Chapter 13 Respiratory Physiology

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Questions and Answers

Which of the following is NOT a function of the respiratory system?

  • Regulation of blood H+ concentration
  • Formation of speech sounds
  • Net uptake of carbon dioxide from the air and removal of oxygen from the blood (correct)
  • Trapping of blood clots
  • Defense against microbes

Which is TRUE about the pleural sac?

  • It is continuous with the atmosphere and protects the lungs from infection.
  • It is a closed sac surrounding each lung and contains a large volume of surfactant.
  • It is a closed sac surrounding each lung that contains only a tiny volume of lubricating fluid. (correct)
  • It is a closed, air-filled space surrounding both lungs that has a negative pressure compared to atmospheric pressure.
  • It is bounded by pleural membranes that are very thin, which allows for abundant gas exchange.

Which structure is NOT part of the "anatomical dead space"?

  • Trachea
  • Bronchus
  • Bronchiole
  • Respiratory bronchiole (correct)
  • Terminal bronchiole

What is one function of the type II alveolar cells?

<p>Production of surfactant (A)</p> Signup and view all the answers

Type II alveolar cells are among the last cells to mature during fetal development. In babies born prematurely, type II alveolar cells are often not ready to perform their function. Which of the following would be TRUE of these babies?

<p>They would be at risk of alveolar collapse due to too much surface tension in the alveoli. (A)</p> Signup and view all the answers

Which of the following is most responsible for keeping the lung surface and the thoracic wall from separating?

<p>Subatmospheric intrapleural pressure (D)</p> Signup and view all the answers

During a yoga class, you take a deep breath, then relax and let the breath out slowly. During that exhalation, which of the following statements would NOT be true?

<p>Intrapleural pressure is greater than alveolar pressure. (B)</p> Signup and view all the answers

Which of these causes inhalation/inspiration?

<p>Flattening (downward movement) of the diaphragm (C)</p> Signup and view all the answers

Which is normally TRUE about the intrapleural pressure?

<p>It is lower than alveolar pressure. (A)</p> Signup and view all the answers

The volume of air flowing into the alveoli during inhalation/inspiration is increased when there is an increase in which of these?

<p>The pressure gradient from the atmosphere to the alveoli (B)</p> Signup and view all the answers

Under normal circumstances, which of the following would result from an increase in transpulmonary pressure?

<p>Inhalation/inspiration (A)</p> Signup and view all the answers

Which of the following statements regarding pulmonary surfactant is TRUE?

<p>It increases the compliance of the lungs. (B)</p> Signup and view all the answers

Under what condition is lung compliance increased?

<p>Emphysema (D)</p> Signup and view all the answers

Type II alveolar cells are among the last cells to mature during fetal development. In babies born prematurely, type II alveolar cells are often not ready to perform their functions. Which of the following drugs would be most likely to help an infant with immature type II alveolar cells?

<p>Pulmonary surfactant (A)</p> Signup and view all the answers

Which of the following is a cause of asthma?

<p>Inflammation of the bronchioles (B)</p> Signup and view all the answers

Which of the following is TRUE during the initial stage of an asthma attack?

<p>R is increased. (C)</p> Signup and view all the answers

Which of the following drugs, administered as an aerosol spray, would be most likely to help a patient during an asthmatic attack?

<p>A B2-adrenergic agonist (B)</p> Signup and view all the answers

During a physical examination, a patient has a resting tidal volume is 550 mL; the average resting respiratory rate is 15 breaths per minute; the total lung capacity is 6,000 mL; and anatomic dead space is 150 mL. The patient's resting alveolar ventilation is

<p>6.0 L/min. (B)</p> Signup and view all the answers

When lying down, a subject's respiratory rate is 12 breaths per minute, anatomical dead space is 150 mL, and minute ventilation is 7 L/min. Which of these is closest to alveolar ventilation in liters per minute?

<p>5.2 (B)</p> Signup and view all the answers

Which of the following statements about the response of arteriolar smooth muscle to changing oxygen partial pressures is TRUE?

