Homeostasis & Disease Concepts
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Questions and Answers

What is the term for an environmental agent that can cause birth defects?

  • Monosomy
  • Teratogen (correct)
  • Carrier
  • Aneuploid
  • What is the term for an individual who carries a recessive gene for a genetic disorder but does not exhibit symptoms themselves?

  • Carrier (correct)
  • Aneuploid
  • Trisomy
  • Monosomy
  • Which of the following is NOT a teratogenic agent?

  • Radiation
  • Vitamin D (correct)
  • Toxoplasmosis
  • Syphilis
  • What is the term for an organism that has an abnormal number of chromosomes?

    <p>Aneuploid (D)</p> Signup and view all the answers

    During which stage of development is the fetus most susceptible to teratogens?

    <p>Early embryonic development (B)</p> Signup and view all the answers

    What is a common characteristic of both Basal Cell Carcinoma and Squamous Cell Carcinoma?

    <p>They are both highly curable if detected and treated early. (B)</p> Signup and view all the answers

    Which of the following is NOT a common symptom of Basal Cell Carcinoma?

    <p>An ulcerated center (B)</p> Signup and view all the answers

    What is a key factor in the etiology of Malignant Melanoma?

    <p>Damage to melanocytes (A)</p> Signup and view all the answers

    Which of the following is NOT a common location for Malignant Melanoma?

    <p>Palms of the hands (A)</p> Signup and view all the answers

    Which of the following is a key difference between Basal Cell Carcinoma and Squamous Cell Carcinoma?

    <p>Basal Cell Carcinoma rarely recurs, while Squamous Cell Carcinoma can recur. (C)</p> Signup and view all the answers

    What is the main characteristic that distinguishes a malignant tumor from a benign tumor?

    <p>Malignant tumors can invade surrounding tissues and metastasize. (C)</p> Signup and view all the answers

    What is the role of the CFTR protein in cystic fibrosis?

    <p>It helps to transport chloride ions across cell membranes. (B)</p> Signup and view all the answers

    What is the underlying cause of Fragile X syndrome?

    <p>A mutation in the FMR1 gene. (B)</p> Signup and view all the answers

    What is a common characteristic associated with Down's Syndrome?

    <p>Trisomy 21. (D)</p> Signup and view all the answers

    Which of the following conditions is characterized by a low platelet count, leading to increased risk of bleeding?

    <p>Thrombocytopenia (C)</p> Signup and view all the answers

    Which of the following terms refers to the process of cancer cells spreading from the primary tumor to other parts of the body?

    <p>Metastasis (D)</p> Signup and view all the answers

    What is the role of oncogenes in the development of cancer?

    <p>They stimulate protein synthesis involved in cell growth. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a benign tumor?

    <p>Ability to metastasize (A)</p> Signup and view all the answers

    Which of these diseases is characterized by a lack of or defective von Willebrand factor, leading to prolonged bleeding time?

    <p>Von Willebrand disease (D)</p> Signup and view all the answers

    Which disease is characterized by a mutation on chromosome 15 that alters fibrillin I production, resulting in defective elastin and collagen formation?

    <p>Marfan Syndrome (A)</p> Signup and view all the answers

    What is the primary function of telomeres?

    <p>To protect the ends of chromosomes from degradation. (B)</p> Signup and view all the answers

    What is 'cachexia'?

    <p>A severe wasting syndrome with lean body mass loss. (C)</p> Signup and view all the answers

    What is the underlying cause of Huntington's Chorea?

    <p>Progressive degeneration of basal ganglia and frontal lobe (C)</p> Signup and view all the answers

    In which disease does normal hemoglobin turn to hemoglobin S, leading to hemolytic anemia, sickle-cell crisis, and infections?

    <p>Sickle-cell Anemia (C)</p> Signup and view all the answers

    In the first few weeks of life, which body parts are most susceptible to disease?

    <p>Central nervous system, heart, extremities, eyes (C)</p> Signup and view all the answers

    Which of these diseases is NOT characterized by a mutation?

    <p>Tay-Sachs disease (C)</p> Signup and view all the answers

    What is the characteristic manifestation of Achondroplasia?

    <p>Dwarfism (Torso normal, limbs shortened) (C)</p> Signup and view all the answers

    Which disease is characterized by neurogenic tumors from Schwann cells and other parts of the PNS?

    <p>Neurofibromatosis (type 1) (B)</p> Signup and view all the answers

    Which of the following is a characteristic of secondary prevention?

    <p>Early detection of disease (B)</p> Signup and view all the answers

    What is the primary function of cortisol in the body's stress response?

    <p>Increasing blood sugar levels (D)</p> Signup and view all the answers

    Which of the following is an example of a sign of a disease?

    <p>Fever (B)</p> Signup and view all the answers

    Which of the following is a risk factor for developing a disease?

