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Questions and Answers
What is the characteristic color of the skin lesions associated with Kaposi's sarcoma?
What is the characteristic color of the skin lesions associated with Kaposi's sarcoma?
What type of cells are involved in the development of Kaposi's sarcoma?
What type of cells are involved in the development of Kaposi's sarcoma?
What is the name of the lymphoma associated with HHV8?
What is the name of the lymphoma associated with HHV8?
How is HHV8 typically transmitted?
How is HHV8 typically transmitted?
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What is the underlying cause of the development of Kaposi's sarcoma?
What is the underlying cause of the development of Kaposi's sarcoma?
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What is the role of vascular endothelial growth factor (VEGF) in Kaposi's sarcoma?
What is the role of vascular endothelial growth factor (VEGF) in Kaposi's sarcoma?
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What is the most common site for Kaposi's sarcoma lesions?
What is the most common site for Kaposi's sarcoma lesions?
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How can Kaposi's sarcoma be differentiated from bartonella henselae?
How can Kaposi's sarcoma be differentiated from bartonella henselae?
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Study Notes
HHV8 and Kaposi's Sarcoma
- HHV8 (Human Herpesvirus 8) is associated with Kaposi's Sarcoma, a type of cancer.
- HHV8 is a DNA virus from the Herpes family.
Characteristics of Kaposi's Sarcoma
- Erythematous violaceous lesions can occur on the nose, extremities, and mucous membranes.
- Lesions can appear as plaques, patches, macules, or nodules.
- Lesions are caused by the proliferation of primitive mesenchymal cells, leading to angiogenesis.
Angiogenesis and VEGF
- Dysregulation of vascular endothelial growth factor (VEGF) contributes to the development of Kaposi's Sarcoma.
Lesion Locations
- The hard palate is the most common location for Kaposi's Sarcoma lesions.
- Intestinal lesions can also occur.
Transmission and Risk Groups
- HHV8 can be transmitted through saliva, with kissing being a possible mode of transmission.
- Elderly Russian men and people from endemic areas in Africa are at increased risk.
Differential Diagnosis
- HHV8-induced Kaposi's Sarcoma must be differentiated from Bartonella henselae infections.
- Lymphocytic infiltrate is characteristic of HHV8-induced lesions, whereas Bacillary angiomatosis has a neutrophil infiltrate.
Treatment and Association with AIDS
- HHV8-induced Kaposi's Sarcoma is often treated with AIDS therapy.
- The virus primarily affects people with weakened immune systems, such as those with AIDS.
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