Human Circulatory System Quiz
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Questions and Answers

What causes varicose veins to develop?

  • Defect or weakness in muscle fibers
  • Excessive physical activity
  • High blood pressure in arteries
  • Defect or weakness in vein walls or valves (correct)
  • Which lifestyle modification is recommended for the treatment of varicose veins?

  • Wearing tight clothing
  • Wearing support stockings (correct)
  • Increased caffeine intake
  • Avoiding leg elevation
  • What is a common sign of thrombophlebitis?

  • Numbness in the leg
  • Color change in the iris
  • Sharp pain in the abdomen
  • Aching, burning, tenderness in affected legs (correct)
  • Which factor is not associated with thrombus development?

    <p>Low cholesterol levels (C)</p> Signup and view all the answers

    What complication can arise from thrombophlebitis?

    <p>Pulmonary embolism (D)</p> Signup and view all the answers

    What is the primary function of erythrocytes?

    <p>Transport oxygen to tissues (D)</p> Signup and view all the answers

    What is the structure that distinguishes arteries from veins?

    <p>Thickness of the tunica media (C)</p> Signup and view all the answers

    Which component of blood is primarily responsible for clotting?

    <p>Thrombocytes (D)</p> Signup and view all the answers

    What initiates the coagulation mechanism during hemolysis?

    <p>Damage to blood vessels (A)</p> Signup and view all the answers

    Which of the following best describes the term 'hemostasis'?

    <p>The process of blood clotting (D)</p> Signup and view all the answers

    What type of circulation is responsible for gas exchange in the lungs?

    <p>Pulmonary circulation (B)</p> Signup and view all the answers

    What role does erythropoietin play in the body?

    <p>Promotes erythrocyte production (C)</p> Signup and view all the answers

    Which component of blood is the liquid medium for transporting cells and nutrients?

    <p>Plasma (B)</p> Signup and view all the answers

    What characterizes the ABO blood groups?

    <p>Presence or absence of specific antigens (C)</p> Signup and view all the answers

    Leukocytosis is often associated with which condition?

    <p>Increased white blood cells (B)</p> Signup and view all the answers

    Which test measures the functional ability of platelets?

    <p>Bleeding time (C)</p> Signup and view all the answers

    What does a reticulocyte count assess?

    <p>Bone marrow function (C)</p> Signup and view all the answers

    Which of the following is a feature of iron deficiency anemia?

    <p>Microcytic, hypochromic RBCs (A)</p> Signup and view all the answers

    What condition is primarily caused by a lack of intrinsic factor?

    <p>Pernicious anemia (A)</p> Signup and view all the answers

    What common symptom is associated with pernicious anemia?

    <p>Enlarged, red, sore tongue (C)</p> Signup and view all the answers

    What type of anemia is characterized by the failure of the bone marrow?

    <p>Aplastic anemia (C)</p> Signup and view all the answers

    What might cause impaired absorption of iron leading to anemia?

    <p>Chronic blood loss (C)</p> Signup and view all the answers

    Which of these is a potential outcome of severe anemia?

    <p>Cardiac arrhythmia (B)</p> Signup and view all the answers

    Which factor is crucial for the absorption of vitamin B12?

    <p>Intrinsic factor (B)</p> Signup and view all the answers

    What blood count condition is indicated by pancytopenia?

    <p>Decrease in all blood cell types (A)</p> Signup and view all the answers

    What can a microscopic examination of erythrocytes indicate?

    <p>Vitamin B12 deficiency (B)</p> Signup and view all the answers

    Which artificial product can expand plasma volume?

    <p>Colloid volume-expanding solutions (A)</p> Signup and view all the answers

    What is a common cause of hemolytic anemia?

    <p>Genetic defects (A)</p> Signup and view all the answers

    Which characteristic is associated with sickle cell anemia?

    <p>Large, misshaped red blood cells (C)</p> Signup and view all the answers

    What often triggers a sickle cell crisis?

