Hormonal Effects and Disorders of Sex Development
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Questions and Answers

What is the organizational/activational hypothesis primarily used to explain?

  • The differences in brain structure between males and females
  • The role of genetics in determining sexual orientation
  • The impact of hormones on behavior during development and adulthood (correct)
  • The evolutionary origins of sex differences
  • Which statement accurately describes the difference between organizational and activational effects of hormones?

  • Organizational effects occur during adulthood, while activational effects occur during development.
  • Organizational effects influence brain structure, while activational effects directly trigger behaviors. (correct)
  • Organizational effects are primarily influenced by environmental factors, while activational effects are primarily genetic.
  • Organizational effects are temporary and reversible, while activational effects are permanent.
  • Which example BEST demonstrates an activational effect of hormones?

  • The development of external genitalia based on the presence or absence of the Y chromosome
  • Exposure to testosterone in utero leading to male-typical brain development
  • A surge in estrogen causing ovulation in females (correct)
  • Differences in brain regions associated with spatial reasoning between males and females
  • Which disorder of sex development (DSD) is mentioned in the text?

    <p>Androgen Insensitivity Syndrome (C)</p> Signup and view all the answers

    What is the primary advantage of studying DSDs in research?

    <p>To gain insights into the interplay of genetics, hormones, and behavior in sexual development (A)</p> Signup and view all the answers

    What is the key difference between chromosomal sex and sexual differentiation?

    <p>Chromosomal sex is a fixed genetic trait, while sexual differentiation is a dynamic process. (D)</p> Signup and view all the answers

    What does the term "homogametic sex" refer to?

    <p>Individuals with two X chromosomes (A)</p> Signup and view all the answers

    Why are animal models used in research on DSDs?

    <p>To ethically study human DSDs without harming human subjects (A)</p> Signup and view all the answers

    What does the Organizational/Activational Hypothesis primarily explain?

    <p>The influence of hormonal exposure on sexually dimorphic behaviors. (D)</p> Signup and view all the answers

    When do organizational effects occur according to the Organizational/Activational Hypothesis?

    <p>Prenatally or perinatally. (A)</p> Signup and view all the answers

    Which hormone is most significantly associated with organizational effects in early development?

    <p>Testosterone. (C)</p> Signup and view all the answers

    How do activational effects differ from organizational effects?

    <p>Activational effects temporarily influence behavior, while organizational effects cause permanent changes. (B)</p> Signup and view all the answers

    What was one significant result observed in 'hermaphrodite' female guinea pigs in Young's Experiment?

    <p>They had similar behaviors to control males. (B)</p> Signup and view all the answers

    What procedure was performed on all animals in Phase 2 of Young's Experiment?

    <p>Gonadectomy to eliminate natural hormone influences. (A)</p> Signup and view all the answers

    What is a primary characteristic of behavioral changes activated during adulthood?

    <p>They depend on the earlier organizational effects of hormones. (B)</p> Signup and view all the answers

    What were the control groups established for in Young's Experiment?

    <p>To compare the effects of high and low doses of testosterone. (C)</p> Signup and view all the answers

    What does the organizational/activational hypothesis propose regarding prenatal hormones?

    <p>They organize the nervous system and activate behaviors later. (D)</p> Signup and view all the answers

    What effect does testosterone have during the sensitive window of perinatal development?

    <p>It permanently masculinizes both genitalia and the brain. (B)</p> Signup and view all the answers

    What behavior is exhibited by unmodified females exposed to early hormones?

    <p>They exhibit male-typical behaviors. (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the hormonal sex of an individual?

    <p>It is determined by the ratio of circulating steroid hormones. (B)</p> Signup and view all the answers

    What was the purpose of removing gonads before day 10 in the hormone treatments?

    <p>To prevent natural hormone exposure. (C)</p> Signup and view all the answers

    What is required for females injected with testosterone before day 10 to show male-typical behavior in adulthood?

    <p>Additional testosterone exposure in adulthood. (D)</p> Signup and view all the answers

    In mammals, which of the following statements about gametic sex is TRUE?

    <p>Females produce larger, more resource-rich gametes than males. (D)</p> Signup and view all the answers

    What is a critical aspect of the hormonal effects during development according to the discussed experiment?

