Hormonal Changes in Pregnancy
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Questions and Answers

Which hormone is directly involved in the development of the ductal system within the mother's breast?

  • Human chorionic somatomammotropin (hCS)
  • Progesterone
  • Relaxin
  • Estrogen (correct)
  • Which hormone is responsible for preparing the breast glands for lactation by stimulating protein deposition and causing retention of nitrogen, potassium, and calcium?

  • Relaxin
  • Progesterone
  • Estrogen
  • Human chorionic somatomammotropin (hCS) (correct)
  • What is the primary estrogen synthesized by the fetoplacental unit during pregnancy?

  • Estradiol
  • Estrone
  • Progesterone
  • Estriol (correct)
  • What is the primary mechanism responsible for the transfer of glucose across the placenta?

    <p>Facilitated diffusion (B)</p> Signup and view all the answers

    Which hormone is responsible for suppressing maternal immune function during pregnancy, reducing the risk of fetal immune rejection?

    <p>Estrogen (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of human chorionic gonadotropin (hCG) in pregnancy?

    <p>hCG is secreted by the placenta and stimulates the production of testosterone in the male fetus. (A)</p> Signup and view all the answers

    Why is the fetal hemoglobin's affinity for oxygen higher than maternal hemoglobin's affinity for oxygen?

    <p>Fetal hemoglobin has a different structure than maternal hemoglobin, allowing it to bind oxygen more effectively at lower oxygen pressures. (A)</p> Signup and view all the answers

    Which hormone promotes the formation of a mucous plug in the cervical canal, preventing vaginal contaminants from reaching the uterus during pregnancy?

    <p>Progesterone (A)</p> Signup and view all the answers

    Which of the following substances are transported across the placenta by active transport?

    <p>Calcium (Ca2+), Phosphate (P), Iron (Fe) (A)</p> Signup and view all the answers

    Which hormone is produced by both the corpus luteum and the placenta, and plays a crucial role in preparing the body for labor and delivery?

    <p>Relaxin (C)</p> Signup and view all the answers

    The placenta's protective function during pregnancy is primarily achieved by:

    <p>Providing a barrier against the transfer of certain harmful materials into the fetus while allowing the passage of essential nutrients and antibodies. (A)</p> Signup and view all the answers

    Which hormone is responsible for the development of decidual cells in the uterine endometrium, which support implantation and nutrition of the early embryo?

    <p>Progesterone (B)</p> Signup and view all the answers

    Which of the following statements regarding carbon dioxide transport across the placenta is correct?

    <p>Carbon dioxide diffuses from the fetal blood to the maternal blood. (D)</p> Signup and view all the answers

    Which hormone is primarily involved in the enlargement of the mother's uterus and external genitalia during pregnancy?

    <p>Estrogen (A)</p> Signup and view all the answers

    In addition to its role in maintaining the corpus luteum, hCG also contributes to:

    <p>The growth of the trophoblast and placenta. (C)</p> Signup and view all the answers

    What is the primary mechanism by which waste products like urea, uric acid, and creatinine are removed from the fetal blood?

    <p>Diffusion from the fetal blood to the maternal blood. (A)</p> Signup and view all the answers

    Which of the following is NOT a stimulus that increases prolactin secretion?

    <p>High levels of dopamine (D)</p> Signup and view all the answers

    Prolactin's primary function during lactation is ___________.

    <p>To stimulate the development and growth of secretory alveoli in the breast (D)</p> Signup and view all the answers

    Which of the following is TRUE about the control of prolactin secretion by the anterior pituitary?

    <p>Prolactin secretion is primarily regulated by an inhibitory factor from the hypothalamus. (B)</p> Signup and view all the answers

    Which of the following hormones plays a crucial role in the release of milk from the mammary glands?

    <p>Oxytocin (A)</p> Signup and view all the answers

    High levels of estrogen during pregnancy have what effect on prolactin?

    <p>They increase prolactin production but inhibit its milk-promoting effect (B)</p> Signup and view all the answers

    What is the primary site of prolactin secretion?

    <p>Anterior Pituitary (B)</p> Signup and view all the answers

    What is the primary physiological stimulus for prolactin secretion?

    <p>Suckling (C)</p> Signup and view all the answers

    Which of the following hormones is NOT directly involved in either breast development or milk production?

    <p>Insulin (B)</p> Signup and view all the answers

    Which of the following is MOST directly responsible for the inhibition of GnRH secretion, leading to lactational amenorrhea?

    <p>Increased prolactin levels (A)</p> Signup and view all the answers

    What is the primary mechanism by which breastfeeding helps to reduce infant infections?

