Podcast
Questions and Answers
What is the main aim of fixation in tissue preservation?
What is the main aim of fixation in tissue preservation?
- To maintain the tissue in a semi-solid state (correct)
- To liquefy the tissue
- To allow bacterial action on the tissue
- To produce a foul odor in the tissue
What is the effect of fixation on the tissue?
What is the effect of fixation on the tissue?
- Causes liquefaction with a foul odor
- Promotes tissue decomposition
- Induces bacterial action on the tissue
- Maintains the tissue in a semi-solid state (correct)
What would happen if fresh tissue is kept at room temperature without fixation?
What would happen if fresh tissue is kept at room temperature without fixation?
- It will become dry and shrunken
- It will become liquefied with a foul odor due to bacterial action (correct)
- It will remain in a semi-solid state
- It will repel bacterial action
Why is preservation of tissue in a semi-solid state important?
Why is preservation of tissue in a semi-solid state important?
What is the role of fixation in preventing putrefaction and autolysis?
What is the role of fixation in preventing putrefaction and autolysis?
Flashcards
What is the main purpose of fixation in tissue preservation?
What is the main purpose of fixation in tissue preservation?
Keeping the tissue in a firm, semi-solid state.
What effect does fixation have on tissue?
What effect does fixation have on tissue?
Fixation stops the tissue from becoming mushy or rotting.
What happens to fresh tissue left at room temperature without fixation?
What happens to fresh tissue left at room temperature without fixation?
It would decompose, creating a foul smell due to bacteria breaking it down.
Why is preserving tissue in a semi-solid state important?
Why is preserving tissue in a semi-solid state important?
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What is the role of fixation in preventing putrefaction and autolysis?
What is the role of fixation in preventing putrefaction and autolysis?
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Study Notes
Fixation in Histopathology
- Fixation is a complex series of chemical events that bring about changes in the various chemical constituents of cells, resulting in hardening, while preserving cell morphology and structural detail.
- It is essential to fix tissues soon after removal from the body to prevent degenerative changes due to autolysis and putrefaction, which would lead to loss of individual cell morphology.
Principle of Fixation
- The fixative brings about crosslinking of proteins, resulting in denaturation or coagulation of proteins.
- This process converts the semifluid state of cells into a semisolid state, maintaining the in vivo relationships between cells.
- The semisolid state facilitates easy manipulation of tissue, making it ideal for histopathological analysis.
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Description
Learn about the complex process of fixation in histopathology, which involves chemical events to preserve cell morphology and structural detail. Understand the importance of timely tissue fixation to prevent degenerative changes and maintain tissue morphology.