    <p>Lowered oxygen levels (B)</p> Signup and view all the answers

    What is a common clinical sign of sickle cell anemia?

    <p>Congestive heart failure (B)</p> Signup and view all the answers

    Which of the following is a treatment for sickle cell anemia?

    <p>Bone marrow transplantation (A)</p> Signup and view all the answers

    What is a characteristic of primary polycythemia?

    <p>Low serum erythropoietin levels (B)</p> Signup and view all the answers

    What is a sign of blood-clotting disorders?

    <p>Persistent bleeding from gums (B)</p> Signup and view all the answers

    Which of the following is true about hemophilia A?

    <p>It primarily affects men due to its X-linked recessive inheritance. (B)</p> Signup and view all the answers

    What is a common symptom of von Willebrand's disease?

    <p>Frequent nosebleeds (B)</p> Signup and view all the answers

    What is a defining characteristic of Disseminated Intravascular Coagulation (DIC)?

    <p>Simultaneous excessive clotting and bleeding (D)</p> Signup and view all the answers

    Which condition is associated with thrombophilia?

    <p>Increased risk of abnormal clots (C)</p> Signup and view all the answers

    What is a possible consequence of myelodysplastic syndromes?

    <p>Anemia due to inadequate cell production (D)</p> Signup and view all the answers

    What is a characteristic feature of leukemias?

    <p>Reduction in functional WBCs (B)</p> Signup and view all the answers

    What type of leukemia is characterized by a high proportion of immature nonfunctional cells and an abrupt onset?

    <p>Acute Lymphoblastic Leukemia (A), Acute Myeloid Leukemia (D)</p> Signup and view all the answers

    Which of the following is a common sign of acute leukemia?

    <p>Frequent uncontrolled infections (C)</p> Signup and view all the answers

    What is the primary treatment for Acute Lymphoblastic Leukemia (ALL) in young children?

    <p>Chemotherapy (A)</p> Signup and view all the answers

    Which of these factors is a modifiable risk factor for atherosclerosis?

    <p>Diabetes mellitus (C)</p> Signup and view all the answers

    What does elevated low-density lipoprotein (LDL) primarily indicate in the context of lipid transport?

    <p>High risk of atheroma formation (B)</p> Signup and view all the answers

    What diagnostic test is used to confirm the presence of immature leukocytes in acute leukemia?

    <p>Bone marrow biopsy (A)</p> Signup and view all the answers

    Which of the following is a common consequence of atherosclerosis?

    <p>Severe hemorrhage (C)</p> Signup and view all the answers

    What is one of the common sites for peripheral vascular disease related to atherosclerosis?

    <p>Femoral arteries (A)</p> Signup and view all the answers

    What is the primary intervention for managing varicose veins?

    <p>Compression stockings (A)</p> Signup and view all the answers

    Which type of aortic aneurysm involves a tear in the arterial wall leading to blood dissecting between tissues?

    <p>Dissecting aneurysm (B)</p> Signup and view all the answers

    What lifestyle change is essential for managing atherosclerosis effectively?

    <p>Cessation of smoking (C)</p> Signup and view all the answers

    What symptom is indicative of intermittent claudication in peripheral vascular disease?

    <p>Leg pain with exercise (D)</p> Signup and view all the answers

    What diagnostic method measures blood flow specifically in peripheral vascular disease?

    <p>Doppler studies (B)</p> Signup and view all the answers

    What dietary modification is commonly recommended for managing serum cholesterol levels?

    <p>Increase fiber-rich foods (A)</p> Signup and view all the answers

    Flashcards

    Hematopoiesis

    The process of blood cell formation, primarily in the bone marrow.

    Erythrocytes

    Red blood cells, containing hemoglobin, responsible for oxygen transport throughout the body.

    Hemoglobin

    A protein in red blood cells that binds to oxygen, enabling its transport in the blood.