    <p>Transfer of maternal antibodies through breast milk (B)</p> Signup and view all the answers

    The statement "For the suckling stimulus to inhibit GnRH secretion completely, the stimulus must be prolonged and frequent" suggests that:

    <p>Breastfeeding can be an effective form of contraception, but only if done consistently and frequently. (C)</p> Signup and view all the answers

    Which of the following is NOT a mechanism directly attributed to breastfeeding in promoting infant health?

    <p>Increased production of gastric digestive enzymes in the infant (C)</p> Signup and view all the answers

    In the context of lactational amenorrhea, the term "amenorrhea" refers to:

    <p>The absence of menstruation (B)</p> Signup and view all the answers

    What is the primary reason behind the pain experienced during the first stage of labor?

    <p>Ischemia of the myometrium muscle due to restricted blood flow during contractions. (A)</p> Signup and view all the answers

    Which of the following hormones is responsible for the growth and branching of the ductal system of the breasts during puberty?

    <p>Estrogen (D)</p> Signup and view all the answers

    What is the primary function of glucocorticoids administered to mothers in premature labor?

    <p>To enhance fetal lung development and reduce the risk of respiratory distress syndrome. (D)</p> Signup and view all the answers

    Which of the following statements about the different stages of labor is NOT correct?

    <p>The second stage of labor ends with the delivery of the placenta. (A)</p> Signup and view all the answers

    What is the significance of ensuring removal of all placental fragments after birth?

    <p>To avoid postpartum bleeding. (A)</p> Signup and view all the answers

    Which of the following correctly describes the role of progesterone in breast development?

    <p>Progesterone primarily contributes to the growth of breast lobules and acini. (D)</p> Signup and view all the answers

    Which of these factors is NOT a contributing factor to the pain experienced during labor?

    <p>The rupture of the amniotic sac. (C)</p> Signup and view all the answers

    What is the main function of the acini in the breast?

    <p>To synthesize and secrete milk. (C)</p> Signup and view all the answers

    Which of the following accurately describes the physiological changes related to glucose intolerance during pregnancy?

    <p>Maternal insulin resistance, induced by human placental lactogen, leads to decreased glucose uptake by the fetus and an increased risk of gestational diabetes. (A)</p> Signup and view all the answers

    Which hormone is primarily responsible for promoting tolerance of the fetus by modulating the immune response during pregnancy?

    <p>Progesterone (D)</p> Signup and view all the answers

    Which of the following mechanisms is NOT directly involved in the onset of labor?

    <p>Increased secretion of progesterone (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of fetal cortisol in the initiation of labor?

    <p>Fetal cortisol initiates a switch in placental hormone synthesis from progesterone to estrogen, promoting the maturation of the fetal respiratory system and hastening labor. (C)</p> Signup and view all the answers

    How does the increased production of estrogen during the final stages of pregnancy contribute to the onset of labor?

    <p>Estrogen directly stimulates the myometrium, increasing its contractility and promoting labor. (C)</p> Signup and view all the answers

    Why is the length of pregnancy calculated from two different starting points: conception and the last menstrual period?

    <p>The length of pregnancy is calculated from the last menstrual period because it is a more reliable indicator of the actual gestational age. (C)</p> Signup and view all the answers

    Which of the following statements correctly describes the role of increased white blood cell count during pregnancy?

    <p>The increase in white blood cell count, primarily neutrophils, helps the mother's immune system fight off infections and protect the fetus. (B)</p> Signup and view all the answers

    Which of the following is NOT a consequence of increased maternal triglyceride, HDL, and LDL levels during pregnancy?

    <p>Increased risk of gestational diabetes. (B)</p> Signup and view all the answers

    Flashcards

    Placenta Functions

    The placenta serves several functions including gas exchange, nutrient transport, waste removal, and endocrine activities during pregnancy.

    Oxygen Diffusion

    Oxygen diffuses from maternal to fetal blood due to a pressure gradient, primarily towards the lower PO2 in fetal blood.

    Fetal Hemoglobin

    Fetal hemoglobin can carry 20-50% more O2 than maternal hemoglobin, enhancing oxygen transport to fetal tissues.

    Bohr Effect

    The Bohr effect describes how increased CO2 in maternal blood decreases its hemoglobin's O2 binding capacity, whereas decreased CO2 in fetal blood increases it.

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    Nutrient Transport

    Nutrients like glucose and amino acids are transported across the placenta via facilitated diffusion and active transport, respectively.

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    Waste Excretion

    The placenta helps excrete fetal wastes such as urea, uric acid, and creatinine into maternal blood.

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    Immune Protection

    The placenta acts as a barrier to prevent certain harmful substances from reaching the fetus while allowing passive immunity through IgG.

