HIV Medications and Resistance Quiz

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Questions and Answers

What is the risk associated with stopping antiretroviral combinations abruptly?

  • Increased risk of functional monotherapy and development of resistance (correct)
  • Decreased risk of functional monotherapy and development of resistance
  • Increased effectiveness of antiretrovirals
  • No risk at all

What percentage of adherence was required for a sustained response in the majority of patients taking their first regimen containing nelfinavir?

  • At least 60% adherence
  • At least 80% adherence
  • At least 90% adherence (correct)
  • At least 70% adherence

What did the study find about patients with adherence below 80%?

  • They experienced virological failure (correct)
  • They experienced fewer hospitalisations
  • They experienced virological success
  • They experienced a better clinical outcome

What does virological success correlate with, according to the clinical trial data?

<p>Better clinical outcomes (A)</p> Signup and view all the answers

What is the main reason to avoid co-administration of this drug with ergotamines and antiarrhythmics?

<p>It may result in significant drug interactions. (A)</p> Signup and view all the answers

Which drug's levels may increase when co-administered with this medication, requiring careful monitoring and potential dose alteration?

<p>Warfarin (C)</p> Signup and view all the answers

How does this medication interact with corticosteroids like fluticasone and budesonide?

<p>It may increase their levels. (D)</p> Signup and view all the answers

Why is caution advised when using this drug with statins like pravastatin?

<p>It may lead to metabolic/lipid/body shape changes. (C)</p> Signup and view all the answers

What is the recommended approach when using this drug with erectile dysfunction agents like sildenafil (Viagra)?

<p>Avoiding co-administration with sildenafil. (D)</p> Signup and view all the answers

What enzyme does this medication inhibit, leading to caution with other drugs that may affect these enzymes?

<p>Cytochrome p450 enzymes (A)</p> Signup and view all the answers

What is the main concern when deciding to prescribe or take PEP?

<p>The careful risk/benefit evaluation (D)</p> Signup and view all the answers

How do nucleotide analogues differ from nucleoside analogues in terms of activation?

<p>Nucleotide analogues require fewer intracellular phosphorylations (B)</p> Signup and view all the answers

Which of the following is not an NRTI licensed in the UK?

<p>Efavirenz (Sustiva®) (A)</p> Signup and view all the answers

Which drug interaction may decrease abacavir levels?

<p>Rifampicin (B)</p> Signup and view all the answers

What is the major/common side effect of Atripla®?

<p>Nausea and vomiting (C)</p> Signup and view all the answers

What is the main purpose of pre-exposure prophylaxis (PREP)?

<p>To reduce transmission before potential exposure to HIV (B)</p> Signup and view all the answers

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