Human Biology Chapter on Skin and Immune System
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Questions and Answers

Which gland produces sebum to lubricate the skin?

  • Sebaceous glands (correct)
  • Sweat glands
  • Mammary glands
  • Ceruminous glands
  • What type of hair is described as fine and short?

  • Coarse hair
  • Terminal hair
  • Vellus hair (correct)
  • Intermediate hair
  • Where do nails grow from?

  • Nail bed
  • Nail fold
  • Cuticle
  • Nail matrix (correct)
  • What is the approximate average growth rate of hair per week?

    <p>2 mm (C)</p> Signup and view all the answers

    What component of hair is located at its core?

    <p>Medulla (D)</p> Signup and view all the answers

    Which type of sweat gland is involved in preventing overheating and is found on the entire skin surface?

    <p>Eccrine glands (B)</p> Signup and view all the answers

    What is the role of arrector pili muscles?

    <p>To cause hair to stand on end (B)</p> Signup and view all the answers

    Which type of hair is typically longer and coarser?

    <p>Terminal hair (C)</p> Signup and view all the answers

    What contributes to the color of hair?

    <p>Presence of melanin (A)</p> Signup and view all the answers

    What role do neutrophils play when they encounter a pathogen?

    <p>They directly engulf and destroy pathogens. (B)</p> Signup and view all the answers

    What is the primary function of interferons (IFNs)?

    <p>To act as key anti-viral proteins. (A)</p> Signup and view all the answers

    How do interleukins function within the immune system?

    <p>They modulate the behavior of other immune cells. (B)</p> Signup and view all the answers

    What happens to neighboring cells when a virus infects a cell and interferons are released?

    <p>They develop an antiviral state to inhibit viral replication. (C)</p> Signup and view all the answers

    What triggers the synthesis and secretion of interleukins?

    <p>Rapidly occurring immune responses to various infections. (A)</p> Signup and view all the answers

    What are the two distinct regions of the integumentary system?

    <p>Epidermis and Dermis (D)</p> Signup and view all the answers

    Which layer of the skin is responsible for temperature regulation?

    <p>Dermis (A)</p> Signup and view all the answers

    Which type of tissue primarily composes the epidermis?

    <p>Epithelium (A)</p> Signup and view all the answers

    What role does melanin play in the skin?

    <p>Protection from UV light (C)</p> Signup and view all the answers

    What is the primary characteristic of the dermal papillae?

    <p>They elevate the overlying epidermis. (B)</p> Signup and view all the answers

    Which of the following correctly describes the hypodermis?

    <p>It is also known as the superficial fascia. (B)</p> Signup and view all the answers

    What factor is primarily responsible for variations in skin color?

    <p>The amount of melanin produced (B)</p> Signup and view all the answers

    Which type of skin cancer is considered the most dangerous?

    <p>Melanoma (D)</p> Signup and view all the answers

    What characteristic is NOT part of the recognition for melanoma?

    <p>Color uniformity (B)</p> Signup and view all the answers

    What type of immunity involves a lag period after the initial exposure to an antigen?

    <p>Acquired immunity (D)</p> Signup and view all the answers

    Which component of the immune system is primarily responsible for phagocytosis?

    <p>Neutrophils (C)</p> Signup and view all the answers

    What is a major function of the skin in the immune system?

    <p>Mechanical barrier against pathogens (B)</p> Signup and view all the answers

    What is the role of normal flora in the immune system?

    <p>It consumes nutrients essential for pathogens. (B)</p> Signup and view all the answers

    Which of the following statements about innate immunity is true?

    <p>It has no time lag. (A)</p> Signup and view all the answers

    Which type of cell is primarily responsible for the humoral response in acquired immunity?

    <p>B-lymphocytes (A)</p> Signup and view all the answers

    What is the primary function of complement proteins in the immune system?

    <p>To assist in the destruction of pathogens (C)</p> Signup and view all the answers

    What is the first line of defense in the immune system?

