3 Questions
What is the main difference between the polymorphism of class I and class II genes in humans?
The polymorphism of class I genes is exclusively in the α chain, while that of class II genes is mainly in the β chains.
What is an MHC haplotype?
The set of MHC genes present on each chromosome, which are inherited together in a Mendelian fashion.
Why are siblings often tested before unrelated individuals for their suitability as donors for transplantation?
Because the chance of finding an HLA match with the recipient is much greater for siblings, as they have a 25% chance of inheriting identical sets of HLA alleles.
Test your knowledge of human immune system genetics with this quiz on HLA gene polymorphism. Learn about the six different class I molecules and the various genes encoding HLA-DP, DQα, DQβ, and DRβ chains.
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