Podcast
Questions and Answers
Which of the following is NOT a key characteristic of extracellular fluid?
Which of the following is NOT a key characteristic of extracellular fluid?
Which organ system is primarily responsible for detecting body states and surroundings, and generating thoughts and reactions?
Which organ system is primarily responsible for detecting body states and surroundings, and generating thoughts and reactions?
What is the primary mechanism used by most control systems in the body to maintain homeostasis?
What is the primary mechanism used by most control systems in the body to maintain homeostasis?
Which of the following is an example of a positive feedback mechanism?
Which of the following is an example of a positive feedback mechanism?
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What is the main role of the immune system in maintaining homeostasis?
What is the main role of the immune system in maintaining homeostasis?
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How does efficient diffusion of substances occur between capillaries and cells?
How does efficient diffusion of substances occur between capillaries and cells?
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Which of these is NOT a factor regulated by control systems in the human body?
Which of these is NOT a factor regulated by control systems in the human body?
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Which of the following is an example of how the endocrine system contributes to homeostasis?
Which of the following is an example of how the endocrine system contributes to homeostasis?
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What is the primary function of the bicarbonate buffer system?
What is the primary function of the bicarbonate buffer system?
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Which of the following is NOT a key factor contributing to edema?
Which of the following is NOT a key factor contributing to edema?
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What is the role of carbonic anhydrase in the bicarbonate buffer system?
What is the role of carbonic anhydrase in the bicarbonate buffer system?
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Which of the following is TRUE about the pH scale?
Which of the following is TRUE about the pH scale?
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Which of the following systems is responsible for the most rapid regulation of blood pH?
Which of the following systems is responsible for the most rapid regulation of blood pH?
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When the blood is becoming too acidic (acidosis), what does the respiratory system do to help regulate pH?
When the blood is becoming too acidic (acidosis), what does the respiratory system do to help regulate pH?
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Which of the following is NOT a mechanism by which the kidneys regulate blood pH?
Which of the following is NOT a mechanism by which the kidneys regulate blood pH?
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What is the primary function of the lymphatic system in relation to edema?
What is the primary function of the lymphatic system in relation to edema?
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Which of the following conditions can cause intracellular edema?
Which of the following conditions can cause intracellular edema?
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How does heart failure contribute to edema?
How does heart failure contribute to edema?
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Why does a slow development of hyponatremia typically reduce the severity of brain cell edema?
Why does a slow development of hyponatremia typically reduce the severity of brain cell edema?
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What is the main reason why low compliance of the interstitium helps prevent edema?
What is the main reason why low compliance of the interstitium helps prevent edema?
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What is the effect of adding hypertonic saline to the extracellular fluid?
What is the effect of adding hypertonic saline to the extracellular fluid?
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Which of these is NOT a direct consequence of reduced plasma protein levels in relation to edema?
Which of these is NOT a direct consequence of reduced plasma protein levels in relation to edema?
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What would happen if the lymphatic vessels that drain spaces between tissues become blocked?
What would happen if the lymphatic vessels that drain spaces between tissues become blocked?
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What is the role of proteins in maintaining blood pH?
What is the role of proteins in maintaining blood pH?
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What is the primary mechanism by which CO2 is transported from cells to the lungs?
What is the primary mechanism by which CO2 is transported from cells to the lungs?
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What is the primary role of carbonic anhydrase in the body?
What is the primary role of carbonic anhydrase in the body?
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Which of the following conditions is characterized by excessive ventilation, leading to a decrease in blood CO2 levels?
Which of the following conditions is characterized by excessive ventilation, leading to a decrease in blood CO2 levels?
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Which of the following conditions is often associated with loss of sodium bicarbonate in feces?
Which of the following conditions is often associated with loss of sodium bicarbonate in feces?
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What is the primary function of DNA in the cell?
What is the primary function of DNA in the cell?
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Which of the following is NOT a nitrogenous base found in DNA?
Which of the following is NOT a nitrogenous base found in DNA?
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What is the process of transferring genetic information from DNA to RNA called?
What is the process of transferring genetic information from DNA to RNA called?
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What is the primary function of ribosomes in the cell?
What is the primary function of ribosomes in the cell?
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Which of the following is NOT involved in the regulation of gene expression?
Which of the following is NOT involved in the regulation of gene expression?
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What is the primary role of the rough endoplasmic reticulum (ER) in protein synthesis?
What is the primary role of the rough endoplasmic reticulum (ER) in protein synthesis?
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What is apoptosis?
What is apoptosis?
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What is the main difference between apoptosis and necrosis?
What is the main difference between apoptosis and necrosis?
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Which of the following is NOT a factor that can increase the probability of mutation?
Which of the following is NOT a factor that can increase the probability of mutation?
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What is the significance of the 23rd pair of chromosomes?
