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Questions and Answers

What is the network of small plasma and membrane-bound proteins that assists in destroying invading organisms called?

  • Complement (correct)
  • Antigens
  • Chemokines
  • Cytokines

Which type of cytokines are specifically responsible for attracting immune cells to sites of infection?

  • Chemokines (correct)
  • Cytokines
  • Interferons
  • Monokines

What characterizes the cellular response in acquired immunity?

  • Involvement of T-lymphocytes (correct)
  • Production of antibodies
  • Involvement of B-lymphocytes
  • Immediate response to pathogens

How does acquired immunity react upon subsequent exposure to the same pathogen?

<p>It is quicker due to prior sensitization. (B)</p> Signup and view all the answers

What initiates the adaptive immune response?

<p>The recognition of antigens (B)</p> Signup and view all the answers

Which immune response is generally known to be faster?

<p>Innate immune response (C)</p> Signup and view all the answers

Which of the following parasites is known to have a narrow host range?

<p>Haematopinus suis (A)</p> Signup and view all the answers

What is the primary role of B-lymphocytes in the immune system?

<p>To produce antibodies (A)</p> Signup and view all the answers

What type of parasites are most parasitic arthropods described as?

<p>Ectoparasites (C)</p> Signup and view all the answers

What factor contributes to the host specificity of a parasite?

<p>Nutritional content of the host (D)</p> Signup and view all the answers

In which scenario might a parasite exhibit different host specificity between life stages?

<p>When larval stages have strong specificity to some hosts (D)</p> Signup and view all the answers

What is a potential consequence of multiple parasitic infections in animals?

<p>Anemia due to hematopoiesis deficit (C)</p> Signup and view all the answers

Which of the following statements best describes Toxoplasma gondii?

<p>Has a wide host range in its asexual stage (C)</p> Signup and view all the answers

Which of the following conditions can result from long-term parasitic infections?

<p>Bone dystrophy and rickets (B)</p> Signup and view all the answers

Which anatomical feature might hinder a parasite's establishment in a host?

<p>Length of intestinal villi (A)</p> Signup and view all the answers

What role does the veterinarian play in the context of parasitic infections in animals?

<p>Limiting economic losses due to production decrease (B)</p> Signup and view all the answers

Which neurological symptom could be connected to parasitic infections?

<p>Accommodative disorders (D)</p> Signup and view all the answers

What type of host specificity is observed in Eimeria at the generic level?

<p>Strong host specificity to individual species (A)</p> Signup and view all the answers

In cases of severe parasitic infections in animals, what can sometimes lead to death?

<p>Medical complications from polyparasitism (C)</p> Signup and view all the answers

What physiological factor may influence a parasite's ability to infect a host?

<p>Bile composition of the host (B)</p> Signup and view all the answers

Which parasite is known for having a wider host range?

<p>Trypanosoma evansi (A)</p> Signup and view all the answers

Which factor could lead to an increased susceptibility to parasites in animals?

<p>Restraining animals from natural behaviors (A)</p> Signup and view all the answers

What is a potential consequence of increasing the host stocking density in an area?

<p>Higher output of parasite eggs or larvae per unit area (B)</p> Signup and view all the answers

How can introducing parasitized animals into a clean area affect local livestock?

<p>It can infect susceptible local livestock (C)</p> Signup and view all the answers

Which of the following environmental changes could make conditions more favorable for parasite development?

<p>Short-term weather patterns and global warming (B)</p> Signup and view all the answers

What is a potential result of selectively breeding animals for production traits?

<p>Increased vulnerability to infections (D)</p> Signup and view all the answers

Which scenario could lead to a surge in intermediate hosts or vectors for parasites?

<p>Changes in weather patterns that favor host reproduction (A)</p> Signup and view all the answers

What might increase the resistance of a parasite population to anti-parasitic medication?

<p>Overuse of a particular anti-parasitic treatment (B)</p> Signup and view all the answers

Which breed characteristic might increase vulnerability to conditions like demodectic mange?