    <p>There is a sensitive window where hormones shape brain development. (B)</p> Signup and view all the answers

    What is the primary function of the SRY gene in mammalian sex determination?

    <p>It initiates the development of testes. (B)</p> Signup and view all the answers

    What does lordosis behavior test for in hormone treatment experiments?

    <p>Female-typical sexual behavior. (D)</p> Signup and view all the answers

    Which of the following is an example of how circulating testosterone levels can influence physical differences between males and females?

    <p>Males typically have a lower body fat percentage than females. (A), Males typically have a higher bone density than females. (C)</p> Signup and view all the answers

    Androgen Insensitivity Syndrome (AIS) is an example of how:

    <p>Hormonal sex can be different from gonadal sex. (A)</p> Signup and view all the answers

    What was a key finding regarding control females in the experiment?

    <p>They did not exhibit any male-typical behavior. (D)</p> Signup and view all the answers

    Which of the following events is necessary for typical female development in mammals?

    <p>Regression of the Wolffian duct. (A), Development of the Müllerian duct. (B)</p> Signup and view all the answers

    What is the role of estrogen in typical female development?

    <p>It promotes the development of the Müllerian duct. (C)</p> Signup and view all the answers

    Which of the following statements is TRUE about secondary sex characteristics in animals?

    <p>They are influenced by circulating sex hormones. (D)</p> Signup and view all the answers

    Which of the following syndromes involves an extra X chromosome in females?

    <p>XXXXX Syndrome (B), XXXX Syndrome (D)</p> Signup and view all the answers

    What is the main evolutionary advantage of sexual reproduction?

    <p>It increases genetic diversity, enhancing adaptability to environmental changes. (D)</p> Signup and view all the answers

    Which of the following is NOT a disadvantage of asexual reproduction?

    <p>Faster population growth. (B)</p> Signup and view all the answers

    What is the main characteristic of parthenogenesis?

    <p>Reproduction where females produce offspring that are genetically identical to them. (C)</p> Signup and view all the answers

    Which of the following animal groups is NOT known to reproduce asexually?

    <p>Insects (A)</p> Signup and view all the answers

    Which of these syndromes is characterized by short stature, developmental delays, and infertility?

    <p>XXXX Syndrome (A), XXXXX Syndrome (D)</p> Signup and view all the answers

    What is the primary reason for the evolutionary advantage of sexual reproduction over asexual reproduction?

    <p>Sexual reproduction creates genetic diversity which helps organisms adapt to changing environments. (D)</p> Signup and view all the answers

    Which of the following is a potential consequence of asexual reproduction?

    <p>Increased vulnerability to pathogens specialized to a single genotype. (D)</p> Signup and view all the answers

    Which hormone is primarily responsible for increasing physical activity levels in boys during prenatal and postnatal development?

    <p>Testosterone (B)</p> Signup and view all the answers

    What is the impact of prenatal stress on the development of sex-specific behaviors?

    <p>Prenatal stress can alter testosterone receptor expression, potentially influencing play behavior. (B)</p> Signup and view all the answers

    Which gene on the Y chromosome initiates the production of testosterone in males?

    <p>SRY (A)</p> Signup and view all the answers

    How do epigenetic influences impact toy preferences in children?

    <p>Maternal diet and exposure to endocrine disruptors can alter androgen receptor sensitivity, influencing toy choices. (A)</p> Signup and view all the answers

    Which hormone is linked to enhanced verbal fluency and corpus callosum connectivity in females?

    <p>Estrogen (B)</p> Signup and view all the answers

    Which of these is NOT mentioned as a factor influencing spatial abilities in either sex?

    <p>Cultural norms (D)</p> Signup and view all the answers

    Which gene is associated with language development and is more active in females?

    <p>FOXP2 (D)</p> Signup and view all the answers

    How does early childhood experience modify FOXP2 expression?

    <p>Early experiences can modify FOXP2 expression via epigenetic changes. (A)</p> Signup and view all the answers

    Which hormone is associated with increased competitiveness and impulsivity in males?

    <p>Testosterone (C)</p> Signup and view all the answers

    The "warrior gene" (MAOA) plays a role in regulating which behavior?

    <p>Aggression (D)</p> Signup and view all the answers

    Which hormone is linked to enhanced emotional processing and social bonding in females?

