Podcast
Questions and Answers
Why are horses considered obligate nasal breathers, a crucial factor in equine anesthesia management?
Why are horses considered obligate nasal breathers, a crucial factor in equine anesthesia management?
- The unique anatomy of their larynx prevents oral airflow even under anesthesia.
- Their epiglottis always rests above the soft palate, directing airflow exclusively through the nasal passages. (correct)
- Behavioral conditioning from a young age makes them resistant to oral breathing.
- Evolutionary adaptation has reduced the capacity of their oral cavity for efficient respiration.
During equine anesthesia, 'blind intubation' is a common technique. What primary anatomical feature necessitates this approach?
During equine anesthesia, 'blind intubation' is a common technique. What primary anatomical feature necessitates this approach?
- The rostral location of the larynx in the equine oral cavity, making direct visualization challenging. (correct)
- The narrow oropharyngeal opening limiting instrument maneuverability.
- The elongated soft palate that obscures the laryngeal inlet from direct view.
- The presence of a prominent interdental space that obstructs direct laryngoscopy.
Myopathy is a significant peri-anesthetic risk in horses. Which of the following is the MOST critical factor in mitigating anesthetic myopathy?
Myopathy is a significant peri-anesthetic risk in horses. Which of the following is the MOST critical factor in mitigating anesthetic myopathy?
- Rapid anesthetic induction to minimize time spent in recumbency.
- Maintaining adequate mean arterial pressure (MAP) throughout anesthesia. (correct)
- Using exclusively inhalant anesthetics to ensure muscle relaxation.
- Administering muscle relaxants pre-emptively to prevent compression.
Neuropraxia in anesthetized horses is often associated with positioning and recumbency. What is the underlying pathophysiological mechanism of anesthetic neuropraxia?
Neuropraxia in anesthetized horses is often associated with positioning and recumbency. What is the underlying pathophysiological mechanism of anesthetic neuropraxia?
Horses are prone to hypoventilation under anesthesia. What is the MOST significant physiological consequence of hypoventilation in an anesthetized horse?
Horses are prone to hypoventilation under anesthesia. What is the MOST significant physiological consequence of hypoventilation in an anesthetized horse?
Ventilation-perfusion (V/Q) mismatch is a common concern in equine anesthesia. Which of the following best describes the primary cause of increased V/Q mismatch in recumbent anesthetized horses?
Ventilation-perfusion (V/Q) mismatch is a common concern in equine anesthesia. Which of the following best describes the primary cause of increased V/Q mismatch in recumbent anesthetized horses?
Consider the alveolar gas equation: $PAO_2 = FiO_2(P_{atm} - P_{H_2O}) - \frac{PaCO_2}{0.8}$. If, at sea level ($P_{atm} = 760 mmHg$), the $P_{H_2O}$ is 47 mmHg, $FiO_2$ is 0.21, and $PaCO_2$ is 60 mmHg in an anesthetized horse, what is the approximate $PAO_2$?
Consider the alveolar gas equation: $PAO_2 = FiO_2(P_{atm} - P_{H_2O}) - \frac{PaCO_2}{0.8}$. If, at sea level ($P_{atm} = 760 mmHg$), the $P_{H_2O}$ is 47 mmHg, $FiO_2$ is 0.21, and $PaCO_2$ is 60 mmHg in an anesthetized horse, what is the approximate $PAO_2$?
In equine anesthesia, a large Alveolar-arterial oxygen difference (A-a gradient) is often observed even with high $FiO_2$. What is the PRIMARY physiological mechanism contributing to this large A-a gradient?
In equine anesthesia, a large Alveolar-arterial oxygen difference (A-a gradient) is often observed even with high $FiO_2$. What is the PRIMARY physiological mechanism contributing to this large A-a gradient?
Despite achieving a high $PAO_2$ by increasing $FiO_2$ to 1.0 in a severely hypoxemic anesthetized horse, the $PaO_2$ remains unexpectedly low. Which of the following best explains why simply increasing $FiO_2$ might be INSUFFICIENT to correct severe hypoxemia in this scenario?
Despite achieving a high $PAO_2$ by increasing $FiO_2$ to 1.0 in a severely hypoxemic anesthetized horse, the $PaO_2$ remains unexpectedly low. Which of the following best explains why simply increasing $FiO_2$ might be INSUFFICIENT to correct severe hypoxemia in this scenario?
Positive End-Expiratory Pressure (PEEP) is sometimes used in equine anesthesia. What is the PRIMARY intended benefit of applying PEEP in anesthetized horses?
