Human Physiology Quiz

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Questions and Answers

What stimulates the conversion of 25-hydroxyvitamin D to its active form?

  • Parathyroid Hormone (PTH) (correct)
  • Insulin
  • Calcitonin
  • Melatonin

Which organ plays a key role in the reabsorption of calcium?

  • Pancreas
  • Intestines
  • Kidneys (correct)
  • Liver

How does calcitonin impact blood calcium levels?

  • Has no effect on blood calcium levels
  • Decreases calcium by inhibiting renal excretion
  • Reduces calcium by promoting bone deposition (correct)
  • Increases calcium by promoting bone resorption

What defines the master clock in the human body?

<p>Suprachiasmatic Nucleus (SCN) (B)</p> Signup and view all the answers

What does the term 'zeitgeber' refer to in circadian rhythm regulation?

<p>An environmental cue that synchronizes biological clocks (B)</p> Signup and view all the answers

Which structure carries light signals from the retina to the master clock?

<p>Retinohypothalamic Tract (RHT) (D)</p> Signup and view all the answers

Which of the following is a physiological consequence of circadian rhythm disruption?

<p>Increased risk of metabolic disorders (B)</p> Signup and view all the answers

What type of light is particularly effective in resetting the circadian clock?

<p>Blue Light (C)</p> Signup and view all the answers

What is the primary function of the GnRH released by the hypothalamus?

<p>To regulate the secretion of FSH and LH from the anterior pituitary. (B)</p> Signup and view all the answers

During which phase does positive feedback occur in the female reproductive cycle?

<p>Ovulation (D)</p> Signup and view all the answers

What characterizes continuous production in males compared to females?

<p>Constant production of testosterone and sperm. (C)</p> Signup and view all the answers

What primarily determines biological sex during embryonic development?

<p>The presence of the SRY gene and hormonal signaling. (C)</p> Signup and view all the answers

What is a characteristic of the process of oogenesis?

<p>Oogonia divide mitotically during fetal development. (B)</p> Signup and view all the answers

How does androgen insensitivity syndrome (AIS) affect individuals with XY chromosomes?

<p>They produce testosterone but cannot respond to it effectively. (C)</p> Signup and view all the answers

What role does FSH play in male reproduction?

<p>It supports spermatogenesis by stimulating Sertoli cells. (C)</p> Signup and view all the answers

Which aspect of gender is distinct from biological sex?

<p>Psychological and social identity (A)</p> Signup and view all the answers

What is the primary role of calcitonin in calcium homeostasis?

<p>Lowers blood calcium levels (B)</p> Signup and view all the answers

Where is the majority of the body's calcium stored?

<p>Bones (B)</p> Signup and view all the answers

Which of the following actions is directly stimulated by parathyroid hormone (PTH)?

<p>Stimulated osteoclast activity (A)</p> Signup and view all the answers

Which of these cells are responsible for the absorption of dietary calcium and phosphate in the small intestine?

<p>Enterocytes (D)</p> Signup and view all the answers

What is the effect of rising blood calcium levels on PTH secretion?

<p>Inhibits PTH secretion (B)</p> Signup and view all the answers

Which vitamin is synthesized in response to UV light exposure?

<p>Vitamin D3 (C)</p> Signup and view all the answers

What effect does PTH have on the kidneys regarding calcium handling?

<p>Enhances calcium reabsorption (C)</p> Signup and view all the answers

Which of the following is NOT a role of osteoclasts?

<p>Stimulating osteoblasts (A)</p> Signup and view all the answers

What is the role of progesterone during the secretory phase of the menstrual cycle?

<p>Maintains the endometrium for implantation (B)</p> Signup and view all the answers

What is the first stage of parturition?

<p>Cervical dilation (B)</p> Signup and view all the answers

Which hormone contributes to the amplification of uterine contractions during childbirth?

<p>Prostaglandins (A)</p> Signup and view all the answers

What is the function of prolactin in lactation?

<p>Stimulates milk production in alveolar cells (D)</p> Signup and view all the answers

What hormonal change occurs during menopause?

<p>Decrease in estrogen and progesterone (C)</p> Signup and view all the answers

How does suckling affect ovulation during lactation?

<p>Suppresses GnRH release (A)</p> Signup and view all the answers

What is the significance of the post-reproductive lifespan in evolutionary terms?

