Podcast
Questions and Answers
Which factor is not associated with an increase in basal metabolic rate (BMR)?
Which factor is not associated with an increase in basal metabolic rate (BMR)?
Which of the following accurately reflects the relationship between age, sex, and BMR?
Which of the following accurately reflects the relationship between age, sex, and BMR?
What percentage of energy released by ATP hydrolysis is primarily converted to heat?
What percentage of energy released by ATP hydrolysis is primarily converted to heat?
Which temperature range is typical for a healthy person at rest?
Which temperature range is typical for a healthy person at rest?
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Which statement about how the body produces heat is incorrect?
Which statement about how the body produces heat is incorrect?
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What physiological change indicates sympathetic nervous system stimulation in heart rate?
What physiological change indicates sympathetic nervous system stimulation in heart rate?
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Which nerve is primarily responsible for inducing parasympathetic effects on heart function?
Which nerve is primarily responsible for inducing parasympathetic effects on heart function?
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Which neurotransmitter is associated with the sympathetic nervous system's effects on the heart?
Which neurotransmitter is associated with the sympathetic nervous system's effects on the heart?
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What does a diagnosis of bradycardia imply about heart rate?
What does a diagnosis of bradycardia imply about heart rate?
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Which specific receptor stimulation leads to increased contractile force in cardiac muscle?
Which specific receptor stimulation leads to increased contractile force in cardiac muscle?
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What primarily causes the plateau in the action potential of cardiac muscle cells?
What primarily causes the plateau in the action potential of cardiac muscle cells?
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How does the conduction velocity of Purkinje fibers compare to cardiac muscle fibers?
How does the conduction velocity of Purkinje fibers compare to cardiac muscle fibers?
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What is the difference between the absolute refractory period and the relative refractory period in cardiac muscle?
What is the difference between the absolute refractory period and the relative refractory period in cardiac muscle?
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Why is extracellular calcium concentration more significant for cardiac muscle contraction compared to skeletal muscle contraction?
Why is extracellular calcium concentration more significant for cardiac muscle contraction compared to skeletal muscle contraction?
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What mechanism initially causes vasoconstriction during exercise?
What mechanism initially causes vasoconstriction during exercise?
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What is the role of potassium ions in the action potential of cardiac muscle?
What is the role of potassium ions in the action potential of cardiac muscle?
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Which factor significantly affects the duration of the cardiac cycle?
Which factor significantly affects the duration of the cardiac cycle?
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What primarily differentiates action potential in cardiac muscle from that in skeletal muscle?
What primarily differentiates action potential in cardiac muscle from that in skeletal muscle?
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Which statement best describes the impact of increased heart rate on the cardiac cycle?
Which statement best describes the impact of increased heart rate on the cardiac cycle?
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What is the primary role of atrial contraction within the cardiac cycle?
What is the primary role of atrial contraction within the cardiac cycle?
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During the period of rapid filling of the ventricles, what primarily causes the AV valves to open?
During the period of rapid filling of the ventricles, what primarily causes the AV valves to open?
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Which of the following correctly explains isovolumetric contraction?
Which of the following correctly explains isovolumetric contraction?
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What distinguishes the 'period of rapid ejection' from the 'period of slow ejection'?
What distinguishes the 'period of rapid ejection' from the 'period of slow ejection'?
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How is ejection fraction calculated, and what is the normal value at rest for healthy individuals?
How is ejection fraction calculated, and what is the normal value at rest for healthy individuals?
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What is the difference in pressures between the right and left ventricles during systole?
What is the difference in pressures between the right and left ventricles during systole?
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Which term describes the end diastolic pressure when the ventricle is filled, directly related to ventricular volume?
Which term describes the end diastolic pressure when the ventricle is filled, directly related to ventricular volume?
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What is the function of intercalated discs in cardiac muscle tissue?
What is the function of intercalated discs in cardiac muscle tissue?
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Which of the following best describes the role of papillary muscles in the heart?
Which of the following best describes the role of papillary muscles in the heart?
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How do semilunar valves differ from atrioventricular (AV) valves?
How do semilunar valves differ from atrioventricular (AV) valves?
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What is the pathway of blood flow in the heart starting from the vena cava?