<p>Inbreeding within certain bloodlines (A)</p> Signup and view all the answers

What process is disrupted by Piroplasma when it grows in red blood cells?

<p>Hematopoiesis (D)</p> Signup and view all the answers

Which clinical sign is NOT associated with anemia caused by parasites?

<p>Increased appetite (C)</p> Signup and view all the answers

What contributes to weight loss and cachexia in infected animals?

<p>Mechanical obstruction in the intestines (A)</p> Signup and view all the answers

How can parasites lead to anemia related to vitamin B12?

<p>By consuming vitamin B12 from the host (D)</p> Signup and view all the answers

Which factor is least likely to contribute to decreased appetite in an infected animal?

<p>High energy expenditure (B)</p> Signup and view all the answers

What type of nutritional deficiency can parasites cause leading to significant health issues?

<p>Imbalance of mineral salts (D)</p> Signup and view all the answers

Which of the following is a direct consequence of parasites consuming host nutrients?

<p>Weight loss due to nutrient depletion (C)</p> Signup and view all the answers

What can the loss of blood proteins in infected animals lead to?

<p>Reduced ability to fight infections (D)</p> Signup and view all the answers

How do extracellular parasitic protozoa primarily get attacked by the immune system?

<p>Phagocyte ingestion and membrane disruption (A)</p> Signup and view all the answers

What is a primary characteristic that differentiates helminths from protozoa in terms of their interaction with the host?

<p>Helminths are multicellular and larger (D)</p> Signup and view all the answers

What mechanism is primarily involved in expelling nematodes from the gastrointestinal tract?

<p>Permeability of the mucosal lining to antibodies (A)</p> Signup and view all the answers

Why is it more challenging for the immune system to respond to helminths compared to protozoa?

<p>Helminths are extracellular and do not multiply within the host (B)</p> Signup and view all the answers

What role does goblet cell hyperplasia play in combating helminths?

<p>Contributes to mucus formation that helps dislodge helminths (C)</p> Signup and view all the answers

What is a key factor that allows the immune system to target intracellular protozoa effectively?

<p>Their vulnerability during movement between host cells (C)</p> Signup and view all the answers

What is the expected outcome of the immune response towards extracellular protozoa?

<p>Quick and effective eradication of the parasite (D)</p> Signup and view all the answers

How do helminths typically avoid being effectively targeted by the host's immune system?

<p>They reside in the lumen away from direct surface contact (B)</p> Signup and view all the answers

Flashcards

Host range

The range of hosts that a parasite can infect.

Broad host range

Parasites that can infect a wide range of species.

Narrow host range

Parasites that can only infect a few specific species.

Life-stage specific host specificity

Host specificity that varies between different life stages of a parasite.

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Factors influencing parasite specificity

Factors that determine a parasite's host range.

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Anatomical factors in host specificity

The shape and size of the host's intestine can prevent a parasite from establishing itself.

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Physiological factors in host specificity

The chemical composition of the host's body can determine if a parasite can survive.

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Nutritional factors in host specificity

The food available in the host can influence a parasite's survival.

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Extracellular Protozoa and Immunity

Protozoa living outside host cells are vulnerable to immune responses like antibodies and phagocytosis.

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Intracellular Protozoa and Immunity

Protozoa living inside host cells are protected from direct attack by humoral immunity.

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Helminth Immune Evasion

Helminths are multicellular organisms with a less direct relationship with host tissues compared to protozoa.

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Helminth and Host Interaction

Helminths are often extracellular and don't reproduce quickly within the host, making them harder to target by the immune system.

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Helminths in the Gut

Helminths living in the gut are not directly exposed to host tissues, making immune targeting difficult.

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Slow Helminth Destruction

The immune system often targets helminths for slow, long-term destruction rather than immediate killing.

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Antibodies against Helminths

The gut lining must become permeable to antibodies to reach helminths, often with increased mucus production.

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Host Response and Parasite Benefit

Excess mucus production due to immune response can benefit some helminths by serving as their food source.

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What is a complement?

