Human Embryology Week 6
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Questions and Answers

What structures contribute to the formation of the upper jaw and cheeks during facial development in the sixth week?

  • Mandibular processes
  • Maxillary processes (correct)
  • Frontonasal prominence
  • Nasal pits
  • What role does the foramen ovale play in fetal circulation during the sixth week of embryonic development?

  • Circulates oxygenated blood to the lungs
  • Facilitates limb development
  • Diverts blood to the stomach
  • Bypasses the non-functional fetal lungs (correct)
  • Which process is essential for the separation of digits in limb development during the sixth week?

  • Mesodermal migration
  • Cell proliferation
  • Neurulation
  • Apoptosis (correct)
  • During the sixth week, what is the main anatomical change that occurs in the cardiac development?

    <p>Septation of the atria and ventricles (C)</p> Signup and view all the answers

    What does the emergence of nasal pits indicate during the sixth week of embryonic development?

    <p>Development of nostrils and nasal cavities (D)</p> Signup and view all the answers

    What is developed by the merging of the mandibular processes during facial development in week six?

    <p>Lower jaw and chin (A)</p> Signup and view all the answers

    What characterizes the heartbeat detection process during the sixth week?

    <p>Coordinated contractions can be observed via ultrasound (C)</p> Signup and view all the answers

    What developmental process indicates the beginning of segmentation for fingers in the limb buds during week six?

    <p>Definition of limb buds (A)</p> Signup and view all the answers

    What significant change occurs at week 6 in the development of upper limb buds?

    <p>They form paddle-like hand plates. (A)</p> Signup and view all the answers

    What is the purpose of apoptosis in the interdigital regions of the upper limbs?

    <p>To sculpt and separate the digits. (A)</p> Signup and view all the answers

    Which of the following events is first observed in the upper limb development before lower limbs?

    <p>Formation of hand plates. (B)</p> Signup and view all the answers

    What do digital rays in the hand plates signify?

    <p>Beginning of finger segmentation. (C)</p> Signup and view all the answers

    At week 6, what is the overall status of the lower limb development compared to the upper limbs?

    <p>They lag slightly behind in differentiation. (B)</p> Signup and view all the answers

    What critical feature do hand plates provide for future limb development?

    <p>Foundation for digit formation. (A)</p> Signup and view all the answers

    What occurs as a result of the midgut's elongation at week 6?

    <p>It begins to herniate into the umbilical cord. (C)</p> Signup and view all the answers

    What does the term 'foot plates' refer to in lower limb development?

    <p>Flattened distal ends of lower limb buds. (D)</p> Signup and view all the answers

    What does the cranial limb of the midgut loop develop into?

    <p>Parts of the small intestine (B)</p> Signup and view all the answers

    What is the direction of the initial rotation of the midgut loop?

    <p>Counterclockwise (D)</p> Signup and view all the answers

    Which structure remains connected to the herniated loop during its development?

    <p>Yolk sac via the vitelline duct (D)</p> Signup and view all the answers

    What eventually happens to the caudal limb of the midgut?

    <p>It forms the large intestine (A)</p> Signup and view all the answers

    During the herniation of the midgut, where does the midgut bulge into?

    <p>The umbilical cord (D)</p> Signup and view all the answers

    What is the significance of the rotation of the midgut loop?

    <p>It ensures proper organ positioning within the abdominal cavity (B)</p> Signup and view all the answers

    During which week does the herniation of the midgut typically occur?

    <p>Week 6 (C)</p> Signup and view all the answers

    What role does the vitelline duct play during midgut development?

    <p>It acts as a conduit for nutrients and waste exchange (B)</p> Signup and view all the answers

    Flashcards

    Ventricular Septation

    The formation of two separate chambers in the heart, the right and left ventricle, through the development of the interventricular septum.

    Maxillary Processes

    During the 6th week, the upper jaw and cheeks form as the maxillary processes expand inward.

    Nasal Pits

    The first stage of nostril development, these depressions appear on the frontonasal prominence during the 6th week.

    Cardiac Morphogenesis

    The process during the 6th week where the heart develops a more defined structure and becomes functional.

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    Atrial Septation

    The initial separation of the right and left atria through the growth of the septum primum and septum secundum.

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    Foramen Ovale

    This opening allows blood to flow directly from the right atrium to the left atrium, bypassing the fetal lungs which are not yet functional.

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    Limb Differentiation

    During week 6, the limb buds develop further and segments for fingers begin to form.

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    Mandibular Processes

    The fusion of two mandibular processes during the 6th week to form the lower jaw and chin.

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    What are hand plates?

    The distal ends of upper limb buds flatten into paddle-like structures during week 6, forming the precursors to the hands. These structures are essential for further limb differentiation.

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    What are digital rays?

    Thickened ridges appearing in the hand plates indicate the future location of fingers. They serve as a blueprint for digit segmentation and help organize the fingers.