What is the pathway of blood flow in the heart starting from the vena cava?
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During rest, what percentage of blood is typically distributed to the brain?
During rest, what percentage of blood is typically distributed to the brain?
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Which statement accurately describes blood flow distribution to the coronary arteries during exercise?
Which statement accurately describes blood flow distribution to the coronary arteries during exercise?
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What distinguishes cardiac muscle from skeletal muscle in terms of structure?
What distinguishes cardiac muscle from skeletal muscle in terms of structure?
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What happens to blood flow to the GI tract during exercise?
What happens to blood flow to the GI tract during exercise?
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What physiological effect does an increase in afterload have on the ventricles?
What physiological effect does an increase in afterload have on the ventricles?
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What is the primary function of the sinoatrial (SA) node in the cardiac conduction system?
What is the primary function of the sinoatrial (SA) node in the cardiac conduction system?
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Which statement best describes the relationship between atrial stretch and heart rate?
Which statement best describes the relationship between atrial stretch and heart rate?
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What aspect of the Frank-Starling mechanism explains the increase in stroke volume?
What aspect of the Frank-Starling mechanism explains the increase in stroke volume?
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Which component of the cardiac conduction system acts as a backup pacemaker?
Which component of the cardiac conduction system acts as a backup pacemaker?
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During which situation are escape beats most likely to occur?
During which situation are escape beats most likely to occur?
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What condition is characterized by ectopic beats?
What condition is characterized by ectopic beats?
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What is the intrinsic heart rate when autonomic influences are absent?
What is the intrinsic heart rate when autonomic influences are absent?
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Which mechanism primarily maintains the plateau phase in the action potential of cardiac muscle?
Which mechanism primarily maintains the plateau phase in the action potential of cardiac muscle?
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What is the difference in conduction velocity between Purkinje fibers and cardiac muscle fibers?
What is the difference in conduction velocity between Purkinje fibers and cardiac muscle fibers?
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Which period in cardiac muscle is characterized by the inability to stimulate the heart to contract at all?
Which period in cardiac muscle is characterized by the inability to stimulate the heart to contract at all?
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How does the requirement for extracellular calcium differ between cardiac muscle and skeletal muscle?
How does the requirement for extracellular calcium differ between cardiac muscle and skeletal muscle?
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What describes the relative refractory period in cardiac muscle contraction?
What describes the relative refractory period in cardiac muscle contraction?
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Which aspect does NOT play a role in the duration of the cardiac cycle?
Which aspect does NOT play a role in the duration of the cardiac cycle?
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Which statement correctly explains the role of vasoconstriction during exercise?
Which statement correctly explains the role of vasoconstriction during exercise?
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Which statement about the histological differences between cardiac and skeletal muscle is correct?
Which statement about the histological differences between cardiac and skeletal muscle is correct?
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What is the primary function of the chordae tendinae in the heart?
What is the primary function of the chordae tendinae in the heart?
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How do semilunar valves function compared to AV valves under pressure conditions?
How do semilunar valves function compared to AV valves under pressure conditions?
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Which of the following correctly describes blood flow distribution to the skeletal muscles at rest compared to during exercise?
Which of the following correctly describes blood flow distribution to the skeletal muscles at rest compared to during exercise?
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What distinguishes the role of intercalated discs in cardiac muscle compared to other muscle types?
What distinguishes the role of intercalated discs in cardiac muscle compared to other muscle types?
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What effect does an increase in afterload have on ventricular function?
What effect does an increase in afterload have on ventricular function?
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Which factor contributes to the greater contractile force in the heart according to the Frank-Starling mechanism?
Which factor contributes to the greater contractile force in the heart according to the Frank-Starling mechanism?
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What is the primary role of the atrioventricular (AV) node in the cardiac conduction system?
What is the primary role of the atrioventricular (AV) node in the cardiac conduction system?
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Which statement correctly compares the intrinsic rhythmical rates of the cardiac conduction components?
Which statement correctly compares the intrinsic rhythmical rates of the cardiac conduction components?
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What is an intrinsic heart rate, and how is it determined?
What is an intrinsic heart rate, and how is it determined?
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What is the primary effect of increased heart rate on diastolic time?