A group of proteins circulating in the blood, which work together to activate the immune system. They are part of the innate immune response, which acts as the first line of defense against infections.

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What are cytokines?

Small signaling molecules produced by cells that help to regulate the immune response. They communicate between different immune cells, activating and directing them.

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What are chemokines?

A special kind of cytokine that attract cells towards each other.

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What is acquired immunity?

The immune response that is specific to a particular pathogen, meaning it targets specific molecules on the pathogen.

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Why is the second exposure to a pathogen faster?

The faster and stronger response that occurs when an animal is exposed to the same pathogen for a second or subsequent time. It relies on the memory of the previous encounter to eliminate the pathogen more efficiently.

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What is an antigen?

A foreign molecule that is recognized by the body as a threat and triggers the immune response.

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What are antigen-presenting cells?

Cells that present antigens to the immune system, triggering the adaptive immune response. They act like messengers to present the threat to the immune cells.

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Describe the cellular response.

The branch of the immune system mediated by T-lymphocytes, targeting infected cells and eliminating them directly.

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Describe the humoral response.

The branch of the immune response mediated by B-lymphocytes and plasma cells, producing antibodies to neutralize the pathogen.

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Anemia

A condition where a decrease in red blood cell production leads to lower levels of oxygen in the blood.

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Bone dystrophy

A condition where bone growth is impaired, often leading to weakened or misshapen bones.

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Rickets

A type of bone dystrophy where soft bones fail to harden properly, leading to deformities. It's commonly caused by vitamin D deficiency.

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Immunosuppression

A condition where the immune system fails to function properly, leading to increased susceptibility to infections.

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Polyparasitism

When multiple parasite species infect the same host.

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What does a lack of certain nutrients cause in an animal with a parasite?

The absence of enough of the vitamins and minerals the body needs, making it difficult for the animal to regain strength.

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How can parasites directly impact an animal's weight?

The parasite can absorb up to 20% of the animal's food, making it harder to gain weight.

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How can parasites indirectly impact an animal's weight?

The parasite can damage the lining of the animal's gut, making it difficult to absorb nutrients.

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How can blood loss affect an animal's weight?

The parasite can cause the animal to lose blood, which contains important nutrients.

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How does a parasite affect an animal's appetite?

The parasite can cause the animal to lose appetite because it feels sick.

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How can a parasite physically block digestion?

The parasite can block the digestive system, preventing food from being absorbed.

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How can a parasite cause a specific nutrient deficiency?

The parasite can cause an imbalance in the animal's nutrient levels, making it impossible to use the food it eats.

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What is cachexia?

A general state of fatigue and weakness often associated with weight loss due to parasitic infection.

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Factors increasing susceptibility to parasites

Factors that increase the susceptibility of animals to parasites, making them more vulnerable to infections.

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Factors increasing parasite prevalence

Factors that lead to increased parasite numbers in a population, leading to a higher risk of infection.

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Exposure to novel parasites

The process of being exposed to parasites that are new to the animal's evolutionary history, leaving them with no natural immunity.

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Restrictions on natural behavior

When animals are prevented from exhibiting natural behaviors that help them avoid or fight off parasites, making them more vulnerable.

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Selective breeding for production traits

The practice of selectively breeding animals for desired traits that may come at the cost of their natural resistance to infection.

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Inbreeding and parasite susceptibility

The phenomenon where animals with reduced genetic diversity due to breeding are more prone to certain parasites.

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How host density impacts parasite numbers

The increase in parasite numbers due to high host density, as more hosts mean a higher parasite output.

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Introducing infected animals

The introduction of infected animals into a parasite-free area, causing the spread of infection to new hosts.

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Study Notes

Host-Parasite Relationships

  • Host-parasite interactions are inseparable. The host tries to eliminate the parasite which can cause host death.
  • The host and parasite co-evolve through the actions of the parasite on the host, host defenses, and parasite defenses.
  • Factors affecting the parasite's effect on the host include the host's age, sex, diet, genetics, immunity, and the parasite's size, number, virulence, mobility, migration cycle, target organs, and feeding habits. These are all independent factors.