<p>Systemic arterioles respond to a decrease in P02 by dilating, but pulmonary arterioles constrict in response to decreased P02. (C)</p> Signup and view all the answers

When you head to bed at night, you bring a glass of tap water with you and set it on the nightstand. Upon waking in the morning, you discover there are tiny gas bubbles along the sides of the container. The best explanation for this is:

<p>the partial pressure of a particular gas in a liquid equilibrates to match the partial pressure of that gas in the air to which the liquid is exposed. (D)</p> Signup and view all the answers

You (a healthy individual) are swimming underwater when you can no longer resist the urge to breathe. This overwhelming urge is probably due to

<p>the increase in plasma H+ (C)</p> Signup and view all the answers

You embark on a hiking trip on Mt. Kilimanjaro (altitude = 19,000 ft; Atmospheric air pressure = 379 mmHg). As you ascend, what happens to thein the alveoli?

<p>Alveolar P02 decreases. (B)</p> Signup and view all the answers

You embark on a hiking trip on Mt. Kilimanjaro (altitude = 19,000 ft; Atmospheric air pressure = 379 mmHg). As you ascend, what are you likely to notice about your breathing?

<p>You need to work harder to inhale, expanding your thoracic size beyond what is normal (B)</p> Signup and view all the answers

You’re resting on the couch watching TV. Which of the following statements regarding the partial pressures of O2 and CO2 is true in a normal person at rest?

<p>The PO2 in the systemic arteries is approximately 100 mmHg and the alveolar PO2 is approximately 105 mmHg. (C)</p> Signup and view all the answers

Regarding the relationships between the rates of oxygen consumption/carbon dioxide production and alveolar ventilation, which of these statements is TRUE?

<p>A decrease in metabolism without a similar decrease in alveolar ventilation would result in hyperventilation. (D)</p> Signup and view all the answers

A decrease in metabolism without a similar, compensatory decrease in alveolar ventilation will have what effect on the systemic pH?

<p>pH will increase. (B)</p> Signup and view all the answers

Which of the following is NOT true regarding ventilation-perfusion inequality?

<p>No inequality exists in normal lungs. (A)</p> Signup and view all the answers

In which form is most of the oxygen carried in arterial blood?

<p>Bound to hemoglobin (A)</p> Signup and view all the answers

If all other factors remain the same, which of these results in an increase in the amount of oxygen bound to hemoglobin?

<p>Increased plasma Po2 (D)</p> Signup and view all the answers

Which of these is demonstrated by the oxygen-hemoglobin dissociation curve?

<p>At normal resting systemic arterial PO2, hemoglobin is almost 100% saturated with oxygen. (B)</p> Signup and view all the answers

Which of the following would cause a decrease in the binding affinity of hemoglobin for oxygen?

<p>Increased temperature of the blood (B)</p> Signup and view all the answers

During a run, your gastrocnemius (calf) muscle has a temperature of 38.5° C, while your biceps brachii (upper arm) muscle has a temperature of 37.5° C. Which of the following is TRUE of the red blood cells as they pass by these muscles?

<p>The hemoglobin molecules will have a higher affinity for oxygen as they pass by the biceps brachii compared to the gastrocnemius. (B)</p> Signup and view all the answers

Carbonic anhydrase catalyzes a reaction that combines which of the following?

<p>H2O and CO2 (B)</p> Signup and view all the answers

After CO2 is produced by tissues, in what form is most of that carbon transported to the lungs for removal from the body?

<p>As dissolved HCO3- (D)</p> Signup and view all the answers

You find a friend in the midst of anxiety-induced hyperventilation. You’re unable to calm them down, so you call an ambulance. When your friend arrives at the ER, which of the following is the likely diagnosis?

<p>Respiratory alkalosis (A)</p> Signup and view all the answers

A patient in the ward was recently in a motor vehicle accident. Their injuries are causing a lot of pain, and as a consequence to the morphine they've been given, respiratory rate is quite low. Which of the following is likely to be TRUE?

<p>The level of H+ ions in their blood has increased. (C)</p> Signup and view all the answers

Which of these correctly describes the chloride shift?

<p>In the tissues, chloride enters red blood cells in exchange for bicarbonate ions. (C)</p> Signup and view all the answers

What brain center has neurons that fire mainly during inspiration and have input to the spinal motor neurons that activate the diaphragm and inspiratory intercostal muscles?