What is the significance of the 23rd pair of chromosomes?
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What is aneuploidy?
What is aneuploidy?
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What is a translocation?
What is a translocation?
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What is the main function of the vasa recta in the process of urine concentration?
What is the main function of the vasa recta in the process of urine concentration?
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Which of the following contributes to the hyperosmolarity of the renal medulla?
Which of the following contributes to the hyperosmolarity of the renal medulla?
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How does antidiuretic hormone (ADH) influence the formation of concentrated urine?
How does antidiuretic hormone (ADH) influence the formation of concentrated urine?
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Which of the following correctly describes the osmolarity changes along the nephron?
Which of the following correctly describes the osmolarity changes along the nephron?
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Which of the following is NOT correctly paired with its effect on urine concentration?
Which of the following is NOT correctly paired with its effect on urine concentration?
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Which of the following describes the role of intercalated cells in acid-base regulation?
Which of the following describes the role of intercalated cells in acid-base regulation?
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Which of the following is a key feature of the countercurrent multiplier mechanism?
Which of the following is a key feature of the countercurrent multiplier mechanism?
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How does urea contribute to the formation of concentrated urine?
How does urea contribute to the formation of concentrated urine?
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What would happen if the kidneys were unable to concentrate urine?
What would happen if the kidneys were unable to concentrate urine?
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In what way are the osmoreceptor system and thirst mechanism linked to the regulation of urine concentration?
In what way are the osmoreceptor system and thirst mechanism linked to the regulation of urine concentration?
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Which of the following is NOT a factor that can affect tubular reabsorption?
Which of the following is NOT a factor that can affect tubular reabsorption?
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Which of the following is a consequence of increased ADH secretion?
Which of the following is a consequence of increased ADH secretion?
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What is the primary function of inulin in renal function studies?
What is the primary function of inulin in renal function studies?
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Which of the following is a potential consequence of prolonged dehydration?
Which of the following is a potential consequence of prolonged dehydration?
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How does the countercurrent mechanism in the loops of Henle contribute to urine concentration?
How does the countercurrent mechanism in the loops of Henle contribute to urine concentration?
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What is a common recommendation for sodium intake in patients with chronic kidney disease (CKD)?
What is a common recommendation for sodium intake in patients with chronic kidney disease (CKD)?
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What characterizes nephrotic syndrome?
What characterizes nephrotic syndrome?
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What condition is characterized by the abrupt onset of hematuria and proteinuria with reduced GFR?
What condition is characterized by the abrupt onset of hematuria and proteinuria with reduced GFR?
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During which condition do patients typically present with flank pain and microscopic hematuria?
During which condition do patients typically present with flank pain and microscopic hematuria?
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What primarily contributes to anemia in chronic kidney disease patients?
What primarily contributes to anemia in chronic kidney disease patients?
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What is the primary role of DNA methylation in gene regulation?
What is the primary role of DNA methylation in gene regulation?
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How do histone modifications influence gene expression?
How do histone modifications influence gene expression?
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Which process allows early embryo cells to potentially develop into any somatic cell?
Which process allows early embryo cells to potentially develop into any somatic cell?
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What is an example of a disorder resulting from genomic imprinting?
What is an example of a disorder resulting from genomic imprinting?
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How does exposure to ethanol in utero affect cognitive development?
How does exposure to ethanol in utero affect cognitive development?
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What mechanism allows the kidneys to help regulate blood pressure?
What mechanism allows the kidneys to help regulate blood pressure?
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What does the secretion of erythropoietin from the kidneys stimulate?
What does the secretion of erythropoietin from the kidneys stimulate?
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Which abnormality can result from genomic imprinting on chromosome 11?
Which abnormality can result from genomic imprinting on chromosome 11?
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What is the potential effect of DNA demethylating agents in cancer treatment?
What is the potential effect of DNA demethylating agents in cancer treatment?
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What impact does nutritional deprivation in utero have on subsequent generations?
What impact does nutritional deprivation in utero have on subsequent generations?
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What is a consequence of monozygotic twins aging under different lifestyles?
What is a consequence of monozygotic twins aging under different lifestyles?
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How do histone deacetylase inhibitors (HDAC) affect chromatin structure?
How do histone deacetylase inhibitors (HDAC) affect chromatin structure?
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What is the genetic conflict hypothesis in relation to imprinting?
What is the genetic conflict hypothesis in relation to imprinting?
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What role does protamine play in sperm biology?
What role does protamine play in sperm biology?
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What stimulates the thirst center in the anterior ventral wall of the third ventricle?
What stimulates the thirst center in the anterior ventral wall of the third ventricle?
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Where is ADH synthesized in the body?
Where is ADH synthesized in the body?
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What effect does aldosterone have on potassium levels in the body?
