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Questions and Answers
Which hormone is directly involved in the development of the ductal system within the mother's breast?
Which hormone is directly involved in the development of the ductal system within the mother's breast?
Which hormone is responsible for preparing the breast glands for lactation by stimulating protein deposition and causing retention of nitrogen, potassium, and calcium?
Which hormone is responsible for preparing the breast glands for lactation by stimulating protein deposition and causing retention of nitrogen, potassium, and calcium?
What is the primary estrogen synthesized by the fetoplacental unit during pregnancy?
What is the primary estrogen synthesized by the fetoplacental unit during pregnancy?
What is the primary mechanism responsible for the transfer of glucose across the placenta?
What is the primary mechanism responsible for the transfer of glucose across the placenta?
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Which hormone is responsible for suppressing maternal immune function during pregnancy, reducing the risk of fetal immune rejection?
Which hormone is responsible for suppressing maternal immune function during pregnancy, reducing the risk of fetal immune rejection?
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Which of the following statements accurately describes the role of human chorionic gonadotropin (hCG) in pregnancy?
Which of the following statements accurately describes the role of human chorionic gonadotropin (hCG) in pregnancy?
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Why is the fetal hemoglobin's affinity for oxygen higher than maternal hemoglobin's affinity for oxygen?
Why is the fetal hemoglobin's affinity for oxygen higher than maternal hemoglobin's affinity for oxygen?
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Which hormone promotes the formation of a mucous plug in the cervical canal, preventing vaginal contaminants from reaching the uterus during pregnancy?
Which hormone promotes the formation of a mucous plug in the cervical canal, preventing vaginal contaminants from reaching the uterus during pregnancy?
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Which of the following substances are transported across the placenta by active transport?
Which of the following substances are transported across the placenta by active transport?
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Which hormone is produced by both the corpus luteum and the placenta, and plays a crucial role in preparing the body for labor and delivery?
Which hormone is produced by both the corpus luteum and the placenta, and plays a crucial role in preparing the body for labor and delivery?
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The placenta's protective function during pregnancy is primarily achieved by:
The placenta's protective function during pregnancy is primarily achieved by:
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Which hormone is responsible for the development of decidual cells in the uterine endometrium, which support implantation and nutrition of the early embryo?
Which hormone is responsible for the development of decidual cells in the uterine endometrium, which support implantation and nutrition of the early embryo?
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Which of the following statements regarding carbon dioxide transport across the placenta is correct?
Which of the following statements regarding carbon dioxide transport across the placenta is correct?
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Which hormone is primarily involved in the enlargement of the mother's uterus and external genitalia during pregnancy?
Which hormone is primarily involved in the enlargement of the mother's uterus and external genitalia during pregnancy?
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In addition to its role in maintaining the corpus luteum, hCG also contributes to:
In addition to its role in maintaining the corpus luteum, hCG also contributes to:
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What is the primary mechanism by which waste products like urea, uric acid, and creatinine are removed from the fetal blood?
What is the primary mechanism by which waste products like urea, uric acid, and creatinine are removed from the fetal blood?
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Which of the following is NOT a stimulus that increases prolactin secretion?
Which of the following is NOT a stimulus that increases prolactin secretion?
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Prolactin's primary function during lactation is ___________.
Prolactin's primary function during lactation is ___________.
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Which of the following is TRUE about the control of prolactin secretion by the anterior pituitary?
Which of the following is TRUE about the control of prolactin secretion by the anterior pituitary?
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Which of the following hormones plays a crucial role in the release of milk from the mammary glands?
Which of the following hormones plays a crucial role in the release of milk from the mammary glands?
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High levels of estrogen during pregnancy have what effect on prolactin?
High levels of estrogen during pregnancy have what effect on prolactin?
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What is the primary site of prolactin secretion?
What is the primary site of prolactin secretion?
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What is the primary physiological stimulus for prolactin secretion?
What is the primary physiological stimulus for prolactin secretion?
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Which of the following hormones is NOT directly involved in either breast development or milk production?
Which of the following hormones is NOT directly involved in either breast development or milk production?
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Which of the following is MOST directly responsible for the inhibition of GnRH secretion, leading to lactational amenorrhea?
Which of the following is MOST directly responsible for the inhibition of GnRH secretion, leading to lactational amenorrhea?
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What is the primary mechanism by which breastfeeding helps to reduce infant infections?
What is the primary mechanism by which breastfeeding helps to reduce infant infections?
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The statement "For the suckling stimulus to inhibit GnRH secretion completely, the stimulus must be prolonged and frequent" suggests that:
The statement "For the suckling stimulus to inhibit GnRH secretion completely, the stimulus must be prolonged and frequent" suggests that:
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Which of the following is NOT a mechanism directly attributed to breastfeeding in promoting infant health?
Which of the following is NOT a mechanism directly attributed to breastfeeding in promoting infant health?
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In the context of lactational amenorrhea, the term "amenorrhea" refers to:
In the context of lactational amenorrhea, the term "amenorrhea" refers to:
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What is the primary reason behind the pain experienced during the first stage of labor?
