Human Physiology Chapter on Nervous and Circulatory Systems
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Questions and Answers

Which of the following accurately describes the role of the autonomic nervous system in organ control?

  • The autonomic nervous system works independently of the endocrine system.
  • The autonomic nervous system is responsible for conscious, voluntary movements.
  • The autonomic nervous system primarily regulates involuntary processes, such as heart rate and digestion. (correct)
  • The autonomic nervous system directly controls all bodily functions.
  • What is the primary neurotransmitter released by postganglionic sympathetic neurons at their target organs?

  • Norepinephrine (NE) (correct)
  • Epinephrine (E)
  • Acetylcholine (Ach)
  • Dopamine (DA)
  • Which of the following best describes the function of the parasympathetic nervous system?

  • Promotes relaxation, digestion, and energy conservation. (correct)
  • Regulates temperature and fluid balance in the body.
  • Prepares the body for physical activity and exertion.
  • Increases heart rate and blood pressure in response to stress.
  • Which of the following is a correct statement about the sympathetic and parasympathetic pathways?

    <p>The parasympathetic pathway only uses acetylcholine as a neurotransmitter. (B)</p> Signup and view all the answers

    Which of the following statements accurately contrasts the endocrine system and the autonomic nervous system?

    <p>The autonomic nervous system provides rapid, short-lived responses, while the endocrine system provides slower, longer-lasting responses. (E)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of veins?

    <p>They have a higher pressure than arteries. (B)</p> Signup and view all the answers

    What is the main function of venous valves?

    <p>To prevent the backflow of blood in veins. (C)</p> Signup and view all the answers

    What is a common cause of varicose veins?

    <p>High blood pressure in the veins. (B)</p> Signup and view all the answers

    Which type of capillaries has the smallest pores and restricts the passage of larger molecules?

    <p>Continuous capillaries (A)</p> Signup and view all the answers

    Which type of capillaries are found in the choroid plexus of the brain?

    <p>Fenestrated capillaries (D)</p> Signup and view all the answers

    Which type of capillaries are most permeable and allow for the passage of even cells?

    <p>Sinusoidal capillaries (C)</p> Signup and view all the answers

    What is the name of the largest vein in the body that carries deoxygenated blood from the lower body to the heart?

    <p>Inferior vena cava (C)</p> Signup and view all the answers

    Which of the following carries oxygenated blood from the lungs to the heart?

    <p>Pulmonary vein (A)</p> Signup and view all the answers

    What is the name of the large artery that carries oxygenated blood from the left ventricle to the rest of the body?

    <p>Aorta (C)</p> Signup and view all the answers

    Where is the heart anatomically located in the body?

    <p>In the thoracic cavity, between the lungs. (B)</p> Signup and view all the answers

    What is the function of the postganglionic neuron in the parasympathetic nervous system?

    <p>Releases acetylcholine, which binds to a muscarinic receptor on the target cell (D)</p> Signup and view all the answers

    Which of the following is NOT a function of blood?

    <p>Production of hormones (D)</p> Signup and view all the answers

    What is the primary component of plasma?

    <p>Water (A)</p> Signup and view all the answers

    What is the function of erythropoietin (EPO)?

    <p>Stimulate the production of red blood cells (A)</p> Signup and view all the answers

    What is the role of iron in hemoglobin?

    <p>It reversibly binds oxygen molecules (A)</p> Signup and view all the answers

    Which type of white blood cell is the first to respond to an injury?

    <p>Neutrophil (B)</p> Signup and view all the answers

    Which white blood cell type is involved in the allergic response?

    <p>Basophil (D)</p> Signup and view all the answers

    What is the term for the process where white blood cells squeeze through gaps in the vessel wall to reach damaged tissue?

    <p>Diapedesis (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of leukocytes?

    <p>Lack a nucleus (A)</p> Signup and view all the answers

    What is the function of macrophages?

    <p>Phagocytize foreign particles and bacteria (C)</p> Signup and view all the answers

    What is the condition caused by a buildup of bilirubin in the blood?

    <p>Jaundice (A)</p> Signup and view all the answers

    What is the name of the neurotransmitter released by the preganglionic neuron in both the sympathetic and parasympathetic nervous systems?

    <p>Acetylcholine (D)</p> Signup and view all the answers

    Which type of cholinergic receptor is stimulated by nicotine?