<p>Enables greater investment in offspring and grandchildren (B)</p> Signup and view all the answers

Which hormone is primarily responsible for initiating labor?

<p>Cortisol (D)</p> Signup and view all the answers

What is the arrangement of pancreatic islets in teleosts compared to mammals?

<p>Teleosts' islets are termed Brockmann bodies. (A)</p> Signup and view all the answers

What is a key difference in the ratio of A-cells and B-cells in the pancreatic islets of teleosts compared to mammals?

<p>A-cells are more prominent in teleosts due to high-protein diets. (D)</p> Signup and view all the answers

Which hormone plays a less significant role in carbohydrate metabolism in teleosts compared to mammals?

<p>Insulin (B)</p> Signup and view all the answers

What can high phosphate levels do to calcium availability in the body?

<p>Reduce calcium availability by binding calcium. (D)</p> Signup and view all the answers

What are the primary functions of the circadian clock?

<p>Orchestrates circadian rhythms by regulating hormone release. (C)</p> Signup and view all the answers

Which of the following hormones is primarily responsible for increasing blood calcium levels?

<p>Parathyroid Hormone (C)</p> Signup and view all the answers

How do core clock genes interact within the circadian clock mechanism?

<p>CLOCK and BMAL1 form a positive feedback loop while PER and CRY provide negative feedback. (A)</p> Signup and view all the answers

What is the role of light in circadian regulation for monarch butterflies?

<p>Light resets their internal clock daily. (C)</p> Signup and view all the answers

What is the primary function of Vitamin D in relation to calcium and phosphate?

<p>Promotes absorption of calcium and phosphate in the gut. (C)</p> Signup and view all the answers

What impact has climate change had on bird migration patterns?

<p>It has shifted migration timing by causing birds to spend more time in northern areas. (D)</p> Signup and view all the answers

How does the exocrine function of the pancreas in teleosts compare to that of mammals?

<p>Both secrete the same types of digestive enzymes. (A)</p> Signup and view all the answers

What role does glucagon play in teleosts compared to mammals?

<p>Glucagon is critical for gluconeogenesis in teleosts. (C)</p> Signup and view all the answers

Which of the following statements correctly describes the function of the endocannabinoid system (ECS)?

<p>ECS consists of endogenous ligands that resemble THC and CBD. (C)</p> Signup and view all the answers

Which of the following genes are considered key in the migratory navigation of monarch butterflies?

<p>PER, CRY, and TIM (Timeless). (D)</p> Signup and view all the answers

What physiological effect does disruption of environmental cues have on birds?

<p>It causes mistimed breeding, impacting population dynamics. (C)</p> Signup and view all the answers

Which molecules are involved in the positive feedback loop of the molecular clock?

<p>CLOCK and BMAL1 activate the expression of downstream output genes. (C)</p> Signup and view all the answers

Flashcards

Calcitriol (1,25-dihydroxyvitamin D)

The active form of vitamin D, produced by the kidneys under the influence of PTH, crucial for calcium absorption and bone health.

Calcitonin

A hormone produced by the thyroid gland that lowers blood calcium levels by promoting calcium deposition in bones and inhibiting calcium absorption.

Parathyroid Hormone (PTH)

Hormone produced by the parathyroid glands, primarily involved in increasing blood calcium levels by stimulating bone resorption, enhancing calcium reabsorption in the kidneys, and promoting vitamin D activation.

Hypocalcemia

A disorder characterized by low blood calcium levels, often leading to muscle spasms, seizures, and cardiac problems.

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Hypercalcemia

A disorder characterized by high blood calcium levels, often leading to kidney stones, bone weakening, and fatigue.

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Suprachiasmatic Nucleus (SCN)

The master clock of the circadian rhythm, located in the hypothalamus, responsible for synchronizing the body's internal clock with the external light-dark cycle.

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Retinohypothalamic Tract (RHT)

The pathway that carries light signals from the retina to the SCN, playing a crucial role in entraining the circadian rhythm to the external environment.

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Circadian Rhythms

Biological rhythms that operate on a roughly 24-hour cycle, driven by internal clocks and influenced by environmental cues.

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What is the Suprachiasmatic Nucleus (SCN)?

