How much do you know about erythropoiesis?

the body, the production of erythropoietin is severely reduced, leading to a marked decrease in red blood cell production. This can be corrected by administration of erythropoietin, which stimulates red blood cell production in the bone marrow.

Summary

Red blood cells are the most abundant cells of the blood and are responsible for carrying oxygen from the lungs to the tissues. They also contain carbonic anhydrase, which enables the transport of carbon dioxide in the blood. Red blood cells have a biconcave shape and are produced in the bone marrow from pluripotential hematopoietic stem cells. The production of red blood cells is regulated by erythropoietin, a hormone primarily produced in the kidneys in response to hypoxia.This passage discusses the process of erythropoiesis, or the production of red blood cells. Erythropoietin is a hormone that stimulates the production of red blood cells in the bone marrow. Lack of erythropoietin can lead to anemia. Vitamin B12 and folic acid are essential for the maturation of red blood cells, and deficiencies in these nutrients can cause abnormal cell formation. Iron is important for the formation of hemoglobin, and the body stores iron in the liver and reticuloendothelial system. Transferrin is a protein that transports iron in the blood, and apotransferrin is involved in the absorption of iron from the small intestine.This passage discusses the process of iron absorption from the intestines and how the body regulates its total iron levels. It also explains the life span of red blood cells and how they are destroyed, leading to various types of anemia. The effects of anemia on the circulatory system, including increased cardiac output and hypoxia during exercise, are also discussed. The passage then goes on to describe polycythemia, a condition where there are too many red blood cells in the body, and its effects on the circulatory system. The article concludes with a bibliography of related research articles.This is a list of references to articles about various topics related to hematology and related diseases:

• Fandrey J. Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol. 2004;286:R977.
• Hentze M.W., Muckenthaler M.U., Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004;117:285.
• Kato G.J., Gladwin M.T. Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA. 2008;300:2638.
• Lappin T. The cellular biology of erythropoietin receptors. Oncologist. 2003;8(Suppl 1):15.
• Maxwell P. HIF-1: an oxygen response system with special relevance to the kidney. J Am Soc Nephrol. 2003;14:2712.
• Metcalf D. Hematopoietic cytokines. Blood. 2008;111:485.
• Nangaku M., Eckardt K.U. Hypoxia and the HIF system in kidney disease. J Mol Med. 2007;85:1325.
• Percy M.J., Rumi E. Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis. Am J Hematol. 2009;84:46.
• Pietrangelo A. Hereditary hemochromatosis—a new look at an old disease. N Engl J Med. 2004;350:2383.
• Platt O.S. Hydroxyurea for the treatment of sickle cell anemia. N Engl J Med. 2008;27:358-1362.