    <p>Nicotinic receptor (A)</p> Signup and view all the answers

    What is the term for a drug that binds to a receptor and stimulates the same response as the natural neurotransmitter?

    <p>Agonist (C)</p> Signup and view all the answers

    Which of the following is an example of dual innervation by the autonomic nervous system?

    <p>Control of heart rate (B)</p> Signup and view all the answers

    What is the role of the hypothalamus in the autonomic nervous system?

    <p>It acts as a master regulator defining the set points for autonomic functions (B)</p> Signup and view all the answers

    Which of the following describes the role of platelets in blood coagulation?

    <p>Platelets release chemicals that attract other platelets to the site of injury, leading to a platelet plug. (D)</p> Signup and view all the answers

    What distinguishes a thrombus from an embolus?

    <p>An embolus is a detached piece of a thrombus that travels through the bloodstream. (A)</p> Signup and view all the answers

    What is the primary function of tPA (tissue plasminogen activator) in the blood coagulation process?

    <p>tPA helps to dissolve blood clots by activating plasminogen. (A)</p> Signup and view all the answers

    Which of the following blood vessel types is characterized by strong, thick walls and a large amount of elastic fibers?

    <p>Elastic arteries (D)</p> Signup and view all the answers

    What is the main structural difference between arteries and veins?

    <p>Arteries have a thicker tunica media (middle layer) with more smooth muscle and elastic fibers than veins. (B)</p> Signup and view all the answers

    Which of the following best describes the role of the tunica media in a blood vessel?

    <p>The tunica media helps to regulate blood flow by controlling vessel diameter. (D)</p> Signup and view all the answers

    Which of the following correctly describes the pathway of blood flow through the pulmonary circulation?

    <p>Right ventricle → pulmonary arteries → lungs → pulmonary veins → left atrium (A)</p> Signup and view all the answers

    Which of the following accurately describes the function of the endothelium in a blood vessel?

    <p>The endothelium regulates the permeability of the vessel and prevents blood clotting. (B)</p> Signup and view all the answers

    What is the main difference between myeloid leukemia and lymphoid leukemia?

    <p>Myeloid leukemia involves abnormal granulocytes, while lymphoid leukemia involves abnormal lymphocytes. (C)</p> Signup and view all the answers

    A person with anemia experiences fatigue and weakness. Which of the following best explains this symptom?

    <p>Anemia reduces the oxygen-carrying capacity of the blood, leading to less oxygen delivery to tissues. (D)</p> Signup and view all the answers

    What is the primary function of alpha blockers in cardiovascular treatment?

    <p>Dilate blood vessels (A)</p> Signup and view all the answers

    Which change in blood vessels is commonly associated with aging?

    <p>Plaque deposits and calcification (C)</p> Signup and view all the answers

    What type of feedback mechanism is primarily utilized by the endocrine system for hormone secretion?

    <p>Negative feedback (C)</p> Signup and view all the answers

    Which of the following hormones is released by the posterior pituitary gland?

    <p>Antidiuretic hormone (A)</p> Signup and view all the answers

    What impact does aging have on cardiac output?

    <p>Decreased due to scar tissue replacement (A)</p> Signup and view all the answers

    What role does the hypothalamus play in the endocrine system?

    <p>Regulates hormone release from the pituitary gland (C)</p> Signup and view all the answers

    What is the primary consequence of decreased hematocrit in older adults?

    <p>Inadequate oxygen delivery (C)</p> Signup and view all the answers

    Which nucleus is NOT associated with the hypothalamus's role in the endocrine system?

    <p>Ventromedial nucleus (A)</p> Signup and view all the answers

    Which drug class reduces both contractility and heart rate?

    <p>Beta Blockers (C)</p> Signup and view all the answers

    What change occurs in the heart as a result of aging?

    <p>Stiffening of heart valves (D)</p> Signup and view all the answers

    What is the primary mechanism by which autoregulation adjusts blood flow within tissues?

    <p>Altering peripheral resistance (C)</p> Signup and view all the answers

    Which of the following factors is associated with local vasodilation?

    <p>Local chemical changes in active tissues (C)</p> Signup and view all the answers

    What is the function of the baroreceptor reflex in the cardiovascular system?

    <p>To restore blood pressure to normal levels (A)</p> Signup and view all the answers

    During strenuous exercise, which of the following happens to blood flow?