The central pacemaker of the circadian rhythm, located in the hypothalamus of the brain. It regulates hormone release, body temperature, and sleep-wake cycles.

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What are Clock Genes?

A group of genes that control the timing of biological processes, operating on a 24-hour cycle.

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What role do CLOCK and BMAL1 play in the circadian rhythm?

Two key clock genes, CLOCK and BMAL1, form a complex that activates the expression of other clock genes, like PER and CRY.

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What is the role of PER and CRY in the circadian rhythm?

PER and CRY form a complex that inhibits the activity of CLOCK/BMAL1, completing the feedback loop.

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How does the circadian rhythm influence monarch butterfly migration?

The monarch butterfly uses its circadian clock to navigate during migration, combining the sun compass and internal clock to determine direction.

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How does light affect the monarch's circadian rhythm?

Light resets the monarch's clock daily, ensuring precise navigation over long distances.

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How does climate change impact bird migration?

Climate change has caused shifts in migration timing in birds, mainly due to changes in temperature and photoperiod.

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What is the impact of disrupted environmental cues on bird reproduction?

Disruptions in environmental cues, like temperature and photoperiod, can lead to mistimed breeding in birds, affecting population dynamics.

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Hypothalamus (in HPG Axis)

The master control center for the process of sexual development, where GnRH (gonadotropin-releasing hormone) is produced, driving the pituitary gland to release FSH (follicle-stimulating hormone) and LH (luteinizing hormone).

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Pituitary Gland (in HPG Axis)

The 'middle man' that responds to the hypothalamus and releases FSH and LH, which then travel to the gonads (testes or ovaries) to control sexual development.

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Gonads (in HPG Axis)

The reproductive organs (testes in males, ovaries in females) that produce sex hormones and gametes (sperm or eggs).

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Hormonal Feedback in HPG Axis

The process where hormones produced by the gonads feedback to the hypothalamus and pituitary gland, influencing the production of GnRH, FSH, and LH. This regulates the levels of sex hormones in the body.

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Positive Feedback in Female Reproduction

The process where high levels of estrogen trigger a surge in LH production, leading to the release of an egg from the ovary (ovulation).

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Biological Sex

An individual's biological characteristics related to reproduction, determined by chromosomal sex (XX or XY), gonadal sex (testes or ovaries), and phenotypic sex (external genitalia).

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Gender

An individual's sense of self, not necessarily aligned with their biological sex, influenced by social and psychological factors.

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Intersex Variations

Situations where an individual's chromosomal, gonadal, or phenotypic sex don't align, leading to variations from typical sex development.

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Secretory Phase

The phase of the menstrual cycle after ovulation where the endometrium prepares for implantation. Progesterone, produced by the corpus luteum, plays a crucial role in this process.

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Luteolysis

The process of shedding the endometrium when implantation doesn't occur, leading to menstruation.

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Parturition

The complex process of labor and delivery, involving coordinated contractions of the uterus and abdominal muscles.

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Cervical Dilation

The first stage of labor, characterized by cervical dilation (opening) due to uterine contractions.

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Delivery of Fetus

The second stage of labor, where the baby is expelled from the uterus through the birth canal.

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Delivery of Placenta

The third stage of labor after the delivery of the fetus, where the placenta detaches from the uterine wall and is expelled.

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Lactation

The process of producing milk in the mammary glands, initiated after childbirth and sustained by hormonal changes.

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Lactational Amenorrhea

A natural form of birth control where the act of breastfeeding suppresses ovulation, delaying a woman's return to fertility.

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Teleost Pancreas Structure

The pancreas in teleosts is dispersed, with endocrine and exocrine cells scattered in the mesentery, liver, or intestines, unlike the centralized organ in mammals.

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Glucagon Dominance in Teleosts

Teleosts primarily rely on protein metabolism for gluconeogenesis, leading to a higher proportion of A-cells (glucagon producers) in their pancreatic islets compared to mammals.

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Teleost Brockmann Bodies

In teleosts, pancreatic islets (Brockmann bodies) are separate structures located near blood vessels, facilitating efficient hormone distribution.

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Parathyroid Hormone (PTH) Function

Parathyroid hormone (PTH) increases blood calcium levels by stimulating bone resorption, enhancing calcium reabsorption in the kidneys, and activating vitamin D.