What effect does aldosterone have on potassium levels in the body?
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What is the primary route for calcium reabsorption in the kidneys?
What is the primary route for calcium reabsorption in the kidneys?
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What happens to urine volume when blood volume and pressure decrease?
What happens to urine volume when blood volume and pressure decrease?
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What condition can occur due to the failure of both ADH and thirst mechanisms?
What condition can occur due to the failure of both ADH and thirst mechanisms?
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Which factor is most influential in potassium secretion?
Which factor is most influential in potassium secretion?
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How does angiotensin II affect sodium excretion?
How does angiotensin II affect sodium excretion?
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What is the primary influence on the release of antidiuretic hormone (ADH)?
What is the primary influence on the release of antidiuretic hormone (ADH)?
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What is a common consequence of congestive heart failure in terms of fluid regulation?
What is a common consequence of congestive heart failure in terms of fluid regulation?
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What typically causes Down syndrome?
What typically causes Down syndrome?
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Which hormone increases sodium reabsorption in the kidneys?
Which hormone increases sodium reabsorption in the kidneys?
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How do kidneys adapt to changes in sodium and water intake?
How do kidneys adapt to changes in sodium and water intake?
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Which of the following describes a recessive gene?
Which of the following describes a recessive gene?
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What role does parathyroid hormone play in phosphate regulation?
What role does parathyroid hormone play in phosphate regulation?
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What is the definition of penetrance in genetics?
What is the definition of penetrance in genetics?
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Which inheritance pattern is characterized by affected individuals transmitting the trait to approximately 50% of their children?
Which inheritance pattern is characterized by affected individuals transmitting the trait to approximately 50% of their children?
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Which of the following is an example of a multifactorial disease?
Which of the following is an example of a multifactorial disease?
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What is an example of a trait influenced by X-linked recessive inheritance?
What is an example of a trait influenced by X-linked recessive inheritance?
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Which genetic condition involves females having only one X chromosome?
Which genetic condition involves females having only one X chromosome?
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Which term refers to a gene's specific location on a chromosome?
Which term refers to a gene's specific location on a chromosome?
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What percentage of individuals with a disease-causing allele may not exhibit the disease phenotype, illustrating incomplete penetrance?
What percentage of individuals with a disease-causing allele may not exhibit the disease phenotype, illustrating incomplete penetrance?
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Which of the following statements about Alzheimer's Disease is correct?
Which of the following statements about Alzheimer's Disease is correct?
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What does precision medicine emphasize in medical treatment?
What does precision medicine emphasize in medical treatment?
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Which of these factors is NOT considered a risk factor for hypertension?
Which of these factors is NOT considered a risk factor for hypertension?
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Which type of study is primarily used to assess the contribution of genetics versus environment by comparing identical and fraternal twins?
Which type of study is primarily used to assess the contribution of genetics versus environment by comparing identical and fraternal twins?
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Which environmental factor is associated with a higher risk of developing certain cancers?
Which environmental factor is associated with a higher risk of developing certain cancers?
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What is the approximate diameter of arterioles?
What is the approximate diameter of arterioles?
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Which type of capillary has tight junctions allowing only small molecules to pass?
Which type of capillary has tight junctions allowing only small molecules to pass?
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What is the primary method of transferring substances between plasma and interstitial fluid?
What is the primary method of transferring substances between plasma and interstitial fluid?
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Which of the following forces tends to force fluid outward from capillaries?
Which of the following forces tends to force fluid outward from capillaries?
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What is the approximate volume of interstitial fluid in the body?
What is the approximate volume of interstitial fluid in the body?
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What is the net filtration pressure under normal conditions?
What is the net filtration pressure under normal conditions?
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Where does the lymphatic system drain excess fluid from?
Where does the lymphatic system drain excess fluid from?
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What is the approximate daily volume of lymph fluid returned to the blood?
What is the approximate daily volume of lymph fluid returned to the blood?
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Which of the following is NOT a factor that increases lymph flow?
Which of the following is NOT a factor that increases lymph flow?
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What is the primary function of the nephron in the kidney?
What is the primary function of the nephron in the kidney?
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What is the approximate daily water intake for an average person?
What is the approximate daily water intake for an average person?
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Which of the following is NOT a significant route of water loss from the body?
Which of the following is NOT a significant route of water loss from the body?
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How does the glomerulus prevent plasma proteins like albumin from passing through?
How does the glomerulus prevent plasma proteins like albumin from passing through?
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What is the approximate volume of intracellular fluid (ICF) in the body?
What is the approximate volume of intracellular fluid (ICF) in the body?
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What triggers the release of renin from the kidneys?
What triggers the release of renin from the kidneys?
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Which of the following electrolytes is found in higher concentrations in ICF than in ECF?