    Hemostasis

    The process by which the body stops bleeding, involving vascular spasm, platelet plug formation, and coagulation.

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    Coagulation

    The process of blood clotting, forming a fibrin mesh to trap blood cells and seal the wound.

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    Erythropoietin

    A hormone produced by the kidneys that stimulates red blood cell production.

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    Plasma

    The fluid portion of blood, containing plasma proteins, water, and electrolytes.

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    Blood Typing

    Antigen-based system for classifying blood types based on the presence or absence of specific antigens on red blood cells.

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    Rh+

    Antigen D present in plasma membrane.

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    Rh-

    Absence of antigen D in plasma membrane.

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    Leukocytosis

    Increased number of white blood cells (WBCs) in the blood, commonly associated with infection or inflammation.

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    Leukopenia

    Decreased number of white blood cells (WBCs) in the blood, often seen in viral infections, radiation exposure, or chemotherapy.

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    Hematocrit

    Blood test that measures the percentage of blood volume occupied by red blood cells.

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    Mean Corpuscular Volume (MCV)

    A measure of the average volume of individual red blood cells, indicating the efficiency of oxygen transport.

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    Reticulocyte Count

    A blood test that estimates the number of newly produced red blood cells, reflecting bone marrow function.

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    Iron Deficiency Anemia

    Anemia caused by insufficient iron, impairing hemoglobin synthesis. Results in small, pale red blood cells.

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    Pernicious Anemia

    Anemia characterized by very large, immature, nucleated red blood cells due to lack of vitamin B12 absorption.

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    Aplastic Anemia

    Anemia resulting from bone marrow failure, leading to a decrease in all blood cell types.

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    Anemia

    A decrease in the oxygen-carrying capacity of blood, resulting from problems with hemoglobin, red blood cells, or both.

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    Epoetin Alpha

    An artificial form of erythropoietin, a hormone stimulating red blood cell production.

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    Blood Dyscrasia

    Any disorder affecting the blood or blood-forming organs.

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    Glossitis

    An inflammatory condition affecting the tongue, often associated with vitamin deficiencies, particularly B12.

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    Hemolytic Anemia

    A condition causing excessive breakdown of red blood cells, leading to anemia. It can be caused by various factors like genetic defects, immune reactions, infections, toxins, and incompatible blood transfusions.

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    Sickle Cell Anemia

    A genetic disorder where red blood cells become abnormally shaped, like sickles, reducing oxygen carrying capacity.

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    Sickle Cell Crisis

    A condition where lower oxygen levels trigger the sickling of red blood cells, resulting in blood vessel blockage and tissue damage.

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    Hyperbilirubinemia

    The presence of abnormally high bilirubin levels in the blood, often seen in conditions like hemolytic anemia.

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    Polycythemia

    A serious condition where there is an abnormal overproduction of red blood cells, leading to thickened blood and potential complications.

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    Secondary Polycythemia

    A type of polycythemia caused by an underlying problem, leading to increased red blood cell production.

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    Primary Polycythemia

    A type of polycythemia characterized by an uncontrolled production of red blood cells in the bone marrow.

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    Blood-Clotting Disorders

    A group of disorders affecting the blood's ability to clot properly, leading to excessive bleeding or clotting.

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    Petechiae

    Tiny, flat, red spots on the skin and mucous membranes, often indicative of bleeding disorders.

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    Hemophilia A

    A severe inherited clotting disorder caused by a deficiency or abnormality of factor VIII.

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    Von Willebrand Disease

    The most common inherited clotting disorder, characterized by abnormalities in the von Willebrand factor.

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    Disseminated Intravascular Coagulation (DIC)

    A life-threatening condition involving both excessive bleeding and clotting, leading to widespread tissue damage and organ failure.

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    Thrombophilia

    A group of inherited or acquired disorders that increase the risk of blood clots forming in veins or arteries.

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    Myelodysplastic Syndromes

    A group of disorders affecting the bone marrow's ability to produce healthy blood cells.

