Homeostasis and Body Systems Quiz
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Questions and Answers

Which of the following is NOT a key characteristic of extracellular fluid?

  • Presence of nutrients like oxygen and glucose
  • High concentrations of potassium ions (correct)
  • High concentrations of sodium ions
  • Movement through capillaries and interstitial fluid
  • Which organ system is primarily responsible for detecting body states and surroundings, and generating thoughts and reactions?

  • Endocrine System
  • Nervous System (correct)
  • Integumentary System
  • Immune System
  • What is the primary mechanism used by most control systems in the body to maintain homeostasis?

  • Positive feedback
  • Negative feedback (correct)
  • Genetic control
  • Hormonal regulation
  • Which of the following is an example of a positive feedback mechanism?

    <p>Blood clotting (B)</p> Signup and view all the answers

    What is the main role of the immune system in maintaining homeostasis?

    <p>Protecting the body from foreign substances (A)</p> Signup and view all the answers

    How does efficient diffusion of substances occur between capillaries and cells?

    <p>The close proximity of cells to capillaries (C)</p> Signup and view all the answers

    Which of these is NOT a factor regulated by control systems in the human body?

    <p>Air pressure (D)</p> Signup and view all the answers

    Which of the following is an example of how the endocrine system contributes to homeostasis?

    <p>Regulating blood sugar levels through insulin production (D)</p> Signup and view all the answers

    What is the primary function of the bicarbonate buffer system?

    <p>To decrease the concentration of hydrogen ions in the blood. (B)</p> Signup and view all the answers

    Which of the following is NOT a key factor contributing to edema?

    <p>Increased lymphatic drainage. (A)</p> Signup and view all the answers

    What is the role of carbonic anhydrase in the bicarbonate buffer system?

    <p>It converts carbon dioxide and water into carbonic acid. (C)</p> Signup and view all the answers

    Which of the following is TRUE about the pH scale?

    <p>It is a logarithmic scale, meaning a change of one pH unit represents a tenfold change in hydrogen ion concentration. (D)</p> Signup and view all the answers

    Which of the following systems is responsible for the most rapid regulation of blood pH?

    <p>Chemical buffer systems (C)</p> Signup and view all the answers

    When the blood is becoming too acidic (acidosis), what does the respiratory system do to help regulate pH?

    <p>Increase the rate and depth of breathing. (D)</p> Signup and view all the answers

    Which of the following is NOT a mechanism by which the kidneys regulate blood pH?

    <p>Excretion of carbon dioxide. (A)</p> Signup and view all the answers

    What is the primary function of the lymphatic system in relation to edema?

    <p>To remove excess fluid from the interstitial spaces. (C)</p> Signup and view all the answers

    Which of the following conditions can cause intracellular edema?

    <p>Hyponatremia. (C)</p> Signup and view all the answers

    How does heart failure contribute to edema?

    <p>By reducing the ability of the heart to pump blood effectively, leading to increased capillary pressure and filtration. (B)</p> Signup and view all the answers

    Why does a slow development of hyponatremia typically reduce the severity of brain cell edema?

    <p>Because the brain cells have time to adjust to the lower sodium concentration. (D)</p> Signup and view all the answers

    What is the main reason why low compliance of the interstitium helps prevent edema?

    <p>It reduces the amount of fluid that can accumulate in the interstitial spaces. (B)</p> Signup and view all the answers

    What is the effect of adding hypertonic saline to the extracellular fluid?

    <p>It causes water to move out of cells, reducing intracellular volume. (A)</p> Signup and view all the answers

    Which of these is NOT a direct consequence of reduced plasma protein levels in relation to edema?

    <p>Increased lymphatic drainage. (A)</p> Signup and view all the answers

    What would happen if the lymphatic vessels that drain spaces between tissues become blocked?

    <p>The interstitial fluid pressure would increase. (A)</p> Signup and view all the answers

    What is the role of proteins in maintaining blood pH?

    <p>They act as buffers by binding to hydrogen ions. (B)</p> Signup and view all the answers

    What is the primary mechanism by which CO2 is transported from cells to the lungs?

    <p>Conversion of CO2 to bicarbonate in the blood (A)</p> Signup and view all the answers

    What is the primary role of carbonic anhydrase in the body?

    <p>Converting CO2 to bicarbonate and vice versa (D)</p> Signup and view all the answers

    Which of the following conditions is characterized by excessive ventilation, leading to a decrease in blood CO2 levels?

    <p>Respiratory alkalosis (D)</p> Signup and view all the answers

    Which of the following conditions is often associated with loss of sodium bicarbonate in feces?

    <p>Metabolic acidosis (C)</p> Signup and view all the answers

    What is the primary function of DNA in the cell?

    <p>Storing and transmitting genetic information (D)</p> Signup and view all the answers

    Which of the following is NOT a nitrogenous base found in DNA?

    <p>Uracil (A)</p> Signup and view all the answers

    What is the process of transferring genetic information from DNA to RNA called?

    <p>Transcription (D)</p> Signup and view all the answers

    What is the primary function of ribosomes in the cell?

    <p>Synthesizing proteins (C)</p> Signup and view all the answers

    Which of the following is NOT involved in the regulation of gene expression?

    <p>Mitochondria (C)</p> Signup and view all the answers

    What is the primary role of the rough endoplasmic reticulum (ER) in protein synthesis?

    <p>Providing a site for ribosome attachment (A)</p> Signup and view all the answers

    What is apoptosis?

    <p>A form of cell death that is programmed and regulated (B)</p> Signup and view all the answers

    What is the main difference between apoptosis and necrosis?

    <p>Apoptosis is a regulated process while necrosis is uncontrolled (B)</p> Signup and view all the answers

    Which of the following is NOT a factor that can increase the probability of mutation?

    <p>Eating a balanced diet (A)</p> Signup and view all the answers

    What is the significance of the 23rd pair of chromosomes?

    <p>They determine an individual's sex (B)</p> Signup and view all the answers

    What is aneuploidy?

    <p>A condition where cells contain an abnormal number of chromosomes (D)</p> Signup and view all the answers

    What is a translocation?

    <p>The interchange of genetic material between non-homologous chromosomes (B)</p> Signup and view all the answers

    What is the main function of the vasa recta in the process of urine concentration?

    <p>To act as a countercurrent exchanger, minimizing the washout of solutes from the interstitium. (D)</p> Signup and view all the answers

    Which of the following contributes to the hyperosmolarity of the renal medulla?