<p>The dorsal respiratory group of the medulla oblongata (C)</p> Signup and view all the answers

Action potentials in neurons in the inspiratory center of the medulla oblongata result in action potentials in the _________ nerves to the diaphragm, which in turn cause _________ of the muscle, resulting in a/an _________ in the volume of the thoracic cage.

<p>motor; contraction; increase (D)</p> Signup and view all the answers

Which of the following are chemoreceptors?

<p>Receptors in the aortic and carotid bodies (B)</p> Signup and view all the answers

Drug X is a new drug to treat Alzheimer’s Disease. This drug is able to cross the blood-brain barrier and circulate in the CSF. The drug is slightly acidic and at the recommended dose it decreases the CSF pH from 7.4 to 7.3. Will Drug X have any effect on respiration?

<p>It will cause an increase in respiratory rate. (A)</p> Signup and view all the answers

What is the primary regulator of the magnitude of alveolar ventilation under normal circumstances?

<p>The H+ concentration in the brain extracellular fluid, which is monitored by central chemoreceptors (A)</p> Signup and view all the answers

Which of the following statements regarding control of respiration is correct?

<p>Increased concentrations of lactic acid stimulate ventilation primarily by acting on peripheral chemoreceptors. (C)</p> Signup and view all the answers

Which of these would tend to increase ventilation?

<p> Breathing air with increased PCO2 (D) Signup and view all the answers

If the nerves from the carotid and aortic bodies are cut, which of these would occur?

<p>A decrease in arterial PCO2 (A)</p> Signup and view all the answers

You’ve just stepped on the treadmill and are beginning to increase your speed. As you reach your maximum, which of the following values will NOT increase?

<p>Arterial PCO2 (A)</p> Signup and view all the answers

Following strenuous exercise, blood levels of lactic acid are_________ compared to pre-exercise levels. This change in acid concentration causes a reflex_________ in ventilation by activating_________.

<p>increased; increase; peripheral chemoreceptors (@)</p> Signup and view all the answers

Which of the following statements regarding hypoxia is correct?

<p>Exposure to high altitude is a form of hypoxic hypoxia. (A)</p> Signup and view all the answers

Which of the following conditions would result in a systemic arterial PO2 lower than is typical of a healthy person at sea level?

<p>Traveling to high altitude (A)</p> Signup and view all the answers

Which is characteristic of a person chronically suffering from hypoxic hypoxia?

<p>Higher-than-normal hematocrit (B)</p> Signup and view all the answers

Which correctly describes the cause of the increase in alveolar ventilation that occurs when a person ascends to high altitude?

<p>The decrease in PCO2 of inspired air decreases alveolar and arterial PCO2, stimulating the peripheral chemoreceptors. (C)</p> Signup and view all the answers

Flashcards

Pleural Sac

It is a closed sac surrounding each lung that contains only a tiny volume of lubricating fluid.

Function of Type II Alveolar Cells

Production of surfactant

Premature Babies and Type II Alveolar Cells

They would be at risk of alveolar collapse due to too much surface tension in the alveoli.

Keeping Lung Surface and Thoracic Wall Together

Subatmospheric intrapleural pressure

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What causes inhalation?

Flattening (downward movement) of the diaphragm

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Intrapleural Pressure

It is lower than alveolar pressure.

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Increased Air Flow During Inhalation

The pressure gradient from the atmosphere to the alveoli

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Result of Increased Transpulmonary Pressure

Inhalation/inspiration

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Pulmonary Surfactant

It increases the compliance of the lungs.

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Condition with Increased Lung Compliance

Emphysema

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Drug for Immature Type II Alveolar Cells

Pulmonary surfactant

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Cause of Asthma

Inflammation of the bronchioles

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Asthma Attack Initial Stage

R is increased.

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Drug for Asthmatic Attack

A B2-adrenergic agonist

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Resting Alveolar Ventilation

  1. 0 L/min.
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Alveolar ventilation in liters per minute

  1. 2
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Arteriolar Smooth Muscle Response

Systemic arterioles respond to a decrease in P02 by dilating, but pulmonary arterioles constrict in response to decreased P02.

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Gas Bubbles in Water

The partial pressure of a particular gas in a liquid equilibrates to match the partial pressure of that gas in the air to which the liquid is exposed.

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Overwhelming Urge to Breathe

The increase in plasma H+

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Alveolar PO2 at High Altitude

Alveolar P02 decreases.

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