Parasite Specificity in Relation to Host Species

  • Parasite specificity is the natural adaptability of a species or groups of parasites to certain species or groups of hosts.
  • It depends on the host's compatibility to the parasite.
  • This adaptation develops over long periods of evolutionary change, crucial for the phenomenon of host specificity or parasite specificity.
  • Parasite specificity is defined in terms of establishment or failure to establish in a host. Factors like number, size, developmental stage, duration, and egg production influence adaptation to a host.
  • Some parasites are highly specific (e.g., Eimeria sp), while others have a broader host range (e.g., Trichinella spiralis).

Parasite Specificity in Relation to Sex

  • Some parasites affect only females, like the trematode Prosthogonimus species, found in female gallinaceous birds' oviducts.
  • Host sex significantly influences helminth burden, particularly in animals with seasonal estrus cycles.

Parasite Specificity in Relation to Breeds

  • Different breeds have varying susceptibility to parasites.
  • Indigenous breeds are often less susceptible to tick-borne diseases than cross or exotic breeds.
  • Some breeds like N'Dama and Mutura in Africa are more tolerant to trypanosomes.

Parasite Specificity in Relation to Location in Hosts

  • Parasites have specific predilection sites in hosts.
  • Examples include Eimeria species (intestinal parasite) and Dictyocaulus species (lung parasite in ruminants), and Paragonimus species (lungs in dogs).

Parasites in Relation to Locality

  • Parasite distribution is often restricted to specific ecological or geographical areas (e.g., African trypanosomes).

Effects of Parasites on Hosts

  • Parasites can utilize host non-nutritional materials (e.g., blood).
  • Parasites can cause obstruction of host organs.
  • Parasites cause tissue reactions like inflammation and thrombi formation.
  • Parasites can cause compression of nearby organs (e.g., cysts in the brain or liver).
  • Parasites can cause trauma during migration or attachment to tissues.

Host's Reactions to the Parasite

  • Host defenses are aimed at eliminating or reducing host parasitism.
  • These mechanisms involve innate (nonspecific) immune responses (e.g., chemical & cellular barriers) and acquired (specific) adaptive immune responses/antibodies.
  • Parasites can induce host behaviors that facilitate their transmission.
  • In some cases, there can be a 'discouraging' local or long-term immune response that may impact host well-being and reproductive ability.

Parasite's Defenses Against Host Immune Responses

  • Parasites employ mechanisms to evade host immune responses. This may include sequestration of parasites, masking surface antigens, or disturbing effector mechanisms.

Host-Parasite Balance

  • Host and parasite coevolution maintains an equilibrium which may involve compromises for both host and parasite populations.
  • This balance depends on the parasite's ability to survive and reproduce while minimizing damage to the host.
  • Disturbances to this equilibrium (e.g., altered host susceptibility, increased parasite numbers) can lead to disease.

Increased Host Susceptibility

  • Stressed, debilitated, immunocompromised hosts are vulnerable.
  • Exposure to novel parasites in new environments can increase susceptibility.
  • Selective breeding for specific traits may impair resistance to infection,
  • Inbred hosts may be more susceptible to some diseases.

Increased Parasite Numbers

  • Increased parasite numbers may occur due to high host density, introduction of infected animals into new areas, environmental factors (e.g., warmer temperatures), or parasite resistance to medication.

Major Syndromes Resulting from Pathological Processes

  • Parasite-related pathologies may result in various syndromes, including diarrhea, anemia, and weight loss with cachexia.

Diarrhea

  • Parasites cause diarrhea by damaging the intestinal lining, inducing secretory disorders, and disrupting gut permeability.

Anemia

  • Blood-sucking parasites cause anemia by blood loss or hemolysis (red blood cell destruction).

Weight loss and cachexia

  • Weight loss and cachexia result from various mechanisms, including nutrient depletion, decreased absorption, and effects from various pathological processes, including secondary diarrhea and anemia.

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