11 Questions
What happens to hormone-responsive tumors when treated with a specific hormone?
They regress
What is the effect of removing a hormonal stimulus on hormone-dependent tumors?
They regress
What is one way to remove hormonal stimuli in advanced prostate cancer?
Surgery
Which drug is used to remove hormonal stimuli in breast cancer?
Tamoxifen
What is the difference between hormone-responsive and hormone-dependent tumors?
One responds to hormone treatment, the other relies on hormone stimuli
What is the effect of tamoxifen on estrogen receptors in breast tissue?
Down-regulation
In which tissues does tamoxifen act as an estrogen agonist?
Bone and endometrium
What is the primary mechanism of action of tamoxifen in breast cancer?
Inhibiting estrogen-induced growth
What is the primary route of excretion for tamoxifen and its metabolites?
Feces
What is a common adverse effect of tamoxifen due to its estrogenic activity?
Hot flashes
What enzymes is tamoxifen known to inhibit?
CYP3A4 and P-glycoprotein
Learn about the different types of hormone-sensitive tumors, including hormone responsive and hormone dependent tumors, and how they can be treated through surgery or drugs. Understand the role of hormonal stimuli in tumor growth and regression.
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