4 Horse Anesthesia: Issues and Logistics

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Questions and Answers

Why are horses considered obligate nasal breathers, a crucial factor in equine anesthesia management?

  • The unique anatomy of their larynx prevents oral airflow even under anesthesia.
  • Their epiglottis always rests above the soft palate, directing airflow exclusively through the nasal passages. (correct)
  • Behavioral conditioning from a young age makes them resistant to oral breathing.
  • Evolutionary adaptation has reduced the capacity of their oral cavity for efficient respiration.

During equine anesthesia, 'blind intubation' is a common technique. What primary anatomical feature necessitates this approach?

  • The rostral location of the larynx in the equine oral cavity, making direct visualization challenging. (correct)
  • The narrow oropharyngeal opening limiting instrument maneuverability.
  • The elongated soft palate that obscures the laryngeal inlet from direct view.
  • The presence of a prominent interdental space that obstructs direct laryngoscopy.

Myopathy is a significant peri-anesthetic risk in horses. Which of the following is the MOST critical factor in mitigating anesthetic myopathy?

  • Rapid anesthetic induction to minimize time spent in recumbency.
  • Maintaining adequate mean arterial pressure (MAP) throughout anesthesia. (correct)
  • Using exclusively inhalant anesthetics to ensure muscle relaxation.
  • Administering muscle relaxants pre-emptively to prevent compression.

Neuropraxia in anesthetized horses is often associated with positioning and recumbency. What is the underlying pathophysiological mechanism of anesthetic neuropraxia?

<p>Ischemic nerve damage due to prolonged compression and reduced blood flow. (C)</p> Signup and view all the answers

Horses are prone to hypoventilation under anesthesia. What is the MOST significant physiological consequence of hypoventilation in an anesthetized horse?

<p>Development of hypercapnia and respiratory acidosis. (D)</p> Signup and view all the answers

Ventilation-perfusion (V/Q) mismatch is a common concern in equine anesthesia. Which of the following best describes the primary cause of increased V/Q mismatch in recumbent anesthetized horses?

<p>Gravitational effects causing atelectasis in dependent lung regions and over-inflation of non-dependent regions. (D)</p> Signup and view all the answers

Consider the alveolar gas equation: $PAO_2 = FiO_2(P_{atm} - P_{H_2O}) - \frac{PaCO_2}{0.8}$. If, at sea level ($P_{atm} = 760 mmHg$), the $P_{H_2O}$ is 47 mmHg, $FiO_2$ is 0.21, and $PaCO_2$ is 60 mmHg in an anesthetized horse, what is the approximate $PAO_2$?

<p>85 mmHg (D)</p> Signup and view all the answers

In equine anesthesia, a large Alveolar-arterial oxygen difference (A-a gradient) is often observed even with high $FiO_2$. What is the PRIMARY physiological mechanism contributing to this large A-a gradient?

<p>Increased intrapulmonary shunting due to atelectasis. (A)</p> Signup and view all the answers

Despite achieving a high $PAO_2$ by increasing $FiO_2$ to 1.0 in a severely hypoxemic anesthetized horse, the $PaO_2$ remains unexpectedly low. Which of the following best explains why simply increasing $FiO_2$ might be INSUFFICIENT to correct severe hypoxemia in this scenario?

<p>The presence of a significant fixed intrapulmonary shunt limits the effectiveness of increased $FiO_2$. (A)</p> Signup and view all the answers

Positive End-Expiratory Pressure (PEEP) is sometimes used in equine anesthesia. What is the PRIMARY intended benefit of applying PEEP in anesthetized horses?

<p>To reduce atelectasis and improve alveolar recruitment. (A)</p> Signup and view all the answers

Hyperkalemic Periodic Paralysis (HYPP) is a breed-specific issue in horses, particularly in Quarter Horses and related breeds. What is the underlying genetic and physiological mechanism of HYPP?

<p>A mutation in the skeletal muscle sodium channel gene leading to abnormal sodium influx and membrane depolarization. (B)</p> Signup and view all the answers

Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disorder that can occur in anesthetized horses. What is the MOST critical initial step in managing a horse exhibiting signs of MH during anesthesia?

<p>Immediately discontinue triggering anesthetic agents and administer 100% oxygen. (D)</p> Signup and view all the answers

Acepromazine is a commonly used premedicant in equine anesthesia. What is the PRIMARY pharmacological action of acepromazine that makes it beneficial in this context?

