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Questions and Answers
What is a determinant of the concentration of a hormone at the target cell?
What is a determinant of the concentration of a hormone at the target cell?
- The metabolism (activation or inactivation) of the hormone in the target cell
- The postreceptor desensitization of the cell
- The proximity of the target cell to the hormone source (dilution effect) (correct)
- The rate of clearance from plasma by other tissues or by digestion, metabolism, or excretion
What can determine the target cell response to a hormone?
What can determine the target cell response to a hormone?
- The conversion of inactive or suboptimally active forms of the hormone into the fully active form
- The dissociation constants of the hormone with specific plasma transport proteins (if any)
- The rate of synthesis and secretion of the hormones
- The number, relative activity, and state of occupancy of the specific receptors on the plasma membrane or in the cytoplasm or nucleus (correct)
What can lead to up- or down-regulation of the receptor consequent to the interaction with the ligand?
What can lead to up- or down-regulation of the receptor consequent to the interaction with the ligand?
- The rate of clearance from plasma by other tissues or by digestion, metabolism, or excretion
- The presence of other factors within the cell that are necessary for the hormone response
- The metabolism (activation or inactivation) of the hormone in the target cell
- The conversion of inactive or suboptimally active forms of the hormone into the fully active form (correct)
What can affect the concentration of a hormone at the target cell due to the dilution effect?
What can affect the concentration of a hormone at the target cell due to the dilution effect?
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What can determine the metabolism (activation or inactivation) of the hormone in the target cell?
What can determine the metabolism (activation or inactivation) of the hormone in the target cell?
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