Pharyngeal Arches Development Quiz
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Questions and Answers

What is primarily derived from multipotent neural crest stem cells during the development of the pharyngeal arches?

  • Ectoderm
  • Nervous tissue
  • Endoderm
  • Mesenchyme (correct)
  • What is the source of endothelial cells in the pharyngeal arches?

  • Neural crest cells
  • Lateral mesoderm and angioblasts (correct)
  • Ectodermal derivatives
  • Paraxial mesoderm
  • Which anatomical structures are primarily formed from the mesenchyme in the pharyngeal arches?

  • Muscle and connective tissue only
  • Maxillary and mandibular prominences, and all connective tissue (correct)
  • Sensory and motor nerves
  • Bones and cartilage only
  • Which of the following is NOT a typical component of a pharyngeal arch?

    <p>An epithelial layer derived from ectoderm (D)</p> Signup and view all the answers

    How is the endothelium of the pharyngeal arches 3 to 6 primarily derived?

    <p>From endothelial progenitors of the second heart field (B)</p> Signup and view all the answers

    What are the main components of the pharyngeal apparatus?

    <p>Pharyngeal arches, pouches, grooves, and membranes (D)</p> Signup and view all the answers

    At what developmental week do the pharyngeal arches begin to develop?

    <p>Fourth week (A)</p> Signup and view all the answers

    Which of the following structures does the maxillary prominence help form?

    <p>Maxilla and vomer bone (D)</p> Signup and view all the answers

    Which pair of pharyngeal arches is associated with the formation of the hyoid bone?

    <p>Second and third arches (B)</p> Signup and view all the answers

    What is the consequence of the persistence of the oropharyngeal membrane?

    <p>Orofacial defects (B)</p> Signup and view all the answers

    How many pairs of pharyngeal arches are visible externally by the end of the fourth week?

    <p>Four pairs (A)</p> Signup and view all the answers

    What type of tissue primarily makes up each pharyngeal arch?

    <p>Mesenchymal tissue (C)</p> Signup and view all the answers

    What does the stomodeum represent in embryonic development?

    <p>The primordial mouth (A)</p> Signup and view all the answers

    Which structure is specifically formed by the dorsal end of the first pharyngeal arch cartilage?

    <p>Malleus and incus (B)</p> Signup and view all the answers

    What is the primary role of the first pharyngeal arch cartilage during development?

    <p>Support in mandible growth (B)</p> Signup and view all the answers

    Which pharyngeal arch is responsible for the muscles of mastication?

    <p>First arch (C)</p> Signup and view all the answers

    From which pharyngeal arch does the intrinsic musculature of the larynx develop?

    <p>Sixth arch (B)</p> Signup and view all the answers

    What does the stylohyoid ligament develop from?

    <p>Perichondrium of the first arch cartilage (C)</p> Signup and view all the answers

    What occurs during the fifth week of development regarding the second pharyngeal arch?

    <p>It enlarges and overgrows the third and fourth arches (B)</p> Signup and view all the answers

    Which pharyngeal arch contributes to the formation of the stapes?

    <p>Second arch (B)</p> Signup and view all the answers

    The greater cornu of the hyoid bone is derived from which pharyngeal arch?

    <p>Third arch (A)</p> Signup and view all the answers

    What is a characteristic of the fifth pharyngeal arch?

    <p>It is rudimentary with no derivatives (D)</p> Signup and view all the answers

    Which cranial nerve is responsible for the major sensory innervation of the face?

    <p>Trigeminal nerve (CN V) (A)</p> Signup and view all the answers

    Which pharyngeal pouch contributes to the formation of the tympanic membrane?

    <p>First pharyngeal pouch (A)</p> Signup and view all the answers

    Which cranial nerves innervate the second to sixth pharyngeal arches?

    <p>Facial nerve (CN VII), Glossopharyngeal nerve (CN IX), and Vagus nerve (CN X) (C)</p> Signup and view all the answers

    What is the primary function of the trigeminal nerve regarding the muscles it innervates?

    <p>Mastication (D)</p> Signup and view all the answers

    What anatomical area is derived from the mesenchyme of the pharyngeal arches?

    <p>Dermis and mucous membranes of the head and neck (A)</p> Signup and view all the answers

    Which nerves primarily supply innervation to the fourth pharyngeal arch?