<p>Alpha-1 adrenergic receptor antagonism, leading to vasodilation and sedation. (A)</p> Signup and view all the answers

Alpha-2 adrenergic agonists, such as xylazine or detomidine, are frequently used in equine anesthesia protocols. What is the MAIN physiological effect of these drugs that contributes to their sedative and analgesic properties?

<p>Activation of presynaptic alpha-2 receptors in the central nervous system, reducing norepinephrine release. (A)</p> Signup and view all the answers

Ketamine is a dissociative anesthetic commonly used for induction in equine anesthesia. What is the primary mechanism of action of ketamine at the neuronal level?

<p>Non-competitive antagonism of NMDA (N-methyl-D-aspartate) receptors. (D)</p> Signup and view all the answers

Propofol is an ultra-short-acting intravenous anesthetic agent sometimes used in equine anesthesia induction. What is the primary molecular target of propofol that mediates its anesthetic effects?

<p>GABA-A receptors, enhancing chloride ion conductance and neuronal inhibition. (B)</p> Signup and view all the answers

Inhalant anesthetics such as isoflurane and sevoflurane are widely used for maintenance of equine anesthesia. What is the generally accepted primary mechanism by which inhalant anesthetics induce general anesthesia?

<p>Multifaceted actions on various neuronal ion channels, primarily enhancing inhibitory and inhibiting excitatory channels. (C)</p> Signup and view all the answers

Large animal anesthetic circuits, typically 30-50 liters in volume, are used in equine anesthesia. What is the PRIMARY reason for needing such large circuit volumes?

<p>To accommodate the large tidal volume and minute ventilation of adult horses. (A)</p> Signup and view all the answers

The 'time constant' of an anesthetic circuit is approximately 3-5 minutes for large animal circuits. What does 'time constant' refer to in the context of anesthetic circuits?

<p>The time it takes to achieve 63% of a change in anesthetic gas concentration within the circuit. (C)</p> Signup and view all the answers

During equine anesthesia monitoring, 'nystagmus' is mentioned as a sign of being 'too light'. What type of nystagmus is typically indicative of inadequate anesthetic depth in horses?

<p>Rapid, horizontal nystagmus. (D)</p> Signup and view all the answers

Ephedrine and dobutamine are mentioned for blood pressure management during equine anesthesia. What is the primary pharmacological difference in their mechanisms of action in raising blood pressure?

<p>Ephedrine is a mixed-acting adrenergic agonist, while dobutamine is primarily a beta-1 adrenergic agonist. (B)</p> Signup and view all the answers

During equine anesthesia, if low compliance is detected in a mechanically ventilated horse, what is the MOST likely consequence on the ventilator settings and pressures?

<p>Higher Peak Inspiratory Pressure (PIP) will be required to deliver the set tidal volume. (A)</p> Signup and view all the answers

Equine anesthetic recovery is described as the 'most critical period'. What is the PRIMARY reason recovery poses a higher risk compared to other phases of equine anesthesia?

<p>Unpredictability of emergence delirium and potential for self-injury in a large, recovering animal. (B)</p> Signup and view all the answers

Mortality rates in equine anesthesia are significantly higher than in small animal anesthesia. Based on the provided data, what is the approximate mortality rate for horses under anesthesia?

<p>0.9-1.0% (A)</p> Signup and view all the answers

Catastrophic fractures are listed as a cause of mortality during equine anesthetic recovery. What is the MOST common mechanism leading to these fractures during recovery?

<p>Trauma from uncontrolled struggling and uncoordinated attempts to stand during emergence delirium. (C)</p> Signup and view all the answers

'Free recovery' is a philosophy for equine anesthetic recovery. What is a key characteristic of 'free recovery' in horses?

<p>Allowing the horse to recover in a padded, undisturbed environment without physical restraint. (D)</p> Signup and view all the answers

'Rope-pulley assisted recovery' is another approach in equine anesthesia. What is the PRIMARY rationale for using rope-pulley systems during equine recovery?

<p>To provide controlled assistance in standing, reducing the risk of falls and injuries during recovery. (D)</p> Signup and view all the answers

'Pool recovery' is mentioned as a recovery method for horses. What is the hypothesized primary advantage of using a pool for equine anesthetic recovery?

<p>Buoyancy of water reduces weight-bearing stress and risk of orthopedic injury during recovery. (B)</p> Signup and view all the answers

The importance of sedation in equine anesthetic recovery is emphasized. What is the MAIN goal of using sedation during the recovery phase?