Positive End-Expiratory Pressure (PEEP) is sometimes used in equine anesthesia. What is the PRIMARY intended benefit of applying PEEP in anesthetized horses?
Hyperkalemic Periodic Paralysis (HYPP) is a breed-specific issue in horses, particularly in Quarter Horses and related breeds. What is the underlying genetic and physiological mechanism of HYPP?
Hyperkalemic Periodic Paralysis (HYPP) is a breed-specific issue in horses, particularly in Quarter Horses and related breeds. What is the underlying genetic and physiological mechanism of HYPP?
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disorder that can occur in anesthetized horses. What is the MOST critical initial step in managing a horse exhibiting signs of MH during anesthesia?
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disorder that can occur in anesthetized horses. What is the MOST critical initial step in managing a horse exhibiting signs of MH during anesthesia?
Acepromazine is a commonly used premedicant in equine anesthesia. What is the PRIMARY pharmacological action of acepromazine that makes it beneficial in this context?
Acepromazine is a commonly used premedicant in equine anesthesia. What is the PRIMARY pharmacological action of acepromazine that makes it beneficial in this context?
Alpha-2 adrenergic agonists, such as xylazine or detomidine, are frequently used in equine anesthesia protocols. What is the MAIN physiological effect of these drugs that contributes to their sedative and analgesic properties?
Alpha-2 adrenergic agonists, such as xylazine or detomidine, are frequently used in equine anesthesia protocols. What is the MAIN physiological effect of these drugs that contributes to their sedative and analgesic properties?
Ketamine is a dissociative anesthetic commonly used for induction in equine anesthesia. What is the primary mechanism of action of ketamine at the neuronal level?
Ketamine is a dissociative anesthetic commonly used for induction in equine anesthesia. What is the primary mechanism of action of ketamine at the neuronal level?
Propofol is an ultra-short-acting intravenous anesthetic agent sometimes used in equine anesthesia induction. What is the primary molecular target of propofol that mediates its anesthetic effects?
Propofol is an ultra-short-acting intravenous anesthetic agent sometimes used in equine anesthesia induction. What is the primary molecular target of propofol that mediates its anesthetic effects?
Inhalant anesthetics such as isoflurane and sevoflurane are widely used for maintenance of equine anesthesia. What is the generally accepted primary mechanism by which inhalant anesthetics induce general anesthesia?
Inhalant anesthetics such as isoflurane and sevoflurane are widely used for maintenance of equine anesthesia. What is the generally accepted primary mechanism by which inhalant anesthetics induce general anesthesia?
Large animal anesthetic circuits, typically 30-50 liters in volume, are used in equine anesthesia. What is the PRIMARY reason for needing such large circuit volumes?
Large animal anesthetic circuits, typically 30-50 liters in volume, are used in equine anesthesia. What is the PRIMARY reason for needing such large circuit volumes?
The 'time constant' of an anesthetic circuit is approximately 3-5 minutes for large animal circuits. What does 'time constant' refer to in the context of anesthetic circuits?
The 'time constant' of an anesthetic circuit is approximately 3-5 minutes for large animal circuits. What does 'time constant' refer to in the context of anesthetic circuits?
During equine anesthesia monitoring, 'nystagmus' is mentioned as a sign of being 'too light'. What type of nystagmus is typically indicative of inadequate anesthetic depth in horses?
During equine anesthesia monitoring, 'nystagmus' is mentioned as a sign of being 'too light'. What type of nystagmus is typically indicative of inadequate anesthetic depth in horses?
Ephedrine and dobutamine are mentioned for blood pressure management during equine anesthesia. What is the primary pharmacological difference in their mechanisms of action in raising blood pressure?
Ephedrine and dobutamine are mentioned for blood pressure management during equine anesthesia. What is the primary pharmacological difference in their mechanisms of action in raising blood pressure?
During equine anesthesia, if low compliance is detected in a mechanically ventilated horse, what is the MOST likely consequence on the ventilator settings and pressures?
During equine anesthesia, if low compliance is detected in a mechanically ventilated horse, what is the MOST likely consequence on the ventilator settings and pressures?
Equine anesthetic recovery is described as the 'most critical period'. What is the PRIMARY reason recovery poses a higher risk compared to other phases of equine anesthesia?
Equine anesthetic recovery is described as the 'most critical period'. What is the PRIMARY reason recovery poses a higher risk compared to other phases of equine anesthesia?
Mortality rates in equine anesthesia are significantly higher than in small animal anesthesia. Based on the provided data, what is the approximate mortality rate for horses under anesthesia?
Mortality rates in equine anesthesia are significantly higher than in small animal anesthesia. Based on the provided data, what is the approximate mortality rate for horses under anesthesia?