What is the primary reason behind the pain experienced during the first stage of labor?
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Which of the following hormones is responsible for the growth and branching of the ductal system of the breasts during puberty?
Which of the following hormones is responsible for the growth and branching of the ductal system of the breasts during puberty?
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What is the primary function of glucocorticoids administered to mothers in premature labor?
What is the primary function of glucocorticoids administered to mothers in premature labor?
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Which of the following statements about the different stages of labor is NOT correct?
Which of the following statements about the different stages of labor is NOT correct?
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What is the significance of ensuring removal of all placental fragments after birth?
What is the significance of ensuring removal of all placental fragments after birth?
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Which of the following correctly describes the role of progesterone in breast development?
Which of the following correctly describes the role of progesterone in breast development?
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Which of these factors is NOT a contributing factor to the pain experienced during labor?
Which of these factors is NOT a contributing factor to the pain experienced during labor?
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What is the main function of the acini in the breast?
What is the main function of the acini in the breast?
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Which of the following accurately describes the physiological changes related to glucose intolerance during pregnancy?
Which of the following accurately describes the physiological changes related to glucose intolerance during pregnancy?
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Which hormone is primarily responsible for promoting tolerance of the fetus by modulating the immune response during pregnancy?
Which hormone is primarily responsible for promoting tolerance of the fetus by modulating the immune response during pregnancy?
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Which of the following mechanisms is NOT directly involved in the onset of labor?
Which of the following mechanisms is NOT directly involved in the onset of labor?
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Which of the following statements accurately describes the role of fetal cortisol in the initiation of labor?
Which of the following statements accurately describes the role of fetal cortisol in the initiation of labor?
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How does the increased production of estrogen during the final stages of pregnancy contribute to the onset of labor?
How does the increased production of estrogen during the final stages of pregnancy contribute to the onset of labor?
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Why is the length of pregnancy calculated from two different starting points: conception and the last menstrual period?
Why is the length of pregnancy calculated from two different starting points: conception and the last menstrual period?
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Which of the following statements correctly describes the role of increased white blood cell count during pregnancy?
Which of the following statements correctly describes the role of increased white blood cell count during pregnancy?
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Which of the following is NOT a consequence of increased maternal triglyceride, HDL, and LDL levels during pregnancy?
Which of the following is NOT a consequence of increased maternal triglyceride, HDL, and LDL levels during pregnancy?
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Flashcards
Placenta Functions
Placenta Functions
The placenta serves several functions including gas exchange, nutrient transport, waste removal, and endocrine activities during pregnancy.
Oxygen Diffusion
Oxygen Diffusion
Oxygen diffuses from maternal to fetal blood due to a pressure gradient, primarily towards the lower PO2 in fetal blood.
Fetal Hemoglobin
Fetal Hemoglobin
Fetal hemoglobin can carry 20-50% more O2 than maternal hemoglobin, enhancing oxygen transport to fetal tissues.
Bohr Effect
Bohr Effect
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Nutrient Transport
Nutrient Transport
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Waste Excretion
Waste Excretion
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Immune Protection
Immune Protection
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Human Chorionic Gonadotropin (hCG)
Human Chorionic Gonadotropin (hCG)
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Premature labor treatment
Premature labor treatment
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Fetoplacental unit
Fetoplacental unit
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Stages of labor
Stages of labor
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Estriol
Estriol
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Progesterone
Progesterone
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1st stage of labor
1st stage of labor
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Ischemia and labor pain
Ischemia and labor pain
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Functions of progesterone
Functions of progesterone
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Relaxin
Relaxin
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2nd stage of labor
2nd stage of labor
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3rd stage of labor
3rd stage of labor
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Human chorionic somatomammotropin (hCS)
Human chorionic somatomammotropin (hCS)
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Estrogens during puberty
Estrogens during puberty
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Functions of estrogen during pregnancy
Functions of estrogen during pregnancy
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DHEA
DHEA
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Progesterone effects
Progesterone effects
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Lactational Amenorrhea
Lactational Amenorrhea
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Prolactin Role
Prolactin Role
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Passive Immunity in Breast Milk
Passive Immunity in Breast Milk
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Oxytocin Release
Oxytocin Release
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Breastfeeding Benefits
Breastfeeding Benefits
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Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD)
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Human placental lactogen (hPL)
Human placental lactogen (hPL)
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Gestational diabetes
Gestational diabetes
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Triglycerides and cholesterol in pregnancy
Triglycerides and cholesterol in pregnancy
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Prolactin secretion
Prolactin secretion
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Immune tolerance in pregnancy
Immune tolerance in pregnancy
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Parturition
Parturition
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Role of fetal cortisol
Role of fetal cortisol
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Prolactin
Prolactin
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Oxytocin
Oxytocin
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Growth Hormone
Growth Hormone
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Cortisol
Cortisol
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Prolactin Inhibiting Hormone (PIH)
Prolactin Inhibiting Hormone (PIH)
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Stimuli for Prolactin Secretion
Stimuli for Prolactin Secretion
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Milk Let-Down Mechanism
Milk Let-Down Mechanism
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Study Notes
Functions of the Placenta
- Oxygen Diffusion: Oxygen diffuses from maternal blood to fetal blood. A pressure gradient of 20 mmHg exists, favoring oxygen transfer. Fetal hemoglobin has greater oxygen-carrying capacity than maternal hemoglobin. Higher fetal blood hemoglobin concentration and the greater CO2 load in fetal blood further aid in oxygen transport.
