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Questions and Answers
What is the male-female ratio in Hirschsprung Disease cases?
What is the male-female ratio in Hirschsprung Disease cases?
- 4:1 (correct)
- 2:1
- 1:4
- 3:1
In Hirschsprung Disease, what percentage of cases are limited to the rectosigmoid?
In Hirschsprung Disease, what percentage of cases are limited to the rectosigmoid?
- 90%
- 75% (correct)
- 25%
- 50%
What is the term for the congenital absence of parasympathetic innervation of the distal intestine?
What is the term for the congenital absence of parasympathetic innervation of the distal intestine?
- Distal Innervation Absence Syndrome
- Aganglionic Megacolon (correct)
- Neural Crest Deficiency
- Parasympathetic Atresia
What is the estimated occurrence of Hirschsprung Disease in live births?
What is the estimated occurrence of Hirschsprung Disease in live births?
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What is the etiology of Hirschsprung Disease attributed to?
What is the etiology of Hirschsprung Disease attributed to?
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Study Notes
Hirschsprung Disease
- The male-female ratio in Hirschsprung Disease cases is approximately 4:1, indicating a higher prevalence in males.
- In about 80% of cases, the disease is limited to the rectosigmoid, which is the lowest part of the large intestine.
- Hirschsprung Disease is characterized by the congenital absence of parasympathetic innervation of the distal intestine, also known as aganglionosis.
- The estimated occurrence of Hirschsprung Disease in live births is about 1 in 5,000.
- The etiology of Hirschsprung Disease is attributed to a combination of genetic and environmental factors, which lead to the failure of neural crest cells to migrate to the distal intestine during fetal development.
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