    <p>Innate immunity (C)</p> Signup and view all the answers

    What is the primary function of neutrophils in the immune system?

    <p>To find, eat, and digest microbes (C)</p> Signup and view all the answers

    Which of the following is contained within the granules of neutrophils?

    <p>Lysozyme (D)</p> Signup and view all the answers

    What happens to monocytes after they migrate into tissues?

    <p>They become macrophages (C)</p> Signup and view all the answers

    What is a key role of natural killer (NK) cells?

    <p>Kill virus/bacteria infected cells and cancer cells (D)</p> Signup and view all the answers

    What do Toll-like receptors (TLRs) primarily do in the innate immune system?

    <p>Bind to microbes and trigger immune responses (A)</p> Signup and view all the answers

    What type of proteins are cytokines in the immune system?

    <p>Signaling molecules (A)</p> Signup and view all the answers

    What type of cells are considered 'Big eaters' in the immune system?

    <p>Macrophages (C)</p> Signup and view all the answers

    Which statement describes the activity of NK cells?

    <p>They release granules containing perforins (D)</p> Signup and view all the answers

    What characterizes the innate immune response?

    <p>It comes into action when external defenses are breached (B)</p> Signup and view all the answers

    Which cells are primarily responsible for antigen presentation in the immune system?

    <p>Macrophages (A)</p> Signup and view all the answers

    Flashcards

    Epidermis

    The outermost layer of skin, composed of stratified squamous epithelium.

    Dermis

    The deeper layer of skin, made of strong connective tissue, containing blood vessels, nerves, and hair follicles.

    Hypodermis

    The layer of tissue beneath the dermis, mainly composed of fat cells, anchoring the skin and providing insulation.

    Melanin

    The main pigment found in skin, responsible for the color variations we observe.

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    Melanocytes

    Special cells in the stratum basale of the epidermis that produce melanin.

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    Carotene

    A natural pigment found in carrots and yellow vegetables, which can contribute to skin coloration.

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    Hemoglobin

    The pigment found in red blood cells, giving the pinkish hue to light skin.

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    Skin Appendages

    Epidermal growths extending into the dermis, including hair, nails, and glands.

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    Nails

    Hard keratin plates protecting fingertips and toes, corresponding to hooves and claws in animals.

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    Nail Matrix

    The part of the nail responsible for its growth.

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    Hair Follicle

    A complex structure composed of epidermal and dermal components, responsible for hair growth.

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    Hair Bulb

    The bulb-shaped base of a hair follicle containing epithelial cells surrounding a papilla.

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    Hair Papilla

    Connective tissue in the hair bulb that supplies nutrients for hair growth.

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    Vellus Hair

    Fine, short hairs found all over the body.

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    Terminal Hair

    Longer, coarser hairs, often pigmented.

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    Sebaceous Glands

    Glands that produce sebum, an oily substance that lubricates the skin.

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    Immune Cells

    Cells that release signaling molecules called cytokines in response to infection.

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    Interferons (IFNs)

    Viral proteins that interfere with virus replication in neighboring cells.

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    Antiviral State

    A state in which cells are primed to resist viral infection through the activation of antiviral proteins.

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    Interleukins

    A type of cytokine with a broad range of immune-modulating effects.

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    Interferons (IFNs)

    A type of cytokine produced by virus-infected monocytes and lymphocytes.

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    Innate Immunity

    A non-specific immune response that provides the first line of defense against pathogens. It's rapid, doesn't require prior exposure, and lacks memory.

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    Adaptive Immunity

    A specific immune response that targets specific pathogens. It's slower than innate immunity but provides long-lasting protection.

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    Phagocyte

    A type of white blood cell responsible for engulfing and destroying pathogens.

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    Complement Protein

    A type of protein that helps kill bacteria by disrupting their cell membrane.

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    Natural Killer (NK) Cell

    A type of immune cell that directly kills infected cells or tumor cells.

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    B-Lymphocyte (B-cell)

    A type of white blood cell that matures into a plasma cell, which produces antibodies.