    <p>Superior laryngeal branch of CN X and recurrent laryngeal branch of CN X (B)</p> Signup and view all the answers

    How many pairs of pharyngeal pouches are well defined during development?

    <p>Four pairs (D)</p> Signup and view all the answers

    What develops as an outpouching of the endoderm between the pharyngeal arches?

    <p>Pharyngeal pouches (B)</p> Signup and view all the answers

    What structure is primarily formed by the second pharyngeal pouch during its development?

    <p>Palatine tonsil (A)</p> Signup and view all the answers

    At what stage does initial lymphoid cell infiltration into the palatine tonsil occur?

    <p>Seventh month of gestation (A)</p> Signup and view all the answers

    Which pharyngeal pouch forms the inferior parathyroid glands?

    <p>Third pharyngeal pouch (A)</p> Signup and view all the answers

    What is the first cleft that persists into postnatal structures?

    <p>First cleft (C)</p> Signup and view all the answers

    What is the developmental result of the merging of medial nasal and maxillary prominences?

    <p>Formation of the upper jaw and lip (A), Separation of the nasal pits from the stomodeum (D)</p> Signup and view all the answers

    What major anomaly is characterized by absence of thymus and parathyroid glands at birth?

    <p>DiGeorge syndrome (B)</p> Signup and view all the answers

    Which embryonic structure primarily contributes to the eyes during development?

    <p>Frontonasal prominence (B)</p> Signup and view all the answers

    What congenital condition is characterized by a failure of mesenchymal tissue to merge properly, leading to defects in the mouth, ears, and mandible?

    <p>First pharyngeal arch syndrome (C)</p> Signup and view all the answers

    What structure do cervical sinuses result from?

    <p>Failure of the second groove to obliterate (C)</p> Signup and view all the answers

    What forms as a result of the failure to canalize the nasolacrimal duct?

    <p>Atresia of the nasolacrimal duct (A)</p> Signup and view all the answers

    Which structure develops from remnants of the second pharyngeal pouch?

    <p>Cervical fistula (C)</p> Signup and view all the answers

    What can contribute to the development of cleft lip and palate?

    <p>Insufficient mesenchyme in prominences (B)</p> Signup and view all the answers

    What is the characteristic orientation of the orbits at the end of facial development?

    <p>Forward-facing (A)</p> Signup and view all the answers

    Flashcards

    Pharyngeal arches

    Structures that develop early in the fourth week of embryonic development, contributing to the formation of the face and neck.

    Pharyngeal arches (appearance)

    Outward folds or ridges along the sides of the developing pharynx.

    Primordial jaws

    The first pair of pharyngeal arches, which develop into the jaws.

    Pharyngeal grooves

    Grooves or indentations that separate the pharyngeal arches, numbered craniocaudally (from head to tail).

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    Oropharyngeal membrane

    A membrane that initially separates the primitive mouth (stomodeum) from the primitive pharynx.

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    Oropharyngeal membrane rupture

    The process of the oropharyngeal membrane breaking, connecting the pharynx and foregut to the amniotic cavity.

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    Stomodeum

    The primitive mouth, located on the surface ectoderm, separated from the pharynx by the oropharyngeal membrane.

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    Primordial pharynx

    Derived from the cranial portion of the foregut, it forms the pharyngeal cavity, supporting the pharyngeal arches.

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    Mesenchyme

    A type of early embryonic connective tissue that gives rise to various cell types, including cartilage, bone, and blood.

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    Neural Crest Cells

    Specialized cells derived from the neural crest, which migrate to the pharyngeal arches and differentiate into various tissues, including connective tissue and bones.

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    Muscle Primordium

    A core of muscle tissue that develops within each pharyngeal arch, contributing to the muscles of the head and neck.

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    Pharyngeal Endoderm

    The layer of cells lining the hollow tube of the pharynx, which plays a crucial role in guiding the development of the pharyngeal arches.

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    Pharyngeal Arch Cartilages

    Cartilages that develop in the pharyngeal arches, contributing to the formation of various structures in the head and neck.

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    Meckel's Cartilage

    The first pharyngeal arch cartilage, involved in ear development and forming the malleus and incus bones.