    <p>Oxytocin (C)</p> Signup and view all the answers

    Which gene is associated with oxytocin receptor methylation and influences social bonding?

    <p>OXTR (A)</p> Signup and view all the answers

    How does chronic stress affect the CRHR1 gene?

    <p>Chronic stress can increase CRHR1 gene expression, leading to greater sensitivity to cortisol. (D)</p> Signup and view all the answers

    Which of the following statements is TRUE about the influence of hormones on stress responses?

    <p>Testosterone and cortisol are primarily responsible for &quot;fight-or-flight&quot; responses while oxytocin encourages &quot;tend-and-befriend&quot; responses. (A)</p> Signup and view all the answers

    Which of the following MOST accurately describes the interaction between hormones and the development of sex-specific behaviors?

    <p>Hormones interact with genetic and environmental factors to shape an individual's sex-specific behaviors. (C)</p> Signup and view all the answers

    Flashcards

    XXYY Syndrome

    A condition with two extra sex chromosomes in males, linked to tall stature and various developmental issues.

    XXXX Syndrome

    A genetic disorder in females characterized by two extra X chromosomes, resulting in developmental delays and short stature.

    XXXXY Syndrome

    A severe disorder in males with three extra X chromosomes, leading to developmental and intellectual challenges.

    XXXXX Syndrome

    A genetic condition in females with three extra X chromosomes, causing significant developmental and language delays.

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    Asexual Reproduction

    A reproductive method where offspring are genetically identical to the parent, lacking genetic variation.

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    Parthenogenesis

    A type of asexual reproduction where females produce offspring without fertilization.

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    Sexual Reproduction

    A reproductive process involving two parents, resulting in genetic diversity among offspring.

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    Evolutionary Advantage

    The benefits that certain traits provide organisms in terms of survival and reproduction.

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    Heterogametic sex

    Sex with two different sex chromosomes (XY in mammals, ZW in birds).

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    Gonadal Sex

    Sex determined by the presence of ovaries or testes.

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    SRY gene

    Gene on the Y chromosome that initiates testicular development.

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    Androgen Insensitivity Syndrome (AIS)

    Condition in XY individuals developing as female due to non-functional androgen receptors.

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    Sexual differentiation

    Process where accessory sex organs are feminized or masculinized.

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    Gametic Sex

    Refers to the type of gametes produced: ova or sperm.

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    Hormonal Sex

    Determined by the ratio of circulating steroid hormones.

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    Testosterone vs Estrogen Levels

    Men have higher testosterone, women have higher estrogen levels.

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    Proximate Cause

    The immediate mechanistic cause of behavior including genetic, neural, hormonal, and environmental influences.

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    Organizational/Activational Hypothesis

    Hypothesis explaining hormonal influence on behavior through early neural shaping and later behavioral triggering.

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    Organizational Effects

    Hormonal actions during critical growth periods that shape neural circuits for long-term changes.

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    Activational Effects

    Temporary hormonal effects later in life that trigger behaviors based on pre-established neural circuits.

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    Disorders of Sex Development (DSD)

    Congenital and acquired syndromes that affect sexual differentiation, leading to variations in sexual identity.

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    Congenital Adrenal Hyperplasia (CAH)

    A genetic condition affecting adrenal hormone production, impacting sexual development and characteristics.

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    Chromosomal Sex

    Defined by the sex chromosomes inherited at fertilization, determining an individual's sexual characteristics.

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    Neural Circuits

    Brain pathways that are shaped by early hormone exposure to respond to later hormonal signals.

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    Testosterone's Role

    A primary hormone that drives organizational effects in the development of male characteristics.

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    Young's Experiment

    An experiment studying hormone effects on behavior using prenatal manipulation in guinea pigs.

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    Hermaphrodite Females

    Female guinea pigs exposed to high testosterone, developing male-like external genitalia.

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    Gonadectomy

    Surgical removal of gonads in animals, used to eliminate natural hormone influence in experiments.

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    Organizational Hypothesis

    The idea that prenatal hormones permanently shape the nervous system's structure.

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    Activational Hypothesis

    The concept that hormones activate pre-existing neural circuits in adults rather than create new behaviors.

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    Critical periods for hormones

    Sensitive windows during development when hormones can influence brain organization irreversibly.

