HIV/AIDS History and Anti-HIV Therapy
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Questions and Answers

What is the shape of the HIV virus?

  • Cylindrical
  • Oval
  • Spherical
  • Icosahedra (correct)

    • What is the function of the knob-like structures on the HIV outer envelope?

  • To replicate the virus
  • To bind to target cells (correct)
  • To protect the virus from the host's immune system
  • To release the virus from the host cell

    • What is the main target cell type for HIV replication?

  • Helper T cells (correct)
  • B cells
  • Macrophages
  • Dendritic cells

    • At which stage does reverse transcription occur in the HIV lifecycle?

    <p>Reverse transcription (A)</p> Signup and view all the answers

    What is the primary mechanism of action of Reverse-Transcriptase Inhibitors (RTIs)?

    <p>Blocking the reproduction of HIV by preventing the synthesis of double-stranded viral DNA (C)</p> Signup and view all the answers

    Which class of drugs inhibits the integration of viral DNA into host chromosomal DNA?

    <p>Integrase inhibitors (C)</p> Signup and view all the answers

    What is the function of Protease inhibitors?

    <p>Inhibiting the release of mature viral particles from the host cell (B)</p> Signup and view all the answers

    What is the primary function of Nucleoside analog reverse-transcriptase inhibitors (NARTIs or NRTIs)?

    <p>Blocking the reproduction of HIV by preventing the synthesis of double-stranded viral DNA (A)</p> Signup and view all the answers

    Which phase of the retrovirus life-cycle is inhibited by Entry inhibitors?

    <p>Binding and entry (B)</p> Signup and view all the answers

    What is the primary mechanism of action of AZT in treating HIV?

    <p>It converts to triphosphate and inhibits viral reverse transcriptase (C)</p> Signup and view all the answers

    What is a key difference between nucleosides and nucleotides?

    <p>Nucleosides do not have a phosphate group while nucleotides do (D)</p> Signup and view all the answers

    What is the name of the class of antiretroviral drugs that tenofovir belongs to?

    <p>Nucleotide Analogue Reverse Transcriptase Inhibitors (NRTIs) (D)</p> Signup and view all the answers

    What is the primary mechanism of action of HIV Protease Inhibitors (PIs)?

    <p>They prevent viral replication by inhibiting the activity of proteases (C)</p> Signup and view all the answers

    What is the name of the first approved treatment for HIV?

    <p>Retrovir (D)</p> Signup and view all the answers

    What is a potential disadvantage of using nucleotides as potential drugs?

    <p>They have a phosphate group that can be difficult to administer (B)</p> Signup and view all the answers

    What is the primary function of Integrase inhibitors?

    <p>To inhibit the action of integrase enzyme (B)</p> Signup and view all the answers

    What is the name of the approved HIV Protease Inhibitor with a molecular weight of 670?

    <p>Saquinavir (D)</p> Signup and view all the answers

    What is the primary purpose ofTransition State Isosteres (TSIs)?

    <p>To mimic the transition state in a chemical reaction (C)</p> Signup and view all the answers

    What is the primary function of entry inhibitors in the HIV replication cycle?

    <p>To block the binding of HIV to CD4+ cells (D)</p> Signup and view all the answers

    Which of the following proteins is closely associated with gp120 and penetrates the cell membrane?

    <p>gp41 (A)</p> Signup and view all the answers

    What is the role of CD4 in the HIV entry process?

    <p>To bind to gp120 (D)</p> Signup and view all the answers

    What is the outcome of blocking the binding of HIV to CD4+ cells?

    <p>The progression from HIV infection to AIDS is slowed (C)</p> Signup and view all the answers

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