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Vitamin D Function

Vitamin D, in its active form (calcitriol), promotes calcium and phosphate absorption in the gut, contributing to bone health and calcium regulation.

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Calcium and Phosphate Balance

Maintaining a balance between calcium and phosphate is crucial for bone health, neuromuscular function, and energy metabolism.

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Phosphate and Calcium Interaction

High phosphate levels can bind to calcium, reducing its availability in the bloodstream. This highlights the interconnection between these two mineral ions.

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Hormonal Control of Minerals

Hormonal regulation of calcium and phosphate ensures their optimal levels in the body, supporting various physiological functions.

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What is calcitonin?

A hormone produced by the thyroid gland, calcitonin acts to lower blood calcium levels by inhibiting bone resorption, effectively putting the brakes on calcium release from bones. It's like a 'calcium saver' that helps maintain the balance of calcium in your blood.

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How does bone function as a calcium reservoir?

99% of the body's calcium reserves are stored in bones as hydroxyapatite, a mineral that strengthens bone structure. This acts as a calcium reservoir, releasing calcium into the bloodstream when blood calcium levels drop.

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What are osteoblasts?

Osteoblasts are bone-forming cells, like builders that deposit calcium and phosphate into the bone matrix, strengthening bones. They're stimulated by calcitonin, the calcium-lowering hormone.

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What are osteoclasts?

Osteoclasts, on the other hand, act as 'bone breakers.' They break down bone matrix, releasing calcium and phosphate into the bloodstream. They are stimulated by PTH when blood calcium levels are low.

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What is parathyroid hormone (PTH)?

This hormone is produced by the parathyroid glands when blood calcium levels drop. It triggers a chain reaction to increase blood calcium: stimulating osteoclasts to break down bone and release calcium, enhancing calcium reabsorption in the kidneys, and indirectly boosting calcium absorption in the intestines.

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How do the kidneys help regulate calcium?

The kidneys play a vital role in regulating calcium and phosphate levels. They filter calcium from the blood and reabsorb 98% of it. PTH increases calcium reabsorption in the distal tubules, helping to conserve calcium within the body.

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What is the role of enterocytes in calcium regulation?

Enterocytes, located in the small intestine, are responsible for absorbing dietary calcium and phosphate, aided by vitamin D. This process is crucial for maintaining adequate levels of calcium and building strong bones.

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How is vitamin D involved in calcium regulation?

Vitamin D, synthesized from cholesterol, plays a crucial role in calcium absorption. UV light converts 7-dehydrocholesterol in the skin to vitamin D3, which is then converted to its active form in the liver and kidneys.

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Study Notes

Mammalian Reproduction

  • The Hypothalamic-Pituitary-Gonadal (HPG) Axis controls pituitary function.
  • Hypothalamus releases GnRH, controlling pituitary function.
  • Anterior Pituitary releases FSH and LH in response to GnRH.
  • Gonads produce hormones:
    • Males: Testes produce testosterone (androgens).
    • Females: Ovaries produce estrogen and progesterone.
  • Hormonal Feedback:
    • Negative feedback regulates GnRH, FSH, and LH levels in males and females.
    • Positive feedback in females during ovulation: High estrogen stimulates an LH surge, causing ovulation.
  • Differences in Males and Females:
    • Males: Continuous sperm and testosterone production.
    • Females: Cyclic ovarian activity (estrous or menstrual cycles).

Sex vs. Gender

  • Biological Sex is defined by physical traits:
    • Chromosomal sex (XX or XY).
    • Gonadal sex (testes or ovaries).
    • Phenotypic sex (external genitalia, secondary sex characteristics).
  • Sex determined during embryonic development, by the SRY gene and hormonal signaling.
  • Gender is psychological and social identity, not necessarily aligned with biological sex and influenced by societal norms.
  • Intersex variations occur when chromosomal, gonadal, or phenotypic sex do not align.
    • Examples: Androgen Insensitivity Syndrome (AIS), Congenital Adrenal Hyperplasia (CAH).