    <p>Increased flow to active muscles through vasodilation (B)</p> Signup and view all the answers

    What immediate response occurs in the cardiovascular system when standing up from a lying position?

    <p>Increase in cardiac output and blood pressure (C)</p> Signup and view all the answers

    Which hormone is primarily involved in increasing blood volume and restoring blood supply after hemorrhage?

    <p>Aldosterone (B)</p> Signup and view all the answers

    Atherosclerosis in the cardiovascular system primarily leads to:

    <p>Reduced blood flow and increased peripheral resistance (A)</p> Signup and view all the answers

    What characteristic is indicative of congestive heart failure?

    <p>Inability to adequately pump blood to organs (D)</p> Signup and view all the answers

    Which procedure is commonly used to restore blood flow to blocked coronary arteries?

    <p>Coronary Artery Bypass Graft (CABG) (B)</p> Signup and view all the answers

    During a hemorrhage, what is one of the short-term responses of the cardiovascular system?

    <p>Increase in peripheral resistance (D)</p> Signup and view all the answers

    What is one consequence of hypertension on blood vessels?

    <p>Thickening and stiffening of the vessel walls (B)</p> Signup and view all the answers

    Which strategy does the sympathetic nervous system use during exercise to redistribute blood flow?

    <p>Selective vasoconstriction in nonessential organs (B)</p> Signup and view all the answers

    What physiological adjustment occurs due to the muscular pump during exercise?

    <p>Increased venous return to the heart (C)</p> Signup and view all the answers

    What determines the cardiac output in the heart?

    <p>Heart rate multiplied by stroke volume (D)</p> Signup and view all the answers

    Which statement accurately defines preload?

    <p>The stretch on the ventricular wall during filling (C)</p> Signup and view all the answers

    How is ejection fraction clinically significant?

    <p>It provides a percentage of blood pumped out during ventricular contraction. (A)</p> Signup and view all the answers

    What primarily influences stroke volume?

    <p>End diastolic volume and end systolic volume (B)</p> Signup and view all the answers

    What factor has the greatest moment-to-moment variability in vascular resistance?

    <p>Vessel diameter (B)</p> Signup and view all the answers

    What best describes the relationship between blood flow, pressure, and resistance?

    <p>Blood flow is directly proportional to pressure and inversely proportional to resistance. (D)</p> Signup and view all the answers

    What defines pulse pressure?

    <p>The difference between systolic and diastolic pressure (A)</p> Signup and view all the answers

    Which condition indicates poor cardiac pumping ability?

    <p>Ejection fraction below 35% (B)</p> Signup and view all the answers

    What role does blood colloid osmotic pressure (BCOP) play in circulation?

    <p>It pulls tissue fluid into the capillaries. (A)</p> Signup and view all the answers

    What is the role of the fibrous pericardium in the heart's structure?

    <p>It offers strong structural support and does not stretch easily. (A)</p> Signup and view all the answers

    What happens in the process of filtration across a capillary?

    <p>Water and small solutes are pushed out of the capillary. (A)</p> Signup and view all the answers

    Which artery primarily supplies blood to the left ventricle?

    <p>Left Anterior Descending Artery (C)</p> Signup and view all the answers

    What is the term for the amount of blood in the left ventricle just before contraction?

    <p>End diastolic volume (B)</p> Signup and view all the answers

    In which sequence does blood flow through the right side of the heart?

    <p>Right Atrium → Tricuspid Valve → Right Ventricle → Pulmonary Valve (B)</p> Signup and view all the answers

    Which of the following factors affects heart rate directly?

    <p>Autonomic nervous system innervation (A)</p> Signup and view all the answers

    What describes afterload in cardiac physiology?

    <p>The pressure needed to open semilunar valves (B)</p> Signup and view all the answers

    How do AV valves differ from semilunar valves in structure and function?

    <p>AV valves allow blood flow into the heart, while semilunar valves allow blood out. (C), AV valves have fibrous cusps anchored to muscular pegs, semilunar valves do not. (D)</p> Signup and view all the answers

    What is the primary pacemaker of the heart?

    <p>Sinoatrial (SA) Node (B)</p> Signup and view all the answers

    What characterizes the cardiac action potential of a contractile myocardial cell?

    <p>A flat baseline followed by a plateau phase. (C)</p> Signup and view all the answers

    What is indicated by the P wave on an ECG?

