Human Physiology: Blood and Extracellular Fluids
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Questions and Answers

What percentage of your total body mass does blood account for?

  • 8% (correct)
  • 10%
  • 15%
  • 5%
  • Blood is less viscous than water.

    False (B)

    What is the liquid ECM of blood called?

    blood plasma

    The three main components of blood include erythrocytes, leukocytes, and _____.

    <p>platelets</p> Signup and view all the answers

    Which component of blood is responsible for transporting oxygen and carbon dioxide?

    <p>Erythrocytes (A)</p> Signup and view all the answers

    The average male has approximately 7–8 liters of blood.

    <p>False (B)</p> Signup and view all the answers

    Match the following blood components with their primary function:

    <p>Erythrocytes = Transport oxygen and carbon dioxide Leukocytes = Fight infection Platelets = Blood clotting Plasma = Liquid ECM</p> Signup and view all the answers

    Blood plasma is composed of _____% water.

    <p>91.5</p> Signup and view all the answers

    What is the average hematocrit percentage for adults?

    <p>47% (B)</p> Signup and view all the answers

    Low hematocrit levels can lead to anemia.

    <p>True (A)</p> Signup and view all the answers

    What process describes the formation of blood cells?

    <p>Hemopoiesis</p> Signup and view all the answers

    Erythropoiesis is stimulated by a reduction in oxygen transport to tissues or _____

    <p>hypoxia</p> Signup and view all the answers

    Match the following blood components with their descriptions:

    <p>Erythrocytes = Transport oxygen and carbon dioxide Leukocytes = Defend against pathogens Platelets = Involved in blood clotting Plasma = Liquid component of blood</p> Signup and view all the answers

    Which type of stem cell develops into lymphoid stem cells?

    <p>Pluripotent stem cells (A)</p> Signup and view all the answers

    All white blood cells can proliferate after leaving the bone marrow.

    <p>False (B)</p> Signup and view all the answers

    What is the primary function of hemoglobin in erythrocytes?

    <p>Transport oxygen</p> Signup and view all the answers

    The kidneys synthesize __________ which increases the number of erythrocyte precursors.

    <p>Erythropoietin</p> Signup and view all the answers

    Match the following leukocytes with their characteristics:

    <p>Neutrophils = Phagocytic cells Eosinophils = Combat parasitic infections Basophils = Release histamine during allergic reactions Monocytes = Differentiate into macrophages</p> Signup and view all the answers

    What percentage of carbon dioxide is carried by red blood cells?

    <p>23% (C)</p> Signup and view all the answers

    Erythrocytes possess a nucleus at maturity.

    <p>False (B)</p> Signup and view all the answers

    What role does nitric oxide (NO) play in the blood?

    <p>Vasodilation</p> Signup and view all the answers

    Macrophages destroy worn-out or damaged red blood cells in the _____ or _____ marrow.

    <p>liver, red bone</p> Signup and view all the answers

    Which type of leukocyte is primarily responsible for defending against parasitic infections?

    <p>Eosinophils (B)</p> Signup and view all the answers

    Basophils primarily release chemicals that promote inflammation and hypersensitivity reactions.

    <p>True (A)</p> Signup and view all the answers

    What is the function of neutrophils at the site of infection?

    <p>Phagocytize pathogens</p> Signup and view all the answers

    Which of the following is NOT a requirement for blood coagulation?

    <p>Vitamin D (B)</p> Signup and view all the answers

    Eosinophils have granules that stain with _____ dyes.

    <p>acidic</p> Signup and view all the answers

    The extrinsic pathway of blood clotting is activated by the contact between damaged endothelial cells and connective tissue.

    <p>False (B)</p> Signup and view all the answers

    Which leukocyte is derived from the lymphoid stem cell lineage?

    <p>Lymphocytes (A)</p> Signup and view all the answers

    The lifespan of platelets is approximately 5 to 9 weeks.