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    T-Lymphocyte (T-cell)

    A type of white blood cell involved in cell-mediated immunity. They recognize and destroy infected cells directly.

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    Cytokine

    A type of chemical messenger that helps regulate and coordinate the immune response.

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    Skin Cancer

    A condition characterized by the uncontrolled growth of abnormal cells in the skin, often caused by excessive sun exposure.

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    Melanoma

    A type of skin cancer that originates from melanocytes, the cells responsible for producing melanin.

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    Neutrophils

    A type of white blood cell that can find, engulf, and destroy microbes by phagocytosis.

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    Neutrophil Granules

    Specialized granules within neutrophils that contain enzymes and other antimicrobial substances.

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    Lysozyme

    An enzyme found in neutrophil granules that breaks down bacterial cell walls.

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    Monocytes

    A type of white blood cell that migrates from the bloodstream into tissues and transforms into macrophages.

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    Macrophages

    Large, phagocytic cells that engulf microbes and other debris in tissues.

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    Phagocytosis

    A process by which cells engulf and destroy foreign particles or microbes.

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    Toll-like Receptors (TLRs)

    Transmembrane proteins found on macrophages and other cells that recognize and bind to specific microbial components.

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    Innate Immune Response

    A complex interplay of cells and proteins that provide the body's first line of defense against pathogens.

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    Study Notes

    Integumentary System

    • The integument includes skin, hair, fingernails, sweat and oil glands.
    • Skin has multiple layers protecting the body, regulating temperature and excreting waste.
    • The skin acts as the first barrier, preventing harmful substances from entering while keeping good substances in.
    • It is composed of two distinct regions: epidermis and dermis.

    Functions of Skin

    • Protection
    • Synthesizes vitamin D with UV.
    • Homeostasis
    • Sensory reception (nerve endings)

    Epithelium: Layers

    • Stratum corneum: dead cells filled with keratin; glycolipids create water resistance.
    • Stratum granulosum: flattened cells with deteriorating organelles and granules (lipids/keratohyaline).
    • Stratum spinosum: cells with bundles of pre-keratin filaments.
    • Stratum basale: actively dividing stem cells; some become superficial layers.
    • Melanocytes: produce melanin, a pigment.
    • Langerhans' cells: part of the immune system.
    • Merkel cells: sensory nerve endings.

    Dermis

    • Strong, flexible connective tissue.
    • Cells: fibroblasts, macrophages, mast cells, WBCs.
    • Fiber types: collagen, elastic, reticular.
    • Rich supply of nerves and vessels, critical for temperature regulation.
    • Two layers: papillary and reticular.
      • Papillary: areolar connective tissue, dermal papillae.
      • Reticular: network of collagen and reticular fibers.

    Skin Appendages

    • Derived from epidermis but extend into dermis.
    • Hair and hair follicles.
    • Sebaceous (oil) glands.
    • Sweat (sudoiferous) glands.
    • Nails

    Fingerprints, Palmprints, Footprints

    • Dermal papillae lie atop dermal ridges.
    • These ridges elevate overlying epidermis.
    • Results in "sweat films" from sweat pores.
    • Genetically determined.
    • Flexion creases formed from continual folding within the dermis.
    • The dermis is the receptive site for the pigment of tattoos.

    Hypodermis

    • "Hypodermis" (Greek) = below the skin.
    • "Subcutaneous" (Latin)=below the skin.
    • Also referred to as superficial fascia.
    • Fatty tissue (areolar tissue and adipose cells).
    • Stores fat and anchors the skin.
    • Different patterns of accumulation for males/females.

    Skin Color

    • Three primary pigments: melanin, carotene, hemoglobin.
    • Melanin produced by melanocytes, amount and type determine skin tone.
    • Carotene from carrots and veggies affects skin color.
    • Hemoglobin in blood vessels gives skin a pinkish tone.
    • Melanin granules travel from melanocytes to keratinocytes to determine skin color.

