Connective Tissue Disease, Vasculitis and Related Disorders

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34 Questions

What is the first-line treatment for mild to moderate cutaneous involvement in vasculitis?

Potent topical steroids

Which of the following autoimmune diseases is Raynaud's phenomenon most commonly associated with?

Systemic sclerosis

What is the most common symptom of Raynaud's phenomenon immediately following exposure to cold?

Color change

In persistent cases of cutaneous vasculitis, what type of medication may be needed as an alternative to corticosteroids?

Immunosuppressants

What distinguishes primary Raynaud's phenomenon from secondary Raynaud's phenomenon?

Symmetry of symptoms

Which of the following is NOT a symptom of Raynaud's phenomenon?

Itching

What is the most common skin involvement seen in systemic lupus erythematosus (SLE) patients?

Erythematous 'butterfly' distribution rash on the face

Which of the following drugs has been known to trigger Systemic Lupus Erythematosus (SLE)?

Chlorpromazine

What is a diagnostic criterion for Systemic Lupus Erythematosus (SLE)?

Malar rash

What type of skin eruption is typically seen in Subacute Lupus Erythematosus?

Erythematous annular and serpiginous eruption

Which of the following is a common manifestation of neonatal lupus erythematosus?

Skin rash

What treatment is usually required for Systemic Lupus Erythematosus (SLE) with organ involvement?

Prednisolone

'Butterfly rash' is associated with which type of Lupus?

Systemic Lupus erythematosus (SLE)

What is the main skin manifestation seen in dermatomyositis affecting the fingers?

Purplish papules

Which antibody may be detected in dermatomyositis?

Anti-Jo-1 antibody

What type of muscle involvement is typically seen in dermatomyositis?

Proximal limb weakness

Which treatment option can help achieve rapid control of symptoms in dermatomyositis?

Pulsed cyclophosphamide

What is the characteristic feature usually seen in mixed connective tissue disease (MCTD) involving the hands?

Sclerodactyly/swollen hands

Which condition is characterized by overlapping features of SLE, scleroderma, and myositis?

Mixed connective tissue disease (MCTD)

In systemic sclerosis (SSc), which diagnostic test is most commonly elevated in patients?

ANA

What is a characteristic symptom seen in CREST syndrome?

Calcinosis Cutis

Which investigation is specifically recommended for diagnosing CREST syndrome?

Anticentromere antibodies

What is the key feature of Morphaea, a benign form of localized systemic sclerosis?

Localized sclerosis with slight inflammation

Which condition mainly affects the genital and perineal regions in women and is described as an itchy eruption?

Lichen Sclerosus

Which treatment is specifically mentioned for managing sclerodactyly in systemic sclerosis (SSc)?

Calcitriol

What is the first symptom typically observed in CREST syndrome?

Raynaud's phenomenon

What is the distinctive color of the atrophic patches and plaques seen in Lichen Sclerosus?

Ivory-white

Which condition may rarely be associated with the development of squamous cell carcinoma in adults?

Lichen Sclerosus

In Lichen Planus, what is the term used to describe the shiny purple-colored flat-topped papules in the 6 Ps mnemonic?

Polygonal

Which skin condition is characterized by the presence of Wickham’s striae on the surface of lesions?

Lichen Planus

What is the main underlying cause of Lichen Planus?

Unknown etiology

In which type of skin, Lichen Planus may present as very hypertrophic and heal with marked hyperpigmentation?

Black skin

Which condition is characterized by fibrosis of the underlying tissues and loss of normal genital architecture?

Lichen Sclerosus

'Koebner phenomenon' is associated with which skin condition presenting as lesions in linear scratches or surgical scars?

Lichen Planus

Explore the histological similarities between Lichen Sclerosus (LS) and lichen planus while understanding their different clinical presentations. Learn about the clinical features of Lichen Sclerosus including well-demarcated atrophic patches with an ivory-white color and fibrosis of underlying tissues.

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