7 Questions
What is the rate-limiting step in the TCA cycle?
Oxidative decarboxylation by IDH
Which of the following are IDH (+) activators?
ADP and Ca2+
What are the IDH (-) inhibitors?
ATP and NADH
Which enzyme carries out the 2nd oxidative decarboxylation in the TCA cycle?
α-Ketoglutarate dehydrogenase (α-KGDH)
What is the metabolic branch point in which intermediates enter or exit the TCA cycle?
Succinyl CoA
What is the starting point for the synthesis of heme?
Succinyl CoA
How many IDH enzymes are there in the TCA cycle?
Two
Test your knowledge on the oxidative decarboxylation process carried out by isocitrate dehydrogenase (IDH) and alpha-ketoglutarate dehydrogenase (α-KGDH) complex. Learn about the rate-limiting step, the role of activators and inhibitors, and the different types of IDH enzymes. Challenge yourself on the metabolic branch point involving succinyl CoA and test your understanding of this important biochemical pathway.
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