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HIV Medications and Resistance Quiz

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Questions and Answers

What is the risk associated with stopping antiretroviral combinations abruptly?

Increased risk of functional monotherapy and development of resistance (correct)

Decreased risk of functional monotherapy and development of resistance

Increased effectiveness of antiretrovirals

No risk at all

What percentage of adherence was required for a sustained response in the majority of patients taking their first regimen containing nelfinavir?

At least 60% adherence

At least 80% adherence

At least 90% adherence (correct)

At least 70% adherence

What did the study find about patients with adherence below 80%?

They experienced virological failure (correct)

They experienced fewer hospitalisations

They experienced virological success

They experienced a better clinical outcome

What does virological success correlate with, according to the clinical trial data?

Better clinical outcomes Signup and view all the answers

What is the main reason to avoid co-administration of this drug with ergotamines and antiarrhythmics?

It may result in significant drug interactions. Signup and view all the answers

Which drug's levels may increase when co-administered with this medication, requiring careful monitoring and potential dose alteration?

Warfarin Signup and view all the answers

How does this medication interact with corticosteroids like fluticasone and budesonide?

It may increase their levels. Signup and view all the answers

Why is caution advised when using this drug with statins like pravastatin?

It may lead to metabolic/lipid/body shape changes. Signup and view all the answers

What is the recommended approach when using this drug with erectile dysfunction agents like sildenafil (Viagra)?

Avoiding co-administration with sildenafil. Signup and view all the answers

What enzyme does this medication inhibit, leading to caution with other drugs that may affect these enzymes?

Cytochrome p450 enzymes Signup and view all the answers

What is the main concern when deciding to prescribe or take PEP?

The careful risk/benefit evaluation Signup and view all the answers

How do nucleotide analogues differ from nucleoside analogues in terms of activation?

Nucleotide analogues require fewer intracellular phosphorylations Signup and view all the answers

Which of the following is not an NRTI licensed in the UK?

Efavirenz (Sustiva®) Signup and view all the answers

Which drug interaction may decrease abacavir levels?

Rifampicin Signup and view all the answers

What is the major/common side effect of Atripla®?

Nausea and vomiting Signup and view all the answers

What is the main purpose of pre-exposure prophylaxis (PREP)?

To reduce transmission before potential exposure to HIV Signup and view all the answers