    <p>Atrial depolarization (C)</p> Signup and view all the answers

    During the cardiac cycle, what occurs directly after atrial systole?

    <p>Atrial diastole begins. (B)</p> Signup and view all the answers

    What condition is characterized by an abnormally slow heart rate?

    <p>Bradycardia (C)</p> Signup and view all the answers

    What effect does an ectopic pacemaker have on heart function?

    <p>It generates a high rate of action potentials independent of the SA node. (A)</p> Signup and view all the answers

    Which part of the conduction system pauses the electrical impulse before it continues?

    <p>AV Node (C)</p> Signup and view all the answers

    What is the main function of the right coronary artery?

    <p>To supply blood to the right atrium and both ventricles. (D)</p> Signup and view all the answers

    What occurs during ventricular diastole - late?

    <p>Ventricles relax and fill with blood from the atria. (D)</p> Signup and view all the answers

    Flashcards

    Homeostasis

    The maintenance of a relatively stable internal environment within the body.

    Endocrine vs Autonomic system

    The endocrine system uses hormones, while the autonomic system manages involuntary actions through neural pathways.

    Sympathetic pathway

    The 'fight or flight' response pathway that uses lightly myelinated preganglionic and nonmyelinated postganglionic axons.

    Parasympathetic pathway

    The 'rest and digest' pathway using lightly myelinated preganglionic and nonmyelinated postganglionic axons.

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    Neurotransmitters in pathways

    Neurotransmitters like Ach and NE affect organ responses in sympathetic and parasympathetic pathways.

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    Bilirubin

    A yellow pigment formed from the breakdown of red blood cells.

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    Anemia

    A decrease in the oxygen-carrying capacity of blood.

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    Sickle Cell Anemia

    A genetic disorder causing abnormal hemoglobin and crescent-shaped red blood cells.

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    Leukemia

    A cancer affecting white blood cells.

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    Platelets

    Cell fragments important for blood clotting.

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    Coagulation Process

    The sequence of events that leads to blood clot formation.

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    Thrombus vs Embolus

    Thrombus: stationary blood clot; Embolus: traveling clot.

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    Systemic Circulation

    Blood flow from the heart to the body and back.

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    Pulmonary Circulation

    Blood flow from the heart to the lungs and back.

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    Elastic Vessels

    Large arteries with high elastic fiber content.

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    Dual innervation

    Most organs receive sympathetic & parasympathetic control.

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    Hypothalamus role

    Acts as a master regulator for the autonomic nervous system.

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    Acetylcholine

    Neurotransmitter released in parasympathetic system.

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    Nicotinic receptor

    Type of acetylcholine receptor that binds nicotine.

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    Muscarinic receptor

    Type of acetylcholine receptor that binds muscarine.

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    Cholinergic neuron

    A neuron that releases acetylcholine.

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    Antagonist

    A drug that blocks a receptor, preventing a response.

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    Agonist

    A drug that mimics a neurotransmitter and produces a response.

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    Blood functions

    Transport, defend, regulate pH, restrict fluid loss, and regulate temperature.

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    Plasma composition

    Liquid component of blood, mainly water, proteins, and electrolytes.

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    Erythropoiesis

    Formation of new red blood cells stimulated by EPO.

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    Hemoglobin structure

    Protein in red blood cells that binds oxygen, consists of 4 heme groups.

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    White blood cell functions

    Defend body, remove toxins, and can perform phagocytosis.

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    Leukocytes

    Another name for white blood cells with varying lifespans.

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    Jaundice

    Condition from bilirubin buildup due to liver issues.

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    Capacitance vessel

    Veins that have little muscle and elastic fibers, holding much blood.

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    Exchange vessel

    Capillaries where materials exchange through the vessel wall.

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    Venous valve

    Valves formed from tunica intima folds, preventing backward blood flow.

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    Consequences of valve failure

    Lead to conditions like varicose veins and hemorrhoids due to backward flow.

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    Continuous capillaries

    Capillaries with a complete endothelial lining, allowing small solutes to pass.

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    Fenestrated capillaries

    Capillaries with small pores, allowing rapid exchange of water and larger solutes.

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    Sinusoidal capillaries

    Capillaries with large gaps permitting free exchange of large proteins and cells.

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    Systemic circulation veins

    Include superior and inferior vena cava transporting blood to the right heart.