What is the primary effect of increased heart rate on diastolic time?
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How much of ventricular filling is attributed to atrial contraction?
How much of ventricular filling is attributed to atrial contraction?
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Which statement best describes isovolumetric contraction?
Which statement best describes isovolumetric contraction?
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What is the nature of pressure in the right ventricle during systole compared to the left ventricle?
What is the nature of pressure in the right ventricle during systole compared to the left ventricle?
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During which part of systole is blood pressure the highest?
During which part of systole is blood pressure the highest?
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What is the typical ejection fraction at rest in healthy individuals?
What is the typical ejection fraction at rest in healthy individuals?
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Which statement correctly differentiates preload from afterload?
Which statement correctly differentiates preload from afterload?
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What primarily causes the rapid filling of the ventricles?
What primarily causes the rapid filling of the ventricles?
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What distinguishes the period of slow ejection from the period of rapid ejection?
What distinguishes the period of slow ejection from the period of rapid ejection?
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How are left ventricular and aortic pressures related during the cardiac cycle?
How are left ventricular and aortic pressures related during the cardiac cycle?
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What function do the intercalated discs serve in cardiac muscle tissue?
What function do the intercalated discs serve in cardiac muscle tissue?
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Which statement accurately contrasts the properties of AV valves and semilunar valves?
Which statement accurately contrasts the properties of AV valves and semilunar valves?
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During rest, which percentage of total blood flow is typically distributed to skeletal muscle?
During rest, which percentage of total blood flow is typically distributed to skeletal muscle?
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Which accurately describes the role of papillary muscles in the heart?
Which accurately describes the role of papillary muscles in the heart?
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What distinguishes cardiac muscle from skeletal muscle in terms of structural features?
What distinguishes cardiac muscle from skeletal muscle in terms of structural features?
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What is the primary mechanism that prolongs depolarization during the action potential of cardiac muscle?
What is the primary mechanism that prolongs depolarization during the action potential of cardiac muscle?
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Which of the following best describes the relationship between heart rate and the duration of the action potential in cardiac muscle?
Which of the following best describes the relationship between heart rate and the duration of the action potential in cardiac muscle?
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What characterizes the absolute refractory period in cardiac muscle contraction?
What characterizes the absolute refractory period in cardiac muscle contraction?
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How does the conduction velocity of cardiac muscle fibers compare to that of Purkinje fibers?
How does the conduction velocity of cardiac muscle fibers compare to that of Purkinje fibers?
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Why is extracellular calcium concentration vital for cardiac muscle contraction?
Why is extracellular calcium concentration vital for cardiac muscle contraction?
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What typically distinguishes the relative refractory period from the absolute refractory period in cardiac muscles?
What typically distinguishes the relative refractory period from the absolute refractory period in cardiac muscles?
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What physiological change occurs initially during exercise concerning vasoconstriction?
What physiological change occurs initially during exercise concerning vasoconstriction?
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What physiological consequence does increased afterload have on ventricular performance?
What physiological consequence does increased afterload have on ventricular performance?
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Which component of the cardiac conduction system has the slowest intrinsic rhythmical rate?
Which component of the cardiac conduction system has the slowest intrinsic rhythmical rate?
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Which statement accurately reflects the Frank-Starling mechanism's role in stroke volume?
Which statement accurately reflects the Frank-Starling mechanism's role in stroke volume?
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What defines the intrinsic heart rate, and which statement is accurate regarding it?
What defines the intrinsic heart rate, and which statement is accurate regarding it?
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Which feature of ectopic beats distinguishes them from escape beats?
Which feature of ectopic beats distinguishes them from escape beats?
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How does increased heart rate affect the time spent in diastole?
How does increased heart rate affect the time spent in diastole?
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What percentage of ventricular filling is attributed to the atrial contraction?
What percentage of ventricular filling is attributed to the atrial contraction?
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What primarily initiates the period of rapid filling of the ventricles?
What primarily initiates the period of rapid filling of the ventricles?
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What is the primary function of isovolumetric contraction?
What is the primary function of isovolumetric contraction?
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Which phase of ejection yields the highest pressure in the left ventricle?
Which phase of ejection yields the highest pressure in the left ventricle?