Which of the following electrolytes is found in higher concentrations in ICF than in ECF?
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What is the function of vasopressin in the kidney?
What is the function of vasopressin in the kidney?
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Which type of diuretic primarily acts on the thick ascending limb of the loop of Henle?
Which type of diuretic primarily acts on the thick ascending limb of the loop of Henle?
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What is the primary function of the cell membrane in relation to fluid compartments?
What is the primary function of the cell membrane in relation to fluid compartments?
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In what way do thiazide diuretics differ from loop diuretics?
In what way do thiazide diuretics differ from loop diuretics?
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Which of the following is NOT a primary cause of edema?
Which of the following is NOT a primary cause of edema?
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What is the total daily volume of fluid filtered from the glomerular capillaries into Bowman's capsule?
What is the total daily volume of fluid filtered from the glomerular capillaries into Bowman's capsule?
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What substance is secreted into the tubular fluid as part of reabsorption and secretion?
What substance is secreted into the tubular fluid as part of reabsorption and secretion?
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How do the kidneys contribute to acid-base homeostasis?
How do the kidneys contribute to acid-base homeostasis?
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Which part of the nephron is involved in the filtration of blood?
Which part of the nephron is involved in the filtration of blood?
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What primarily determines the glomerular filtration rate (GFR)?
What primarily determines the glomerular filtration rate (GFR)?
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What is the primary action of aldosterone in the kidneys?
What is the primary action of aldosterone in the kidneys?
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What happens when hydrostatic pressure increases in Bowman's capsule?
What happens when hydrostatic pressure increases in Bowman's capsule?
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Which mechanism contributes to urine concentration in the loop of Henle?
Which mechanism contributes to urine concentration in the loop of Henle?
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What occurs as a result of excessive solutes in the renal tubules during osmotic diuresis?
What occurs as a result of excessive solutes in the renal tubules during osmotic diuresis?
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What characterizes juxtamedullary nephrons compared to cortical nephrons?
What characterizes juxtamedullary nephrons compared to cortical nephrons?
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Which type of muscle is the detrusor muscle in the bladder wall?
Which type of muscle is the detrusor muscle in the bladder wall?
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Which part of the kidney is primarily responsible for calcium regulation?
Which part of the kidney is primarily responsible for calcium regulation?
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What role do the internal and external sphincters play in micturition?
What role do the internal and external sphincters play in micturition?
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How does sympathetic stimulation affect urine movement in the ureters?
How does sympathetic stimulation affect urine movement in the ureters?
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What is one key mechanism for urine excretion that involves the kidneys?
What is one key mechanism for urine excretion that involves the kidneys?
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What type of substances are completely reabsorbed in the nephron?
What type of substances are completely reabsorbed in the nephron?
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Which of the following statements is TRUE regarding solute handling in the kidneys?
Which of the following statements is TRUE regarding solute handling in the kidneys?
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What initiates the micturition reflex when the bladder fills?
What initiates the micturition reflex when the bladder fills?
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What is the general role of reabsorption in the nephron?
What is the general role of reabsorption in the nephron?
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Which of the following accurately describes the composition of the cell membrane?
Which of the following accurately describes the composition of the cell membrane?
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Which of the following substances can typically diffuse directly through the cell membrane?
Which of the following substances can typically diffuse directly through the cell membrane?
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What is the role of integral membrane proteins in transport?
What is the role of integral membrane proteins in transport?
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What is the primary difference between simple diffusion and facilitated diffusion?
What is the primary difference between simple diffusion and facilitated diffusion?
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Which of the following is NOT a factor that affects diffusion through the cell membrane?
Which of the following is NOT a factor that affects diffusion through the cell membrane?
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What is the role of aquaporins in the cell membrane?
What is the role of aquaporins in the cell membrane?
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How do ligand-gated channels differ from voltage-gated channels?
How do ligand-gated channels differ from voltage-gated channels?
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Which of the following is an example of active transport?
Which of the following is an example of active transport?
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What is the main function of the sodium-potassium pump?
What is the main function of the sodium-potassium pump?
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How does a concentration gradient influence diffusion?
How does a concentration gradient influence diffusion?
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Which of the following is NOT a factor influencing transport across the cell membrane?
Which of the following is NOT a factor influencing transport across the cell membrane?
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What is meant by the term 'Vmax' in the context of facilitated diffusion?
What is meant by the term 'Vmax' in the context of facilitated diffusion?
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Which of the following statements about transport through the cell membrane is FALSE?
Which of the following statements about transport through the cell membrane is FALSE?
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What is the key difference between pinocytosis and phagocytosis?
What is the key difference between pinocytosis and phagocytosis?
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What is the role of carbonic anhydrase inhibitors in the renal tubules?
What is the role of carbonic anhydrase inhibitors in the renal tubules?