    <p>Exposure to environmental toxins (A)</p> Signup and view all the answers

    What is the role of the hypothalamus in the stress response?

    <p>Stimulating the release of corticotropin-releasing factor (CRF) (C)</p> Signup and view all the answers

    Which of the following is an example of a psychosomatic disorder?

    <p>Depression (A)</p> Signup and view all the answers

    Which of the following is an accurate description of neoplasia?

    <p>The uncontrolled growth of abnormal cells (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a systemic disease?

    <p>Specific to a particular organ (C)</p> Signup and view all the answers

    Which of the following statements accurately characterizes the progression phase of carcinogenesis?

    <p>Cells undergo further genetic mutations, acquiring the ability to invade surrounding tissues and metastasize. (D)</p> Signup and view all the answers

    What is the primary function of metastasis in cancer development?

    <p>To establish new tumors in distant parts of the body, leading to widespread disease. (A)</p> Signup and view all the answers

    Which of the following statements about the staging of cancer is TRUE?

    <p>Staging primarily focuses on evaluating the size and spread of the primary tumor, while grading assesses the tumor's aggressiveness. (A)</p> Signup and view all the answers

    In the TNM staging system, what does "N1" indicate?

    <p>Involvement of a single lymph node or a small group of nodes near the primary tumor. (A)</p> Signup and view all the answers

    What is the significance of the "M" component in the TNM staging system?

    <p>It signifies the presence or absence of distant metastases. (A)</p> Signup and view all the answers

    Which of the following scenarios reflects a favorable prognosis in cancer staging?

    <p>T1, N0, M0 (A)</p> Signup and view all the answers

    Which of the following statements is FALSE regarding the effects of cancer on the body?

    <p>Cancers can lead to weight gain and increased appetite due to uncontrolled cell growth. (A)</p> Signup and view all the answers

    What is the main difference between a tumor that is well-differentiated and one that is poorly differentiated?

    <p>A well-differentiated tumor closely resembles the normal tissue from which it originated, while a poorly-differentiated tumor has a more abnormal appearance. (D)</p> Signup and view all the answers

    Which of the following is NOT a typical characteristic of a malignant tumor?

    <p>Encapsulation (D)</p> Signup and view all the answers

    Flashcards

    Aneuploid

    An organism with an abnormal number of chromosomes.

    Carrier

    An individual who carries a gene for a recessive genetic disorder but does not show symptoms.

    Monosomy

    A condition where an individual has one less chromosome than normal, totaling 45 chromosomes.

    Teratogen

    An environmental agent that causes abnormalities during embryonic or fetal development.

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    Trisomy

    A condition characterized by having one extra chromosome than normal, resulting in 46 chromosomes.

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    Mortality

    Causes of death and death rate in a population.

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    Necrosis

    Injury that causes massive cell death.

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    Neoplasia

    Abnormal new growth of cells, unresponsive to controls.

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    Pathogenesis

    How the disease process evolves over time.

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    Psychosomatic

    Disorders with psychological origins affecting the body.

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    Risk factors

    Elements that predispose someone to a disease.

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    Cortisol effects

    Cortisol impacts metabolism and stress response in the body.

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    Primary prevention

    Measures to prevent disease from ever occurring.

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    Basal Cell Carcinoma

    A skin cancer caused by UV light affecting basal layer cells, leading to small lesions.

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    Squamous Cell Carcinoma

    Skin cancer from UV damage to keratinized epidermis; ulcerated lesions can develop.

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    Malignant Melanoma

    Aggressive skin cancer originating from melanocytes, especially in sun-exposed areas.

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    Etiology of Skin Cancers

    The study of causes for skin cancers, including UV damage and genetic factors.

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    Pathogenesis of Skin Cancers

    The development process of skin cancers including morphological changes.

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    Cystic Fibrosis

    Genetic disorder caused by a defect on chromosome 7 affecting chloride transport.

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    Fragile X Syndrome

    X-linked condition caused by a repeat in the FMR1 gene leading to developmental issues.

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    Hemophilia A

    X-linked disorder caused by lack of clotting factor VIII, leading to excessive bleeding.

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    Duchenne Muscular Dystrophy

    Genetic disorder from mutated dystrophin gene causing muscle weakness.

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    Down’s Syndrome

    Genetic disorder caused by trisomy 21 leading to characteristic features and cognitive delays.

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    Turner’s Syndrome

    Condition due to monosomy X leading to female phenotypes and developmental delays.

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    Klinefelter’s Syndrome

    Condition resulting from trisomy XXY causing male phenotype with female characteristics.

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    Cancer

    A disorder characterized by uncontrolled cell growth and differentiation changes.

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    Metastasis

    Process by which cancer cells spread from a primary tumor to other body parts.

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    Tumor Suppressor Gene

    Gene that normally prevents excessive cell division and cancer growth.

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    Progression phase

    Final stage in cancer development where mutated cells become fully cancerous.