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    Leukemias

    A group of cancers affecting white blood cells, leading to uncontrolled growth and abnormal function.

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    Varicose Veins

    A condition where veins in the legs become enlarged, twisted, and often bulging, usually due to weakened vein walls or valves.

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    Thrombophlebitis/Phlebothrombosis

    A blood clot that forms in a vein, often in the legs. It can be accompanied by inflammation (thrombophlebitis) or occur without inflammation (phlebothrombosis).

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    Stasis of Blood

    One of the factors contributing to the formation of a blood clot in a vein. It involves blood flow that is slowed or stagnant.

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    Endothelial Injury

    One of the factors contributing to the formation of a blood clot in a vein. It involves damage to the inner lining of blood vessels.

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    Increased Blood Coagulability

    One of the factors contributing to the formation of a blood clot in a vein. It involves a tendency for blood to clot more easily than normal.

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    Arteriosclerosis

    Any type of change in arteries, leading to a decrease in elasticity and narrowing of the lumen, often causing high blood pressure.

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    Atherosclerosis

    A specific type of arteriosclerosis where plaques build up in large arteries, consisting of fat, calcium, and potentially clots. It's linked to diet, exercise, and stress.

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    Low-density lipoprotein (LDL)

    A type of lipoprotein that carries cholesterol from the liver to the cells, often contributing to the formation of atheromas in atherosclerosis.

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    High-density lipoprotein (HDL)

    Carries cholesterol away from cells back to the liver for processing, reducing the risk of atheromas - often referred to as 'good' cholesterol.

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    Acute Leukemia

    A type of leukemia characterized by a high proportion of immature, nonfunctional white blood cells, usually with an abrupt onset and a rapid course.

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    Chronic Leukemia

    A type of leukemia characterized by a higher proportion of mature white blood cells but with reduced function, typically with a slower, insidious onset and a better prognosis.

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    Aortic Aneurysm

    A localized dilation or weakening in an arterial wall, often due to a defect in the middle layer, with different shapes including bulging on one side, a wider section, or a tear causing blood to separate tissues.

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    Saccular Aneurysm

    A type of aneurysm that bulges outwards on one side of the arterial wall, like a sac.

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    Fusiform Aneurysm

    An aneurysm that affects a wider section of the artery with circumferential widening of the vessel wall.

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    Dissecting Aneurysm

    A type of aneurysm where a tear in the inner layer of the aorta allows blood to flow between the layers, separating the tissues like a dissection.

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    Peripheral Vascular Disease

    A condition affecting arteries outside of the heart, often occurring in the legs and abdomen, caused by atherosclerosis. It's more common with diabetes.

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    Intermittent Claudication

    Pain in the legs that comes and goes, caused by insufficient blood flow to muscles during exercise, a classic symptom of peripheral vascular disease.

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    Doppler Studies

    A test that uses sound waves to assess blood flow through arteries, often used to diagnose peripheral vascular disease.

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    Study Notes

    Circulatory System Disorders

    • The circulatory system comprises the cardiovascular and lymphatic systems. This section focuses on blood vessels, blood, and related disorders.
    • Arteries carry blood away from the heart. Veins return blood to the heart. Capillaries facilitate microcirculation within tissues for gas, nutrient, and waste exchange. Systemic circulation involves tissue exchange, while pulmonary circulation handles gas exchange in the lungs.
    • Arteries and veins have distinct histological layers: tunica intima (innermost endothelium), tunica media (smooth muscle-rich middle layer), and tunica adventitia (outer connective tissue).

    Blood Composition and Function

    • Blood functions in oxygen and nutrient delivery, waste removal, immune defense, and maintaining homeostasis.
    • Blood plasma, a liquid component, contains proteins. Blood cells include erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets).

    Erythrocytes (Red Blood Cells)

    • Mature red blood cells are biconcave discs without a nucleus, containing hemoglobin (globin and heme).
    • Their lifespan is approximately 120 days. Erythropoietin, produced in the kidneys, regulates red blood cell production.