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Which medication serves as a potassium-sparing diuretic by antagonizing aldosterone?
Which medication serves as a potassium-sparing diuretic by antagonizing aldosterone?
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What characterizes acute kidney injury (AKI)?
What characterizes acute kidney injury (AKI)?
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Which type of acute kidney injury is caused by obstruction in the urinary collection system?
Which type of acute kidney injury is caused by obstruction in the urinary collection system?
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What leads to metabolic acidosis in patients taking carbonic anhydrase inhibitors?
What leads to metabolic acidosis in patients taking carbonic anhydrase inhibitors?
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What can chronic kidney disease (CKD) ultimately lead to?
What can chronic kidney disease (CKD) ultimately lead to?
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Which of the following causes can lead to intra-renal acute kidney injury?
Which of the following causes can lead to intra-renal acute kidney injury?
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What is a significant cause of chronic kidney disease in patients?
What is a significant cause of chronic kidney disease in patients?
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What happens in the kidneys during the progression of chronic kidney disease (CKD)?
What happens in the kidneys during the progression of chronic kidney disease (CKD)?
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Which of the following is NOT a symptom of acute kidney injury?
Which of the following is NOT a symptom of acute kidney injury?
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Which electrolyte imbalance can result from acute kidney injury?
Which electrolyte imbalance can result from acute kidney injury?
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What is a primary risk factor for end-stage renal disease?
What is a primary risk factor for end-stage renal disease?
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How does the renal medulla's oxygen environment affect its susceptibility to injury?
How does the renal medulla's oxygen environment affect its susceptibility to injury?
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How does constriction of the afferent arterioles affect glomerular hydrostatic pressure?
How does constriction of the afferent arterioles affect glomerular hydrostatic pressure?
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What primarily determines renal blood flow?
What primarily determines renal blood flow?
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Which mechanism can lead to increased sodium chloride delivery to the distal tubule?
Which mechanism can lead to increased sodium chloride delivery to the distal tubule?
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What is the role of nitric oxide in kidney function?
What is the role of nitric oxide in kidney function?
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What is one of the primary pathways for tubular reabsorption?
What is one of the primary pathways for tubular reabsorption?
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Which substance undergoes secondary active transport primarily in the proximal tubule?
Which substance undergoes secondary active transport primarily in the proximal tubule?
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What determines the permeability of water in the distal tubules and collecting ducts?
What determines the permeability of water in the distal tubules and collecting ducts?
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Which of the following is actively reabsorbed in the proximal tubule?
Which of the following is actively reabsorbed in the proximal tubule?
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What effect does strong activation of the renal sympathetic nerves have on renal blood flow?
What effect does strong activation of the renal sympathetic nerves have on renal blood flow?
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What is the primary function of active transport in tubular reabsorption?
What is the primary function of active transport in tubular reabsorption?
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Which of the following substances is almost entirely excreted because it is not reabsorbed?
Which of the following substances is almost entirely excreted because it is not reabsorbed?
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What happens to glomerular hydrostatic pressure when angiotensin II constricts efferent arterioles?
What happens to glomerular hydrostatic pressure when angiotensin II constricts efferent arterioles?
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What is one effect of norepinephrine and epinephrine on renal blood flow?
What is one effect of norepinephrine and epinephrine on renal blood flow?
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What is the primary factor that determines the resting membrane potential of a nerve fiber?
What is the primary factor that determines the resting membrane potential of a nerve fiber?
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During the depolarization stage of an action potential, what happens to the membrane potential?
During the depolarization stage of an action potential, what happens to the membrane potential?
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What is the role of voltage-gated sodium channels during the repolarization stage of an action potential?
What is the role of voltage-gated sodium channels during the repolarization stage of an action potential?
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What is the function of the myelin sheath in nerve fibers?
What is the function of the myelin sheath in nerve fibers?
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What is the principle underlying the propagation of action potentials along a nerve fiber?
What is the principle underlying the propagation of action potentials along a nerve fiber?
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Which of the following statements is TRUE about the sodium-potassium pump?
Which of the following statements is TRUE about the sodium-potassium pump?
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What is the Nernst equation used to calculate?
What is the Nernst equation used to calculate?
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What is the threshold potential that must be reached for an action potential to be triggered?
What is the threshold potential that must be reached for an action potential to be triggered?
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What is the term used to describe the jumping of depolarization from one node of Ranvier to the next in myelinated axons?
What is the term used to describe the jumping of depolarization from one node of Ranvier to the next in myelinated axons?
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Which of the following ions is NOT a major contributor to the resting membrane potential?
Which of the following ions is NOT a major contributor to the resting membrane potential?
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What is the primary function of the voltage-gated potassium channels during an action potential?
What is the primary function of the voltage-gated potassium channels during an action potential?