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    Human Chorionic Gonadotropin (hCG)

    hCG is a glycoprotein secreted by trophoblasts that maintains the corpus luteum and stimulates trophoblast growth; it's an early pregnancy indicator.

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    Premature labor treatment

    Administering glucocorticoids to mothers before 34 weeks to help fetal lung development.

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    Fetoplacental unit

    The combined functioning of fetal and placental tissues to produce estrogen.

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    Stages of labor

    Labor is divided into three stages: dilation, expulsion, and placental.

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    Estriol

    The primary estrogen synthesized by the fetoplacental unit during pregnancy.

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    Progesterone

    A hormone synthesized by the placenta to support pregnancy soon after implantation.

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    1st stage of labor

    Longest stage, lasting 8-24 hours for primipara, involves cervical dilation.

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    Ischemia and labor pain

    Pain during labor is caused by reduced blood supply to uterine muscles.

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    Functions of progesterone

    Includes increasing secretion in fallopian tubes, maintaining pregnancy, and forming a mucous plug.

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    Relaxin

    A polypeptide hormone that relaxes pelvic ligaments and dilates the cervix during pregnancy.

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    2nd stage of labor

    Begins with full cervical dilation and ends with the delivery of the baby, lasting 40-60 minutes.

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    3rd stage of labor

    From birth to delivery of the placenta, usually lasts around 15 minutes.

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    Human chorionic somatomammotropin (hCS)

    A protein hormone secreted by the placenta that prepares breasts for lactation and acts like growth hormone.

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    Estrogens during puberty

    Stimulates growth, branching of ducts, and fat deposition in breasts.

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    Functions of estrogen during pregnancy

    Includes uterine enlargement, breast ductal development, and relaxing pelvic ligaments.

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    DHEA

    Dehydroepiandrosterone, an androgen hormone converted to estrogen by the placenta.

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    Progesterone effects

    Enhances growth of immature breast lobules and acini during puberty.

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    Lactational Amenorrhea

    A temporary absence of menstruation during breastfeeding due to hormonal changes.

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    Prolactin Role

    Prolactin inhibits GnRH release, reducing ovulation and menstrual cycles during lactation.

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    Passive Immunity in Breast Milk

    Breast milk provides passive immunity via maternal immunoglobulins and immune cells, reducing infections.

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    Oxytocin Release

    Suckling triggers oxytocin secretion, which aids in milk ejection during breastfeeding.

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    Breastfeeding Benefits

    Breastfeeding lowers risks of asthma, allergies, diabetes, obesity, and cancers in mothers.

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    Gastroesophageal reflux disease (GERD)

    A condition caused by relaxation of the lower esophageal sphincter leading to acid reflux and nausea.

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    Human placental lactogen (hPL)

    A hormone that induces maternal insulin resistance to ensure nutrient transport to the fetus, resulting in glucose intolerance.

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    Gestational diabetes

    A form of diabetes occurring during pregnancy due to decreased insulin response, potentially leading to high blood sugar.

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    Triglycerides and cholesterol in pregnancy

    During pregnancy, triglycerides, HDLs, LDLs, and total cholesterol increase, aiding steroid hormone production.

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    Prolactin secretion

    Increased secretion of prolactin occurs as the pituitary gland enlarges during pregnancy.

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    Immune tolerance in pregnancy

    Progesterone reduces immune response to prevent rejection of the fetus, promoting tolerance.

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    Parturition

    The process of childbirth marked by uterine contractions and cervix dilation.

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    Role of fetal cortisol

    Fetal cortisol switches placental hormone synthesis from progesterone to estrogen late in pregnancy, aiding lung maturity.

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    Prolactin

    A hormone secreted by the anterior pituitary that stimulates milk production and mammary gland development.

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    Oxytocin

    A hormone that triggers milk ejection during breastfeeding via suckling stimulation.

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    Growth Hormone

    A hormone that supports mammary tissue growth and milk synthesis during lactation.

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    Cortisol

    A steroid hormone that contributes to the process of lactation by supporting mammary tissue development.

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    Prolactin Inhibiting Hormone (PIH)

    A hormone (dopamine) that inhibits prolactin secretion from the anterior pituitary.

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    Stimuli for Prolactin Secretion

    Factors like TSH, pregnancy, suckling, and sleep that increase prolactin levels in the body.

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    Milk Let-Down Mechanism

    The process of milk ejection triggered by oxytocin in response to suckling.