    <p>All of the above. (D)</p> Signup and view all the answers

    How does antidiuretic hormone (ADH) influence the formation of concentrated urine?

    <p>ADH increases water permeability in the distal tubules and collecting ducts, allowing for greater water reabsorption. (D)</p> Signup and view all the answers

    Which of the following correctly describes the osmolarity changes along the nephron?

    <p>The osmolarity remains relatively constant in the proximal tubule, increases in the descending loop of Henle, and decreases in the ascending loop of Henle. (C)</p> Signup and view all the answers

    Which of the following is NOT correctly paired with its effect on urine concentration?

    <p>Parathyroid hormone: Increases calcium reabsorption, leading to concentrated urine. (B)</p> Signup and view all the answers

    Which of the following describes the role of intercalated cells in acid-base regulation?

    <p>Type A cells secrete hydrogen ions, while type B cells secrete bicarbonate ions, helping to regulate blood pH. (A)</p> Signup and view all the answers

    Which of the following is a key feature of the countercurrent multiplier mechanism?

    <p>The ascending loop of Henle actively transports sodium and chloride ions out of the tubule, creating a hypertonic environment. (D)</p> Signup and view all the answers

    How does urea contribute to the formation of concentrated urine?

    <p>ADH activates urea transporters in the collecting duct, allowing urea to diffuse into the interstitium, increasing its osmolarity. (A)</p> Signup and view all the answers

    What would happen if the kidneys were unable to concentrate urine?

    <p>The body would excrete large volumes of dilute urine, leading to dehydration. (A)</p> Signup and view all the answers

    In what way are the osmoreceptor system and thirst mechanism linked to the regulation of urine concentration?

    <p>Both the osmoreceptor system and thirst mechanism directly stimulate ADH release, leading to concentrated urine formation. (B)</p> Signup and view all the answers

    Which of the following is NOT a factor that can affect tubular reabsorption?

    <p>The rate of blood flow through the afferent arteriole. (D)</p> Signup and view all the answers

    Which of the following is a consequence of increased ADH secretion?

    <p>Increased water reabsorption, leading to concentrated urine. (A)</p> Signup and view all the answers

    What is the primary function of inulin in renal function studies?

    <p>To measure the rate of glomerular filtration, as it is neither reabsorbed nor secreted by the tubules. (A)</p> Signup and view all the answers

    Which of the following is a potential consequence of prolonged dehydration?

    <p>The kidneys will conserve water by producing concentrated urine, potentially leading to electrolyte imbalances. (A)</p> Signup and view all the answers

    How does the countercurrent mechanism in the loops of Henle contribute to urine concentration?

    <p>The descending loop passively reabsorbs water, while the ascending loop actively reabsorbs sodium and chloride ions, creating a hypertonic medullary interstitium. (C)</p> Signup and view all the answers

    What is a common recommendation for sodium intake in patients with chronic kidney disease (CKD)?

    <p>Two grams a day or less (D)</p> Signup and view all the answers

    What characterizes nephrotic syndrome?

    <p>Proteinuria and albuminemia (C)</p> Signup and view all the answers

    What condition is characterized by the abrupt onset of hematuria and proteinuria with reduced GFR?

    <p>Acute glomerulonephritis (C)</p> Signup and view all the answers

    During which condition do patients typically present with flank pain and microscopic hematuria?

    <p>Renal stones (D)</p> Signup and view all the answers

    What primarily contributes to anemia in chronic kidney disease patients?

    <p>Decreased production of erythropoietin (C)</p> Signup and view all the answers

    What is the primary role of DNA methylation in gene regulation?

    <p>To silence genes by adding methyl groups to cytosine bases. (A)</p> Signup and view all the answers

    How do histone modifications influence gene expression?

    <p>By determining the tightness of DNA binding to histones. (D)</p> Signup and view all the answers

    Which process allows early embryo cells to potentially develop into any somatic cell?

    <p>Totipotency. (B)</p> Signup and view all the answers

    What is an example of a disorder resulting from genomic imprinting?

    <p>Prader-Willi syndrome. (C)</p> Signup and view all the answers

    How does exposure to ethanol in utero affect cognitive development?

    <p>It may impair neural stem cell differentiation. (C)</p> Signup and view all the answers

    What mechanism allows the kidneys to help regulate blood pressure?

    <p>Managing sodium and water levels. (C)</p> Signup and view all the answers

    What does the secretion of erythropoietin from the kidneys stimulate?

    <p>Red blood cell production in bone marrow. (A)</p> Signup and view all the answers

    Which abnormality can result from genomic imprinting on chromosome 11?

    <p>Russell-Silver syndrome. (D)</p> Signup and view all the answers

    What is the potential effect of DNA demethylating agents in cancer treatment?

    <p>They may reverse epigenetic modifications. (A)</p> Signup and view all the answers

    What impact does nutritional deprivation in utero have on subsequent generations?

    <p>It can have long-term health consequences. (B)</p> Signup and view all the answers

    What is a consequence of monozygotic twins aging under different lifestyles?

    <p>They can display different DNA methylation patterns. (D)</p> Signup and view all the answers

    How do histone deacetylase inhibitors (HDAC) affect chromatin structure?

    <p>They reduce chromatin compaction. (D)</p> Signup and view all the answers

    What is the genetic conflict hypothesis in relation to imprinting?

    <p>It implies mothers and fathers have different evolutionary interests. (A)</p> Signup and view all the answers

    What role does protamine play in sperm biology?

    <p>It allows for greater DNA compaction than histones. (D)</p> Signup and view all the answers

    What stimulates the thirst center in the anterior ventral wall of the third ventricle?

    <p>Decreased extracellular fluid volume (A)</p> Signup and view all the answers

    Where is ADH synthesized in the body?

    <p>Supraoptic and paraventricular nuclei of the hypothalamus (A)</p> Signup and view all the answers

    What effect does aldosterone have on potassium levels in the body?

    <p>Increases potassium secretion (C)</p> Signup and view all the answers

    What is the primary route for calcium reabsorption in the kidneys?

    <p>Active transport in the loop of Henle (B)</p> Signup and view all the answers

    What happens to urine volume when blood volume and pressure decrease?

    <p>Urine volume decreases (B)</p> Signup and view all the answers

    What condition can occur due to the failure of both ADH and thirst mechanisms?

    <p>Hypernatremia (A)</p> Signup and view all the answers

    Which factor is most influential in potassium secretion?