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What does the ejection fraction represent?
What does the ejection fraction represent?
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What is the typical pressure difference between the right and left ventricles during systole?
What is the typical pressure difference between the right and left ventricles during systole?
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Which concept describes the pressure during the initial filling phase of the ventricle?
Which concept describes the pressure during the initial filling phase of the ventricle?
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During what phase does the greatest blood volume flow out of the heart occur?
During what phase does the greatest blood volume flow out of the heart occur?
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Which of the following best describes the physiological significance of atrial pressure during the cardiac cycle?
Which of the following best describes the physiological significance of atrial pressure during the cardiac cycle?
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Study Notes
Basal Metabolic Rate (BMR)
- BMR is the minimum amount of energy your body needs to function at rest.
- Muscle mass increases BMR because it requires more energy to maintain.
- Hormones like growth hormone, testosterone, and thyroxine increase metabolic rate.
- Fever increases BMR.
- Sleep decreases BMR.
- Malnutrition decreases BMR as the body becomes more efficient.
- Females and older individuals generally have lower BMR due to differences in muscle mass, body fat, and sex hormone levels.
Heat Production in the Body
- Approximately one-third of the energy released from ATP hydrolysis is converted to heat.
- Friction at the microscopic level contributes to heat production such as blood flow and movement within the musculoskeletal system.
Oral Temperature Ranges
- Resting oral temperature ranges from 97 to 99.5 degrees Fahrenheit.
- During exercise, oral temperature can rise between 101 and 104 degrees Fahrenheit.
- In cold conditions, oral temperature can decrease.
- Rectal temperature is typically higher than oral temperature.
Cardiac Anatomy and Function
- Blood flows through the heart in the following order: Right Atrium → Tricuspid Valve → Right Ventricle → Pulmonary Valve → Pulmonary Artery → Lungs → Pulmonary Vein → Left Atrium → Mitral Valve → Left Ventricle → Aortic Valve → Aorta
- Cardiac muscle, like skeletal muscle, is striated due to the presence of actin and myosin however cardiac muscle has intercalated discs and a syncytial arrangement
- Intercalated discs allow for rapid diffusion of ions between cardiac muscle cells, facilitating electrical conduction
- Papillary muscles attach to the atrioventricular (AV) valves via chordae tendinae, preventing valve prolapse and regurgitation into the atria
- Semilunar valves (pulmonary and aortic) are thicker and stronger than AV valves, with faster blood flow and more mechanical abrasion
- Semilunar valves function passively due to high pressure in arteries, not requiring chordae tendinae for closure
Blood Flow Distribution at Rest
- Approximately 15% of blood flow is directed to the brain at rest; this percentage decreases during exercise, but absolute volume remains constant
- Coronary arteries receive about 5% of blood flow, increasing proportionally during exercise to meet the increased metabolic demands of the working myocardium.
- Kidneys receive 25% of blood flow at rest making it a key site for adjusting vascular resistance
- The GI tract also receives 25% of blood flow at rest, significantly reduced during exercise
- Skeletal muscle receives 25% of blood flow at rest, dramatically increasing during exercise with working muscles receiving the greatest flow
- Skin receives 5% of blood flow, varying based on body temperature.