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    Pulmonary circulation veins

    Pulmonary veins carry blood from lungs back to the heart.

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    Anatomical position of the heart

    The heart lies in the thoracic cavity, left of midline, posterior to sternum.

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    Edema

    Visible swelling in tissues, especially legs and arms.

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    Atherosclerosis

    Plaque buildup in arteries causing reduced blood flow.

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    Alpha Blockers

    Drugs that dilate blood vessels to lower blood pressure.

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    Beta Blockers

    Drugs that decrease heart rate and contractility.

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    Calcium Channel Blockers

    Medications that reduce heart contractility by blocking calcium.

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    Hypothalamus

    Master regulator that controls hormone release.

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    Anterior Pituitary Gland

    Secretes hormones for stress, growth, and lactation.

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    Posterior Pituitary Gland

    Stores and releases oxytocin and ADH (vasopressin).

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    Feedback Mechanisms

    Regulatory systems for hormone secretion in the body.

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    Cardiac Output Changes with Aging

    Age-related changes affect the heart's pumping effectiveness.

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    Heart Wall Structure

    The heart wall consists of three layers: outer fibrous pericardium, inner serous pericardium, and the myocardium.

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    Coronary Arteries

    Arteries that supply blood to the heart, including the Left Coronary Artery and Right Coronary Artery.

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    Left Coronary Artery

    The uppermost artery on the left side, splits into Circumflex and LAD.

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    Circumflex Artery

    Branch of the left coronary artery supplying the left atrium and posterior wall.

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    Left Anterior Descending Artery

    Branch of the left coronary artery supplying the anterior ventricles.

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    Right Coronary Artery

    Artery that supplies the right atrium, both ventricles, and conduction nodes.

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    Blood Flow Right Side

    Blood returns from the body through the vena cava, enters right atrium, goes to right ventricle, leaves through pulmonary valve.

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    Blood Flow Left Side

    Blood returns from lungs via pulmonary veins into left atrium, leaves through aortic valve to aorta.

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    AV Valve Function

    AV valves open for blood entering the heart, supported by chordae tendineae and papillary muscles.

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    Semilunar Valve Function

    Semilunar valves allow blood to leave the heart; no muscles or chordae tendineae involved.

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    Pacemaker Action Potential

    Pacemaker cells depolarize to generate action potentials, with SA nodes firing the fastest.

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    Conduction System Sequence

    Impulse generated by SA node, pauses at AV node, flows through AV bundle, branches to ventricles.

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    Bradycardia

    Abnormally slow heart rate; often under 60 bpm.

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    Ectopic Pacemaker

    Abnormal cells produce faster action potentials, disrupting normal heart rhythm.

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    ECG Waves

    P wave indicates atrial depolarization, QRS complex indicates ventricular depolarization, and T wave indicates ventricular repolarization.

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    Cardiac Output

    The volume of blood pumped by the left ventricle in one minute.

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    Heart Rate

    The number of beats per minute, directly affects cardiac output.

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    Stroke Volume

    The amount of blood pumped from the left ventricle with each contraction.

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    Preload

    The stretch on the ventricle wall when it fills during diastole.

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    Afterload

    The force required to open the semilunar valve and eject blood.

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    Contractility

    The strength of heart muscle contraction.

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    Ejection Fraction

    The percentage of end diastolic volume pumped out in one beat.

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    Blood Flow

    The movement of blood through the circulatory system influenced by pressure and resistance.

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    Mean Arterial Pressure

    Average blood pressure in a person's arteries during one cardiac cycle.

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    Pulse Pressure

    The difference between systolic and diastolic pressure.

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    Vascular Resistance

    The resistance blood encounters as it flows through the vessels.

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    Filtration

    Process pushing water and solutes out of capillaries into tissues due to blood pressure.

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    Reabsorption

    Process pulling water back into capillaries from interstitial fluid.

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    Capillary Hydrostatic Pressure

    The pressure within capillaries that drives filtration.

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    Autoregulation of blood flow

    Immediate, localized adjustments in blood flow based on tissue needs.

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    Local vasodilators

    Substances that increase blood flow in active tissues, like chemicals from metabolism.

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    Local vasoconstrictors

    Substances that decrease blood flow in quiet tissues, often from damaged areas.

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    Baroreceptor reflex

    Reflex that restores blood pressure to normal when it changes.

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    Endocrine mechanisms

    Hormonal pathways activated for long-term regulation of blood volume and pressure.