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    Reichert's Cartilage

    The second pharyngeal arch cartilage, contributing to the stapes bone, styloid process, and hyoid bone.

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    Cervical Sinus Formation

    The process of the second arch cartilage developing over the third and fourth arches, creating a temporary depression in the neck.

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    Mandibular Primordium

    The ventral part of the first arch cartilage that forms the base of the mandible.

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    Intramembranous Ossification of Mandible

    The process of the mandible developing around the first arch cartilage and replacing it with bone.

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    Pharyngeal Arch Muscles

    The muscles derived from the pharyngeal arches, responsible for functions like mastication, facial expressions, and swallowing.

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    Pharyngeal Arch Nerves

    The nerves that supply each pharyngeal arch, playing a crucial role in sensory and motor functions of the head and neck.

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    Hypopharyngeal Eminence

    A protrusion on the floor of the embryonic pharynx, contributing to the formation of the hyoid bone and epiglottis.

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    Laryngeal Cartilages

    The cartilages that form the larynx, except for the epiglottis, which originates from the hypopharyngeal eminence.

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    Pharyngeal Arch Nerve Supply

    The special visceral efferent (branchial) components of cranial nerves supply muscles derived from the pharyngeal arches. These nerves also innervate the dermis and mucous membranes of the head and neck because mesenchyme from the arches contributes to these areas.

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    Trigeminal Nerve (CN V) Function

    CN V (trigeminal nerve) is the main sensory nerve of the head and neck. It also controls the muscles of chewing (mastication). Its sensory branches innervate the face, teeth, and mucous membranes of the nasal cavities, palate, and tongue.

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    Nerves of Pharyngeal Arches 2-6

    The facial nerve (CN VII), glossopharyngeal nerve (CN IX), and vagus nerve (CN X) supply the second, third, and fourth to sixth pharyngeal arches, respectively.

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    Fourth Pharyngeal Arch Innervation

    The fourth pharyngeal arch is innervated by the superior laryngeal branch and the recurrent laryngeal branch of the vagus nerve (CN X).

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    Nerve Distribution in Arches 2-6

    The nerves of the second to sixth pharyngeal arches primarily innervate the mucous membranes of the tongue, pharynx, and larynx, having limited innervation of the skin.

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    Pharyngeal Pouch Development

    The pharyngeal pouches are outpocketings of the endoderm that form between the pharyngeal arches. They are numbered craniocaudally (from head to tail) and contact the ectoderm of the pharyngeal grooves.

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    Pharyngeal Pouch Derivatives

    The endodermal epithelial lining of the pharyngeal pouches contributes to the formation of important head and neck structures. For example, the first pharyngeal pouch forms the tubotympanic recess, which contributes to the tympanic membrane (eardrum) and the tympanic cavity.

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    Tubotympanic Recess Derivatives

    The cavity of the tubotympanic recess develops into the tympanic cavity and mastoid antrum. This recess contributes to the formation of the tympanic membrane together with the first pharyngeal groove.

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    Pharyngotympanic tube (Auditory tube) formation

    The connection between the tubotympanic recess and the pharynx elongates to form the pharyngotympanic tube, also known as the auditory tube.

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    Tonsillar sinus formation

    The second pharyngeal pouch, largely obliterated as the palatine tonsil develops, retains a small part called the tonsillar sinus. This sinus is a depression between the palatoglossal and palatopharyngeal arches.

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    Second pharyngeal pouch bud formation

    The endoderm of the second pharyngeal pouch proliferates and invades the underlying mesenchyme, forming buds.

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    Tonsillar crypt formation

    The central part of the buds formed from the second pharyngeal pouch breaks down, creating tonsillar crypts.

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    Tonsillar crypt lining formation

    The endoderm of the second pharyngeal pouch forms the surface epithelium and lining of the tonsillar crypts.

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    Palatine tonsil lymphatic nodule formation

    Around 20 weeks, the mesenchyme surrounding the tonsillar crypts differentiates into lymphoid tissue, forming lymphatic nodules of the palatine tonsil.

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    Third pharyngeal pouch expansion

    The third pharyngeal pouch expands to form a solid dorsal, bulbar portion and a hollow, elongated ventral part.

