HIV Attachment Process to CD4+ T-cells
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Questions and Answers

Which demographic group has the highest infection incidence of HIV in the US?

  • Black and Hispanic women
  • Transgender women
  • Individuals in subsaharan Africa
  • Young men who have sex with men (correct)

Which gene encodes the envelope proteins of HIV?

  • tat
  • pol
  • env (correct)
  • gag

What is the process by which HIV binds to the CD4 receptor on T-cells?

  • Maturation
  • Budding
  • Viral entry (correct)
  • Reverse transcription

Which group has a rare occurrence of vertical transmission of HIV in the US?

<p>Heterosexual persons (A)</p> Signup and view all the answers

What does the pol gene in HIV encode for?

<p>Enzymes required for replication (D)</p> Signup and view all the answers

What is the main reason there is no cure for HIV?

<p>The integrated virus forms a viral reservoir in host cells. (C)</p> Signup and view all the answers

What is the main goal of Antiretroviral therapy (ART)?

<p>To decrease the circulation of HIV in the community. (B)</p> Signup and view all the answers

What is the purpose of Pre-exposure Prophylaxis (PrEP)?

<p>To prevent sexual transmission of HIV by more than 95%. (A)</p> Signup and view all the answers

Which component does a first-line antiretroviral therapy regimen typically contain?

<p>One integrase inhibitor + two NRTIs (D)</p> Signup and view all the answers

Why does the reverse transcriptase enzyme in HIV lead to mutations?

<p>It generates millions of mutant copies within the same replication cycle. (D)</p> Signup and view all the answers

Which viral protein is responsible for the attachment of HIV to the CD4 receptor on the cell surface?

<p>GP120 (B)</p> Signup and view all the answers

After binding to the CD4 receptor, which co-receptor on the cell surface does the second arm of GP120 interact with during HIV entry?

<p>CCR5 (D)</p> Signup and view all the answers

What is the term used for the stage when HIV DNA integrates with host DNA in the nucleus?

<p>Proviral DNA (D)</p> Signup and view all the answers

During the reverse transcription process, what is the initial step that occurs in the cytoplasm of the cell?

<p>Conversion of viral RNA to DNA (D)</p> Signup and view all the answers

Which enzyme facilitates the integration of HIV DNA with host DNA in the nucleus?

<p>Integrase (D)</p> Signup and view all the answers

Which of the following best describes the impact of colonialism, slave trade, and medical injections on the global spread of HIV?

<p>They contributed to the global dissemination of HIV. (C)</p> Signup and view all the answers

What type of cells does HIV primarily target and infect?

<p>T cells (C)</p> Signup and view all the answers

During the viral attachment process, what is the role of the CD4 receptor?

<p>It allows the virus to enter the host cell. (A)</p> Signup and view all the answers

What is the function of reverse transcription in the HIV life cycle?

<p>It converts viral RNA into DNA inside the host cell. (C)</p> Signup and view all the answers

Which proteins are encoded by HIV genes and play a crucial role in viral replication and infection?

<p>Reverse transcriptase and protease (C)</p> Signup and view all the answers

What is the impact of detectable viremia in the setting of low CD4 count in HIV infection?

<p>Increased risk of opportunistic infections (C)</p> Signup and view all the answers

Which unique contraindication must be considered before using Cabotegravir as PrEP?

<p>Active gluteal implants (C)</p> Signup and view all the answers

What is the purpose of POST-exposure Prophylaxis (PEP) in HIV management?

<p>To prevent infection after possible exposure (D)</p> Signup and view all the answers

How often is Cabotegravir administered for PrEP?

<p>Every 8 weeks (A)</p> Signup and view all the answers

In what situations would POST-exposure Prophylaxis (PEP) typically be initiated?

<p>After needle prick of unknown source (C)</p> Signup and view all the answers

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