    <p>Extracellular potassium concentration (D)</p> Signup and view all the answers

    How does angiotensin II affect sodium excretion?

    <p>Promotes sodium retention (A)</p> Signup and view all the answers

    What is the primary influence on the release of antidiuretic hormone (ADH)?

    <p>Increased osmolarity (D)</p> Signup and view all the answers

    What is a common consequence of congestive heart failure in terms of fluid regulation?

    <p>Increased blood volume and extracellular fluid volume (A)</p> Signup and view all the answers

    What typically causes Down syndrome?

    <p>Trisomy 21 (C)</p> Signup and view all the answers

    Which hormone increases sodium reabsorption in the kidneys?

    <p>Aldosterone (D)</p> Signup and view all the answers

    How do kidneys adapt to changes in sodium and water intake?

    <p>Match excretion with intake (D)</p> Signup and view all the answers

    Which of the following describes a recessive gene?

    <p>Must be homozygous to be expressed (B)</p> Signup and view all the answers

    What role does parathyroid hormone play in phosphate regulation?

    <p>Inhibits phosphate reabsorption (A)</p> Signup and view all the answers

    What is the definition of penetrance in genetics?

    <p>The proportion of individuals with a genotype that express the expected phenotype (B)</p> Signup and view all the answers

    Which inheritance pattern is characterized by affected individuals transmitting the trait to approximately 50% of their children?

    <p>Autosomal dominant (C)</p> Signup and view all the answers

    Which of the following is an example of a multifactorial disease?

    <p>Height (D)</p> Signup and view all the answers

    What is an example of a trait influenced by X-linked recessive inheritance?

    <p>Hemophilia (B)</p> Signup and view all the answers

    Which genetic condition involves females having only one X chromosome?

    <p>Turner syndrome (B)</p> Signup and view all the answers

    Which term refers to a gene's specific location on a chromosome?

    <p>Locus (C)</p> Signup and view all the answers

    What percentage of individuals with a disease-causing allele may not exhibit the disease phenotype, illustrating incomplete penetrance?

    <p>25% (D)</p> Signup and view all the answers

    Which of the following statements about Alzheimer's Disease is correct?

    <p>The risk doubles if there is an affected first-degree relative. (C)</p> Signup and view all the answers

    What does precision medicine emphasize in medical treatment?

    <p>Tailoring treatment based on genetic and environmental factors (D)</p> Signup and view all the answers

    Which of these factors is NOT considered a risk factor for hypertension?

    <p>High likelihood of twin birth (B)</p> Signup and view all the answers

    Which type of study is primarily used to assess the contribution of genetics versus environment by comparing identical and fraternal twins?

    <p>Twin studies (D)</p> Signup and view all the answers

    Which environmental factor is associated with a higher risk of developing certain cancers?

    <p>Tobacco use (B)</p> Signup and view all the answers

    What is the approximate diameter of arterioles?

    <p>10-15 micrometers (A)</p> Signup and view all the answers

    Which type of capillary has tight junctions allowing only small molecules to pass?

    <p>Brain capillaries (B)</p> Signup and view all the answers

    What is the primary method of transferring substances between plasma and interstitial fluid?

    <p>Diffusion (D)</p> Signup and view all the answers

    Which of the following forces tends to force fluid outward from capillaries?

    <p>Capillary pressure (B)</p> Signup and view all the answers

    What is the approximate volume of interstitial fluid in the body?

    <p>1/6 of total body fluid (A)</p> Signup and view all the answers

    What is the net filtration pressure under normal conditions?

    <p>Slightly positive (A)</p> Signup and view all the answers

    Where does the lymphatic system drain excess fluid from?

    <p>Interstitial spaces (A)</p> Signup and view all the answers

    What is the approximate daily volume of lymph fluid returned to the blood?

    <p>2-3 liters (A)</p> Signup and view all the answers

    Which of the following is NOT a factor that increases lymph flow?

    <p>Decreased plasma protein concentration (C)</p> Signup and view all the answers

    What is the primary function of the nephron in the kidney?

    <p>Reabsorbs filtered substances and produces urine (B)</p> Signup and view all the answers

    What is the approximate daily water intake for an average person?

    <p>2100 ml (B)</p> Signup and view all the answers

    Which of the following is NOT a significant route of water loss from the body?

    <p>Digestion (B)</p> Signup and view all the answers

    How does the glomerulus prevent plasma proteins like albumin from passing through?

    <p>Through a fenestrated capillary structure with negative charges (B)</p> Signup and view all the answers

    What is the approximate volume of intracellular fluid (ICF) in the body?

    <p>28-42 liters (C)</p> Signup and view all the answers

    What triggers the release of renin from the kidneys?

    <p>Low effective circulating volume or low perfusion pressure (B)</p> Signup and view all the answers

    Which of the following electrolytes is found in higher concentrations in ICF than in ECF?

    <p>Potassium (D)</p> Signup and view all the answers

    What is the function of vasopressin in the kidney?

    <p>Promotes water reabsorption in the collecting duct (B)</p> Signup and view all the answers

    Which type of diuretic primarily acts on the thick ascending limb of the loop of Henle?

    <p>Loop diuretics (D)</p> Signup and view all the answers

    What is the primary function of the cell membrane in relation to fluid compartments?

    <p>Separating ICF from ECF (C)</p> Signup and view all the answers

    In what way do thiazide diuretics differ from loop diuretics?

    <p>They primarily affect the early distal tubules (B)</p> Signup and view all the answers

    Which of the following is NOT a primary cause of edema?

    <p>Increased lymphatic drainage (C)</p> Signup and view all the answers

    What is the total daily volume of fluid filtered from the glomerular capillaries into Bowman's capsule?

    <p>180 liters (D)</p> Signup and view all the answers

    What substance is secreted into the tubular fluid as part of reabsorption and secretion?

    <p>Creatinine (B)</p> Signup and view all the answers

    How do the kidneys contribute to acid-base homeostasis?

    <p>By excreting excess hydrogen and restoring bicarbonate levels (A)</p> Signup and view all the answers

    Which part of the nephron is involved in the filtration of blood?

    <p>Glomerulus (D)</p> Signup and view all the answers

    What primarily determines the glomerular filtration rate (GFR)?

    <p>Net filtration pressure (D)</p> Signup and view all the answers

    What is the primary action of aldosterone in the kidneys?

    <p>Facilitates sodium reabsorption in exchange for potassium (A)</p> Signup and view all the answers

    What happens when hydrostatic pressure increases in Bowman's capsule?