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    Third pharyngeal pouch duct degeneration

    The third pharyngeal pouch's connection to the pharynx narrows down to a duct, which eventually degenerates.

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    Inferior parathyroid gland formation

    The epithelium of the dorsal bulbar part of the third pharyngeal pouch differentiates into the inferior parathyroid gland around the sixth week.

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    Third pharyngeal pouch ventral part obliteration

    The epithelial cells of the elongated ventral parts of the third pharyngeal pouch multiply, obliterating the cavity.

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    Thymus formation

    The ventral parts of the third pharyngeal pouch come together in the middle to form the thymus.

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    Thymus and parathyroid gland migration

    The developing thymus and inferior parathyroid glands lose their connection to the pharynx as the brain and associated structures grow upwards.

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    Parathyroid gland final location

    During development, the parathyroid glands separate from the thymus and end up on the dorsal surface of the thyroid gland.

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    Fourth pharyngeal pouch development

    The fourth pharyngeal pouch also expands into a dorsal bulbar part and an elongated ventral part, losing its connection to the pharynx.

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    Superior parathyroid gland formation

    The dorsal bulbar part of the fourth pharyngeal pouch develops into the superior parathyroid gland, positioned on the dorsal surface of the thyroid gland.

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    Study Notes

    Development of Pharyngeal Apparatus, Head and Face

    • The pharyngeal apparatus comprises pharyngeal arches, pouches, grooves, and membranes
    • These embryonic structures contribute to face and neck development

    Pharyngeal Arches

    • Pharyngeal arches begin to develop in the fourth week
    • Neural crest cells migrate to the head and neck region
    • The first arch, the primordial jaws, appears as surface elevations lateral to the developing pharynx
    • Additional arches form as ridges on either side of the future head and neck
    • By the end of the fourth week, four pairs of arches are visible externally
    • The fifth and sixth arches are rudimentary and not visible externally

    Separation of Pharyngeal Arches

    • Pharyngeal arches are separated by pharyngeal grooves (clefts)
    • Grooves are numbered in a craniocaudal sequence
    • The first arch separates into maxillary and mandibular prominences
    • The maxillary prominence forms the maxilla and part of the vomer bone
    • The mandibular prominence forms the mandible and squamous temporal bone
    • The second arch contributes to the formation of the hyoid bone, along with the third arch

    Pharyngeal Arch Components

    • Each arch consists of a core of mesenchyme
    • The mesenchyme is covered by ectoderm externally and endoderm internally
    • Most mesenchyme derives from neural crest cells that migrate into the arches during the fourth week
    • Myogenic mesoderm from paraxial regions moves into each arch, forming a central core of muscle primordium
    • Endothelial cells are derived from lateral mesoderm and invasive angioblasts
    • Endothelial progenitors from the second heart field create the endothelium of arches 3-6
    • Pharyngeal endoderm is essential in regulating arch development

    Typical Pharyngeal Arch

    • A typical arch contains an artery, cartilage, and muscle components and is innervated by nerves from the primordial brain
    • The artery branches from the truncus arteriosus of the primordial heart, passing around the primordial pharynx to enter the dorsal aorta
    • Cartilage forms the skeleton of the arch
    • Muscle differentiates into muscles for the head and neck
    • Sensory and motor nerves originate from neuroectoderm of the primordial brain and supply to mucosa and muscles within the arch

    Fate of Pharyngeal Arches

    • Arches contribute to the face, nasal cavities, mouth, larynx, pharynx, and neck
    • The second arch enlarges during the fifth week, overgrowing the third and fourth arches, forming the cervical sinus
    • By the seventh week the second, third, and fourth grooves and cervical sinus have all disappeared leaving a smooth contour

    Derivatives of Pharyngeal Arch Cartilages

    • The dorsal end of the first arch cartilage (Meckel's cartilage) is associated with the developing ear
    • Early nodules break away from the cartilage to form the malleus and incus (middle ear bones)
    • The midpart of Meckel's cartilage regresses, perichondrium forms anterior ligament malleus and sphenomandibular ligament
    • Ventral part of first arch cartilage forms horseshoe-shaped primordium of the mandible
    • First arch cartilage guides mandible development, disappearing during intramembranous ossification

    Derivatives of Pharyngeal Arch Cartilages (continued)

