How Well Do You Know Uncoupling Reagents?
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Questions and Answers

Which of the following best describes the function of uncoupling reagents?

  • They decrease ATP synthesis
  • They enhance oxidative phosphorylation
  • They increase ATP synthesis
  • They prevent oxidative phosphorylation (correct)

    • What happens to the H+ electrochemical gradient in the presence of an uncoupler?

  • It is reversed
  • It is enhanced
  • It is dissipated (correct)
  • It is maintained

    • What is the role of uncouplers in the mitochondrial membrane?

  • They act as proton pumps
  • They generate reactive oxygen species
  • They function as carriers for H+ (correct)
  • They synthesize ATP

    • What is the effect of uncouplers on the development of mitochondrial membrane potential?

    <p>They decrease it</p> Signup and view all the answers

    What is the consequence of an uncoupler consuming ∆pH and ∆Ψ without synthesis of ATP?

    <p>Respiration proceeds without ATP synthesis</p> Signup and view all the answers

    What is the chemical nature of uncoupling reagents?

    <p>They are lipid-soluble weak acids</p> Signup and view all the answers

    What is the mechanism by which uncouplers prevent oxidative phosphorylation?

    <p>By dissipating the H+ electrochemical gradient</p> Signup and view all the answers

    What is the effect of uncouplers on the synthesis of ATP?

    <p>They inhibit ATP synthesis</p> Signup and view all the answers

    Which of the following best describes the function of uncoupling reagents?

    <p>They prevent oxidative phosphorylation</p> Signup and view all the answers

    What happens to the H+ electrochemical gradient in the presence of an uncoupler?

    <p>It is dissipated</p> Signup and view all the answers

    What is the role of uncouplers in the mitochondrial membrane?

    <p>They function as carriers for H+</p> Signup and view all the answers

    What is the effect of uncouplers on the development of mitochondrial membrane potential?

    <p>They decrease it</p> Signup and view all the answers

    What is the consequence of an uncoupler consuming ∆pH and ∆Ψ without synthesis of ATP?

    <p>Respiration proceeds without ATP synthesis</p> Signup and view all the answers

    What is the chemical nature of uncoupling reagents?

    <p>They are lipid-soluble weak acids</p> Signup and view all the answers

    What is the mechanism by which uncouplers prevent oxidative phosphorylation?

    <p>By dissipating the H+ electrochemical gradient</p> Signup and view all the answers

    What is the effect of uncouplers on the synthesis of ATP?

    <p>They inhibit ATP synthesis</p> Signup and view all the answers

    Which of the following statements about uncoupling reagents is true?

    <p>They prevent oxidative phosphorylation by dissipating the H+ electrochemical gradient</p> Signup and view all the answers

    What is the effect of an uncoupler on the mitochondrial membrane potential?

    <p>It decreases the ∆pH and ∆Ψ</p> Signup and view all the answers

    What is the role of H+ in the function of uncoupling reagents?

    <p>They are carriers for uncouplers</p> Signup and view all the answers

    What is the effect of an uncoupler on the synthesis of ATP?

    <p>It has no effect on the synthesis of ATP</p> Signup and view all the answers

    What is the effect of an uncoupler on respiration?

    <p>It has no effect on respiration</p> Signup and view all the answers

    Which of the following is a characteristic of uncoupling reagents?

    <p>They are hydrophobic</p> Signup and view all the answers

    What happens to protons pumped out in the presence of an uncoupler?

    <p>They are pumped back into the mitochondrial matrix</p> Signup and view all the answers

    Which of the following is a function of uncoupling reagents?

    <p>They dissipate the H+ electrochemical gradient</p> Signup and view all the answers

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