    Skin Disorders: Burns

    • Threat to life due to catastrophic loss of body fluids, dehydration, and circulatory shock.
    • Infection is a concern.
    • First degree burns: redness (e.g., sunburn).
    • Second degree burns: epidermis and upper dermis; blistering.
    • Third degree burns: full thickness.
    • Infections and wounds can also impair the skin's ability to heal.
    • Skin cancer is also a concern.

    Tumors of the Skin

    • Benign tumors (e.g., warts).
    • Cancer: associated with UV exposure.
      • Types: Aktinic keratosis, basal cell, squamous cell, melanoma (melanocytes; most dangerous).
      • Recognition factors for skin cancer: Asymmetry, border irregularity, colors, and diameter greater than 6 mm.

    Immune System

    • A functional system, not an organ system.
    • Complex system incorporating skin, mucous membranes, secretions, blood cells, vasculature (WBCs), bone marrow, liver (complement proteins), lymphatic system, and lymphoid organs.
    • Most tissues have resident immune cells.

    Innate Immunity vs Adaptive Immunity

    • Innate—no time lag, not antigen specific, no memory.
    • Adaptive—lag period, antigen specific, development of memory.

    Anatomical Barriers: Mechanical Factors

    • Skin: physical barrier.
    • Mucociliary escalator: expels foreign materials.
    • Flushing action: saliva, tears, and urine rinse microbes and foreign materials mechanically.

    Anatomical Barriers: Chemical Factors

    • Antimicrobial peptides in sweat and other secretions.
    • Lysozymes in tears and saliva are enzymes that damage microbial cell walls.
    • Stomach acid and other stomach secretions break down foreign materials and kill pathogens.

    Anatomical Barriers: Biological Factors

    • Normal microbiota: microbes naturally found on body surfaces.
    • Normal flora competes with pathogens for nutrients and space, making the environment less hospitable for them.

    Innate Immune System: Internal Defenses - Cellular Components

    • Neutrophils: most abundant white blood cells, efficient phagocytes, crucial for innate immunity.
    • Monocytes/Macrophages: monocytes migrate into tissues becoming macrophages which phagocytose microbes in tissues.
    • Natural killer (NK) cells: kill virus/bacteria infected cells and cancer cells part of innate immunity.

    Innate Immune System: Internal Defenses - Extracellular Components

    • Cytokines: small signalling proteins secreted by immune cells, influencing other cell behavior.
    • Complement proteins: a set of plasma proteins that interact in a cascade and function in activating immune cells and disrupting cell membranes of pathogens.
    • Coagulation Proteins: a pathway involving platelets, coagulation factors and Vitamin K; stops bleeding after any damage to blood vessels.

    Toll-like Receptors (TLRs)

    • Transmembrane proteins present on macrophages and some other cells.
    • Conserved across vertebrates.
    • They are an important part of innate immunity and look out for microbes (or their components)
    • They bind to microbes and trigger a cascade of events to kill or protect against pathogens.

    Cytokines

    • Small proteins secreted by cells of the immune system.
    • Affect the behavior of other cells.
    • Signaling molecules.
    • Key players in innate and acquired immunity: examples—interferons, interleukins, TNF.

    Antibodies

    • Produced by plasma cells (B lymphocytes).
    • Essential part of adaptive immunity.
    • Specifically bind unique antigenic epitopes (antigenic determinants).
    • Possess antigen-binding sites for targeting specific antigens.
    • Members of the immunoglobulin protein class.
    • Exist in two forms: soluble (in blood and tissues) and membrane-bound (B-cell receptor: BCR).

    Specific Response

    • Antigen-antibody relationship; vaccination.
    • Involves lymphocytes (B, T) and plasma cells.

    Key Points Summary

    • Integumentary system—skin and its appendages.
    • Skin structure; critical for defense and homeostasis.
    • Immune system—functional components.
    • Innate and adaptive immunity.

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    Description

    Test your knowledge on skin anatomy and the immune system with this quiz. Questions cover aspects such as hair types, gland functions, and immune responses. Perfect for students studying human biology or related fields.

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