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What is the CD4 count at which HIV infection meets one of the Centers for Disease Control and Prevention's definitions of AIDS?
What is the CD4 count at which HIV infection meets one of the Centers for Disease Control and Prevention's definitions of AIDS?
What is the recommended daily regimen for sexually active adults at a substantial risk of HIV acquisition?
What is the recommended daily regimen for sexually active adults at a substantial risk of HIV acquisition?
What is a common consequence of a CD4 count below 50 cells/mm3?
What is a common consequence of a CD4 count below 50 cells/mm3?
What is a characteristic of patients with AIDS?
What is a characteristic of patients with AIDS?
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What is a common dermatological manifestation of HIV disease?
What is a common dermatological manifestation of HIV disease?
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What is a potential complication of HIV disease when the CD4 count drops below 200 cells/mm3?
What is a potential complication of HIV disease when the CD4 count drops below 200 cells/mm3?
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What is being tested as a potential prevention method for HIV?
What is being tested as a potential prevention method for HIV?
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What is a common experience of patients with AIDS?
What is a common experience of patients with AIDS?
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What is the primary goal of long-term suppressive therapy for opportunistic infections in patients with HIV/AIDS?
What is the primary goal of long-term suppressive therapy for opportunistic infections in patients with HIV/AIDS?
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What is the purpose of ongoing intravenous (IV) therapies in patients with HIV/AIDS?
What is the purpose of ongoing intravenous (IV) therapies in patients with HIV/AIDS?
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What is a fundamental aspect of palliative care for patients with HIV/AIDS?
What is a fundamental aspect of palliative care for patients with HIV/AIDS?
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What is a common comorbidity experienced by patients with HIV/AIDS?
What is a common comorbidity experienced by patients with HIV/AIDS?
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What is the primary role of an interprofessional team in palliative care for patients with HIV/AIDS?
What is the primary role of an interprofessional team in palliative care for patients with HIV/AIDS?
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What is the primary goal of health prevention measures in patients with HIV/AIDS?
What is the primary goal of health prevention measures in patients with HIV/AIDS?
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What is a common consequence of opportunistic infections in patients with HIV/AIDS?
What is a common consequence of opportunistic infections in patients with HIV/AIDS?
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What is the primary goal of administering primary prophylaxis in HIV patients?
What is the primary goal of administering primary prophylaxis in HIV patients?
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What has been the significant outcome of the effectiveness of Antiretroviral Therapy (ART) in HIV patients?
What has been the significant outcome of the effectiveness of Antiretroviral Therapy (ART) in HIV patients?
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What is the administration of a pharmacological agent to prevent future occurrences of infection referred to as?
What is the administration of a pharmacological agent to prevent future occurrences of infection referred to as?
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What is the main goal of palliative care and symptom management in HIV patients?
What is the main goal of palliative care and symptom management in HIV patients?
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Why is prophylaxis for life for HIV-related coinfections no longer necessary in many cases?
Why is prophylaxis for life for HIV-related coinfections no longer necessary in many cases?
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Match the following data with the correct year:
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Match the following reasons with why patients may wish to continue ART:
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Match the following terms with their corresponding effects on the immune system:
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Match the following terms with their corresponding characteristics of HIV infection:
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Match the following terms with their corresponding goals of care in HIV/AIDS:
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Match the following aspects of QOL with their impact on daily living:
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Match the following medications with their potential benefits for pain relief:
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Match the following researchers with their findings on QOL in individuals with HIV/AIDS:
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Study Notes
Opportunistic Infections and HIV/AIDS
- Most opportunistic infections are incurable and can only be palliated to control acute stages and prevent recurrence through long-term suppressive therapy.
- HIV/AIDS patients often experience concurrent or consecutive opportunistic infections and various malignancies, causing severe symptoms.
- Opportunistic infections can be prevented through health prevention measures, such as ongoing intravenous (IV) therapies to prevent blindness from cytomegalovirus (CMV) retinitis.
Morbidity and Mortality
- HIV-infected patients have a higher risk for non-AIDS-related diseases and cardiovascular, renal, and non-AIDS-defining cancers than uninfected patients.
- The onset of these diseases occurs at similar ages in both groups.
- Gynecological infections are common in women with HIV disease, as well as dermatological manifestations, including bacterial, fungal, viral, neoplastic, and other conditions.
HIV Prevention and Treatment
- Pre-exposure prophylaxis (PreP) has become an important part of HIV prevention since its approval by the FDA in 2012.
- Daily regimen with tenofovir disoproxil fumarate (TDF) is recommended for sexually active adults at a substantial risk of HIV acquisition.
- Prophylaxis for life for HIV-related coinfections is no longer necessary in many cases due to the effectiveness of ART.
Palliative Care and Quality of Life
- Palliative care (PC) includes comprehensive care with respect for patient goals, preferences, and choices, and acknowledgment of caregivers' concerns.
- PC is fundamental in addressing the complex needs of patients and families with HIV/AIDS and requires the coordinated care of an interprofessional team.
- HIV/AIDS patients often experience bouts of severe illness and debilitation, alternating with periods of symptom stabilization.
- The administration of prophylactic and/or suppressive therapies can support and maintain the immune system, decreasing the frequency or severity of opportunistic infections.
- Identifying changes in QOL and implementing appropriate interventions can improve QOL outcomes for HIV/AIDS patients.
HIV/AIDS Overview
- 36.7 million people are living with HIV globally, and 18.2 million people are receiving Antiretroviral Therapy (ART) by mid-2016.
- The global expansion of access to HIV treatment is considered one of the great recent achievements in public health.
Incidence and Prevalence
- New HIV infections fell by 35%, and AIDS-related deaths fell by 28% between 2011 and 2015.
- In 2015, there were 1.1 million AIDS-related deaths, compared to 1.7 million in 2011.
- Approximately 8,500 women living with HIV give birth annually, with advances in HIV research, prevention, and treatment allowing them to give birth without transmitting the virus.
- An estimated 21,956 cases of perinatally acquired HIV infections were prevented between 1994 and 2010.
Pathogenesis of HIV
- HIV survives by reproducing itself in host cells, replacing genetic machinery, and eventually destroying the cell.
- The HIV life cycle consists of attachment, replication, and destruction of host cells.
Disease Trajectory
- Without treatment, HIV infection progresses to life-threatening illness characterized by opportunistic infections and cancers.
- The disease trajectory is associated with progressive immune-system dysfunction and persistent viral replication.
Symptom Management in HIV Disease
- Symptom management is crucial in HIV care, with patients experiencing a high burden of pain and chronic symptoms.
- Key symptoms experienced by patients include lack of energy, drowsiness, difficulty sleeping, and pain.
- Symptom relief is a primary consideration in ART continuation decisions.
Palliative Care and HIV/AIDS
- Palliative care focuses on symptom relief, comfort, and quality of life (QOL) for patients with HIV/AIDS.
- QOL is associated with health maintenance, physical and emotional symptoms, and functioning in activities of daily living and social functioning.
- Effective symptom management can improve QOL for individuals with HIV/AIDS.
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Description
This quiz covers the treatment of chronic and acute opportunistic infections in HIV/AIDS patients, including the importance of long-term suppressive therapy and maintaining a good quality of life.