<p>To promote a smoother, quieter emergence and reduce the incidence of emergence delirium. (B)</p> Signup and view all the answers

Which of the following is considered a 'breed-specific issue' that can significantly impact equine anesthesia management?

<p>Hyperkalemic Periodic Paralysis (HYPP). (D)</p> Signup and view all the answers

Draft breeds are mentioned in the context of breed issues in equine anesthesia. What is a common anesthetic consideration specific to draft horses?

<p>Challenges related to their large size and logistics. (D)</p> Signup and view all the answers

Upper airway obstruction is listed as a cause of mortality in equine anesthetic recovery. What is the MOST common cause of upper airway obstruction in recovering horses?

<p>Pharyngeal or laryngeal collapse due to residual muscle relaxation and loss of airway tone. (D)</p> Signup and view all the answers

Compared to smaller animal anesthesia, equine anesthesia necessitates greater attention to 'logistics and personnel'. Which of the following BEST exemplifies a logistical challenge unique to equine, versus canine, anesthesia?

<p>The physical strength and number of personnel required to move and position a large animal. (A)</p> Signup and view all the answers

During equine anesthesia induction, 'chemical and/or physical restraint' is often required. In what scenario would physical restraint be considered MOST necessary, even when chemical restraint is planned?

<p>For fractious or uncooperative horses to ensure safety during initial drug administration. (C)</p> Signup and view all the answers

Flashcards

Equine Anesthesia Induction

Horses require physical and chemical control during anesthesia induction.

Logistics in Equine Anesthesia

Moving horses around, especially when anesthetized, can be tough and requires a helping hand.

Equine Intubation

Horses are obligate nasal breathers, making nasal intubation a common practice.

Myopathy in Equine Anesthesia

Damage to muscle due to compression or poor blood flow. Proper padding and positioning are important.

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Neuropathy in Equine Anesthesia

Neuropraxia is nerve dysfunction due to poor positioning, time down during anesthesia, or recovery issues. It typically resolves with time.

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Hypoventilation in Equine Anesthesia

Horses tend to hypoventilate under anesthesia. Isoflurane and sevoflurane can cause unpredictable respiratory patterns. Injectables cause modest hypoventilation.

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Recumbency Effects on Oxygenation

Anesthetic recumbency can compromise oxygenation due to severe compression atelectasis and progressive absorption. Major changes post-induction include:

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Reduced minute ventilation during anesthesia

Horses can be prone to oxygenation issues due to anatomic (thoracic cavity, diaphragmatic angle, large abdominal viscera) and recumbency reasons.

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PAO2 Equation

Post induction, recumbency in horses promotes increased shunt fractions and A PaO2 = FiO2(Patm-PH2O) - PaCO2/0.8.

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Breed-Specific Anesthesia Issues

Hyperkalemic periodic paralysis and malignant hyperthermia are breed issues in equine anesthesia.

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Premedications for Equine Inhalant Anesthesia

Acepromazine, alpha-2 agonists, and opioids are common premedications for inhalant anesthesia in horses.

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Induction for Equine Inhalant Anesthesia

Ketamine, propofol and midazolam are used for the induction of inhalant anesthesia.

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Blind Intubation

Blind intubation is a common equine intubation technique.

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Monitoring parameters during Equine Anesthesia

BP, ECG, et CO2, et inhalant, SpO2 are the usual monitoring parameters.

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Ventilation settings during Equine Anesthesia

Tidal volume 10 ml/kg as a starting point and low compliance results in higher PIP during ventilation.

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Blood Pressure Management in Equine Anesthesia

Ephedrine and dobutamine are medications to manage blood pressure.

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Recovery in Equine Anesthesia

The recovery period is the most critical time in equine anesthesia. Anesthesia time is not over until the horse stands.

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Techniques for Equine Recovery

Free-recovery, rope-pulley assisted recovery and pool recovery are some techniques.