    <p>GFR decreases (B)</p> Signup and view all the answers

    Which mechanism contributes to urine concentration in the loop of Henle?

    <p>Counter current multiplication (A)</p> Signup and view all the answers

    What occurs as a result of excessive solutes in the renal tubules during osmotic diuresis?

    <p>Large volumes of fluid flushed into urine (C)</p> Signup and view all the answers

    What characterizes juxtamedullary nephrons compared to cortical nephrons?

    <p>They have specialized vasa recta for concentrated urine (C)</p> Signup and view all the answers

    Which type of muscle is the detrusor muscle in the bladder wall?

    <p>Smooth muscle (A)</p> Signup and view all the answers

    Which part of the kidney is primarily responsible for calcium regulation?

    <p>Distal collecting duct (B)</p> Signup and view all the answers

    What role do the internal and external sphincters play in micturition?

    <p>They control urine release (B)</p> Signup and view all the answers

    How does sympathetic stimulation affect urine movement in the ureters?

    <p>Inhibits peristaltic contractions (C)</p> Signup and view all the answers

    What is one key mechanism for urine excretion that involves the kidneys?

    <p>Tubular secretion (A)</p> Signup and view all the answers

    What type of substances are completely reabsorbed in the nephron?

    <p>Glucose (C)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding solute handling in the kidneys?

    <p>Some substances are secreted into the tubules (A)</p> Signup and view all the answers

    What initiates the micturition reflex when the bladder fills?

    <p>Tension in the bladder walls (D)</p> Signup and view all the answers

    What is the general role of reabsorption in the nephron?

    <p>To retain essential substances (C)</p> Signup and view all the answers

    Which of the following accurately describes the composition of the cell membrane?

    <p>A bilayer of lipids with embedded proteins and carbohydrates. (C)</p> Signup and view all the answers

    Which of the following substances can typically diffuse directly through the cell membrane?

    <p>Oxygen (A)</p> Signup and view all the answers

    What is the role of integral membrane proteins in transport?

    <p>Facilitating the movement of large molecules. (C)</p> Signup and view all the answers

    What is the primary difference between simple diffusion and facilitated diffusion?

    <p>Simple diffusion requires carrier proteins, while facilitated diffusion does not. (B)</p> Signup and view all the answers

    Which of the following is NOT a factor that affects diffusion through the cell membrane?

    <p>Presence of enzymes (D)</p> Signup and view all the answers

    What is the role of aquaporins in the cell membrane?

    <p>Facilitating the diffusion of water molecules. (B)</p> Signup and view all the answers

    How do ligand-gated channels differ from voltage-gated channels?

    <p>Ligand-gated channels are opened by chemicals binding to them, while voltage-gated channels are opened by electrical signals. (C)</p> Signup and view all the answers

    Which of the following is an example of active transport?

    <p>The movement of sodium ions from a low concentration to a high concentration. (C)</p> Signup and view all the answers

    What is the main function of the sodium-potassium pump?

    <p>To maintain a constant concentration of sodium and potassium ions inside the cell. (C)</p> Signup and view all the answers

    How does a concentration gradient influence diffusion?

    <p>The steeper the concentration gradient, the faster the rate of diffusion. (B)</p> Signup and view all the answers

    Which of the following is NOT a factor influencing transport across the cell membrane?

    <p>The pH of the solution. (D)</p> Signup and view all the answers

    What is meant by the term 'Vmax' in the context of facilitated diffusion?

    <p>The maximum rate at which the carrier protein can change states. (B)</p> Signup and view all the answers

    Which of the following statements about transport through the cell membrane is FALSE?

    <p>Simple diffusion is limited by the number of carrier proteins. (D)</p> Signup and view all the answers

    What is the key difference between pinocytosis and phagocytosis?

    <p>Pinocytosis involves the uptake of fluids, while phagocytosis involves the uptake of large particles. (D)</p> Signup and view all the answers

    What is the role of carbonic anhydrase inhibitors in the renal tubules?

    <p>Decrease bicarbonate reabsorption (A)</p> Signup and view all the answers

    Which medication serves as a potassium-sparing diuretic by antagonizing aldosterone?

    <p>Spironolactone (B)</p> Signup and view all the answers

    What characterizes acute kidney injury (AKI)?

    <p>Accumulation of nitrogen waste in blood (D)</p> Signup and view all the answers

    Which type of acute kidney injury is caused by obstruction in the urinary collection system?

    <p>Post-renal AKI (D)</p> Signup and view all the answers

    What leads to metabolic acidosis in patients taking carbonic anhydrase inhibitors?

    <p>Decreased bicarbonate reabsorption (A)</p> Signup and view all the answers

    What can chronic kidney disease (CKD) ultimately lead to?

    <p>Complete kidney failure (C)</p> Signup and view all the answers

    Which of the following causes can lead to intra-renal acute kidney injury?

    <p>Medications and ischemia (D)</p> Signup and view all the answers

    What is a significant cause of chronic kidney disease in patients?

    <p>Diabetes (B)</p> Signup and view all the answers

    What happens in the kidneys during the progression of chronic kidney disease (CKD)?

    <p>Compensatory changes causing further injury (D)</p> Signup and view all the answers

    Which of the following is NOT a symptom of acute kidney injury?

    <p>Excessive urine output (A)</p> Signup and view all the answers

    Which electrolyte imbalance can result from acute kidney injury?

    <p>Hyperkalemia (C)</p> Signup and view all the answers

    What is a primary risk factor for end-stage renal disease?

    <p>Hypertension (A)</p> Signup and view all the answers

    How does the renal medulla's oxygen environment affect its susceptibility to injury?

    <p>It is prone to ischemic injury (B)</p> Signup and view all the answers

    How does constriction of the afferent arterioles affect glomerular hydrostatic pressure?

    <p>It decreases glomerular hydrostatic pressure and GFR. (D)</p> Signup and view all the answers

    What primarily determines renal blood flow?

    <p>Pressure gradient across the renal vasculature and vascular resistance. (B)</p> Signup and view all the answers

    Which mechanism can lead to increased sodium chloride delivery to the distal tubule?

    <p>Tubuloglomerular feedback. (A)</p> Signup and view all the answers

    What is the role of nitric oxide in kidney function?

    <p>Is important for maintaining normal kidney function through vasodilation. (B)</p> Signup and view all the answers

    What is one of the primary pathways for tubular reabsorption?

