How Well Do You Know Uncoupling Reagents?
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Questions and Answers

Which of the following best describes the function of uncoupling reagents?

  • They decrease ATP synthesis
  • They enhance oxidative phosphorylation
  • They increase ATP synthesis
  • They prevent oxidative phosphorylation (correct)

What happens to the H+ electrochemical gradient in the presence of an uncoupler?

  • It is reversed
  • It is enhanced
  • It is dissipated (correct)
  • It is maintained

What is the role of uncouplers in the mitochondrial membrane?

  • They act as proton pumps
  • They generate reactive oxygen species
  • They function as carriers for H+ (correct)
  • They synthesize ATP

What is the effect of uncouplers on the development of mitochondrial membrane potential?

<p>They decrease it (D)</p> Signup and view all the answers

What is the consequence of an uncoupler consuming ∆pH and ∆Ψ without synthesis of ATP?

<p>Respiration proceeds without ATP synthesis (A)</p> Signup and view all the answers

What is the chemical nature of uncoupling reagents?

<p>They are lipid-soluble weak acids (D)</p> Signup and view all the answers

What is the mechanism by which uncouplers prevent oxidative phosphorylation?

<p>By dissipating the H+ electrochemical gradient (A)</p> Signup and view all the answers

What is the effect of uncouplers on the synthesis of ATP?

<p>They inhibit ATP synthesis (C)</p> Signup and view all the answers

Which of the following best describes the function of uncoupling reagents?

<p>They prevent oxidative phosphorylation (C)</p> Signup and view all the answers

What happens to the H+ electrochemical gradient in the presence of an uncoupler?

<p>It is dissipated (C)</p> Signup and view all the answers

What is the role of uncouplers in the mitochondrial membrane?

<p>They function as carriers for H+ (B)</p> Signup and view all the answers

What is the effect of uncouplers on the development of mitochondrial membrane potential?

<p>They decrease it (C)</p> Signup and view all the answers

What is the consequence of an uncoupler consuming ∆pH and ∆Ψ without synthesis of ATP?

<p>Respiration proceeds without ATP synthesis (C)</p> Signup and view all the answers

What is the chemical nature of uncoupling reagents?

<p>They are lipid-soluble weak acids (C)</p> Signup and view all the answers

What is the mechanism by which uncouplers prevent oxidative phosphorylation?

<p>By dissipating the H+ electrochemical gradient (D)</p> Signup and view all the answers

What is the effect of uncouplers on the synthesis of ATP?

<p>They inhibit ATP synthesis (D)</p> Signup and view all the answers

Which of the following statements about uncoupling reagents is true?

<p>They prevent oxidative phosphorylation by dissipating the H+ electrochemical gradient (C)</p> Signup and view all the answers

What is the effect of an uncoupler on the mitochondrial membrane potential?

<p>It decreases the ∆pH and ∆Ψ (B)</p> Signup and view all the answers

What is the role of H+ in the function of uncoupling reagents?

<p>They are carriers for uncouplers (B)</p> Signup and view all the answers

What is the effect of an uncoupler on the synthesis of ATP?

<p>It has no effect on the synthesis of ATP (D)</p> Signup and view all the answers

What is the effect of an uncoupler on respiration?

<p>It has no effect on respiration (D)</p> Signup and view all the answers

Which of the following is a characteristic of uncoupling reagents?

<p>They are hydrophobic (B)</p> Signup and view all the answers

What happens to protons pumped out in the presence of an uncoupler?

<p>They are pumped back into the mitochondrial matrix (A)</p> Signup and view all the answers

Which of the following is a function of uncoupling reagents?

<p>They dissipate the H+ electrochemical gradient (A)</p> Signup and view all the answers

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