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What is the 'all or nothing' principle of action potential propagation?
What is the 'all or nothing' principle of action potential propagation?
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What is the Goldman equation used to calculate?
What is the Goldman equation used to calculate?
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What happens to the membrane potential during the resting stage of an action potential?
What happens to the membrane potential during the resting stage of an action potential?
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During the repolarization stage of an action potential, why does the membrane potential return to its resting state?
During the repolarization stage of an action potential, why does the membrane potential return to its resting state?
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What is the difference between primary and secondary active transport?
What is the difference between primary and secondary active transport?
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Which of the following is an example of secondary active transport?
Which of the following is an example of secondary active transport?
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Flashcards
Homeostasis
Homeostasis
The body's ability to maintain a stable internal environment.
Extracellular Fluid
Extracellular Fluid
Fluid outside cells; rich in sodium, chloride, and nutrients.
Intracellular Fluid
Intracellular Fluid
Fluid inside cells; contains potassium, magnesium, and phosphate.
Negative Feedback
Negative Feedback
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Positive Feedback
Positive Feedback
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Control Systems
Control Systems
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Nervous System
Nervous System
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Immune System
Immune System
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Osmosis
Osmosis
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Osmotic Pressure
Osmotic Pressure
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Primary Active Transport
Primary Active Transport
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Sodium-Potassium Pump
Sodium-Potassium Pump
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Calcium Pumps
Calcium Pumps
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Hydrogen Pumps
Hydrogen Pumps
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Secondary Active Transport
Secondary Active Transport
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Symport
Symport
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Antiport
Antiport
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Membrane Potential
Membrane Potential
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Resting Membrane Potential
Resting Membrane Potential
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Action Potential
Action Potential
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Depolarization
Depolarization
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Myelin Sheath
Myelin Sheath
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Saltatory Conduction
Saltatory Conduction
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Cell Composition
Cell Composition
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Cell Membrane
Cell Membrane
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Lipid Bilayer
Lipid Bilayer
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Integral Proteins
Integral Proteins
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Peripheral Proteins
Peripheral Proteins
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Glycocalyx
Glycocalyx
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Endoplasmic Reticulum (ER)
Endoplasmic Reticulum (ER)
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Golgi Apparatus
Golgi Apparatus
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Lysosomes
Lysosomes
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Mitochondria
Mitochondria
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Active Transport
Active Transport
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Facilitated Diffusion
Facilitated Diffusion
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Diffusion
Diffusion
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Concentration Gradient
Concentration Gradient
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Protein Channels
Protein Channels
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Tonicity
Tonicity
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Isotonic solution
Isotonic solution
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Hypotonic solution
Hypotonic solution
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Hypertonic solution
Hypertonic solution
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Cellular edema
Cellular edema
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Extracellular edema
Extracellular edema
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Sodium's role in fluid distribution
Sodium's role in fluid distribution
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Chemical buffer systems
Chemical buffer systems
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Bicarbonate buffer system
Bicarbonate buffer system
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Respiratory system's role in pH
Respiratory system's role in pH
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Kidneys' role in pH regulation
Kidneys' role in pH regulation
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Hyponatremia
Hyponatremia
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Compliance of interstitium
Compliance of interstitium
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Edema causes
Edema causes
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Bicarbonate Formation
Bicarbonate Formation
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Carbonic Anhydrase
Carbonic Anhydrase
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Respiratory Acidosis
Respiratory Acidosis
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Respiratory Alkalosis
Respiratory Alkalosis
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Metabolic Acidosis
Metabolic Acidosis
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Anion Gaps
Anion Gaps
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Gene Structure
Gene Structure
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Transcription
Transcription
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Translation
Translation
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Cell Cycle
Cell Cycle
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Apoptosis
Apoptosis
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Cancer Development
Cancer Development
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Chromosomal Abnormalities
Chromosomal Abnormalities
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Germline Mutations
Germline Mutations
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Somatic Cells
Somatic Cells
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Fragile Sites
Fragile Sites
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Down Syndrome
Down Syndrome
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Turner Syndrome
Turner Syndrome
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Klinefelter's Syndrome
Klinefelter's Syndrome