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    Testosterone's role in behavior

    Testosterone masculinizes not only external genitalia but also the brain during development.

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    Effects of early testosterone on females

    Females injected with testosterone early develop male-like brain organization but need testosterone in adulthood for male behaviors.

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    Young’s Experiment

    An experiment focusing on the effects of hormonal exposure during sensitive periods of development.

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    Removing gonads before day 10

    Experiment manipulation that prevents natural hormone exposure affecting early development.

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    Subtle neural changes

    Even in unmodified females, early hormones can alter brain function leading to masculinized behaviors.

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    Hormones in Behavior

    Hormones influence the development of sex-specific behaviors through genetics, environment, and hormones.

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    Rough-and-Tumble Play

    Boys engage more in intense physical play compared to girls, often encouraged by social factors.

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    Toy Preferences

    Boys prefer mechanical toys, while girls gravitate towards nurturing toys, influenced by genes and environment.

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    Verbal Abilities

    Girls generally show higher verbal fluency and better language processing than boys.

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    Spatial Abilities

    Boys typically excel at spatial reasoning and navigation tasks compared to girls.

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    Aggression & Risk-Taking

    Boys exhibit more physical aggression and risk-taking behavior than girls.

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    Empathy & Social Sensitivity

    Girls tend to have higher empathy and better social sensitivity, compared to boys.

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    Stress Response

    Boys are more likely to respond to stress with 'fight-or-flight', while girls often tend-and-befriend.

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    Estrogen's Influence

    Estrogen enhances verbal fluency and emotional processing in females.

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    Genetic Factors

    Specific genes, like SRY, influence sexually dimorphic behaviors and traits.

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    Epigenetic Influences

    Environmental factors can modify gene expression, impacting behaviors and preferences.

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    Oxytocin's Role

    Oxytocin is involved in social bonding and emotional processing, more active in females.

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    MAOA Gene

    The 'warrior gene' relates to aggression regulation, influencing male behavior.

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    Cortisol's Impact

    Cortisol influences stress responses differently in males and females.

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    Study Notes

    Sex Differences in Behavior

    • Sex is a biological concept classifying organisms based on reproductive structures and functions.
    • Sex is determined at multiple levels: chromosomal, gonadal, hormonal, morphological, and behavioral.
    • Sex is often seen as binary (male/female), but variations exist.
    • Examples of variations include Turner syndrome (XO) and Klinefelter syndrome (XXY), which challenge a strict binary model.

    Understanding Sex and Gender

    • Sex: Biological state with distinct facets (genetic, chromosomal, gonadal, hormonal, phenotypic).
    • Gender: Subjective, self-identified social construct, influenced by biological, personal, and societal factors.
    • Gender can vary widely (single, multiple, fluid).
    • Intersex states (DSDs) occur when facets conflict.

    Chromosomal Variations

    • Turner Syndrome (45,X): Missing one X chromosome, leading to short stature, webbed neck, broad chest, and infertility.
    • Klinefelter Syndrome (47,XXY): One extra X chromosome in males, characterized by tall stature, reduced muscle mass, breast development, and small testes.
    • Triple X Syndrome (47,XXX): One extra X chromosome in females, with tall stature and sometimes mild developmental delays..
    • XYY Syndrome (47,XYY): One extra Y chromosome in males, characterized by tall stature and sometimes developmental delays.
    • XXYY Syndrome (48,XXYY): Two extra sex chromosomes (one X and one Y), resulting in tall stature, dental issues, and developmental delays.
    • XXXX Syndrome (48,XXXX): Three extra X chromosomes in females.
    • XXXXY Syndrome (49,XXXXY): Three extra X chromosomes and one Y chromosome, resulting in intellectual disability, speech and language delays.
    • XXXXX Syndrome (49,XXXXX): Three extra X chromosomes in females. Significant intellectual disability, behavioral issues are more common.

    Ultimate Causes of Sex Differences

    • Ultimate cause: Evolutionary, adaptive reason for a behavior.
    • Sexual dimorphism: Variations in appearance and behavior between sexes.
    • Evolutionary analysis compares sexually monomorphic (similar-looking) species with sexually dimorphic (distinct traits) species.
    • Monogamy: One mating partner, with decreased sexual dimorphism.
    • Polygamy: Multiple partners, with stronger selection for exaggerated male traits.
    • Example: Prairie voles (monogamous) vs. elk (polygynous).

