Cryptococcosis

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Questions and Answers

What is the recommended sample volume for fluid analysis in the diagnosis of cryptococcosis?

More than 10 mL (correct)

Between 1-5 mL

Less than 1 mL

Between 5-10 mL

What is the most common symptom of meningoencephalitis caused by Cryptococcus neoformans?

Dizziness (correct)

Meningeal irritation

Acute fever

Impaired vision

What is the main virulence factor of Cryptococcus spp.?

Polysaccharide capsule (correct)

Melanin production

Ability to grow at 37°C

Production of other enzymes

What is the main cause of mortality in AIDS patients due to Cryptococcosis?

Outbreaks caused by Cryptococcus gattii Signup and view all the answers

What is the recommended treatment for severe cryptococcosis?

A combination of Amphotericin B and flucytosine Signup and view all the answers

What is the prognosis associated with a short duration (<2 weeks) between onset of symptoms and consultation for patients with Cryptococcus neoformans CNS involvement?

Poor prognosis Signup and view all the answers

What is the prevalence of infection among HIV-infected Cambodian patients with <200 CD4 + /mm 3?

18% Signup and view all the answers

What is the difference between the inflammatory response of C. neoformans and C. gattii?

C. gattii causes more inflammation than C. neoformans Signup and view all the answers

What is the recommended duration of maintenance therapy for milder forms of cryptococcal disease?

6-10 weeks Signup and view all the answers

Which staining method is used to highlight the capsule in tissue sections for the diagnosis of cryptococcosis?

Mucicarmine Signup and view all the answers

What is the case fatality rate for patients without underlying disease?

Approximately 20% Signup and view all the answers

What is the immune reconstitution inflammatory syndrome (IRIS)?

A granulomatous tissue reaction induced by restoration of a Th1 response after HAART Signup and view all the answers

Which disease is NOT a risk factor for cryptococcosis in HIV-negative persons?

Tuberculosis Signup and view all the answers

What is the role of antigen titers in the diagnosis of cryptococcosis?

Antigen titers correlate with meningitis Signup and view all the answers

What is the most common neurological abnormality associated with Cryptococcus neoformans infection?

Palsies Signup and view all the answers

What is the most common symptom of cryptococcal pneumonia?

Chest pain Signup and view all the answers

What is the recommended treatment for elevated intracranial pressure in cryptococcal meningitis?

Therapeutic lumbar punctures Signup and view all the answers

What is the recommended duration of maintenance therapy for AIDS patients with cryptococcal disease?

Until immune reconstitution has occurred Signup and view all the answers

What is the most common site of involvement for Cryptococcus neoformans infections in AIDS patients?

Blood Signup and view all the answers

Study Notes

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Description

Test your knowledge on Cryptococcosis, a potentially fatal fungal infection that is a major cause of mortality in AIDS patients. This quiz covers the epidemiology, symptoms, diagnosis, and treatment options for Cryptococcosis caused by C. neoformans and C. gattii. Brush up on your knowledge of this important infectious disease and its impact on global health.