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    Staging of tumors

    Determines how far a tumor has spread in the body.

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    TMN staging system

    A system for staging cancers based on Tumor, Nodes, and Metastasis.

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    T in TMN

    T represents the size and extent of the primary tumor.

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    N in TMN

    N indicates involvement of lymph nodes.

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    M in TMN

    M indicates whether there is metastasis present.

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    Cancer effects on the body

    Cancer can disrupt normal function and invade tissues, impacting overall health.

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    Achondroplasia

    Dwarfism caused by mutation in Fibroblast Growth Factor Receptor, leading to impaired cartilage formation.

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    Marfan Syndrome

    Disorder from a mutation on chromosome 15 affecting fibrillin I, causing skeletal, cardiovascular, and eye issues.

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    Neurofibromatosis Type 1

    Genetic disorder from a tumor suppressor gene defect on chromosome 17, leading to neurogenic tumors.

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    Von Willebrand Disease

    Blood disorder due to lack of or defective von Willebrand factor, causing prolonged bleeding time.

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    Huntington’s Chorea

    Genetic disorder on chromosome 4 causing degeneration of the basal ganglia and frontal lobe, resulting in fatal symptoms.

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    Phenylketonuria (PKU)

    Condition due to deficiency of phenylalanine hydroxylase, potentially leading to mental retardation.

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    Tay-Sachs Disease

    Lysosomal storage disease where GM2 ganglioside accumulates in neurons, leading to their destruction.

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    Sickle-cell Anemia

    Genetic condition where normal hemoglobin becomes hemoglobin S, causing hemolytic anemia and sickle crisis.

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    Study Notes

    Homeostasis & Disease

    • Acute: Short and strong
    • Anaplasia: Cells begin to form backward
    • Apoptosis: Programmed cell suicide
    • Atrophy: Cells decrease in size, or decrease in an organ's size
    • Calor: Heat
    • Chronic: Long and weak
    • Congenital: Occurs during gestation (born with it)
    • Disease: Abnormal condition affecting structure or function
    • Dolor: Pain
    • Dysplasia: Chronic irritation causing abnormal cell growth and maturation, disordered cells that don't look like normal cells. Always pre-cancerous.
    • Epidemiology: Study of disease occurrence in populations
    • Etiology: The cause of a disease, what sets it in motion (Biological, physical, chemical, or nutritional factors or excess/deficits)
    • Focal: Local and specific
    • Genetic/Hereditary/Familial: Passed on genetically (Cystic Fibrosis, Cardiovascular Disease)
    • Hyperplasia: Increase in the number of cells in an organ or tissue
    • Hypertrophy: Enlargement of cells, which increases organ size
    • Hypoxia: Deficiency of oxygen
    • Iatrogenic: Medical environment (surgery)
    • Idiopathic: Unknown cause
    • Infarction: Tissue death due to lack of blood
    • Inflammation: Reaction of vascular tissues to cell injury (goal: minimize injury, remove damage, generate new tissue)
    • Metabolic: Involving more than one organ system
    • Metaplasia: Replacing one cell type with another
    • Morbidity: Relative incidence of disease and its impact on quality of life
    • Morphology: Basic structure/form of cells and tissues (changes with disease)
    • Mortality: Death rate and causes of death in a population
    • Necrosis: Injury causing massive cell death
    • Neoplasia: Abnormal new growth of cells, unresponsive to controls (benign vs malignant)
    • Nosocomial: Occurring in a medical environment (e.g., infection)
    • Pathogenesis: How a disease process evolves
    • Predisposition: Potential to develop a disease, due to specific environmental stimuli
    • Pyrogen: Risk factors that reset the thermostatic set point.

    Genetic Disorders

    • Aneuploid: Organism with abnormal chromosome number
    • Carrier: Individual who carries a recessive gene without exhibiting symptoms.
    • Monosomy: Having one less chromosome than normal (45 total chromosomes)
    • Teratogen: Environmental agent causing abnormalities during embryonic/fetal development.
    • Trisomy: Having one extra chromosome than normal (47 chromosomes)

    Neoplasia & Cancer

    • Anemia: Lack of healthy blood cells (insufficient oxygen)
    • Angiogenesis: Formation of new blood vessels from existing ones.
    • Anorexia: Loss of appetite or reduced desire to eat
    • Cachexia: Wasting syndrome, severe loss of lean body mass.
    • Cancer: Disorder of altered cell differentiation & growth
    • Carcinogen: Substance causing cancer
    • Leukopenia: Lower than normal white blood cell count
    • Metastasis: Cancer cells spreading from a primary tumor to other parts of the body

    Musculoskeletal Disorders (Independent study)

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    Test your knowledge on key terms and concepts related to homeostasis and various diseases. This quiz covers definitions and distinctions between acute and chronic conditions, the importance of epidemiology, and biological factors affecting health. Challenge yourself with this comprehensive quiz!

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