    <p>False (B)</p> Signup and view all the answers

    What is the primary antigen that is tested in ABO blood typing?

    <p>glycolipid</p> Signup and view all the answers

    Blood clots may result in __________ if they block small vessels.

    <p>embolism</p> Signup and view all the answers

    What is the main role of monocytes once they arrive at the site of infection?

    <p>Differentiate into macrophages</p> Signup and view all the answers

    Match the following blood disorders with their descriptions:

    <p>Anemia = Condition of insufficient red blood cells Hemophilia = Inherited disorder of insufficient clotting factors Polycythemia = Excessive number of red blood cells Sickle cell disease = Genetic mutation affecting hemoglobin</p> Signup and view all the answers

    Hemostasis is the process that prevents _____ from occurring.

    <p>hemorrhage</p> Signup and view all the answers

    What is released by platelets to promote vasoconstriction?

    <p>ADP (A)</p> Signup and view all the answers

    What happens to the second Rh+ fetus if the mother has generated anti-Rh antibodies during her first pregnancy?

    <p>The fetus is at risk for hemolytic disease of the newborn (A)</p> Signup and view all the answers

    Individuals with blood type O have both A and B antigens on their erythrocytes.

    <p>False (B)</p> Signup and view all the answers

    What chemical signaling leads to vascular spasm during hemostasis?

    <p>Reflexes initiated by pain receptors</p> Signup and view all the answers

    Match the following leukocytes with their primary functions:

    <p>Neutrophils = Fast response to bacterial infections Lymphocytes = Defend against viral infections and cancer cells Eosinophils = Fight parasitic infections Basophils = Release histamine during inflammation</p> Signup and view all the answers

    What kind of antibodies does an individual with blood type O produce?

    <p>anti-A and anti-B</p> Signup and view all the answers

    Sickle cell disease is characterized by a genetic mutation in the _________ gene.

    <p>globin</p> Signup and view all the answers

    Neutrophils release _____ to disrupt bacterial membranes.

    <p>lysozyme</p> Signup and view all the answers

    Chemotaxis is the process that allows white blood cells to move toward chemical signals released by invaders.

    <p>True (A)</p> Signup and view all the answers

    Match the types of hemoglobin with their characteristics:

    <p>Normal hemoglobin = Disc-shaped red blood cells Sickle hemoglobin = Elongated red blood cells Oxygen-carrying capacity = Affected in sickle cell disease Protection against malaria = Advantage of sickle cell alleles</p> Signup and view all the answers

    What type of granules do basophils contain that stains with basic dyes?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following treatment options is commonly used for hemophilia?

    <p>Infusions of synthetic clotting factors (D)</p> Signup and view all the answers

    What is released in response to tissue damage to help activate platelets?

    <p>ADP</p> Signup and view all the answers

    Individuals with sickle cell disease have a lower risk of malaria.

    <p>True (A)</p> Signup and view all the answers

    What is the main consequence of excessive clot formation in blood vessels?

    <p>thrombosis</p> Signup and view all the answers

    In the common pathway for blood clotting, activated factor X joins with factor V to form __________.

    <p>prothrombinase</p> Signup and view all the answers

    Flashcards

    Blood Composition

    Blood is made of two main parts: plasma (liquid) and formed elements (cells).

    Blood Plasma

    The liquid part of blood, mostly water with dissolved substances like proteins, electrolytes, nutrients, and waste products.

    Formed Elements

    The cellular components of blood, including red blood cells (erythrocytes), white blood cells (leukocytes), and platelets.

    Erythrocytes

    Red blood cells that carry oxygen and carbon dioxide.

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    Leukocytes

    White blood cells that fight infection and disease.

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    Platelets

    Cell fragments that help stop bleeding by forming blood clots.

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    Blood Function: Transportation

    Blood carries oxygen, nutrients, hormones, heat, and waste products throughout the body.