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    Cardiac response to standing

    Baroreceptor reflex quickly increases cardiac output when changing positions.

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    Exercise adaptation

    Increased blood flow and cardiac output during activity through vasodilation.

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    Strenuous Exercise

    Intense physical activity that activates sympathetic nervous system enhancing heart function.

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    Hemorrhage response

    Cardiovascular adjustments to maintain blood pressure and restore volume after blood loss.

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    Hypertension

    Condition of elevated blood pressure, leading to thickening of blood vessels.

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    CAD procedures

    Methods like CABG or angioplasty to restore heart blood flow.

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    Congestive heart failure

    Heart's inability to pump sufficient blood, causing back-up and pressure increase.

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    Erythropoietin (EPO)

    Hormone that stimulates red blood cell production, especially after blood loss.

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    Frank-Starling Principle

    The heart's stroke volume increases with greater ventricular stretch due to venous return.

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    Study Notes

    Homeostasis and ANS Review

    • Homeostasis is the maintenance of a relatively stable internal environment.
    • The endocrine and autonomic nervous systems influence organ function, but in different ways.
    • The endocrine system uses hormones transported through the bloodstream to target cells.
    • The autonomic nervous system has two branches:
      • Parasympathetic ("rest and digest"): typically has a single preganglionic axon leading to a ganglion and a postganglionic axon that releases acetylcholine targeting effector cells.
      • Sympathetic ("fight or flight"): typically has two lightly myelinated preganglionic axons leading to a ganglion for release of acetylcholine. A postganglionic axon releases norepinephrine targeting effector cells. An alternate pathway leads to the adrenal medulla and causes the release of epinephrine and norepinephrine into the blood stream that effects distant targets in the body.
    • Both systems work together to regulate organ function.
    • Most organs receive both sympathetic and parasympathetic input.

    Autonomic Transmitters and Receptors

    • The parasympathetic system uses acetylcholine (ACh) as its neurotransmitter.
    • Acetylcholine binds to two main types of receptors:
      • Nicotinic receptors (found on postganglionic neurons): They respond to nicotine.
      • Muscarinic receptors (found on target cells): They respond to muscarine.
    • The sympathetic system uses acetylcholine at the preganglionic synapse and norepinephrine at the postganglionic synapse to target cells.
    • Agonists mimic the actions of neurotransmitters.
    • Antagonists block neurotransmitter action.

    Blood

    • Blood functions include transporting gases, nutrients, and waste; defending against pathogens, regulating pH, ion composition, and temperature; and clotting at injury sites.
    • Plasma comprises 46-63% of blood volume, consisting of water (91%), proteins (8%), and other substances (1%).
    • Red blood cells (erythrocytes): lack nuclei and organelles, carry oxygen, and are produced via erythropoiesis (stimulated by decreased oxygen availability and erythropoietin).
    • Hemoglobin (in RBCs): binds oxygen reversibly and comprises 95% of RBC protein. Hemoglobin comprises two alpha subunits and two beta subunits, each with a heme group containing iron, with each hemoglobin molecule capable of binding four oxygen molecules.
    • White blood cells (leukocytes): defend the body against pathogens and toxins. Phagocytic leukocytes are capable of engulfing foreign material. Leukocytes include granulocytes (neutrophils, eosinophils, basophils) and agranulocytes (lymphocytes, monocytes).
    • Diseases related to blood include jaundice (bilirubin buildup), anemia (decreased oxygen-carrying capacity, including iron deficiency, hemorrhagic, and aplastic types), sickle cell anemia, and leukemia (cancer of white blood cells).
    • Platelets: help in blood clot formation from fragments of megakaryocytes.
    • Clot formation involves vascular spasm, platelet plug formation, and coagulation (fibrin formation).
    • tPA (tissue plasminogen activator): dissolves blood clots.
    • Thrombus: blood clot in a vessel.
    • Embolus: a detached thrombus in the bloodstream.

    Circulation Overview and Vessels

    • Systemic circulation: transports blood to body organs except lungs.
    • Pulmonary circulation: transports blood to the lungs.
    • Blood vessels have three layers: tunica intima, tunica media, and tunica externa.
    • Arteries generally have thicker walls than veins, with more smooth muscle and elastic fibers.
    • Veins have valves to prevent backflow.
    • Blood vessel types include elastic vessels, resistance vessels(arterioles), capacitance vessels (veins), and exchange vessels (capillaries).
    • Capillaries allow for the exchange of materials between blood and tissues, and capillary types include continuous, fenestrated, and sinusoidal capillaries.
    • Venous valves prevent backflow and maintain one way flow of blood.