    <p>Transcellular and paracellular pathways. (A)</p> Signup and view all the answers

    Which substance undergoes secondary active transport primarily in the proximal tubule?

    <p>Glucose. (C)</p> Signup and view all the answers

    What determines the permeability of water in the distal tubules and collecting ducts?

    <p>Antidiuretic hormone (ADH). (D)</p> Signup and view all the answers

    Which of the following is actively reabsorbed in the proximal tubule?

    <p>Sodium. (A)</p> Signup and view all the answers

    What effect does strong activation of the renal sympathetic nerves have on renal blood flow?

    <p>Decreases renal blood flow and GFR. (A)</p> Signup and view all the answers

    What is the primary function of active transport in tubular reabsorption?

    <p>To move solutes against an electrochemical gradient. (C)</p> Signup and view all the answers

    Which of the following substances is almost entirely excreted because it is not reabsorbed?

    <p>Creatinine. (A)</p> Signup and view all the answers

    What happens to glomerular hydrostatic pressure when angiotensin II constricts efferent arterioles?

    <p>It increases while renal blood flow decreases. (C)</p> Signup and view all the answers

    What is one effect of norepinephrine and epinephrine on renal blood flow?

    <p>They constrict afferent and efferent arterioles, reducing both GFR and renal blood flow. (D)</p> Signup and view all the answers

    What is the primary factor that determines the resting membrane potential of a nerve fiber?

    <p>The concentration of potassium ions inside the cell (B)</p> Signup and view all the answers

    During the depolarization stage of an action potential, what happens to the membrane potential?

    <p>It becomes more positive. (C)</p> Signup and view all the answers

    What is the role of voltage-gated sodium channels during the repolarization stage of an action potential?

    <p>They close, preventing further sodium influx. (C)</p> Signup and view all the answers

    What is the function of the myelin sheath in nerve fibers?

    <p>To increase the speed of nerve signal transmission. (B)</p> Signup and view all the answers

    What is the principle underlying the propagation of action potentials along a nerve fiber?

    <p>Local current flow from depolarized areas triggers depolarization in adjacent resting areas. (C)</p> Signup and view all the answers

    Which of the following statements is TRUE about the sodium-potassium pump?

    <p>It is responsible for maintaining the resting membrane potential. (D)</p> Signup and view all the answers

    What is the Nernst equation used to calculate?

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    What is the threshold potential that must be reached for an action potential to be triggered?

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    What is the term used to describe the jumping of depolarization from one node of Ranvier to the next in myelinated axons?

    <p>Saltatory conduction (A)</p> Signup and view all the answers

    Which of the following ions is NOT a major contributor to the resting membrane potential?

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    What is the primary function of the voltage-gated potassium channels during an action potential?

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    What is the 'all or nothing' principle of action potential propagation?

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    What is the Goldman equation used to calculate?

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    What happens to the membrane potential during the resting stage of an action potential?

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    During the repolarization stage of an action potential, why does the membrane potential return to its resting state?

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    What is the difference between primary and secondary active transport?

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    Which of the following is an example of secondary active transport?

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    Flashcards

    Homeostasis

    The body's ability to maintain a stable internal environment.

    Extracellular Fluid

    Fluid outside cells; rich in sodium, chloride, and nutrients.

    Intracellular Fluid

    Fluid inside cells; contains potassium, magnesium, and phosphate.

    Negative Feedback

    A control system that returns factors to normal when abnormal.

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    Positive Feedback

    A mechanism that amplifies an initial stimulus.

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    Control Systems

    Systems that regulate body functions, including genetic controls.

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    Nervous System

    Coordinates body responses; includes sensory input and motor output.

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    Immune System

    Protects body from foreign substances using white blood cells.

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    Osmosis

    Water movement across a selectively permeable membrane, influenced by osmotic pressure.

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    Osmotic Pressure

    The pressure required to stop osmosis; determined by particle concentration.

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    Primary Active Transport

    Transport method using ATP directly to move ions against their gradient.

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    Sodium-Potassium Pump

    A primary active transport mechanism that exchanges 3 Na+ out and 2 K+ in per ATP cycle.

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    Calcium Pumps

    Transport mechanisms that move calcium ions out of the cell or into storage like the sarcoplasmic reticulum.

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    Hydrogen Pumps

    Transport proteins important for acid-base balance in stomach and kidneys.

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    Secondary Active Transport

    Uses the energy from ionic gradients established by primary transport to move other substances.

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    Symport

    A type of secondary active transport where two substances move in the same direction into the cell.

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    Antiport

    A secondary active transport where one ion moves in while another moves out.

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    Membrane Potential

    The voltage difference across a membrane due to ion concentration differences.

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    Resting Membrane Potential

    The stable voltage across a membrane at rest, typically around -70 mV for nerve fibers.

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    Action Potential

    Rapid change in membrane potential that propagates nerve signals.

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    Depolarization

    Phase in action potential where the membrane becomes more positive due to sodium influx.

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    Myelin Sheath

    Insulating layer around the axon that speeds up nerve signal conduction.

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    Saltatory Conduction

    The process where action potentials jump between nodes of Ranvier, increasing transmission speed.

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    Cell Composition

    Cells are primarily composed of water and organic molecules.

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    Cell Membrane

    A lipid bilayer that regulates substance entry and exit.

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    Lipid Bilayer

    Two layers of lipids with hydrophilic heads and hydrophobic tails.

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    Integral Proteins

    Proteins that span the membrane, aiding in transport.

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    Peripheral Proteins

    Proteins that attach to one surface of the membrane.

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    Glycocalyx

    Carbohydrate layer on the cell surface, forms receptors.

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    Endoplasmic Reticulum (ER)

    Network of tubules for processing and transporting molecules.

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    Golgi Apparatus

    Packages and processes substances from the ER.

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    Lysosomes

    Organelles containing enzymes to digest waste and damaged structures.

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    Mitochondria

    Self-replicating organelles that produce ATP, the energy currency.

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    Active Transport

    Movement of substances against a gradient, requiring energy.

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    Facilitated Diffusion

    Requires a carrier protein to move substances across the membrane.

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    Diffusion

    Movement of molecules from high to low concentration.

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    Concentration Gradient

    Difference in concentration of ions inside vs outside the cell.

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    Protein Channels

    Selective pathways for specific molecules to cross the membrane.

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    Tonicity

    Effect of a solution on cell volume changes.

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    Isotonic solution

    Solution causing no cell volume change.

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    Hypotonic solution

    Solution that causes cell swelling due to water influx.