    Blood Clotting (Hemostasis)

    • Hemostasis involves three phases: vascular spasm, platelet plug formation, and coagulation.
    • This process results in a fibrin mesh trapping cells, ultimately forming a blood clot. Plasmin eventually breaks down the clot.

    Blood Typing

    • Blood typing relies on antigens on red blood cell membranes.
    • The ABO system categorizes blood based on the presence or absence of A and B antigens. Corresponding antibodies exist in the plasma.
    • The Rh system classifies blood based on the presence (Rh+) or absence (Rh-) of the D antigen.

    Diagnostic Tests

    • Complete Blood Count (CBC) measures red blood cells, white blood cells, and platelets. Leukocytosis indicates inflammation/infection, while leukopenia suggests viral infections or treatments like chemotherapy, radiation.
    • Morphology studies cell shape and size. Hematocrit measures packed cell volume, while hemoglobin assesses hemoglobin content. Mean corpuscular volume (MCV) reflects oxygen-carrying capacity.
    • Reticulocyte count evaluates bone marrow function. Chemical analyses determine serum levels of components like iron, B12, folic acid, cholesterol, urea, and glucose. Bleeding time measures platelet function. Prothrombin time (PT), partial thromboplastin time (PTT), and the International Normalized Ratio (INR) assess coagulation factors and their function.

    Blood Therapies

    • Whole blood, packed red blood cells, and packed platelets treat anemia and thrombocytopenia.
    • Plasma or colloids maintain blood volume. Artificial blood products, while functional, do not replicate all normal blood functions.
    • Epoetin alpha, a synthetic erythropoietin, aids in treating certain types of anemia and before some surgical procedures.

    Anemias

    • Anemia reduces oxygen transport capacity, leading to decreased energy production, impaired cellular metabolism, and compensation mechanisms like tachycardia.
    • Clinical signs include fatigue, pallor, dyspnea, and tachycardia. Epithelial cell regeneration issues can lead to inflammation, stomatitis, cracked lips, and dysphagia. Severe anemia can cause angina or congestive heart failure.

    Iron Deficiency Anemia

    • Insufficient iron hinders hemoglobin production, resulting in microcytic, hypochromic red blood cells.
    • Dietary iron deficiency, chronic blood loss, impaired duodenal absorption, and severe liver damage can cause iron deficiency.

    Pernicious Anemia

    • Pernicious anemia results from inadequate vitamin B12 absorption, often due to lack of intrinsic factor, a stomach-secreted protein required for intestinal B12 absorption. Red blood cells are abnormally large, immature, and carry less hemoglobin.
    • Genetic factors, chronic gastritis, and gastric surgery may also play a role. Primarily found in light-skinned women of northern European descent.

    Vitamin B12 and Nerve Function

    • Vitamin B12 is critical for neuron maintenance and function. Deficiency elicits peripheral nerve symptoms, which might be reversible.

    Aplastic Anemia

    • Aplastic anemia results from bone marrow impairment, which can be temporary or permanent. Possible causes include myelotoxins (radiation, chemicals, drugs), viruses (particularly hepatitis C), genetic abnormalities (like myelodysplastic syndrome and Fanconi anemia). Pancytopenia (low red blood cells, white blood cells, and platelets) is common in the blood.

    Hemolytic Anemia

    • Hemolytic anemia is excessive red blood cell destruction. Underlying causes include genetic defects, immune reactions and reactions to blood components, infections (like malaria), toxins, or incompatible blood transfusions. Erythroblastosis fetalis is an example of this regarding incompatibility of blood types.

    Sickle Cell Anemia

    • Sickle cell anemia is an inherited autosomal incomplete dominant genetic disorder. Abnormal hemoglobin (HbS) causes sickle-shaped red blood cells, especially in hypoxic states. These cells have trouble moving through the microcirculation because of their changed shape, leading to obstruction and multiple infarctions (areas of necrosis).
    • Multiple infarctions impact the brain, bones, and organs. Other symptoms include hyperbilirubinemia, jaundice, gallstones, splenomegaly, and vascular occlusions. Symptoms usually appear after 12 months.