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    Study Notes

    Functions of the Placenta

    • Oxygen Diffusion: Oxygen diffuses from maternal blood to fetal blood. A pressure gradient of 20 mmHg exists, favoring oxygen transfer. Fetal hemoglobin has greater oxygen-carrying capacity than maternal hemoglobin. Higher fetal blood hemoglobin concentration and the greater CO2 load in fetal blood further aid in oxygen transport.
    • Carbon Dioxide Diffusion: Carbon dioxide diffuses from fetal to maternal blood, achieved by simple diffusion across the placenta.
    • Nutrient Transport: Glucose is transported via facilitated diffusion. Amino acids are actively transported, while fats are transported in early pregnancy and are synthesized in the fetus later on.
    • Electrolyte Transport: Electrolytes like sodium, potassium, chloride, calcium, and phosphate are transported by simple diffusion. Iron transport uses active transport mechanisms.
    • Waste Product Excretion: Waste products like urea, uric acid, and creatinine are excreted from fetal to maternal blood.
    • Protective Function: The placenta acts as a barrier against harmful materials and pathogens. IgG and antitoxins cross the placenta, imparting passive immunity to the fetus.

    Endocrine Functions of the Placenta

    • Human Chorionic Gonadotropin (hCG): A glycoprotein secreted by trophoblast, crucial for maintaining the corpus luteum (CL) after fertilization. hCG can be detected in blood as early as 6 days and in urine a few days later. Essential for pregnancy.
    • Estrogen: The placenta does not produce estrogen directly. It relies on a complex interaction with fetal tissues to produce estrogen, primarily estriol. The fetoplacental unit converts androgens from the fetal adrenal cortex (DHEA) into estrogen.
    • Progesterone: The placenta synthesizes progesterone soon after implantation. crucial for maintaining the pregnancy.
    • Human Chorionic Somatomammotropin (hCS/hPL): A protein hormone secreted after the fifth week of pregnancy, acting like a maternal growth hormone. It promotes protein deposition, nitrogen, potassium, and calcium retention, and lipolysis, decreasing glucose utilization, directing glucose to the fetus.

    Physiological Changes during Pregnancy

    • Osmoregulation: Pregnancy involves significant fluid increases, similar to fluid overload in congestive heart failure. The fetus, placenta, and amniotic fluid contribute considerably to this increase.
    • Urinary System: Fetal positioning can lead to changes in bladder capacity and urinary frequency. Volume overload affects blood urea, creatinine, and uric acid levels, increasing effective renal plasma flow and glomerular filtration rate. Renal tubular absorptive capacity is also elevated.
    • Cardiovascular System: Heart rate and stroke volume increase, resulting in a 30-50% rise in cardiac output. Blood pressure tends to decrease initially due to progesterone's effect on smooth muscle but returns to baseline later.

    Maternal Physiological Changes during Pregnancy

    • Hematological System: Blood volume rises by approximately 50%, with plasma expansion leading to physiological anemia. The mother's blood clotting ability rises.
    • Respiratory System: The diaphragm elevation decreases the residual volume of the lungs, but tidal volume and inspiratory capacity increase, resulting in chronic hyperventilation.
    • Digestive System: Effects of hemodilution, estrogen, and progesterone result in low albumin and total protein levels and decreased sphincter tone in the intestines, resulting in constipation and potential gallstone formation. Esophageal reflux is also more common.
    • Endocrine System: hPL induces maternal insulin resistance for fetal nutrient use and cortisol increases during pregnancy as a precursor for steroid synthesis.

    Parturition (Labor)

    • Hormonal Control: Fetal cortisol triggers a switch in the placenta, increasing estrogen production. Estrogen and prostaglandins increase myometrial contractility (uterine contractions, to induce labor.
    • Stages: Labor involves three stages:
      • 1st Stage (Dilatation): Longest stage lasting 8-24 hours, marked by uterine contractions opening the cervix.
      • 2nd Stage (Expulsion): Begins with full cervical dilation and ends with the baby's delivery. Usually lasts 40-60 minutes.
      • 3rd Stage (Placental): The delivery of the placenta after childbirth; usually takes approximately 15 minutes.

    Lactation

    • Hormonal Control: Lactation is primarily controlled by prolactin and oxytocin. Estrogen and progesterone block milk production during pregnancy, however, milk production starts after birth. Prolactin is increased during suckling and is essential for milk production.
    • Milk Production: Prolactin increases milk production, while oxytocin is essential for milk ejection. Suckling stimulation triggers the release of both.
    • Maintenance of Lactation: Breastfeeding triggers prolactin secretion; milk production is maintained as long as suckling continues.
    • Post-natal effects on hormonal control: Prolactin levels fall to non-pregnant levels. Suppression of fertility is common with breastfeeding.

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    Functions of the Placenta (PDF)

    Description

    Test your knowledge on the various hormones involved in pregnancy and their roles in fetal development and maternal adaptation. From lactation preparation to immune suppression, this quiz will cover critical hormonal functions and mechanisms that support a healthy pregnancy.

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