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    Hypertonic solution

    Solution that causes cell shrinking due to water efflux.

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    Cellular edema

    Swelling of cells due to excess water retention.

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    Extracellular edema

    Fluid accumulation outside cells, often due to blood vessel leakage.

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    Sodium's role in fluid distribution

    Sodium chloride influences fluid movement between ICF and ECF.

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    Chemical buffer systems

    Quickly respond to acidic changes in body pH.

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    Bicarbonate buffer system

    Combines CO2 and H2O to regulate pH via carbonic acid.

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    Respiratory system's role in pH

    Removes CO2 to help regulate extracellular pH quickly.

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    Kidneys' role in pH regulation

    Excrete acid or alkaline urine over hours to days.

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    Hyponatremia

    Low sodium in plasma causing rapid fluid shifts.

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    Compliance of interstitium

    Resistance of tissue spaces to fluid accumulation.

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    Edema causes

    Abnormal fluid accumulation due to several factors, including heart failure.

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    Bicarbonate Formation

    Bicarbonate combines with hydrogen to form carbonic acid, dissociating into CO2 and H2O.

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    Carbonic Anhydrase

    An enzyme that catalyzes the formation of carbonic acid from CO2 and H2O.

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    Respiratory Acidosis

    Acidosis caused by impaired CO2 elimination, often linked to respiratory conditions.

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    Respiratory Alkalosis

    Condition resulting from excessive ventilation, common at high altitude.

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    Metabolic Acidosis

    Acidosis not caused by increased CO2 levels, often due to bicarbonate loss.

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    Anion Gaps

    The difference between measured cations and anions in the blood to help diagnose acid-base disorders.

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    Gene Structure

    Genes are DNA segments located in the nucleus, composed of phosphoric acid, deoxyribose, and bases.

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    Transcription

    The process of copying the genetic code from DNA to RNA.

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    Translation

    The synthesis of proteins in the ribosome, where mRNA is read.

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    Cell Cycle

    The life cycle of a cell, including growth, DNA replication, and division.

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    Apoptosis

    Programmed cell death where cells shrink and are digested by neighbors.

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    Cancer Development

    Occurs from mutations or abnormal gene activation affecting cell growth.

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    Chromosomal Abnormalities

    Includes deletions, duplications, inversions, and translocations of genetic material.

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    Germline Mutations

    Mutations that can be passed to future generations, affecting offspring.

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    Somatic Cells

    Diploid cells containing 23 pairs of chromosomes, excluding gametes.

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    Fragile Sites

    Areas on chromosomes that show breaks or gaps, like in fragile X syndrome.

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    Down Syndrome

    Usually caused by trisomy 21; more common with older mothers.

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    Turner Syndrome

    A condition in females where only one X chromosome is present, totaling 45 chromosomes.

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    Klinefelter's Syndrome

    A condition in males with two X chromosomes and one Y chromosome (XXY).

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    Locus

    The specific location of a gene on a chromosome.

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    Allele

    Different forms of a gene that occupy the same locus.

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    Genotype

    The genetic composition at a specific locus.

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    Phenotype

    The observable characteristics resulting from genotype and environment interaction.

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    Dominant Gene

    An allele that masks the effects of other alleles in a heterozygous condition.

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    Recessive Gene

    An allele that is expressed only in homozygous form.

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    Autosomal Dominant

    Traits that appear in both sexes equally, with 50% transmission to offspring from affected parents.

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    X-linked Recessive

    Traits more common in males; affected fathers pass the trait to all daughters (who are carriers).

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    Penetrance

    The percentage of individuals with a specific genotype that exhibit the expected phenotype.

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    Incomplete Penetrance

    When individuals with a disease-causing allele do not show the disease phenotype.

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    Precision Medicine

    Medical treatment tailored to individual genetic and environmental factors.

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    DNA Methylation

    The addition of methyl groups to DNA, affecting gene regulation.

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    Histone Modification

    Chemical changes to histones that influence DNA packaging and gene access.

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    RNA-based Mechanisms

    Role of RNA in regulating gene expression and epigenetic changes.

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    Totipotency

    The ability of early embryo cells to become any somatic cell.

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    X-Chromosome Inactivation

    Random inactivation of one X chromosome in female cells during development.

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    Genomic Imprinting

    Non-Mendelian inheritance where one gene copy is silenced based on parent origin.

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    Prader-Willi Syndrome

    Disorder caused by a deletion on chromosome 15 from the father.

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    Angelman Syndrome

    Disorder caused by a deletion on chromosome 15 from the mother.

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    Beckwith-Wiedemann Syndrome

    Caused by inheriting two copies of chromosome 11 from the father.

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    Cognitive Development

    Influence of factors like prenatal alcohol on brain development and gene methylation.

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    Nutrition's Impact

    Nutritional deprivation in utero can affect health across generations.

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    Aging and Methylation

    Monozygotic twins show different methylation patterns as they age.

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    Epigenetic Treatments

    Potentially reversible epigenetic modifications for disease therapy.

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    Histone Deacetylase Inhibitors

    Drugs that reduce chromatin compaction, promising for cancer treatment.

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    MicroRNA-based Drugs

    Emerging treatments targeting specific genes altered in cancer.

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    Microcirculation

    The circulation of blood through the smallest blood vessels including capillaries.

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    Capillary Structure

    Capillaries have thin walls (0.5 micrometers) to facilitate rapid diffusion.

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    Precapillary Sphincters

    Muscular rings that regulate blood flow into capillaries.

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    Starling Forces

    Forces determining fluid movement across capillary membranes: capillary pressure and osmotic pressures.

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    Net Filtration Pressure

    The difference between forces pushing fluid out and those pulling it in; determines direction of fluid movement.

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    Lymphatic System

    Accessory route for fluid drainage from interstitial spaces to blood; helps with fluid balance.

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    Interstitial Fluid

    Fluid found in the spaces between cells, containing nutrients and waste products.

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    Fluid Filtration and Reabsorption

    Fluid is filtered out at the arterial end of capillaries and reabsorbed at the venous end.

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    Hydrostatic Pressure

    Pressure exerted by a liquid at rest, which can push fluids out of capillaries.

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    Oxygen's Role in Circulation

    Oxygen concentration regulates blood vessel diameter and flow.

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    Capillary Permeability Variation

    Capillary clefts vary by organ; some are tight (brain), wide (liver), or fenestrated (kidneys).

