Podcast
Questions and Answers
What is one of the radical techniques mentioned in the text for curing autoimmune diseases?
What is one of the radical techniques mentioned in the text for curing autoimmune diseases?
How many people have received the radical immune system replacement treatment according to the text?
How many people have received the radical immune system replacement treatment according to the text?
What was the outcome for about one third of the participants who received the immune system replacement treatment?
What was the outcome for about one third of the participants who received the immune system replacement treatment?
Why do doctors use intense chemotherapy and radiation before bone marrow transplants in immune system replacement treatment?
Why do doctors use intense chemotherapy and radiation before bone marrow transplants in immune system replacement treatment?
Signup and view all the answers
Which autoimmune diseases were specifically mentioned in the text as examples of those that can have tragic effects?
Which autoimmune diseases were specifically mentioned in the text as examples of those that can have tragic effects?
Signup and view all the answers
What is a common effect of autoimmune diseases on patients?
What is a common effect of autoimmune diseases on patients?
Signup and view all the answers
What is the main reason why each B cell only produces one kind of antibody?
What is the main reason why each B cell only produces one kind of antibody?
Signup and view all the answers
What was the problem Georges Köhler and César Milstein's technique aimed to solve?
What was the problem Georges Köhler and César Milstein's technique aimed to solve?
Signup and view all the answers
What is the key factor that allows hybridoma cells to produce homogeneous monoclonal antibodies?
What is the key factor that allows hybridoma cells to produce homogeneous monoclonal antibodies?
Signup and view all the answers
Why is it not possible for each B cell to be a direct source of homogeneous antibodies by cloning?
Why is it not possible for each B cell to be a direct source of homogeneous antibodies by cloning?
Signup and view all the answers
Which aspect enabled the production of antibodies to almost any antigen in quantity using monoclonal antibodies?
Which aspect enabled the production of antibodies to almost any antigen in quantity using monoclonal antibodies?
Signup and view all the answers
What distinguishes the resulting hybridoma cells from normal lymphocytes?
What distinguishes the resulting hybridoma cells from normal lymphocytes?
Signup and view all the answers
What is the primary vector used in ex vivo gene therapy for SCID?
What is the primary vector used in ex vivo gene therapy for SCID?
Signup and view all the answers
Why are the gag, pol, and env genes removed from the MMLV used in gene therapy?
Why are the gag, pol, and env genes removed from the MMLV used in gene therapy?
Signup and view all the answers
In ex vivo gene therapy for SCID, what happens to the MMLV particles after they infect the packaging cell line?
In ex vivo gene therapy for SCID, what happens to the MMLV particles after they infect the packaging cell line?
Signup and view all the answers
What is the main purpose of using controls in ex vivo gene therapy with MMLV?
What is the main purpose of using controls in ex vivo gene therapy with MMLV?
Signup and view all the answers
Which method of human gene therapy involves removing somatic cells from the patient for manipulation?
Which method of human gene therapy involves removing somatic cells from the patient for manipulation?
Signup and view all the answers
What is the main target of infection in ex vivo gene therapy for SCID using MMLV?
What is the main target of infection in ex vivo gene therapy for SCID using MMLV?
Signup and view all the answers