Hormone-Sensitive Tumors and Their Treatment
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Questions and Answers

What happens to hormone-responsive tumors when treated with a specific hormone?

  • They remain unchanged
  • They grow rapidly
  • They become hormone-dependent
  • They regress (correct)

What is the effect of removing a hormonal stimulus on hormone-dependent tumors?

  • They regress (correct)
  • They continue to grow
  • They remain stable
  • They become hormone-responsive

What is one way to remove hormonal stimuli in advanced prostate cancer?

  • Radiotherapy
  • Drugs
  • Hormone therapy
  • Surgery (correct)

Which drug is used to remove hormonal stimuli in breast cancer?

<p>Tamoxifen (A)</p> Signup and view all the answers

What is the difference between hormone-responsive and hormone-dependent tumors?

<p>One responds to hormone treatment, the other relies on hormone stimuli (B)</p> Signup and view all the answers

What is the effect of tamoxifen on estrogen receptors in breast tissue?

<p>Down-regulation (A)</p> Signup and view all the answers

In which tissues does tamoxifen act as an estrogen agonist?

<p>Bone and endometrium (A)</p> Signup and view all the answers

What is the primary mechanism of action of tamoxifen in breast cancer?

<p>Inhibiting estrogen-induced growth (C)</p> Signup and view all the answers

What is the primary route of excretion for tamoxifen and its metabolites?

<p>Feces (A)</p> Signup and view all the answers

What is a common adverse effect of tamoxifen due to its estrogenic activity?

<p>Hot flashes (B)</p> Signup and view all the answers

What enzymes is tamoxifen known to inhibit?

<p>CYP3A4 and P-glycoprotein (A)</p> Signup and view all the answers

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