    Polycythemia

    • Polycythemia vera involves increased red blood cell production, while secondary polycythemia (erythrocytosis) is a response to prolonged hypoxia, characterized by increasing erythropoietin secretion as a compensatory mechanism.

    Blood-Clotting Disorders

    • Disorders may cause excessive bleeding (epistaxis, petechiae, purpura, ecchymosis, hemarthroses, hemoptysis, hematemesis, and blood in feces). Hemophilia A, a common inherited clotting disorder, lacks or affects Factor VIII and causes prolonged bleeding after injury. Von Willebrand disease is another common hereditary clotting disorder with varying types and severity causing various types of bleeding problems

    Disseminated Intravascular Coagulation (DIC)

    • DIC involves excessive bleeding and clotting, presenting a poor prognosis. It might result from obstetric complications, infections, cancers, and major trauma.

    Thrombophilia

    • Thrombophilia encompasses inherited or acquired disorders increasing clot risk in veins or arteries.

    Myelodysplastic Syndromes

    • Deficiencies in bone marrow production lead to symptoms such as anemia, dependent on the specific deficiency. Causes include idiopathic cases, chemotherapy, and radiation. Treatment varies by cause and depends on the deficiency type.

    Leukemias

    • Leukemias are neoplastic disorders involving uncontrolled white blood cell production in bone marrow or lymph nodes. Cells are undifferentiated, immature, non-functional, and released into the circulation, potentially accumulating in other organs.
    • Acute leukemias (ALL and AML) have a high proportion of immature cells, are generally more abrupt in onset with worse symptoms. Chronic leukemias (CLL and CML) have some mature cells in the blood but have impaired function, are insidious, and have a better overall prognosis.

    Arteriosclerosis and Atherosclerosis

    • Arteriosclerosis refers to all arterial changes, causing loss of elasticity and lumen narrowing. Atherosclerosis is characterized by atheromas (plaque buildup), including lipids, calcium, or clots, in large arteries.
      • Lipid transport is important as LDLs deliver cholesterol to cells, contributing to atheroma formation, whereas HDLs carry cholesterol away from cells to the liver, effectively being a "good" lipoprotein.

    Risk Factors for Atherosclerosis

    • Nonmodifiable: age, gender, genetic factors.
    • Modifiable: obesity, sedentary lifestyle, smoking, diabetes, poorly controlled hypertension, combination of oral contraceptives and smoking.

    Peripheral Vascular Disease (PVD)

    • Atherosclerosis impacting arteries outside the heart is known as PVD. Common in individuals with diabetes. Symptoms include leg pain associated with exercise (intermittent claudication), sensory changes (tingling, numbness), and changes in skin appearance (pallor, cyanosis, dry skin and hairless areas, thick and hard toenails).

    Aortic Aneurysm

    • Aortic aneurysm is a localized weakening and dilation of the arterial wall, potentially developing from defects, atherosclerosis, trauma, or infections (like syphilis). Types include saccular (bulging wall on one side), fusiform (circumferential dilation along an artery section), and dissecting (involving a tear in artery wall with dissecting tissues).

    Venous Disorders

    • Varicose veins are dilated, tortuous superficial veins often seen in legs due to valve or wall defects. Risks include increased body mass index, parity, and weight lifting. Thrombophlebitis is thrombus formation in an inflamed vein, while phlebothrombosis is clot formation in a vein without prior inflammation. Factors include blood stasis, endothelial damage, and increased blood coagulability.

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    Test your knowledge on the human circulatory system with this quiz. Explore topics like varicose veins, thrombophlebitis, and blood components. This quiz covers essential functions and structure related to circulation and blood clotting.

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