- Vasoconstriction occurs in cold temperatures, initially during exercise, and during hot temperatures to eliminate heat
- Vasodilation occurs during hot temperatures and during exercise for heat elimination
Cardiac Muscle Contractility
- The action potential plateau in cardiac muscle is a slower calcium influx from L-type calcium channels, allowing greater inflow of Na+ and Ca2+ compared to skeletal muscle, where only Na+ channels are involved
- The slower calcium channels contribute to the prolonged depolarization and plateau in the action potential of cardiac muscle
- The plateau is also sustained by decreased permeability for potassium ions, preventing rapid repolarization
- Purkinje fibers conduct electrical signals much faster than cardiac muscle fibers, enabling quick and efficient spread of the conduction signal through the heart
- The absolute refractory period represents a time when the heart cannot be stimulated to contract, while the relative refractory period allows contraction only to a strong stimulus
- Extracellular calcium is crucial for cardiac muscle contraction due to the direct connection of t-tubules to the extracellular space, providing a source of calcium for contraction
Cardiac Cycle
- Increased heart rate shortens the action potential plateau, decreases the duration of systole and diastole, and increases the ratio of systole to diastole
- During the cardiac cycle, ventricular volume increases during diastole, atrial pressure increases during atrial contraction, aortic pressure increases during ventricular ejection, and ventricular pressure increases during systole
- Atrial contraction contributes to ventricular filling by pumping blood into the ventricles before ventricular contraction
- The period of rapid filling of ventricles is driven by increased atrial pressure pushing blood through the open AV valves into the low-pressure ventricles
- Isovolumetric contraction occurs before ejection because sufficient pressure must be generated to overcome the pressure in the aorta and pulmonary artery
- The period of rapid ejection is characterized by higher pressure and a greater ejection fraction than the period of slow ejection
- Ejection fraction is calculated as the ratio of stroke volume (EDV-ESV) to end diastolic volume (EDV) and is normally around 60% at rest
- The right ventricle generates pressures about 1/6th of the left ventricle during systole
- Preload refers to the end diastolic pressure, representing ventricular tension prior to contraction and reflecting filling pressure
- Afterload refers to the resistance to blood flow in the aorta, effectively the pressure that the ventricle must overcome to eject blood; it is represented by the aortic diastolic pressure
- The Frank-Starling mechanism asserts that greater ventricular filling leads to greater contractile force and stroke volume, which is attributed to increased elastic energy and more optimal actin-myosin overlap
Conductive System of the Heart
- The electrical impulse travels through the heart in the following sequence: Sinoatrial (SA) Node → Internodal Pathways → Atrioventricular (AV) Node → Atrioventricular Bundle → Bundle Branches → Ventricular Muscle
- The SA node has the highest intrinsic rate of 70-80 beats per minute, followed by the AV node at 40-60 bpm, and the Purkinje fibers of the ventricles at 15-40 bpm
- Ectopic beats originate from sites other than the SA node, while escape beats occur when the ventricle contracts independently due to a slower supraventricular impulse rate
- The intrinsic heart rate, the rate in the absence of autonomic nervous system influence, is approximately 70-90 beats per minute
- Sympathetic stimulation increases heart rate, while parasympathetic stimulation decreases heart rate
Autonomic Regulation of Heart Rate and Impulses
- Sympathetic nerves innervate all parts of the heart, releasing norepinephrine (NE) to increase SA node discharge, conduction rate, and contractile force
- Parasympathetic nerves predominantly supply the SA node and AV junctional fibers, releasing acetylcholine (ACh) to slow down the conduction process and decrease heart rate
- The sympathetic nervous system increases contractile force through stimulation of beta-adrenergic receptors leading to
- increased intracellular calcium levels
Heart Rate Terminology
- Tachycardia is a faster than normal resting heart rate, while bradycardia is a slower than normal resting heart rate
- These terms are descriptive, and their presence does not always indicate pathology
Cardiovascular System: Blood Flow
- Blood Flow Path: Blood enters the heart through the vena cava into the right atrium. It then passes through the tricuspid valve into the right ventricle. From there, it is pumped through the pulmonary valve into the pulmonary artery and flows to the lungs. After oxygenation, the blood returns to the heart via the pulmonary veins to the left atrium. Through the mitral valve, it enters the left ventricle and is then pumped through the aortic valve into the aorta.
- Cardiac Muscle vs Skeletal Muscle: Both types of muscle are striated due to the presence of actin and myosin, but they differ in structure and function. Cardiac muscle possesses intercalated discs that allow for communication and rapid diffusion of ions between cells. Cardiac muscle also has a syncytial arrangement, meaning that the cells connect and function as a unit.
- Intercalated Discs Function: These structures allow for the rapid conduction of electrical signals throughout the heart, ensuring coordinated contraction.
- Papillary Muscles & Chordae Tendinae: These structures work together to prevent the atrioventricular (AV) valves from buldging back into the atria during ventricular contraction, preventing regurgitation.
- AV & Semilunar Valve Function: AV valves are thin and regulate blood flow between the atria and ventricles. Semilunar valves are stronger and handle the higher velocity blood flow in the arteries. They function passively, opening and closing based on pressure gradients.
