function as a calcium reservoir?
How does bone function as a calcium reservoir?
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What are osteoblasts?
What are osteoblasts?
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What are osteoclasts?
What are osteoclasts?
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What is parathyroid hormone (PTH)?
What is parathyroid hormone (PTH)?
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How do the kidneys help regulate calcium?
How do the kidneys help regulate calcium?
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What is the role of enterocytes in calcium regulation?
What is the role of enterocytes in calcium regulation?
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How is vitamin D involved in calcium regulation?
How is vitamin D involved in calcium regulation?
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Study Notes
Mammalian Reproduction
- The Hypothalamic-Pituitary-Gonadal (HPG) Axis controls pituitary function.
- Hypothalamus releases GnRH, controlling pituitary function.
- Anterior Pituitary releases FSH and LH in response to GnRH.
- Gonads produce hormones:
- Males: Testes produce testosterone (androgens).
- Females: Ovaries produce estrogen and progesterone.
- Hormonal Feedback:
- Negative feedback regulates GnRH, FSH, and LH levels in males and females.
- Positive feedback in females during ovulation: High estrogen stimulates an LH surge, causing ovulation.
- Differences in Males and Females:
- Males: Continuous sperm and testosterone production.
- Females: Cyclic ovarian activity (estrous or menstrual cycles).
Sex vs. Gender
- Biological Sex is defined by physical traits:
- Chromosomal sex (XX or XY).
- Gonadal sex (testes or ovaries).
- Phenotypic sex (external genitalia, secondary sex characteristics).
- Sex determined during embryonic development, by the SRY gene and hormonal signaling.
- Gender is psychological and social identity, not necessarily aligned with biological sex and influenced by societal norms.
- Intersex variations occur when chromosomal, gonadal, or phenotypic sex do not align.
- Examples: Androgen Insensitivity Syndrome (AIS), Congenital Adrenal Hyperplasia (CAH).
Gametogenesis
- Spermatogenesis:
- Location: Seminiferous tubules in the testes.
- Process: Spermatogonia (diploid stem cells) divide mitotically, primary spermatocytes undergo meiosis I, secondary spermatocytes undergo meiosis II, spermatids mature into spermatozoa.
- Oogenesis:
- Location: Ovarian follicles.
- Process: Oogonia divide mitotically during fetal development. Primary oocytes are arrested in prophase I until puberty. During ovulation, meiosis I completes, forming a secondary oocyte (arrested in metaphase II) and a polar body. Meiosis II only completes with fertilization. FSH stimulates follicular growth, and LH triggers ovulation and corpus luteum formation.
Sexual Differentiation
- SRY gene on the Y chromosome encodes Testis-Determining Factor (TDF), which induces Sertoli and Leydig cell differentiation in males.
- Sertoli cells secrete anti-Müllerian hormone (AMH) causing regression of Müllerian ducts.
- Leydig cells produce testosterone, promoting Wolffian duct differentiation.
- In the absence of the SRY gene, gonadal ridge differentiates into ovaries.
- Müllerian ducts persist and develop into the uterus, fallopian tubes, and upper vagina
- Lack of testosterone causes regression of Wolffian ducts.
Reproductive Cycles
- Estrous Cycle (Non-Primate Mammals): Proestrus, Estrus, Metestrus, Diestrus.
- Menstrual Cycle (Primates): Follicular and Luteal phases regulated by estrogen and progesterone.
- Seasonal Breeders: Cycles controlled by photoperiod.
Hormonal Regulation of Reproduction
- FSH and LH stimulate follicular development and ovulation in females.
- Estrogen promotes endometrial regrowth.
- Progesterone maintains the endometrium during the secretory phase, supporting pregnancy.
- Hormones influence the timing of reproductive cycles, like timing of breeding seasons and ovulation
Parturition (Childbirth)
- Stages: Cervical dilation (uterine contractions), Delivery of Fetus (coordinated uterine and abdominal contractions), Delivery of the Placenta (placenta detaches).
- Hormonal control: Estrogen increases uterine sensitivity to oxytocin, prostaglandins amplify contractions, fetal cortisol enhances placental estrogen production.
Lactation
- Pre-pregnancy: Estrogen promotes ductal growth, progesterone influences lobular-alveolar development.
- Prolactin prepares mammary glands for milk synthesis.
- After parturition: Progesterone and estrogen levels fall, enabling prolactin stimulated milk production.
- Oxytocin promotes milk ejection by contracting myoepithelial cells.
- Lactational amenorrhea: Suckling suppresses GnRH, reducing FSH and LH secretion.
Menopause
- Definition: Permanent cessation of menstrual cycles due to ovarian follicle depletion.
- Hormonal changes: Declining estrogen and progesterone, increased FSH and LH.
Other topics
- Feeding and Metabolism: Various non-mammalian feeding strategies (herbivores, carnivores, etc.), adaptations in digestive systems like stomach-less teleosts and pyloric caecae. Non-mammals often rely more on protein catabolism for energy.
- Calcium and Phosphate Homeostasis: Bone health, hormonal regulation of calcium and phosphate (PTH, vitamin D, calcitonin), key cells (osteoblasts, osteoclasts, osteocytes), kidney and intestinal involvement.
- Diabetes: Blood sugar control, type 1 and 2 diabetes, endocrine complications, impact on metabolism, glucosuria.
- Stress Response: Hypothalamic-Pituitary-Adrenal (HPA) axis, acute and chronic stress, effects of stress on hormone regulation.
- Endocrine System: Role of endocrine hormones like ghrelin, leptin, insulin, CCK, PYY, and various other hormones.
- Opioids: Endogenous Opioid system, role in stress response and pain modulation.
- Endocannabinoid System: ECS ligand modulation, stress, and seasonal hormonal cycles.
- Clock Regulation: Circadian rhythms, SCN, light signaling, environmental factors impacting synchronization. This includes reproductive cycles affected by light and temperature.
- Types of Reproduction and Key Differences: Monotremes (oviparous), Marsupials (short gestation), Eutherians (placental).
- Nonmammalian Reproductive Biology: Focusing on specifics from the readings, including examples for the various reproduction types, like amphibians, reptiles, birds, fish, etc., covering reproduction methods (internal vs external, how they reproduce, eggs, etc.). Key difference discussion between tropical and temperate crocodilians (including seasonal reproduction cycles, temperature variation, and egg incubation).
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