29 Questions
Which serologic test is commonly used for diagnosing celiac disease?
All of the above
What is the most common cause of congenital intestinal obstruction?
Hirschsprung’s Disease
What is a characteristic feature of Hirschsprung’s Disease?
Absence of ganglion cells in Meissner and Auerbach’s plexus
What is the pathogenesis of diverticular disease?
Herniation of colonic wall at sites of focal defects
What is a characteristic feature of Pseudo Membranous Colitis?
Formation of fibrinopurulent-necrotic debris (PSEUDOMEMBRANES)
Which condition exhibits intermittent rectal bleeding, bloody diarrhea, and abdominal pain, typically continuous colonic involvement?
Ulcerative colitis
What is a characteristic feature of Crohn disease?
Patchy transmural involvement
Which type of inflammation is limited to the colon?
Ulcerative Colitis
Which condition is associated with Primary Sclerosing Cholangitis (PSC)?
Ulcerative Colitis
Which type of inflammation can affect any part of the gastrointestinal tract from mouth to anus?
Crohn’s disease
Which condition has a higher risk of developing malignancy and neoplasia?
Ulcerative Colitis
Which type of inflammation is sharply delimited and transmural by an inflammatory process?
Crohn’s disease
Which condition is characterized by the presence of non-caseating granulomas?
Crohn’s disease
Which condition is associated with HLA-DRB1?
Ulcerative Colitis
Which condition can mimic inflammatory bowel disease?
Chronic ischemic colitis
Which condition is an enteropathy triggered by the ingestion of gluten in a genetically susceptible individual?
Celiac Disease
Which condition is characterized by dilatation proximal to obstruction, leading to megacolon and rectum is always affected?
Hirschsprung’s Disease
Which condition is associated with lack of dietary fiber leading to sustained bowel contractions and increased intraluminal pressure?
Diverticular Disease
Which condition is associated with broad-spectrum antibiotic use and exhibits raised yellow plaques in the colon, particularly the rectosigmoid?
Pseudo Membranous Colitis
Which condition exhibits more variable symptoms than Ulcerative Colitis, including abdominal pain, fatigue, weight loss, and fever?
Crohn Disease
Which condition presents with lamina propria hemorrhage, erosion, and neutrophil infiltration in the colon?
Infectious Colitis
Which condition is always associated with MHC class II antigen, specifically HLA DQ2?
Celiac Disease
Which condition is characterized by the presence of granulomatous inflammation and mucosal fissuring with the formation of fistulas?
Crohn Disease
Which condition is triggered by non-granulomatous inflammation that starts in the rectum and then extends proximally to involve the whole of the colon ?
Ulcerative Colitis
Which condition is characterized by chronic inflammation and fibrosis with stricture formation, most commonly in the splenic flexure?
Diverticular disease
Which condition presents with toxin-mediated damage, superficially damaged crypts distended by mucopurulent exudate, and the formation of a mushrooming cloud from erupting exudate?
Pseudo Membranous Colitis
Which condition is associated with inadequate flow of oxygenated blood to the intestine, leading to chronic ischemic colitis?
Ischemic bowel disease
What is the characteristic shape of the structures in diverticular disease?
Flask-like
What is the result of incomplete involution of the vitelline duct?
Meckel’s Diverticulum
Study Notes
Celiac Disease
- Diagnosed using serologic tests, commonly involving the use of specific antibodies
Congenital Intestinal Obstruction
- Most commonly caused by intestinal atresia or stenosis
Hirschsprung's Disease
- Characterized by the absence of ganglion cells in the distal intestine
Diverticular Disease
- Results from the pathogenesis of a low-fiber diet, constipation, and increased intra-abdominal pressure
- Characterized by the formation of pouches or sacs in the intestinal wall
Pseudo Membranous Colitis
- Characterized by the presence of raised yellow plaques in the colon, particularly the rectosigmoid
- Associated with broad-spectrum antibiotic use
Inflammatory Bowel Disease (IBD)
- Characterized by intermittent rectal bleeding, bloody diarrhea, and abdominal pain
- Typically involves continuous colonic involvement
Crohn Disease
- Characterized by sharp, transmural, and granulomatous inflammation
- Can affect any part of the gastrointestinal tract from mouth to anus
- Has a higher risk of developing malignancy and neoplasia
- Associated with Primary Sclerosing Cholangitis (PSC) and HLA-DQB1
Ulcerative Colitis
- Characterized by mucosal inflammation limited to the colon
- Can exhibit more variable symptoms than Crohn's disease
Other Conditions
- Hirschsprung's disease is characterized by dilatation proximal to obstruction, leading to megacolon, and the rectum is always affected
- Diverticular disease is associated with a lack of dietary fiber, leading to sustained bowel contractions and increased intraluminal pressure
- Ischemic colitis is associated with inadequate flow of oxygenated blood to the intestine, leading to chronic ischemic colitis
- Intestinal atresia or stenosis is the most common cause of congenital intestinal obstruction
- The characteristic shape of the structures in diverticular disease is sac-like
- Meckel's diverticulum results from incomplete involution of the vitelline duct
Test your knowledge of Celiac Disease and Hirschsprung's Disease with this quiz. Explore topics such as genetic susceptibility, serologic tests, and MHC class II antigen expression. Perfect for medical students and professionals.
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