Blood Flow Distribution
-
Organ Blood Flow at Rest:
- Brain: 15%
- Coronary Arteries: 5%
- Kidneys: 25%
- GI Tract: 25%
- Skeletal Muscle: 25%
- Skin: 5%
Cardiac Muscle Contractility
- Cardiac Action Potential Plateau: Caused mainly by the activation of slow calcium channels (L-type calcium channels) and decreased permeability to potassium ions.
- Slow Calcium Channels: Their activation in cardiac muscle prolongs depolarization, creating the plateau in the action potential. This is unlike skeletal muscle.
- Purkinje Fiber Conduction: Purkinje fibers conduct electrical signals much faster than cardiac muscle fibers, ensuring efficient spread of the signal throughout the heart.
-
Refractory Periods:
- Absolute: The heart cannot be stimulated to contract regardless of the strength of the signal.
- Relative: The heart cannot be excited by a normal signal but can be stimulated by an especially strong signal.
- Extracellular Calcium & Contraction: Contraction in cardiac muscle depends on calcium influx from the extracellular fluid, unlike skeletal muscle where calcium is primarily released from the sarcoplasmic reticulum.
Cardiac Cycle
- Heart Rate & Cardiac Cycle Duration: Increasing heart rate decreases the duration of the action potential plateau, resulting in a shorter systole and diastole. It also reduces the relative filling time.
-
Cardiac Cycle Events:
- Ventricular Filling: Begins with passive filling followed by atrial contraction.
- Isovolumetric Contraction: Muscle contracts but no blood is ejected, pressure builds up to overcome aortic pressure.
- Ejection: Rapid ejection occurs during the first third of systole, followed by slower ejection.
- Ejection Fraction: The percentage of blood ejected from the ventricle during each contraction, calculated as (EDV-ESV)/EDV, with a normal resting value of 60%.
- Ventricular Pressures: The pressure in the right ventricle is much lower than the left during systole.
-
Preload & Afterload:
- Preload: End diastolic pressure when the ventricle is filled, reflecting the degree of tension at the start of contraction.
- Afterload: Pressure in the aorta (resistance in circulation), which the ventricle must overcome to eject blood.
- Frank-Starling Mechanism: The heart's ability to increase stroke volume in response to increased preload, due to greater stretch and elastic energy, and increased contractile strength.
Cardiac Conduction System
- Conduction Pathway: Electrical impulse originates at the SA node and travels through the internodal pathways to the AV node. It then progresses through the AV bundle, bundle branches, and lastly to the ventricular muscle, ensuring coordinated contraction.
Automaticity
-
Intrinsic Rhythm Rates:
- SA Node: 70-80 beats/minute
- AV Node: 40-60 beats/minute
- Purkinje Fibers: 15-40 beats/minute
- Ectopic Beats: Originate from sites outside the SA node.
- Escape Beats: Occur when the ventricle is not stimulated by impulses from the SA node and takes over the pacemaking role because of the intrinsic rate in the ventricle.
- Intrinsic Heart Rate: (~70-90 bpm) Represents the heart rate in the absence of autonomic nervous system influence.
Autonomic Regulation
-
Sympathetic & Parasympathetic Distribution:
- Sympathetic: Innervate all parts of the heart.
- Parasympathetic: Primarily target the SA node and AV junctional fibers.
- Parasympathetic Nerve: Vagus nerve.
-
Neurotransmitters:
- Sympathetic: Epinephrine (adrenaline) and norepinephrine.
- Parasympathetic: Acetylcholine.
- Sympathetic Influence on Contractility: Increases contractile force through beta-adrenergic receptor stimulation, leading to increased calcium influx.
Heart Rate Terminology
- Tachycardia: Faster than normal resting heart rate.
- Bradycardia: Slower than normal resting heart rate.
- Note: These terms merely describe heart rate and do not necessarily indicate pathology.
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Description
Explore the fascinating concepts of Basal Metabolic Rate (BMR) and heat production in the human body. This quiz covers factors affecting BMR, the role of hormones, and normal oral temperature ranges during different states. Test your understanding of physiological processes essential for maintaining body function.