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    Blood Function: Regulation

    Blood controls pH, body temperature, and osmotic pressure.

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    Hematocrit

    The percentage of blood volume occupied by red blood cells.

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    Low hematocrit

    A hematocrit below the normal range (<40), indicating too few red blood cells.

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    High hematocrit

    A hematocrit above the normal range (>65), indicating too many red blood cells.

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    Hemopoiesis

    The process of blood cell formation in red bone marrow.

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    Pluripotent stem cells

    Stem cells that can develop into multiple types of blood cells.

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    Myeloid stem cells

    A lineage of blood stem cells that give rise to red blood cells, platelets, and most white blood cells.

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    Lymphoid stem cells

    A lineage of blood stem cells that gives rise to lymphocytes (a type of white blood cell).

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    Erythropoietin (EPO)

    A hormone that increases the number of red blood cell precursors.

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    Biconcave disc

    The characteristic shape of red blood cells, maximizing surface area for gas exchange.

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    Anucleate

    Without a nucleus. Red blood cells lack a nucleus after maturation.

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    Hemoglobin

    The protein in red blood cells that carries oxygen.

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    Carbonic anhydrase

    An enzyme in red blood cells that converts carbon dioxide into bicarbonate.

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    Hypoxia

    A condition of low oxygen levels in tissues.

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    Granular leukocytes

    White blood cells with granules in their cytoplasm.

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    Neutrophils

    Phagocytic white blood cells that are part of the innate immune system.

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    Phagocytosis

    The process of engulfing and destroying pathogens by immune cells like neutrophils.

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    Eosinophils

    Immune cells that defend against parasites, particularly worms

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    Basophils

    Immune cells involved in inflammatory and hypersensitivity reactions, releasing histamine, heparin, and serotonin

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    Lymphocytes

    Agranular immune cells that fight viral infection and cancer; including B and T cells

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    Monocytes

    Immune cells that differentiate into macrophages (cleaning up cellular debris) or osteoclasts

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    Chemotaxis

    The movement of cells towards a chemical stimulus, like injured tissues or invaders. 

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    Hemostasis

    The process that prevents excessive bleeding (hemorrhage).

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    Vascular Spasm

    Narrowing of blood vessels to limit blood loss following damage.

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    Platelet Plug Formation

    Platelets clump together to form a temporary plug at a blood vessel injury site.

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    Blood Clot

    A reinforced platelet plug (containing protein fibers), preventing further blood loss.

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    Macrophages

    Specialized immune cells derived from monocytes, functioning to remove cellular debris.

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    Megakaryocytes

    Large cells in the bone marrow that break up to form platelets.

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    Coagulation

    The process of blood clot formation. It requires clotting factors like calcium ions, enzymes from the liver, and substances released by platelets and damaged tissues.

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    Intrinsic Pathway

    A blood clotting pathway triggered by damage within the blood vessels themselves. It involves contact with connective tissue, activation of factor XII, and release of phospholipids by platelets.

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    Extrinsic Pathway

    A blood clotting pathway activated by an external substance, tissue factor (TF), released from damaged blood vessel cells. TF activates factor X, starting the clotting cascade.

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    Tissue Factor (TF)

    A substance released from damaged blood vessel cells that activates the extrinsic pathway of blood clotting. It's composed of phospholipids and lipoproteins.

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    Common Pathway

    The final phase of blood clotting, where activated factor X joins with factor V to form prothrombinase. Prothrombinase converts prothrombin into thrombin, which in turn converts soluble fibrinogen into insoluble fibrin, forming the clot.

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    Thrombin

    An enzyme that plays a crucial role in blood clotting. It converts fibrinogen into fibrin, forming the mesh-like structure of the clot and also activates factor XIII, stabilizing the fibrin threads.

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    Fibrinogen

    A soluble protein found in blood plasma. Thrombin converts it into fibrin, an insoluble protein that forms the mesh-like structure of a blood clot.