    Anatomy of the Heart

    • The heart's position is in the thoracic cavity, to the left of midline.
    • The heart wall has three layers: fibrous pericardium, serous pericardium, and myocardium.
    • Coronary arteries supply the heart with oxygenated blood, and include the left and right coronary arteries and their branches including circumflex, left anterior descending, and branch arteries.
    • Blood flow through the heart involves the right and left sides of the heart, including the atria, ventricles, and valves.
    • AV (atrioventricular) valves prevent backflow from ventricles into atria.
    • Semilunar valves prevent backflow from arteries into ventricles.
    • Pacemaker cells (SA and AV nodes): have the ability to spontaneously depolarize to action potential.
    • The electrical conduction system governs cardiac contraction. Impulses originate from the SA node and spread sequentially to the AV node, then the AV bundle and its branches to the Purkinje fibers, depolarizing cardiac contractile cells resulting in a coordinated contraction.

    The Cardiac Cycle

    • The cardiac cycle involves atrial and ventricular systole and diastole, with corresponding pressure changes and valve actions.
    • ECG (electrocardiogram): records the heart's electrical activity, with waves corresponding to atrial and ventricular depolarization and repolarization.
    • The cardiac cycle involves atrial systole, ventricular systole (in two phases), and ventricular diastole.

    Cardiodynamics

    • Cardiac output (CO) is the volume of blood pumped per minute and is a function of heart rate (HR) and stroke volume (SV), CO= HR X SV,.
    • Factors affecting CO include heart rate, end-diastolic volume (EDV), end-systolic volume (ESV).
    • Heart rate is regulated by the autonomic nervous system.
    • Stroke volume is regulated by preload, afterload, and contractility.
    • Ejection fraction (EF): is the percentage of EDV pumped out in one beat, a measure of the heart's pumping efficiency

    Regulation of Blood Flow

    • Blood flow is proportional to pressure difference and inversely proportional to resistance (F = ΔP/R).
    • Blood pressure changes throughout the systemic circulation, and mean arterial pressure (MAP) reflects the average pressure.
    • Pulse pressure is the difference between systolic and diastolic pressure.
    • Vascular resistance is determined by vessel diameter, blood viscosity, and turbulence.
    • Capillary exchange is driven by blood pressure (filtration) and osmosis (reabsorption).

    Cardiovascular Adaptation

    • Autoregulation adjusts blood flow locally to meet tissue needs.
    • Baroreceptors: detect changes in blood pressure and trigger adjustments to maintain homeostasis.
    • Hormonal reflexes: regulate longer-term cardiovascular adjustments (e.g., blood volume change).
    • Cardiovascular adaptations occur in postural changes, exercise, and hemorrhage.

    Disorders of the Cardiovascular System

    • Risk factors for heart disease include hypertension, obesity, diabetes, and high cholesterol.
    • Atherosclerosis and hypertension alter vessel structure and function.
    • Procedures to restore blood flow to the heart wall include coronary artery bypass graft (CABG), balloon angioplasty, and stent insertion.
    • Congestive heart failure: occurs when the heart cannot pump enough blood to meet the body's needs.
    • Drugs used in cardiovascular treatments include alpha blockers, beta blockers, and calcium channel blockers.
    • The cardiovascular system changes with age due to changes in the blood, blood vessels, and the heart.

    Endocrine System I

    • Neurotransmitters act locally, hormones act systemically.
    • Endocrine signaling uses G-protein receptors to amplify signals.
    • Cyclic AMP (cAMP) is commonly used in signaling cascades.
    • The hypothalamus regulates hormone release.
    • Anterior and posterior pituitary glands have different functions and relationships with the hypothalamus.
    • Feedback loops are the main regulators of hormone secretion for homeostasis, often using negative feedback.

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    Description

    Test your understanding of the autonomic nervous system and its role in organ control, along with key concepts about veins and capillaries. This quiz covers neurotransmitters, the functions of sympathetic and parasympathetic pathways, and details about various types of capillaries. Prepare to explore the interconnections between the nervous and circulatory systems.

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