HLA Gene Polymorphism Quiz
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Questions and Answers

What is the main difference between the polymorphism of class I and class II genes in humans?

  • The polymorphism of class I genes is exclusively in the α chain, while that of class II genes is mainly in the β chains. (correct)
  • The polymorphism of class I and class II genes is mainly in the α chains.
  • The polymorphism of class I genes is mainly in the β chains, while that of class II genes is exclusively in the α chain.
  • The polymorphism of class I and class II genes is mainly in the β chains.
  • What is an MHC haplotype?

  • The total number of expressed class II molecules in an individual.
  • The extra DRβ genes present in some individuals.
  • The chance that two siblings will inherit identical sets of HLA alleles.
  • The set of MHC genes present on each chromosome, which are inherited together in a Mendelian fashion. (correct)
  • Why are siblings often tested before unrelated individuals for their suitability as donors for transplantation?

  • Because siblings have a higher probability of developing immune rejection after transplantation.
  • Because siblings have a higher probability of carrying infectious diseases that can be transmitted to the recipient.
  • Because siblings are more likely to have a higher level of HLA antibodies than unrelated individuals.
  • Because the chance of finding an HLA match with the recipient is much greater for siblings, as they have a 25% chance of inheriting identical sets of HLA alleles. (correct)
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