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    Fibrin

    An insoluble protein formed from fibrinogen by thrombin. It forms the mesh-like structure of a blood clot, trapping blood cells and platelets.

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    Thrombosis

    The formation of an abnormal blood clot inside a blood vessel, which can obstruct blood flow. It can lead to embolism, stroke, or pulmonary embolism.

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    Embolism

    A blockage in a blood vessel caused by a blood clot, air bubble, or other debris traveling through the bloodstream.

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    ABO Blood Groups

    A classification of blood types based on the presence or absence of specific antigens (glycolipids) on the surface of red blood cells. These antigens determine the antibodies present in the plasma.

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    Agglutinins

    Antibodies found in the plasma that recognize and bind to A or B antigens on red blood cells, leading to agglutination (clumping) of the cells.

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    Agglutination

    The clumping of red blood cells when they come into contact with agglutinins (antibodies) that recognize their specific surface antigens.

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    Rhesus Factor (Rh)

    A protein antigen found on the surface of red blood cells. Individuals with the Rh antigen are Rh-positive (+), while those without it are Rh-negative (-)

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    Hemolytic Disease of the Newborn (HDN)

    A condition that can occur when an Rh-negative mother carries an Rh-positive fetus. During pregnancy, the mother's immune system may develop anti-Rh antibodies, which can cross the placenta and attack the fetus's red blood cells, leading to anemia and jaundice in the newborn.

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    Study Notes

    Extracellular Fluids of the Body

    • Three extracellular fluids: blood, interstitial fluid, and lymph
    • Nutrients move from blood to interstitial fluid to cells.

    Blood: Composition and Function

    • Blood is a connective tissue with formed elements (cells) in a liquid extracellular matrix (plasma).
    • Blood accounts for ~8% of body mass.
    • Average male blood volume: 5-6 L; average female: 4-5 L.
    • Blood is more viscous than water.
    • Blood temperature: ~38ºC; pH: 7.35-7.45.
    • Three main functions:
      • Transportation (oxygen, nutrients, hormones, heat, waste)
      • Regulation (pH, body temperature, osmotic pressure)
      • Protection (against blood loss, invasion, disease)

    Composition of Blood

    • Two components:
      • Blood plasma (55%):
        • Liquid extracellular matrix containing dissolved substances (91.5% water, 8.5% solutes).
        • Proteins: albumin (maintains osmotic pressure), globulins (antibodies, transport proteins), fibrinogen (blood clotting).
        • Other solutes: electrolytes, nutrients, enzymes, hormones, gases, metabolic wastes.
      • Formed elements (45%):
        • Erythrocytes (red blood cells): most abundant, transport O2 and CO2. Lack organelles at maturity to maximize space for hemoglobin.
        • Leukocytes (white blood cells): various types, fight infection and invasion.
        • Platelets (thrombocytes): cell fragments, crucial for clotting.

    Blood Cell Formation (Hemopoiesis)

    • Blood cells are continuously replenished.
    • Hemopoiesis occurs in red bone marrow.
    • Starts from pluripotent stem cells.
    • Develops into two lineages: myeloid stem cells and lymphoid stem cells.
    • Each lineage produces precursor cells that differentiate into formed elements.
    • WBCs divide after leaving bone marrow.

    Regulation of Blood Cell Formation

    • Hematopoietic growth factors (hormones affecting blood cell formation):
      • Erythropoietin (EPO): increases erythrocyte production, produced in kidneys.
      • Thrombopoietin (TPO): stimulates platelet formation, produced in the liver.
      • Cytokines: stimulate leukocyte and lymphocyte proliferation, produced in red bone marrow.