Catastrophic fractures are listed as a cause of mortality during equine anesthetic recovery. What is the MOST common mechanism leading to these fractures during recovery?
Catastrophic fractures are listed as a cause of mortality during equine anesthetic recovery. What is the MOST common mechanism leading to these fractures during recovery?
'Free recovery' is a philosophy for equine anesthetic recovery. What is a key characteristic of 'free recovery' in horses?
'Free recovery' is a philosophy for equine anesthetic recovery. What is a key characteristic of 'free recovery' in horses?
'Rope-pulley assisted recovery' is another approach in equine anesthesia. What is the PRIMARY rationale for using rope-pulley systems during equine recovery?
'Rope-pulley assisted recovery' is another approach in equine anesthesia. What is the PRIMARY rationale for using rope-pulley systems during equine recovery?
'Pool recovery' is mentioned as a recovery method for horses. What is the hypothesized primary advantage of using a pool for equine anesthetic recovery?
'Pool recovery' is mentioned as a recovery method for horses. What is the hypothesized primary advantage of using a pool for equine anesthetic recovery?
The importance of sedation in equine anesthetic recovery is emphasized. What is the MAIN goal of using sedation during the recovery phase?
The importance of sedation in equine anesthetic recovery is emphasized. What is the MAIN goal of using sedation during the recovery phase?
Which of the following is considered a 'breed-specific issue' that can significantly impact equine anesthesia management?
Which of the following is considered a 'breed-specific issue' that can significantly impact equine anesthesia management?
Draft breeds are mentioned in the context of breed issues in equine anesthesia. What is a common anesthetic consideration specific to draft horses?
Draft breeds are mentioned in the context of breed issues in equine anesthesia. What is a common anesthetic consideration specific to draft horses?
Upper airway obstruction is listed as a cause of mortality in equine anesthetic recovery. What is the MOST common cause of upper airway obstruction in recovering horses?
Upper airway obstruction is listed as a cause of mortality in equine anesthetic recovery. What is the MOST common cause of upper airway obstruction in recovering horses?
Compared to smaller animal anesthesia, equine anesthesia necessitates greater attention to 'logistics and personnel'. Which of the following BEST exemplifies a logistical challenge unique to equine, versus canine, anesthesia?
Compared to smaller animal anesthesia, equine anesthesia necessitates greater attention to 'logistics and personnel'. Which of the following BEST exemplifies a logistical challenge unique to equine, versus canine, anesthesia?
During equine anesthesia induction, 'chemical and/or physical restraint' is often required. In what scenario would physical restraint be considered MOST necessary, even when chemical restraint is planned?
During equine anesthesia induction, 'chemical and/or physical restraint' is often required. In what scenario would physical restraint be considered MOST necessary, even when chemical restraint is planned?
Flashcards
Equine Anesthesia Induction
Equine Anesthesia Induction
Horses require physical and chemical control during anesthesia induction.
Logistics in Equine Anesthesia
Logistics in Equine Anesthesia
Moving horses around, especially when anesthetized, can be tough and requires a helping hand.
Equine Intubation
Equine Intubation
Horses are obligate nasal breathers, making nasal intubation a common practice.
Myopathy in Equine Anesthesia
Myopathy in Equine Anesthesia
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Neuropathy in Equine Anesthesia
Neuropathy in Equine Anesthesia
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Hypoventilation in Equine Anesthesia
Hypoventilation in Equine Anesthesia
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Recumbency Effects on Oxygenation
Recumbency Effects on Oxygenation
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Reduced minute ventilation during anesthesia
Reduced minute ventilation during anesthesia
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PAO2 Equation
PAO2 Equation
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Breed-Specific Anesthesia Issues
Breed-Specific Anesthesia Issues
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Premedications for Equine Inhalant Anesthesia
Premedications for Equine Inhalant Anesthesia
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Induction for Equine Inhalant Anesthesia
Induction for Equine Inhalant Anesthesia
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Blind Intubation
Blind Intubation
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Monitoring parameters during Equine Anesthesia
Monitoring parameters during Equine Anesthesia
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Ventilation settings during Equine Anesthesia
Ventilation settings during Equine Anesthesia
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Blood Pressure Management in Equine Anesthesia