- Carbon Dioxide Diffusion: Carbon dioxide diffuses from fetal to maternal blood, achieved by simple diffusion across the placenta.
- Nutrient Transport: Glucose is transported via facilitated diffusion. Amino acids are actively transported, while fats are transported in early pregnancy and are synthesized in the fetus later on.
- Electrolyte Transport: Electrolytes like sodium, potassium, chloride, calcium, and phosphate are transported by simple diffusion. Iron transport uses active transport mechanisms.
- Waste Product Excretion: Waste products like urea, uric acid, and creatinine are excreted from fetal to maternal blood.
- Protective Function: The placenta acts as a barrier against harmful materials and pathogens. IgG and antitoxins cross the placenta, imparting passive immunity to the fetus.
Endocrine Functions of the Placenta
- Human Chorionic Gonadotropin (hCG): A glycoprotein secreted by trophoblast, crucial for maintaining the corpus luteum (CL) after fertilization. hCG can be detected in blood as early as 6 days and in urine a few days later. Essential for pregnancy.
- Estrogen: The placenta does not produce estrogen directly. It relies on a complex interaction with fetal tissues to produce estrogen, primarily estriol. The fetoplacental unit converts androgens from the fetal adrenal cortex (DHEA) into estrogen.
- Progesterone: The placenta synthesizes progesterone soon after implantation. crucial for maintaining the pregnancy.
- Human Chorionic Somatomammotropin (hCS/hPL): A protein hormone secreted after the fifth week of pregnancy, acting like a maternal growth hormone. It promotes protein deposition, nitrogen, potassium, and calcium retention, and lipolysis, decreasing glucose utilization, directing glucose to the fetus.
Physiological Changes during Pregnancy
- Osmoregulation: Pregnancy involves significant fluid increases, similar to fluid overload in congestive heart failure. The fetus, placenta, and amniotic fluid contribute considerably to this increase.
- Urinary System: Fetal positioning can lead to changes in bladder capacity and urinary frequency. Volume overload affects blood urea, creatinine, and uric acid levels, increasing effective renal plasma flow and glomerular filtration rate. Renal tubular absorptive capacity is also elevated.
- Cardiovascular System: Heart rate and stroke volume increase, resulting in a 30-50% rise in cardiac output. Blood pressure tends to decrease initially due to progesterone's effect on smooth muscle but returns to baseline later.
Maternal Physiological Changes during Pregnancy
- Hematological System: Blood volume rises by approximately 50%, with plasma expansion leading to physiological anemia. The mother's blood clotting ability rises.
- Respiratory System: The diaphragm elevation decreases the residual volume of the lungs, but tidal volume and inspiratory capacity increase, resulting in chronic hyperventilation.
- Digestive System: Effects of hemodilution, estrogen, and progesterone result in low albumin and total protein levels and decreased sphincter tone in the intestines, resulting in constipation and potential gallstone formation. Esophageal reflux is also more common.
- Endocrine System: hPL induces maternal insulin resistance for fetal nutrient use and cortisol increases during pregnancy as a precursor for steroid synthesis.
Parturition (Labor)
- Hormonal Control: Fetal cortisol triggers a switch in the placenta, increasing estrogen production. Estrogen and prostaglandins increase myometrial contractility (uterine contractions, to induce labor.
- Stages: Labor involves three stages:
- 1st Stage (Dilatation): Longest stage lasting 8-24 hours, marked by uterine contractions opening the cervix.
- 2nd Stage (Expulsion): Begins with full cervical dilation and ends with the baby's delivery. Usually lasts 40-60 minutes.
- 3rd Stage (Placental): The delivery of the placenta after childbirth; usually takes approximately 15 minutes.
Lactation
- Hormonal Control: Lactation is primarily controlled by prolactin and oxytocin. Estrogen and progesterone block milk production during pregnancy, however, milk production starts after birth. Prolactin is increased during suckling and is essential for milk production.
- Milk Production: Prolactin increases milk production, while oxytocin is essential for milk ejection. Suckling stimulation triggers the release of both.
- Maintenance of Lactation: Breastfeeding triggers prolactin secretion; milk production is maintained as long as suckling continues.
- Post-natal effects on hormonal control: Prolactin levels fall to non-pregnant levels. Suppression of fertility is common with breastfeeding.
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Description
Test your knowledge on the various hormones involved in pregnancy and their roles in fetal development and maternal adaptation. From lactation preparation to immune suppression, this quiz will cover critical hormonal functions and mechanisms that support a healthy pregnancy.