    Erythrocytes (Structure and Function)

    • Biconcave discs: large surface area to volume ratio, flexible for capillary passage.
    • Anucleate at maturity; lack most organelles except for hemoglobin (Hb).
    • Hb transports oxygen (~250 million Hb/erythrocyte).
    • Also carry ~23% of body's CO2.
    • Contain carbonic anhydrase: converts CO2 to carbonic acid (important blood buffer).
    • Nitric oxide (NO) acts as a hormone, released by endothelial cells in response to stress, causing vasodilation.
    • Life span: ~120 days.
    • Worn-out erythrocytes are destroyed by macrophages in the liver, spleen, or red bone marrow.

    Erythrocyte Life Cycle

    • Hemoglobin broken down; globin into amino acids (recycled); iron (ferric) bound to transferrin, stored in ferritin or transported to bone marrow for new erythropoiesis.
    • Iron-less heme products: yellow products excreted by kidneys, others in feces.
    • Erythropoiesis is stimulated by reduced oxygen transport (hypoxia) via EPO.

    Leukocytes (Structure and Function)

    • Granular leukocytes: neutrophils, eosinophils, basophils (contain visible granules).
    • Agranular leukocytes: lymphocytes (derived from lymphoid stem cells), monocytes (derived from myeloid stem cells, differentiate into macrophages).
    • Major functions: infection and invasion defense.

    Leukocyte Function: Inflammation and Immunity

    • WBCs defend against infection, express MHC proteins (self-identifying).
    • Invaders trapped, cilia sweep away debris.
    • WBCs accumulate at infection site (emigration), chemotaxis.
    • Neutrophils: fast responders, phagocytize pathogens, release lysozyme, oxidizing chemicals, defensins.
    • Eosinophils: fight parasites, secrete histaminase to disrupt signaling.
    • Basophils: inflammatory and hypersensitivity reactions, release heparin, histamine, serotonin.
    • Lymphocytes: circulate and reside in lymphatic system, B lymphocytes produce antibodies, T lymphocytes and natural killer cells fight infected and cancerous cells.
    • Monocytes: differentiate into wandering macrophages, clean up cell debris.
    • Inflammation leads to emigration, chemotaxis, tissue disinfection, and tissue healing.

    Platelets

    • Formed from megakaryocytes which divide themselves into fragments that are now platelets.
    • Contain granules with clotting factors.
    • Life span: 5-9 days.

    Hemostasis

    • Hemostasis prevents excessive bleeding:
      • Vascular spasm: blood vessel damage causes smooth muscle spasm
      • Platelet plug formation: platelets adhere, activate, aggregate (clumping).
      • Blood clotting (coagulation): platelet plug + insoluble protein fibers for reinforcement.

    Blood Clot Formation

    • Clotting factors (including Ca2+, liver-made enzymes, platelet substances): intrinsic (internal damage) and extrinsic (external factor) pathways.
    • Activation of factor X leads to formation of prothrombinase from factor X and V which then converts prothrombin to thrombin.
    • Thrombin acts on fibrinogen converting it into fibrin.
    • Factor XIII stabilizes fibrin threads.

    Blood Clotting Regulation

    • Tightly controlled: thrombosis (clumping) = blocked vessels, emboli (embolism) = stroke, pulmonary embolism; hemorrhage (excessive bleeding) = anemia, shock.

    Diseases and Disorders of Blood

    • ABO blood groups: glycolipid antigens; agglutinins (antibodies) clump erythrocytes (agglutination), individuals make antibodies against foreign antigens.
    • Hemolytic Disease of the Newborn (HDN): Rh factor incompatibility between mother and fetus.
    • Anemia: reduced oxygen carrying capacity (many causes).
    • Sickle cell disease: genetic mutation in globin gene, elongated cells, protects against malaria.
    • Hemophilia: insufficient clotting factors.
    • Polycythemia: too many erythrocytes, thickened blood.

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    Description

    This quiz covers the composition and functions of blood as well as the three types of extracellular fluids: blood, interstitial fluid, and lymph. It delves into the roles blood plays in transportation, regulation, and protection within the body, providing essential knowledge for understanding human physiology.

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