Blood Pressure Management in Equine Anesthesia
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Recovery in Equine Anesthesia
Recovery in Equine Anesthesia
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Techniques for Equine Recovery
Techniques for Equine Recovery
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Study Notes
- Cats are not small dogs, and horses are not large cats or dogs
Issues Specific to Horses
- Horses need specific considerations due to logistics, induction/intubation, myopathy, and neuropathy
- Other issues include ventilation, oxygenation mismatch, recovery, breed-specific issues, morbidity, mortality, and choice of inhalant vs injectable anesthesia
Induction
- Inducing horse anesthesia requires physical control and either chemical or physical restraint
Logistics
- Moving anesthetized horses can be challenging because of size and weight
- Enough personnel must be available to assist
Intubation
- Intubation techniques include blind, nasal, or oral intubation
- Horses are obligate nasal breathers
- They are prone to laryngospasm
Myopathy
- Myopathy, or muscle damage, results from compression and poor blood flow during anesthesia
- Inhalants are less of an issue than older injectable anesthetics
- Proper padding and positioning are important to consider
- Be aware that the "up" leg is just as likely to experience myopathy as the "down" leg in lateral recumbency
- Anesthetic considerations for myopathy include inhalant, minimum mean arterial pressure, vasopressors, and duration of anesthesia
- Mean Arterial Pressure = Area under the curve/ cardiac cycle time
Neuropathy
- Neuropraxia results from poor positioning, time down, or recovery issues
- Neuropraxia can usually be resolved with time
Hypoventilation
- Horses tend to hypoventilate under anesthesia
- Isoflurane and sevoflurane can cause unpredictable respiratory patterns
- Injectable anesthetics may produce modest hypoventilation
Oxygenation
- Oxygenation is a significant concern in equine anesthesia
- Understanding the relationship between FiO2, PAO2, PaO2, and SpO2 is crucial
Ventilation-Perfusion Mismatch
- Ventilation and perfusion mismatch is a contributing factor to oxygenation issues
- Shunting and positioning also affect oxygenation
- Anatomic reasons contribute to oxygenation problems in horses
Thoracic cavity in horses
- Horses have an expanded thoracic cavity meaning increased capacity for gas exchange
- The diaphragmatic angle and large abdominal viscera affect ventilation
- Recumbency is unnatural for horses
- Severe compression and progressive absorption atelectasis worsens the alveolar ventilation
- Major changes that occurs post-induction and due to recumbency are increased shunt fraction, widening of V/Q ratios, and reduced minute ventilation
PAO2
- PAO2 = FiO2(Patm-PH2O) - PaCO2/0.8
- PAO2= 0.21(733-47) – 40/0.8
- PAO2= 144 mmHg – 50 mmHg = 94 mmHg
- PAO2= 94 mmHg, PaO2 = 84mmHg: A-a difference is 10
- If FiO2 is 1.0: 1.0(733 – 47) – 50/0.8, Then PAO2 = 686 - 63 = 623 mmHg, PaO2 = 84 mmHg: A-a difference is HUGE
Hypoxemia
- Strategies to manage hypoxemia that is often unsuccessful is increasing FiO2, IV or inhaled beta-2 agonist, PEEP and recruitment maneuvers
- Severe hypoxemia is not associated with increased morbidity or mortality
- In one example, FiO2 was 1.0, A-a was 418 mmHg
- In another example, FiO2 was 1.0, A-a was 574 mmHg
Specific Horse Breeds
- Specific horse breeds can be pre-disposed to hyperkalemic periodic paralysis, malignant hyperthermia, and drafts
Inhalant Anesthesia
- Premedications for inhalant anesthesia include acepromazine, alpha-2 agonists, and opioids
- Induction is often with ketamine, propofol, midazolam, or thiopental
Intubation
- Blind intubation is a common method
Monitoring Anesthesia
- Monitoring should include blood pressure, ECG, end-tidal CO2, inhalant concentration, and SpO2
- Eye signs, like unpredictable palpebral reflex or nystagmus, are useful indicators for anesthetic depth: nystagmus is a sign of too light meaning decreased anesthetic depth so more is needed
Management During Anesthesia
- Management during anesthesia may include, ventilation with 10 ml/kg of tidal volume as a starting point, be mindful that low compliance = higher PIP, as well as considering giving blocks for localized analgesia
- Blood pressure support may require ephedrine, dobutamine, or other vasopressors
Recovery
- Recovery is the most critical period in equine anesthesia
- It's not over until the horse stands
- Mortality rates in veterinary anesthesia: Dogs: 0.01-0.05%, Cats: 0.11%, Horses: 0.9-1.0%
- Causes of mortality include catastrophic fractures, neuropathy/myopathy, and upper airway obstruction
Philosophies on Equine Recovery
- Philosophies on equine recovery include free, rope-pulley assisted, or pool recovery, all with/without a mattress
- Driving factors for optimal recovery include patient temperament, procedure performed, and institutional policies
- Sedation is also important for a safe recovery
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