    • The second arch cartilage (Reichert's cartilage) contributes to the development of the stapes (middle ear bone) and styloid process of the temporal bone
    • Cartilage between the styloid and hyoid processes regresses, perichondrium of regresses cartilage forms stylohyoid ligaments
    • The ventral end of the second arch cartilage ossifies to form the hyoid lesser cornu (lesser horn)
    • The third arch cartilage ossifies to form the greater cornu of the hyoid and superior cornu of thyroid cartilages
    • The body of the hyoid bone forms from the hypobranchial eminence
    • Components of fourth/sixth arches form laryngeal cartilages, except epiglottis
    • Cartilage of epiglottis originates from mesenchyme in the hypopharyngeal eminence

    Derivatives of Pharyngeal Arch Muscles

    • The muscular components derive from unsegmented paraxial mesoderm and prechordal plate
    • First arch muscles are involved in mastication
    • Second arch muscles form stapedius, styloid, and posterior belly of digastric
    • Third arch muscles form stylopharyngeus
    • Fourth arch muscles include cricothyroid, levator veli palatini, and constrictors of pharynx
    • Sixth arch muscles form intrinsic muscles of the larynx

    Derivatives of Pharyngeal Arch Nerves

    • Each arch is supplied by its own cranial nerve
    • Special visceral efferent (branchial) components of these nerves supply muscles
    • Mesenchyme from the arches contributes to the dermis and mucous membranes of the head and neck
    • These areas receive sensory innervation from special visceral afferent nerves (specific nerves supplying mucous membranes, face, teeth, tongue, palate)
    • Trigeminal nerve (CN V) is principal sensory and motor nerve of muscles in mastication
    • Facial nerve (CN VII), glossopharyngeal (CN IX), and vagal nerve (CN X) supply second, third, and fourth to sixth arches respectively

    Pharyngeal Pouches

    • The pharyngeal pouches are evaginations of the endoderm of the pharynx
    • These pouches develop in a craniocaudal sequence between the arches
    • The first pouch forms the auditory tube and tympanic cavity
    • The second pouch forms part of the palatine tonsil
    • Third pouch develops the inferior parathyroid gland
    • The fourth pouch forms the superior parathyroid gland and ultimobranchial body
    • Parts of the 4th & 6th pouches form parts of the thyroid gland
    • Fifth pouch is rudimentary

    Derivatives of the Pharyngeal Pouches

    • The endodermal epithelial lining of the pouches creates important organs in the head and neck
    • The first pouch expands into a tubotympanic recess that touches the first groove, eventually forming the tympanic membrane
    • The second pouch cavity is largely obliterated, becoming the tonsillar sinus
    • The third pouch yields the inferior parathyroid gland
    • The fourth pouch gives rise to the superior parathyroid gland and ultimobranchial body

    Cervical (Branchial) Sinuses

    • External cervical sinuses are uncommon
    • They result from failure of the second groove and cervical sinus to obliterate
    • They open near the anterior border of the sternocleidomastoid muscle in the lower third of the neck
    • Internal cervical sinuses open to the tonsillar sinus or near the palatopharyngeal arches
    • Persistence of second pouch proximal portion can cause these sinuses

    Cervical (Branchial) Fistula

    • A fistula is an abnormal canal opening internally into the tonsillar sinus and externally on the side of the neck due to persistence in part of the 2nd pouch
    • The canal ascends the neck through the subcutaneous tissue and platysma muscle, passing between the internal and external carotid arteries, to open into the tonsillar sinus

    Piriform Sinus Fistula

    • A piriform sinus fistula results from persistence of remnants of the ultimopharyngeal body extending to the thyroid gland

    Cervical (Branchial) Cysts

    • Remnants of cervical sinus or 2nd groove may persist, forming a spherical or elongated cyst in the neck inferior to the angle of the mandible
    • They often appear as painless, slowly enlarging swellings in childhood or early adulthood
    • Cysts enlarge due to the accumulation of fluid and cellular debris

    First Pharyngeal Arch Syndrome

    • Abnormal components of the first arch result in birth defects of the eyes, ears, mandible, and palate
    • The most common types of this anomaly are Treacher Collins syndrome and Pierre Robin sequence