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    How do fingers separate from each other?

    Programmed cell death, or apoptosis, eliminates tissue between the digital rays, sculpting individual fingers. It plays a crucial role in shaping the digits.

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    What is the state of lower limb development in week 6 compared to upper limbs?

    The lower limbs show slight elongation and differentiation by week 6, but develop slightly later than the upper limbs. The foot plates, the precursors to the feet, begin to form during this stage.

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    What happens to the midgut in week 6?

    The midgut elongates rapidly and forms a loop that pushes into the umbilical cord to accommodate its growth, due to limited space in the abdominal cavity.

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    What is the herniation of the midgut?

    The midgut extends outward into the umbilical cord as it grows, creating a temporary hernia.

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    Midgut Herniation

    The midgut, the portion of the developing gut that will become the small and large intestines, grows rapidly and protrudes out of the abdominal cavity into the umbilical cord.

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    Vitelline Duct

    The temporary connection between the herniated midgut and the yolk sac is called the vitelline duct. It serves as a passage for nutrients and waste.

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    Cranial Limb Development

    The upper part of the herniated midgut loop develops into the duodenum, jejunum, and part of the ileum, responsible for nutrient absorption.

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    Caudal Limb Development

    The lower part of the herniated midgut loop forms the cecum, appendix, and part of the colon, responsible for water absorption and waste processing.

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    Midgut Loop Rotation

    The midgut loop rotates 90 degrees counterclockwise around the superior mesenteric artery (SMA) during the 6th week, placing the intestines in their proper position.

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    Counterclockwise Rotation

    The initial 90-degree counterclockwise rotation of the midgut loop around the superior mesenteric artery.

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    Organ Positioning

    The cranial limb of the midgut loop moves to the right side of the body, while the caudal limb moves to the left.

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    Role of Superior Mesenteric Artery

    The superior mesenteric artery (SMA) serves as the axis around which the midgut loop rotates, ensuring correct anatomical positioning of the intestines.

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    Study Notes

    Human Embryology - Week 6

    • The sixth week of embryonic development brings significant changes, including the growth of pharyngeal arches (nasal, maxillary, and mandibular processes).
    • Cardiac morphogenesis is crucial, involving atrial and ventricular septation.
    • The foramen ovale plays a role in fetal circulation.
    • Hand and foot plates form, and apoptosis sculpts digits, crucial for upper limb differentiation.
    • Herniation of the midgut occurs accommodating rapid growth.
    • Cranial and caudal limbs form, contributing to the development of the small and large intestines.

    Facial Development - Week 6

    • Facial features undergo rapid morphological changes in the face, influenced by the pharyngeal arches.
    • Key components are the frontonasal prominence, maxillary, and mandibular processes.
    • Nasal pits originate as depressions on the frontonasal prominence, developing into nasal cavities.
    • Surrounding mesenchymal tissue forms nasal structures.
    • Maxillary processes grow medially to form the upper jaw and cheeks.
    • Mandibular processes merge to form the lower jaw and chin.

    Cardiac Development - Week 6

    • The heart continues morphogenesis, becoming more complex structurally.
    • Atrial septation occurs, with the septum primum and septum secundum refining the separation between the right and left atria.
    • A notable structure, the foramen ovale, assists fetal blood flow by bypassing the non-functional fetal lungs.
    • Ventricular septum develops, dividing the ventricles into right and left chambers.
    • Ultrasound can detect coordinated heart contractions, typically around 100–160 beats per minute during transvaginal scans.

    Limb Differentiation - Week 6

    • Limb buds become more defined, and finger segmentation begins.
    • Hand plates form from the distal ends of upper limb buds, flattening into paddle-like structures.
    • These are precursors to hands.
    • Digital rays (thickened ridges) emerge in the hand plates, marking the future fingers.
    • Apoptosis shapes digits.
    • Lower limbs show initial signs of elongation and differentiation; they lag behind upper limb development.
    • Foot plates form, acting as precursors to the feet..

    Midgut Development - Week 6

    • Midgut elongates, forming a loop that temporarily protrudes into the umbilical cord to accommodate rapid growth due to its insufficient abdominal space.
    • This protrusion connects to the yolk sac via the vitelline duct.
    • Cranial limb of the midgut forms parts of the small intestine (duodenum, jejunum, and ileum). This segment is critical for nutrient absorption and digestive function.
    • Caudal limb forms parts of the large intestine (cecum, appendix, and colon). This part deals with water absorption and fecal matter formation.
    • Midgut loops rotate 90 degrees counterclockwise around the superior mesenteric artery, positioning the small and large intestines correctly within the abdominal cavity.

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    Description

    Explore the significant changes during the sixth week of embryonic development, including the growth of pharyngeal arches and cardiac morphogenesis. This week is vital for the formation of facial features, hand and foot plates, and the development of the gastrointestinal tract. Discover how these changes set the stage for further differentiation in the embryo.

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