How much do you know about skin lesions and melanocytic neoplasms?

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Questions and Answers

What is Seborrhoeic Keratosis?

A firm outgrowth of keratinocytes with a ‘church spire’ architecture, commonly found on hands and feet.

A skin cancer that arises from UV light exposure, burns, radiation, and immunosuppression.

A tumour composed of malignant melanocytes invading the dermis.

A benign proliferating lesion of keratinocytes that appears as a pigmented lesion protruding above the skin surface, commonly found on the trunk of adults. (correct)

What are the risk factors for developing melanoma?

Hair follicular epithelium, sun-exposed areas of the skin, and Gorlin syndrome.

Keratinocytes, non-sun exposed areas of the skin, and Bowen’s disease.

UV light exposure, family history, multiple naevi, and immunosuppression. (correct)

Human papilloma virus infection, sun-exposed areas of the skin, and immunosuppression.

What is Actinic Keratosis?

A benign proliferating lesion of keratinocytes that appears as a pigmented lesion protruding above the skin surface, commonly found on the trunk of adults.

A firm outgrowth of keratinocytes with a ‘church spire’ architecture, commonly found on hands and feet.

A tumour composed of malignant melanocytes invading the dermis.

A very common lesion that appears on sun-exposed areas of the skin, can occur in immunosuppression, and can progress to squamous cell carcinoma in situ and invasive squamous cell carcinoma. (correct)

What is the function of PDL1?

Allows some cancer cells to avoid attack from T lymphocytes. Signup and view all the answers

What is Verruca Vulgaris?

Caused by human papilloma virus infection and appears as a firm outgrowth of keratinocytes with a ‘church spire’ architecture, commonly found on hands and feet. Signup and view all the answers

What are Melanocytic Neoplasms?

Include benign naevi (moles), dysplastic naevi, and malignant melanoma. Signup and view all the answers

What is the prognosis of Invasive Squamous Cell Carcinoma?

Depends on size, depth of invasion, and lymphovascular invasion. Signup and view all the answers

What is Seborrhoeic Keratosis?

A benign skin lesion Signup and view all the answers

What is the cause of Verruca Vulgaris?

Human papilloma virus infection Signup and view all the answers

What is the common location for Actinic Keratosis?

Sun-exposed areas of the skin Signup and view all the answers

What is the difference between Squamous cell carcinoma in-situ and invasive Squamous Cell Carcinoma?

Invasive Squamous Cell Carcinoma is a skin cancer that arises from UV light exposure Signup and view all the answers

What is the common location for Basal cell carcinoma?

Sun-exposed areas of the skin Signup and view all the answers

What is Dysplastic Naevus Syndrome?

An autosomal dominant mutation affecting the CDKN2A gene Signup and view all the answers

What is PDL1 and why is it important in the treatment of malignant melanoma?

A protein that allows cancer cells to avoid attack from T lymphocytes Signup and view all the answers

Study Notes

Overview of Skin Lesions and Melanocytic Neoplasms

Seborrhoeic Keratosis is a benign proliferating lesion of keratinocytes that appears as a pigmented lesion protruding above the skin surface, commonly found on the trunk of adults.
Verruca Vulgaris, also known as warts, is caused by human papilloma virus infection and appears as a firm outgrowth of keratinocytes with a ‘church spire’ architecture, commonly found on hands and feet.
Actinic Keratosis is a very common lesion that appears on sun-exposed areas of the skin, can occur in immunosuppression, and can progress to squamous cell carcinoma in situ and invasive squamous cell carcinoma.
Squamous cell carcinoma in-situ, also known as Bowen’s disease, appears on both sun and non-sun exposed areas of the skin, and can progress to invasive squamous cell carcinoma.
Invasive Squamous Cell Carcinoma is a skin cancer that arises from UV light exposure, burns, radiation, and immunosuppression, and its prognosis depends on size, depth of invasion, and lymphovascular invasion.
Basal cell carcinoma is a common skin cancer that arises from hair follicular epithelium and is commonly found on sun-exposed areas of the skin, and can be associated with syndromes such as Gorlin syndrome.
Melanocytic Neoplasms include benign naevi (moles), dysplastic naevi, and malignant melanoma.
Benign naevi are very common and can recur if incompletely excised, while dysplastic naevi are controversial but are important as risk factors for developing melanoma.
Risk of melanoma is increased with larger and more atypical naevi that have irregular borders and irregular discoloration, and with multiple naevi regardless of their appearance.
Dysplastic Naevus Syndrome is an autosomal dominant mutation affecting the CDKN2A gene, where individuals have over 100 naevi and an increased risk of melanoma.
Malignant Melanoma is a tumour composed of malignant melanocytes invading the dermis, and its risk factors include UV light exposure, family history, multiple naevi, and immunosuppression.
PDL1 is a protein that allows some cancer cells to avoid attack from T lymphocytes, and PDL1 inhibitors are sometimes employed to treat malignant melanoma after testing the tumour for PDL1 protein expression using a stain called PDL1 immunohistochemistry.

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Description

Test your knowledge on skin lesions and melanocytic neoplasms with this informative quiz! Learn about common benign and malignant lesions, their presentation, and risk factors for developing skin cancer. From seborrhoeic keratosis to malignant melanoma, this quiz covers it all. You'll also discover the importance of dysplastic naevi and PDL1 protein expression in the diagnosis and treatment of skin cancer. Don't miss out on this opportunity to expand your dermatological knowledge!