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Study Notes

  • Cats are not small dogs, and horses are not large cats or dogs

Issues Specific to Horses

  • Horses need specific considerations due to logistics, induction/intubation, myopathy, and neuropathy
  • Other issues include ventilation, oxygenation mismatch, recovery, breed-specific issues, morbidity, mortality, and choice of inhalant vs injectable anesthesia

Induction

  • Inducing horse anesthesia requires physical control and either chemical or physical restraint

Logistics

  • Moving anesthetized horses can be challenging because of size and weight
  • Enough personnel must be available to assist

Intubation

  • Intubation techniques include blind, nasal, or oral intubation
  • Horses are obligate nasal breathers
  • They are prone to laryngospasm

Myopathy

  • Myopathy, or muscle damage, results from compression and poor blood flow during anesthesia
  • Inhalants are less of an issue than older injectable anesthetics
  • Proper padding and positioning are important to consider
  • Be aware that the "up" leg is just as likely to experience myopathy as the "down" leg in lateral recumbency
  • Anesthetic considerations for myopathy include inhalant, minimum mean arterial pressure, vasopressors, and duration of anesthesia
  • Mean Arterial Pressure = Area under the curve/ cardiac cycle time

Neuropathy

  • Neuropraxia results from poor positioning, time down, or recovery issues
  • Neuropraxia can usually be resolved with time

Hypoventilation

  • Horses tend to hypoventilate under anesthesia
  • Isoflurane and sevoflurane can cause unpredictable respiratory patterns
  • Injectable anesthetics may produce modest hypoventilation

Oxygenation

  • Oxygenation is a significant concern in equine anesthesia
  • Understanding the relationship between FiO2, PAO2, PaO2, and SpO2 is crucial

Ventilation-Perfusion Mismatch

  • Ventilation and perfusion mismatch is a contributing factor to oxygenation issues
  • Shunting and positioning also affect oxygenation
  • Anatomic reasons contribute to oxygenation problems in horses

Thoracic cavity in horses

  • Horses have an expanded thoracic cavity meaning increased capacity for gas exchange
  • The diaphragmatic angle and large abdominal viscera affect ventilation
  • Recumbency is unnatural for horses
  • Severe compression and progressive absorption atelectasis worsens the alveolar ventilation
  • Major changes that occurs post-induction and due to recumbency are increased shunt fraction, widening of V/Q ratios, and reduced minute ventilation

PAO2

  • PAO2 = FiO2(Patm-PH2O) - PaCO2/0.8
  • PAO2= 0.21(733-47) – 40/0.8
  • PAO2= 144 mmHg – 50 mmHg = 94 mmHg
  • PAO2= 94 mmHg, PaO2 = 84mmHg: A-a difference is 10
  • If FiO2 is 1.0: 1.0(733 – 47) – 50/0.8, Then PAO2 = 686 - 63 = 623 mmHg, PaO2 = 84 mmHg: A-a difference is HUGE

Hypoxemia

  • Strategies to manage hypoxemia that is often unsuccessful is increasing FiO2, IV or inhaled beta-2 agonist, PEEP and recruitment maneuvers
  • Severe hypoxemia is not associated with increased morbidity or mortality
  • In one example, FiO2 was 1.0, A-a was 418 mmHg
  • In another example, FiO2 was 1.0, A-a was 574 mmHg

Specific Horse Breeds

  • Specific horse breeds can be pre-disposed to hyperkalemic periodic paralysis, malignant hyperthermia, and drafts

Inhalant Anesthesia

  • Premedications for inhalant anesthesia include acepromazine, alpha-2 agonists, and opioids
  • Induction is often with ketamine, propofol, midazolam, or thiopental

Intubation

  • Blind intubation is a common method

Monitoring Anesthesia

  • Monitoring should include blood pressure, ECG, end-tidal CO2, inhalant concentration, and SpO2
  • Eye signs, like unpredictable palpebral reflex or nystagmus, are useful indicators for anesthetic depth: nystagmus is a sign of too light meaning decreased anesthetic depth so more is needed

Management During Anesthesia

  • Management during anesthesia may include, ventilation with 10 ml/kg of tidal volume as a starting point, be mindful that low compliance = higher PIP, as well as considering giving blocks for localized analgesia
  • Blood pressure support may require ephedrine, dobutamine, or other vasopressors

Recovery

  • Recovery is the most critical period in equine anesthesia
  • It's not over until the horse stands
  • Mortality rates in veterinary anesthesia: Dogs: 0.01-0.05%, Cats: 0.11%, Horses: 0.9-1.0%
  • Causes of mortality include catastrophic fractures, neuropathy/myopathy, and upper airway obstruction

Philosophies on Equine Recovery

  • Philosophies on equine recovery include free, rope-pulley assisted, or pool recovery, all with/without a mattress
  • Driving factors for optimal recovery include patient temperament, procedure performed, and institutional policies
  • Sedation is also important for a safe recovery

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