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Locus
Locus
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Allele
Allele
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Genotype
Genotype
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Phenotype
Phenotype
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Dominant Gene
Dominant Gene
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Recessive Gene
Recessive Gene
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Autosomal Dominant
Autosomal Dominant
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X-linked Recessive
X-linked Recessive
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Penetrance
Penetrance
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Incomplete Penetrance
Incomplete Penetrance
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Precision Medicine
Precision Medicine
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DNA Methylation
DNA Methylation
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Histone Modification
Histone Modification
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RNA-based Mechanisms
RNA-based Mechanisms
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Totipotency
Totipotency
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X-Chromosome Inactivation
X-Chromosome Inactivation
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Genomic Imprinting
Genomic Imprinting
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Prader-Willi Syndrome
Prader-Willi Syndrome
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Angelman Syndrome
Angelman Syndrome
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Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome
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Cognitive Development
Cognitive Development
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Nutrition's Impact
Nutrition's Impact
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Aging and Methylation
Aging and Methylation
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Epigenetic Treatments
Epigenetic Treatments
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Histone Deacetylase Inhibitors
Histone Deacetylase Inhibitors
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MicroRNA-based Drugs
MicroRNA-based Drugs
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Microcirculation
Microcirculation
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Capillary Structure
Capillary Structure
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Precapillary Sphincters
Precapillary Sphincters
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Starling Forces
Starling Forces
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Net Filtration Pressure
Net Filtration Pressure
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Lymphatic System
Lymphatic System
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Interstitial Fluid
Interstitial Fluid
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Fluid Filtration and Reabsorption
Fluid Filtration and Reabsorption
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Hydrostatic Pressure
Hydrostatic Pressure
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Oxygen's Role in Circulation
Oxygen's Role in Circulation
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Capillary Permeability Variation
Capillary Permeability Variation
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Daily Water Intake
Daily Water Intake
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Body Fluid Compartments
Body Fluid Compartments
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Fluid Loss Methods
Fluid Loss Methods
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Lymph Flow Regulation
Lymph Flow Regulation
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Renal Cortex and Medulla
Renal Cortex and Medulla
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Renal Pyramids
Renal Pyramids
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Calyces
Calyces
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Urinary Bladder
Urinary Bladder
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Micturition Reflex
Micturition Reflex
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Detrusor Muscle
Detrusor Muscle
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Nephrons
Nephrons
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Glomerulus
Glomerulus
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Tubular Reabsorption
Tubular Reabsorption
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Glomerular Filtration Rate (GFR)
Glomerular Filtration Rate (GFR)
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Filtration Barrier
Filtration Barrier
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Urine Flow
Urine Flow
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Efferent Arterioles
Efferent Arterioles
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Peristaltic Contraction
Peristaltic Contraction
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Secretion
Secretion
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Chronic Kidney Disease (CKD) Complications
Chronic Kidney Disease (CKD) Complications
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Nephrotic Syndrome
Nephrotic Syndrome
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Acute Glomerulonephritis
Acute Glomerulonephritis
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Renal Stones Symptoms
Renal Stones Symptoms
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Anemia in CKD
Anemia in CKD
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Intercalated Cells
Intercalated Cells
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Type A Cells
Type A Cells
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Type B Cells
Type B Cells
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Aldosterone
Aldosterone
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Angiotensin II
Angiotensin II
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ADH (Vasopressin)
ADH (Vasopressin)
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Natriuretic Peptide (ANP)
Natriuretic Peptide (ANP)
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Tubuloglomerular Balance
Tubuloglomerular Balance
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Inulin
Inulin
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Renal Clearance
Renal Clearance
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Countercurrent Multiplier
Countercurrent Multiplier
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Urea's Role in Osmolarity
Urea's Role in Osmolarity
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Vasa Recta
Vasa Recta
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Osmolarity Changes in Nephrons
Osmolarity Changes in Nephrons
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Sodium Regulation
Sodium Regulation
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Glomerular Hydrostatic Pressure
Glomerular Hydrostatic Pressure
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Afferent Arteriolar Resistance
Afferent Arteriolar Resistance
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Efferent Arteriolar Resistance
Efferent Arteriolar Resistance
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Renal Blood Flow
Renal Blood Flow
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Sympathetic Nervous System Effects
Sympathetic Nervous System Effects
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Hormonal Control of GFR
Hormonal Control of GFR
