HIV Protease Inhibitors Overview

Fat maldistribution, including loss of fat from the extremities

They are potent inhibitors of CYP450 isoenzymes

Accumulation of stepwise mutations of the protease gene

<p>Drug resistance</p> Signup and view all the answers

<p>High number of capsules needed to be taken (pill burden)</p> Signup and view all the answers

<p>HIV protease inhibitors bind to the site where protein cutting occurs, preventing the enzyme from releasing individual core proteins, thus hindering the maturation of new viral particles.</p> Signup and view all the answers

<p>HIV protease inhibitors are metabolized by the CYP3A4 isoenzyme and other CYP450 isoenzymes, with hepatic metabolism being extensive.</p> Signup and view all the answers

<p>Adverse effects include GI disturbances (nausea, vomiting, diarrhea), hyperglycemia, hyperlipidemia, and hepatic injury.</p> Signup and view all the answers

<p>Lovastatin and simvastatin levels are elevated by protease inhibitors, increasing the risk of complications in coronary heart disease.</p> Signup and view all the answers

<p>Dosage adjustments are unnecessary in renal impairment because the inhibitors are primarily eliminated through biliary excretion and are not excreted unchanged in urine.</p> Signup and view all the answers