Podcast
Questions and Answers
What is the primary concern when considering hormone dosing?
What is the primary concern when considering hormone dosing?
- It is easy to determine the correct dosage alone.
- It can be done safely without supervision.
- Working with a knowledgeable health professional is essential. (correct)
- Hormones should be dosed according to personal experience.
Which hormone is considered first in the triad hierarchy?
Which hormone is considered first in the triad hierarchy?
- Insulin
- Progesterone
- Adrenals (correct)
- Thyroid
What principle applies to the use of progesterone regarding its dosage?
What principle applies to the use of progesterone regarding its dosage?
- The 'Goldilocks principle' suggests finding a balanced dose. (correct)
- Excessive amounts always lead to better results.
- Dosing can be based solely on individual symptoms.
- Hormones do not require careful measurement.
What happens if the adrenals are not supported in the hormone triad?
What happens if the adrenals are not supported in the hormone triad?
What is the safety status of progesterone?
What is the safety status of progesterone?
Which hormones are most closely interrelated in the triad?
Which hormones are most closely interrelated in the triad?
What is a common symptom of both too little and too much progesterone?
What is a common symptom of both too little and too much progesterone?
In hormone management, which comes after treating adrenals?
In hormone management, which comes after treating adrenals?
What percentage of cholesterol levels comes from dietary sources?
What percentage of cholesterol levels comes from dietary sources?
Which hormone is primarily derived from cholesterol in women?
Which hormone is primarily derived from cholesterol in women?
What is one role of progesterone during pregnancy?
What is one role of progesterone during pregnancy?
Which statement best describes the effect of progesterone on the brain?
Which statement best describes the effect of progesterone on the brain?
What is the corpus luteum primarily associated with?
What is the corpus luteum primarily associated with?
What health systems does progesterone contribute to?
What health systems does progesterone contribute to?
During the menstrual cycle, what does progesterone help prepare?
During the menstrual cycle, what does progesterone help prepare?
Which hormone is NOT derived directly from cholesterol?
Which hormone is NOT derived directly from cholesterol?
Which structure secretes progesterone after ovulation?
Which structure secretes progesterone after ovulation?
What is the relationship between testosterone and estrogen?
What is the relationship between testosterone and estrogen?
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Study Notes
Overview of Progesterone
- Progesterone is a steroid hormone primarily secreted by the ovaries, adrenal cortex, and placenta.
- It is vital for the menstrual cycle, pregnancy, cardiovascular health, central nervous system function, and immune system health.
Hormonal Hierarchy
- Hormone treatment priority: adrenals first, then thyroid, followed closely by progesterone.
- Adrenals, thyroid, and progesterone form an interrelated triad affecting each other’s functionality.
Importance of Cholesterol
- Cholesterol is the precursor for all sex hormones, with about 20% derived from dietary sources.
- High cholesterol levels can stem from a poor diet rich in refined carbohydrates.
- Healthy cholesterol is essential for hormone production.
Functions of Progesterone
- Protects and prepares the endometrium (the uterine lining) for potential implantation of fertilized eggs.
- Plays a protective role during pregnancy, supporting gestation.
- Exhibits neuroprotective properties, providing calming effects on the brain and reducing anxiety.
- Influences sleep induction and overall emotional stability.
Biological Mechanism
- Progesterone production begins with cholesterol, which then converts into several hormones, including pregnenolone, cortisol, DHEA, testosterone, and estradiol.
- The corpus luteum, formed after ovulation, secretes progesterone.
Progesterone as a Neurosteroid
- Progesterone is classified as a neurosteroid, with receptors found in every type of neural cell in the brain.
- Modulates amygdala activity, impacting emotional responses, particularly in conditions like PTSD.
Considerations for Use
- Considered very safe and available over the counter in many states, with virtually no contraindications.
- Careful dosage management is crucial, as symptoms of too little or too much progesterone can be similar.
- It is recommended to consult with knowledgeable health professionals for hormone dosing and management.
Additional Reference
- The book "Natural Progesterone" by Dr. John Lee is a notable resource on the topic.
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