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Autoregulation in Kidneys
Autoregulation in Kidneys
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Tubuloglomerular Feedback
Tubuloglomerular Feedback
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Active Transport in Reabsorption
Active Transport in Reabsorption
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Reabsorption Locations
Reabsorption Locations
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Transport Maximum
Transport Maximum
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Tubular Secretion
Tubular Secretion
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Urea Reabsorption
Urea Reabsorption
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Renal Tubule
Renal Tubule
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Renin-Angiotensin-Aldosterone System (RAAS)
Renin-Angiotensin-Aldosterone System (RAAS)
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Osmotic Diuresis
Osmotic Diuresis
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Loop Diuretics
Loop Diuretics
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Thiazide Diuretics
Thiazide Diuretics
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Acid-Base Homeostasis
Acid-Base Homeostasis
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Erythropoietin
Erythropoietin
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Calcium Regulation
Calcium Regulation
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Vasopressin
Vasopressin
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Carbonic Anhydrase Inhibitors
Carbonic Anhydrase Inhibitors
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Spironolactone
Spironolactone
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Sodium Channel Blockers
Sodium Channel Blockers
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Acute Kidney Injury (AKI)
Acute Kidney Injury (AKI)
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Chronic Kidney Disease (CKD)
Chronic Kidney Disease (CKD)
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Types of AKI
Types of AKI
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Effects of AKI
Effects of AKI
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Progression of CKD
Progression of CKD
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Kidney Failure Symptoms
Kidney Failure Symptoms
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Glomerular Diseases
Glomerular Diseases
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Renal Medulla Susceptibility
Renal Medulla Susceptibility
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Kidneys' Functions
Kidneys' Functions
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Retaining Sodium in Tubules
Retaining Sodium in Tubules
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Diabetes as a CKD Cause
Diabetes as a CKD Cause
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Thirst Center
Thirst Center
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ADH Synthesis
ADH Synthesis
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ADH Release Triggers
ADH Release Triggers
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Thirst Mechanism
Thirst Mechanism
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Obligatory Urine Volume
Obligatory Urine Volume
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Potassium Regulation
Potassium Regulation
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Influences on Potassium Secretion
Influences on Potassium Secretion
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Phosphate Excretion
Phosphate Excretion
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Fluid Volume Regulation
Fluid Volume Regulation
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Aldosterone Function
Aldosterone Function
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ADH Role in Urine
ADH Role in Urine
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Congestive Heart Failure Effects
Congestive Heart Failure Effects
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Natriuresis
Natriuresis
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Study Notes
Renal Anatomy and Function
- Kidneys are retroperitoneal organs receiving 20% of cardiac output.
- Nephrons are the functional units, comprising glomerulus and renal tubule.
- Each kidney contains approximately one million nephrons.
- Glomerulus filters blood; renal tubule reabsorbs substances.
- Normal adult kidney filters 100-120mL/minute.
- Glomerulus is a capillary tuft with afferent and efferent arterioles.
Glomerular Filtration
- Glomerular capillary endothelium is fenestrated; negatively charged glycoproteins prevent large proteins (like albumin) from passing.
- Podocytes (epithelial cells) with foot processes line the basement membrane.
Reabsorption and Secretion
- Reabsorption along renal tubules is extensive and selective, varying by substance and location. (e.g., 60-70% sodium)
- Substances like creatinine, histamine, drugs, and toxins are secreted into tubular fluid.
Urine Concentration
- Kidneys can generate urine with osmolarity varying from 50 to 1200-1400 mOsm/L.
- The countercurrent multiplier mechanism in the loop of Henle concentrates urine.
- Water permeability in the collecting ducts is regulated by antidiuretic hormone (ADH).
- Sodium is reabsorbed under aldosterone control.
Blood Pressure Regulation
- Kidneys regulate blood pressure through sodium and water balance.
- Macula densa senses sodium, and juxtaglomerular complex senses blood pressure.
- Low sodium/perfusion triggers renin release, leading to angiotensin II production.
- Angiotensin II raises blood pressure by vasoconstriction and stimulating aldosterone/sodium and water retention.
- Vasopressin (ADH) increases water reabsorption in the collecting duct.
Renin-Angiotensin-Aldosterone System (RAAS)
- RAAS activation is triggered by reduced effective circulating volume.
- Conditions like edema or reduced oncotic pressure can activate RAAS.
- Vascular diseases like atherosclerosis can impair blood flow, triggering renin release and hypertension.
Acid-Base Balance
- Kidneys play a crucial role in acid-base homeostasis, secreting extra hydrogen to restore bicarbonate levels.
- Excretion occurs in the distal collecting duct where hydrogen combines with ammonia to form ammonium (NH4+) and is excreted.
Electrolyte Balance
- Calcium regulation primarily occurs in distal collecting duct.
- Aldosterone controls extracellular potassium levels.
- Hyperkalemia arises from shifts, extrarenal/renal losses.
Hormone Production and Regulation
- Kidneys convert vitamin D to its active form, affecting calcium absorption.
- Kidneys are the target site for parathyroid hormone and regulate calcium/phosphate balance.
- Kidneys produce erythropoietin, stimulating red blood cell production.
Glomerular Filtration Rate (GFR) Regulation
- Kidneys regulate GFR in response to solute concentration in the distal renal tubule (tubuloglomerular feedback).
- High sodium concentration triggers afferent arteriole vasoconstriction, decreasing GFR.
- Kidneys adjust cortical/medullary blood flow to maintain GFR and prevent anoxic injury.
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Description
Test your knowledge on the key characteristics of extracellular fluid, the organ systems involved in homeostasis, and the mechanisms that regulate body functions. This quiz covers topics such as feedback mechanisms, the immune system's role, diffusion, the endocrine system, and buffer systems.