    Mating Systems and Sexual Selection

    • Subcategory of natural selection.
    • Male competition and female choice: Males develop traits (e.g., antlers in elk) to enhance reproductive success.

    Proximate Causes of Sex Differences

    • Proximate cause: Immediate, mechanistic cause of a behavior, focusing on how it occurs.
    • Includes genetic, neural, hormonal, and environmental influences.
    • Organizational effects: Early hormonal actions shaping neural circuits.
    • Examples: Testosterone exposure influencing brain differentiation.
    • Activational effects: Later hormonal actions triggering behaviors.
    • Example: Testosterone promoting aggressive or reproductive behaviors.

    Disorders of Sex Development (DSD)

    • Congenital and acquired syndromes affecting sexual differentiation.
    • May result from genetic mutations, endocrine disruptions, or environmental influences.
    • Examples: Androgen Insensitivity Syndrome (AIS) and Congenital Adrenal Hyperplasia (CAH).
    • Clinical and experimental studies provide insights into hormonal influences.
    • Animal models are used to understand gender identity and sexual orientation.

    Mammalian Sexual Differentiation

    • Chromosomal sex: Defined by the sex chromosomes inherited at fertilization (XX for female, XY for male).
    • Homogametic sex: Possesses two similar sex chromosomes.
    • Heterogametic sex: Possesses two different sex chromosomes.
    • Example: XX females in mammals, XY males in mammals.
    • Gonadal sex: Determined by presence of ovaries or testes.
    • SRY gene (on the Y chromosome) initiates testicular development.
    • In absence of SRY, gonads develop into ovaries.

    Gametic Sex

    • Gametes: Produced by ovaries (ova) or testes (sperm).
    • Ova are large, immobile, and resource-rich.
    • Sperm are numerous, small, and mobile.
    • Essential for sexual reproduction and genetic diversity.
    • Example: Mammals produce fewer, high-investment ova in comparison to millions of daily sperm.

    Differences in Circulating Testosterone and Estrogen Levels Between Men and Women

    • Testosterone: Primarily produced in testes, higher levels in men. Physical and psychological differences include greater muscle mass, higher bone density, higher libido, and increased aggression.
    • Estrogen: Primarily produced in ovaries, lower levels in men. Physical and psychological differences include lower muscle mass, contributes to sperm maturation, cardiovascular function and mood regulation.

    Hormonal Differences and Their Effects on Men and Women

    • Hormonal influence on libido differs between men and women:
    • Hormones may impact cognitive function, spatial skills, social behaviors and emotional processing differently.

    Morphological Sex

    • Physical differences (e.g., size, external genitalia, secondary sexual characteristics) between males and females.
    • Examples include coloration, horns, antlers.
    • Behavioral sex: Sex-typical behaviors in different species (e.g., parental care, territorial defense, mating behaviors).

    Effects of Hormones on Sexually Dimorphic Behaviors

    • Hormonal influences lead to distinct behaviors exhibited by males and females.
    • Animal models help understand neural, hormonal, and molecular mechanisms behind these behaviors.
    • The role of hormones, notably gonadal steroids, in sex-specific behaviors: Hormones interact with genetics and environment to create behavior differences.

    Experiment Summary

    • Manipulation of hormones is important in understanding how hormones affect sexually dimorphic behaviors.
    • Control groups are used to understand effect of removal or introduction of hormones.
    • Males and females who have been raised with similar hormone levels to the other sex will generally display similar behaviours.

    The Organizational/Activational Hypothesis

    • Explanations of how hormones influence sexually dimorphic behaviors in mammals.
    • Proposes a dual action of hormones during development:
    • Organizational effects (early development): Establish permanent structural changes shaping the brain.
    • Activational effects (later in life): Cause temporary influences on behavior by acting on pre-existing circuits.

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    Description

    Explore critical concepts related to hormones and their effects in this quiz. Understand the distinctions between organizational and activational effects, and delve into disorders of sexual development (DSDs) and their significance in research. Test your knowledge on chromosomal sex, sexual differentiation, and the use of animal models.

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