Gametogenesis

  • Spermatogenesis:
    • Location: Seminiferous tubules in the testes.
    • Process: Spermatogonia (diploid stem cells) divide mitotically, primary spermatocytes undergo meiosis I, secondary spermatocytes undergo meiosis II, spermatids mature into spermatozoa.
  • Oogenesis:
    • Location: Ovarian follicles.
    • Process: Oogonia divide mitotically during fetal development. Primary oocytes are arrested in prophase I until puberty. During ovulation, meiosis I completes, forming a secondary oocyte (arrested in metaphase II) and a polar body. Meiosis II only completes with fertilization. FSH stimulates follicular growth, and LH triggers ovulation and corpus luteum formation.

Sexual Differentiation

  • SRY gene on the Y chromosome encodes Testis-Determining Factor (TDF), which induces Sertoli and Leydig cell differentiation in males.
  • Sertoli cells secrete anti-Müllerian hormone (AMH) causing regression of Müllerian ducts.
  • Leydig cells produce testosterone, promoting Wolffian duct differentiation.
  • In the absence of the SRY gene, gonadal ridge differentiates into ovaries.
  • Müllerian ducts persist and develop into the uterus, fallopian tubes, and upper vagina
  • Lack of testosterone causes regression of Wolffian ducts.

Reproductive Cycles

  • Estrous Cycle (Non-Primate Mammals): Proestrus, Estrus, Metestrus, Diestrus.
  • Menstrual Cycle (Primates): Follicular and Luteal phases regulated by estrogen and progesterone.
  • Seasonal Breeders: Cycles controlled by photoperiod.

Hormonal Regulation of Reproduction

  • FSH and LH stimulate follicular development and ovulation in females.
  • Estrogen promotes endometrial regrowth.
  • Progesterone maintains the endometrium during the secretory phase, supporting pregnancy.
  • Hormones influence the timing of reproductive cycles, like timing of breeding seasons and ovulation

Parturition (Childbirth)

  • Stages: Cervical dilation (uterine contractions), Delivery of Fetus (coordinated uterine and abdominal contractions), Delivery of the Placenta (placenta detaches).
  • Hormonal control: Estrogen increases uterine sensitivity to oxytocin, prostaglandins amplify contractions, fetal cortisol enhances placental estrogen production.

Lactation

  • Pre-pregnancy: Estrogen promotes ductal growth, progesterone influences lobular-alveolar development.
  • Prolactin prepares mammary glands for milk synthesis.
  • After parturition: Progesterone and estrogen levels fall, enabling prolactin stimulated milk production.
  • Oxytocin promotes milk ejection by contracting myoepithelial cells.
  • Lactational amenorrhea: Suckling suppresses GnRH, reducing FSH and LH secretion.

Menopause

  • Definition: Permanent cessation of menstrual cycles due to ovarian follicle depletion.
  • Hormonal changes: Declining estrogen and progesterone, increased FSH and LH.

Other topics

  • Feeding and Metabolism: Various non-mammalian feeding strategies (herbivores, carnivores, etc.), adaptations in digestive systems like stomach-less teleosts and pyloric caecae. Non-mammals often rely more on protein catabolism for energy.
  • Calcium and Phosphate Homeostasis: Bone health, hormonal regulation of calcium and phosphate (PTH, vitamin D, calcitonin), key cells (osteoblasts, osteoclasts, osteocytes), kidney and intestinal involvement.
  • Diabetes: Blood sugar control, type 1 and 2 diabetes, endocrine complications, impact on metabolism, glucosuria.
  • Stress Response: Hypothalamic-Pituitary-Adrenal (HPA) axis, acute and chronic stress, effects of stress on hormone regulation.
  • Endocrine System: Role of endocrine hormones like ghrelin, leptin, insulin, CCK, PYY, and various other hormones.
  • Opioids: Endogenous Opioid system, role in stress response and pain modulation.
  • Endocannabinoid System: ECS ligand modulation, stress, and seasonal hormonal cycles.
  • Clock Regulation: Circadian rhythms, SCN, light signaling, environmental factors impacting synchronization. This includes reproductive cycles affected by light and temperature.
  • Types of Reproduction and Key Differences: Monotremes (oviparous), Marsupials (short gestation), Eutherians (placental).
  • Nonmammalian Reproductive Biology: Focusing on specifics from the readings, including examples for the various reproduction types, like amphibians, reptiles, birds, fish, etc., covering reproduction methods (internal vs external, how they reproduce, eggs, etc.). Key difference discussion between tropical and temperate crocodilians (including seasonal reproduction cycles, temperature variation, and egg incubation).

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