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    Daily Water Intake

    The average daily intake of water is about 2100 ml plus 200 ml from metabolism.

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    Body Fluid Compartments

    Fluids are divided into intracellular (ICF) and extracellular (ECF) compartments, balancing fluid distribution.

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    Fluid Loss Methods

    Water loss occurs through evaporation, diffusion, sweat, and urine; need to balance with intake.

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    Lymph Flow Regulation

    Factors like interstitial fluid pressure increase lymphatic drainage from tissues.

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    Renal Cortex and Medulla

    The two main regions of the kidney; cortex is outer, medulla is inner.

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    Renal Pyramids

    8-10 triangular structures in the renal medulla that end in papillae.

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    Calyces

    Structures that collect urine from papillae and form the renal pelvis.

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    Urinary Bladder

    The organ that stores urine before excretion; has body and neck.

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    Micturition Reflex

    The reflex initiated by bladder tension that leads to urination.

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    Detrusor Muscle

    Muscle in the bladder wall that contracts to expel urine.

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    Nephrons

    Functional units of the kidney; each kidney has 800k to 1 million.

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    Glomerulus

    A cluster of capillaries for blood filtration in each nephron.

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    Tubular Reabsorption

    Process of reabsorbing water and solutes back into the blood from tubules.

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    Glomerular Filtration Rate (GFR)

    Rate at which blood is filtered through the kidneys, approx. 180L daily.

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    Filtration Barrier

    Structure formed by capillary membranes that selectively filters blood.

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    Urine Flow

    The movement of urine from the kidneys through the ureters to the bladder.

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    Efferent Arterioles

    Blood vessels that carry blood away from the glomerulus to peritubular capillaries.

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    Peristaltic Contraction

    Involuntary muscle contractions that move urine towards the bladder via the ureters.

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    Secretion

    Process where substances are moved from blood into the nephron tubules.

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    Chronic Kidney Disease (CKD) Complications

    CKD can lead to excess sodium, water retention, hyperkalemia, and metabolic acidosis.

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    Nephrotic Syndrome

    A condition marked by proteinuria, edema, and decreased oncotic pressure due to glomerular damage.

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    Acute Glomerulonephritis

    Abrupt onset of hematuria and proteinuria with decreased GFR, causing salt and water retention.

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    Renal Stones Symptoms

    Flank pain, possible hematuria, occurring when stones move to the ureter.

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    Anemia in CKD

    Decreased erythropoietin production leads to low red blood cell counts in CKD patients.

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    Intercalated Cells

    Cells in the kidney that regulate acid-base balance by secreting hydrogen or bicarbonate ions.

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    Type A Cells

    A subtype of intercalated cells that secrete hydrogen ions to decrease acidity.

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    Type B Cells

    A subtype of intercalated cells that secrete bicarbonate to increase blood pH.

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    Aldosterone

    A hormone that increases sodium and water retention while promoting potassium and hydrogen secretion.

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    Angiotensin II

    A hormone that promotes sodium and fluid retention, enhancing renal reabsorption of sodium.

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    ADH (Vasopressin)

    A hormone that increases water permeability in the kidneys, reducing urine output when needed.

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    Natriuretic Peptide (ANP)

    A hormone that inhibits sodium and water reabsorption, promoting diuresis.

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    Tubuloglomerular Balance

    The process where increased tubular load enhances reabsorption rates in the kidneys.

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    Inulin

    A substance used to measure glomerular filtration rate (GFR) as it is neither reabsorbed nor secreted.

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    Renal Clearance

    The volume of plasma cleared of a substance by the kidneys per unit time.

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    Countercurrent Multiplier

    A mechanism in the loops of Henle that establishes a concentration gradient for water reabsorption.

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    Urea's Role in Osmolarity

    Urea contributes significantly to the osmolarity of renal medullary interstitium, helping reabsorb water.

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    Vasa Recta

    Blood vessels surrounding the loops of Henle that act as countercurrent exchangers to maintain medullary osmolarity.

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    Osmolarity Changes in Nephrons

    Osmolarity varies in different nephron segments, influenced by solute and water reabsorption.

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    Sodium Regulation

    Sodium concentration is maintained between 104-145 mEq/L, impacting fluid balance in the body.

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    Glomerular Hydrostatic Pressure

    The pressure within the glomerulus that drives filtration in the kidneys.

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    Afferent Arteriolar Resistance

    Resistance in the blood vessels supplying the glomerulus, affecting GFR.

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    Efferent Arteriolar Resistance

    Resistance in blood vessels leaving the glomerulus, influencing renal blood flow.

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    Renal Blood Flow

    The volume of blood delivered to the kidneys per unit time.

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    Sympathetic Nervous System Effects

    Activation constricts renal arterioles, reducing blood flow and GFR.

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    Hormonal Control of GFR

    Norepinephrine and angiotensin II constrict arterioles to reduce GFR.

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    Autoregulation in Kidneys

    Kidneys maintain consistent GFR despite blood pressure changes.

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    Tubuloglomerular Feedback

    Mechanism linking sodium chloride concentration with kidney blood flow adjustment.

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    Active Transport in Reabsorption

    Energy-requiring process to move substances against their concentration gradient.

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    Reabsorption Locations

    Specific sections of the nephron where reabsorption occurs.

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    Transport Maximum

    The saturation limit for reabsorption of certain substances.

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    Tubular Secretion

    Active process of substances being secreted into the renal tubules.

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    Urea Reabsorption

    Process of reabsorbing only half of the filtered urea in the kidneys.

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    Renal Tubule

    Reclaims salts and water after filtration.

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    Renin-Angiotensin-Aldosterone System (RAAS)

    Regulates blood pressure via sodium and water balance.

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    Osmotic Diuresis

    Increased urine production due to high solute concentration.

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    Loop Diuretics

    Medications that block reabsorption in the loop of Henle.

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    Thiazide Diuretics

    Block sodium-chloride reabsorption in early distal tubules.

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    Acid-Base Homeostasis

    The kidneys manage body pH by excreting or reabsorbing acids and bases.

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    Erythropoietin

    Hormone produced by the kidneys that stimulates red blood cell production.

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    Calcium Regulation

    Managed primarily in the distal collecting duct under hormonal influence.

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    Vasopressin

    Hormone that promotes water reabsorption in the kidneys.

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    Carbonic Anhydrase Inhibitors

    Medications that inhibit carbonic anhydrase, reducing bicarbonate reabsorption in kidneys.