    DiGeorge Syndrome

    • Infants with DiGeorge syndrome are born without a thymus and parathyroid glands, having defects in cardiac outflow tracts
    • In some cases, ectopic glandular tissue is present
    • This syndrome is characterized by congenital susceptibility to hyperparathyroidism, increased infections, and birth defects

    Ectopic Parathyroid Glands

    • Ectopic parathyroid glands may lie near or within the thyroid or thymus
    • The superior glands tend to be more constant in position than the inferior ones
    • Multiple parathyroid glands are less common, likely occurring from division of original primordia

    Development of Face

    • Facial primordia emerge early in the fourth week around the stomodeum
    • Facial development depends on inductive influences of the forebrain, frontonasal ectoderm, and developing eye
    • Five facial primordia appear as prominences around the stomodeum
    • Frontonasal prominence
    • Paired maxillary prominences
    • Paired mandibular prominences

    Development of Face (continued)

    • Maxillary and mandibular prominences are derivatives of the first pair of pharyngeal arches
    • They are formed primarily from the expansion of neural crest cells originating from mesencephalic and rostral rhombencephalic neural folds
    • These cells form the main connective tissue, cartilage, bone, and ligaments for the face and oral regions

    Development of Face (continued)

    • The frontonasal prominence surrounds the ventrolateral portion of the forebrain's optic vesicles, forming the eyes
    • The frontal part of the frontonasal prominence creates the forehead, nasal portion creates the rostral boundary of the stomadeum and nose
    • The maxillary prominences form the lateral boundary of the stomodeum and mandibular prominences form the caudal boundary of the stomodeum
    • The facial prominences exhibit active growth centers in the underlying mesenchyme. This tissue is continuous

    Facial Development (continued)

    • Facial development is primarily between the fourth and eighth weeks of development
    • By the end of the embryonic period, the face displays characteristic human features.
    • Lower jaw and lower lip form through medial fusion of mandibular prominences. The incomplete fusion of these prominences creates a chin dimple
    • The nose becomes more distinct and the mandible shows more growth during the fetal period

    Nasal Development

    • By the end of the fourth week, bilateral oval thickenings (nasal placodes) form on the infralateral aspects of the frontonasal prominence
    • These nasal placodes expand, forming horseshoe-shaped medial and lateral nasal prominences
    • Nasal placodes create nasal pits, which become the nostrils
    • Lateral nasal prominences develop the alae (sides of the nose)

    Auricle Development

    • By the end of the fifth week, primordia of the auricles begin development
    • Six auricular hillocks form around the first pharyngeal groove
    • External acoustic meatus develops near these structures
    • The auricles migrate to the sides of the head at the level of the eyes

    Nasolacrimal Duct Development

    • The nasolacrimal duct forms from an ectodermal thickening in the nasolacrimal groove.
    • This thickening develops into a solid cord that separates from ectoderm and sinks into mesenchyme, canalizing to form a duct
    • The superior end of the duct expands into the lacrimal sac.

    Development of Nasal Prominences

    • Medial nasal prominences fuse with maxillary prominences between weeks 7-10
    • This merging generates continuity of the upper jaw and lip while separating the nasal pits from the stomodeum

    Development of Intermaxillary Segment

    • The medial nasal prominences merge to form the intermaxillary segment
    • This segment forms the middle part (philtrum) of the upper lip, the premaxillary part of the maxilla, its associated gingivae, and primary palate
    • Maxillary prominences extend medially to cover and shape the lower parts of the medial nasal prominences, creating the philtrum

    Formation of Palate and Lips

    • Early in the sixth week, the primordial jaws comprise mesenchymal masses
    • Lip and gingival development arise from a thickening of ectoderm called a labiogingival lamina, which penetrates underlying mesenchyme
    • Most labiogingival lamina degenerates, leaving the labiogingival groove
    • A small area remains to form the frenum of the upper lip
    • Face development continues slowly throughout the fetal period with changes in relative proportion and positions of facial components
    • During the early fetal period, the nose is relatively flat, and the mandible is underdeveloped

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    Test your knowledge on the development of pharyngeal arches with this comprehensive quiz. Explore the origins of components such as endothelial cells and mesenchyme, as well as the anatomical structures formed from these arches. Perfect for students of embryology and anatomy looking to deepen their understanding of this vital developmental process.

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