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    Spironolactone

    A potassium-sparing diuretic that antagonizes aldosterone, reducing sodium reabsorption.

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    Sodium Channel Blockers

    Agents like amiloride that inhibit sodium reabsorption in the kidneys.

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    Acute Kidney Injury (AKI)

    A rapid loss of kidney function characterized by high serum creatinine and low urine output.

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    Chronic Kidney Disease (CKD)

    A progressive, irreversible loss of nephron function, often caused by diabetes or hypertension.

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    Types of AKI

    AKI can be pre-renal (blood supply), intra-renal (kidney damage), or post-renal (urinary obstruction).

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    Effects of AKI

    Leads to water retention, harmful waste buildup, and symptoms like edema and hypertension.

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    Progression of CKD

    Initial damage leads to adaptations in nephrons that may worsen over time, risking further loss.

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    Kidney Failure Symptoms

    Symptoms include fatigue, malaise, hypertension, and uremic symptoms due to waste buildup.

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    Glomerular Diseases

    Disorders categorized by symptoms like proteinuria and hematuria, indicating glomerular damage.

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    Renal Medulla Susceptibility

    Region of the kidney prone to ischemic injury due to low oxygen levels.

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    Kidneys' Functions

    Kidneys filter blood, maintain fluid balance, regulate electrolytes, and excrete waste products.

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    Retaining Sodium in Tubules

    Sodium retention in kidneys occurs when sodium reabsorption is decreased, affecting fluid balance.

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    Diabetes as a CKD Cause

    Diabetes is a leading cause of chronic kidney disease due to its impact on blood vessels and nephrons.

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    Thirst Center

    Located in the anterior ventral wall of the third ventricle; stimulated by high osmolarity, low volume, and angiotensin II.

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    ADH Synthesis

    ADH is synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and stored in the posterior pituitary.

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    ADH Release Triggers

    Released due to increased osmolarity, decreased blood pressure, or blood volume.

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    Thirst Mechanism

    Stimulated by increased osmolarity, decreased volume, and angiotensin II; the threshold for drinking is about 2 mOsm/L above normal.

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    Obligatory Urine Volume

    The minimum amount of water the kidneys must excrete to remove excess solutes, determined by kidney concentrating ability.

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    Potassium Regulation

    Potassium levels around 4.2 mEq/L are tightly controlled; kidneys excrete 90-95%.

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    Influences on Potassium Secretion

    Secretion is influenced by extracellular potassium, aldosterone, and tubular flow rate.

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    Phosphate Excretion

    Primarily controlled by an overflow mechanism; parathyroid hormone promotes phosphate excretion.

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    Fluid Volume Regulation

    Water and salt balance maintained mainly by the kidneys through filtration and reabsorption.

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    Aldosterone Function

    Increases sodium reabsorption and potassium secretion in kidneys.

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    ADH Role in Urine

    ADH enables the kidneys to create concentrated urine while excreting normal sodium levels.

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    Congestive Heart Failure Effects

    Can increase blood volume and extracellular fluid volume due to sodium retention.

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    Natriuresis

    The excretion of sodium in urine, often increased by atrial natriuretic peptide (ANP).

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    Study Notes

    Renal Anatomy and Function

    • Kidneys are retroperitoneal organs receiving 20% of cardiac output.
    • Nephrons are the functional units, comprising glomerulus and renal tubule.
    • Each kidney contains approximately one million nephrons.
    • Glomerulus filters blood; renal tubule reabsorbs substances.
    • Normal adult kidney filters 100-120mL/minute.
    • Glomerulus is a capillary tuft with afferent and efferent arterioles.

    Glomerular Filtration

    • Glomerular capillary endothelium is fenestrated; negatively charged glycoproteins prevent large proteins (like albumin) from passing.
    • Podocytes (epithelial cells) with foot processes line the basement membrane.

    Reabsorption and Secretion

    • Reabsorption along renal tubules is extensive and selective, varying by substance and location. (e.g., 60-70% sodium)
    • Substances like creatinine, histamine, drugs, and toxins are secreted into tubular fluid.

    Urine Concentration

    • Kidneys can generate urine with osmolarity varying from 50 to 1200-1400 mOsm/L.
    • The countercurrent multiplier mechanism in the loop of Henle concentrates urine.
    • Water permeability in the collecting ducts is regulated by antidiuretic hormone (ADH).
    • Sodium is reabsorbed under aldosterone control.

    Blood Pressure Regulation

    • Kidneys regulate blood pressure through sodium and water balance.
    • Macula densa senses sodium, and juxtaglomerular complex senses blood pressure.
    • Low sodium/perfusion triggers renin release, leading to angiotensin II production.
    • Angiotensin II raises blood pressure by vasoconstriction and stimulating aldosterone/sodium and water retention.
    • Vasopressin (ADH) increases water reabsorption in the collecting duct.

    Renin-Angiotensin-Aldosterone System (RAAS)

    • RAAS activation is triggered by reduced effective circulating volume.
    • Conditions like edema or reduced oncotic pressure can activate RAAS.
    • Vascular diseases like atherosclerosis can impair blood flow, triggering renin release and hypertension.

    Acid-Base Balance

    • Kidneys play a crucial role in acid-base homeostasis, secreting extra hydrogen to restore bicarbonate levels.
    • Excretion occurs in the distal collecting duct where hydrogen combines with ammonia to form ammonium (NH4+) and is excreted.

    Electrolyte Balance

    • Calcium regulation primarily occurs in distal collecting duct.
    • Aldosterone controls extracellular potassium levels.
    • Hyperkalemia arises from shifts, extrarenal/renal losses.

    Hormone Production and Regulation

    • Kidneys convert vitamin D to its active form, affecting calcium absorption.
    • Kidneys are the target site for parathyroid hormone and regulate calcium/phosphate balance.
    • Kidneys produce erythropoietin, stimulating red blood cell production.

    Glomerular Filtration Rate (GFR) Regulation

    • Kidneys regulate GFR in response to solute concentration in the distal renal tubule (tubuloglomerular feedback).
    • High sodium concentration triggers afferent arteriole vasoconstriction, decreasing GFR.
    • Kidneys adjust cortical/medullary blood flow to maintain GFR and prevent anoxic injury.

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    Description

    Test your knowledge on the key characteristics of extracellular fluid, the organ systems involved in homeostasis, and the mechanisms that regulate body functions. This quiz covers topics such as feedback mechanisms, the immune system's role, diffusion, the endocrine system, and buffer systems.

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