Podcast
Questions and Answers
Which biologic drug is used for treating melanoma with BRAF V600E mutation?
Which biologic drug is used for treating melanoma with BRAF V600E mutation?
- Imatinib
- Ipilimumab
- Rituximab
- Vemurafenib (correct)
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
- Dacarbazine
- Pembrolizumab (correct)
- Ipilimumab
- Nivolumab
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
- Vemurafenib
- Cobimetinib
- Ipilimumab (correct)
- Trametinib
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
Which biologic drug targets the MEK pathway in the treatment of melanoma?
Which biologic drug targets the MEK pathway in the treatment of melanoma?
In the treatment of melanoma, what is the target of Imatinib and Nilotinib?
In the treatment of melanoma, what is the target of Imatinib and Nilotinib?
Which drug is used as a third-line treatment for melanoma in patients with metastasis involving less than 5 organs?
Which drug is used as a third-line treatment for melanoma in patients with metastasis involving less than 5 organs?
What is the target of Ipilimumab in the treatment of melanoma?
What is the target of Ipilimumab in the treatment of melanoma?
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Case of melanoma with spread to LN, what is the treatment?
Case of melanoma with spread to LN, what is the treatment?
Which of the following is the mechanism of action of Vismodegib?
Which of the following is the mechanism of action of Vismodegib?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the next step in the management of a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
What is the next step in the management of a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
Which gene product is associated with Gorlin Syndrome?
Which gene product is associated with Gorlin Syndrome?
What type of tumor is indicated by a scalp lesion showing keratoacanthoma?
What type of tumor is indicated by a scalp lesion showing keratoacanthoma?
What is the mechanism of action of Bleomycin for intralesional therapy?
What is the mechanism of action of Bleomycin for intralesional therapy?
What immunohistochemical stain would be helpful in making the diagnosis of Lymphomatoid papulosis?
What immunohistochemical stain would be helpful in making the diagnosis of Lymphomatoid papulosis?
Activation of which protein leads to cell cycle arrest?
Activation of which protein leads to cell cycle arrest?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
The histopathology of spindle cells in a storiform pattern is associated with which genetic abnormality?
The histopathology of spindle cells in a storiform pattern is associated with which genetic abnormality?
In a male patient presenting with plaque pigmentation on the leg and testing positive for HHV8, what treatment would be most appropriate?
In a male patient presenting with plaque pigmentation on the leg and testing positive for HHV8, what treatment would be most appropriate?
What is the association of keratoacanthoma with intralesional therapy?
What is the association of keratoacanthoma with intralesional therapy?
What is the best treatment for a patient with mycosis fungoides, patch stage for 3 years?
What is the best treatment for a patient with mycosis fungoides, patch stage for 3 years?
Which protein inhibits the BCl2 apoptosis inhibitor, leading to cell death?
Which protein inhibits the BCl2 apoptosis inhibitor, leading to cell death?
What is another site where a small yellow nodule on the scalp, as seen in a small girl, might occur?
What is another site where a small yellow nodule on the scalp, as seen in a small girl, might occur?
How does activation of P21 (CDK inhibitor) affect the cell cycle?
How does activation of P21 (CDK inhibitor) affect the cell cycle?
A patient presents with recurrent crops of papules that ulcerate and then spontaneously heal with hyperpigmentation. What is the treatment for lymphomatoid papulosis?
A patient presents with recurrent crops of papules that ulcerate and then spontaneously heal with hyperpigmentation. What is the treatment for lymphomatoid papulosis?
What is the next investigation for an ulcerated melanoma with a Breslow depth of 0.85?
What is the next investigation for an ulcerated melanoma with a Breslow depth of 0.85?
What is the most common malignant tumor arising from nevus sebaceous?
What is the most common malignant tumor arising from nevus sebaceous?
In the context of Muir-Torre syndrome (Lynch syndrome), what DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
In the context of Muir-Torre syndrome (Lynch syndrome), what DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
What is the treatment for Actinic Keratosis if it presents as multiple lesions?
What is the treatment for Actinic Keratosis if it presents as multiple lesions?
In the histopathology of Squamous Cell Carcinoma, what is the typical site of the lesion?
In the histopathology of Squamous Cell Carcinoma, what is the typical site of the lesion?
What is the most common benign tumor arising from nevus sebaceous?
What is the most common benign tumor arising from nevus sebaceous?
What is the next step for a brown lesion on the back that has been present for 6 weeks?
What is the next step for a brown lesion on the back that has been present for 6 weeks?
Which gene defect is associated with Birt-hogg-Dube syndrome?
Which gene defect is associated with Birt-hogg-Dube syndrome?
In a case of malignant melanoma with a Breslow depth of invasion measuring 0.8mm, what is the safety margin of excision (in mm)?
In a case of malignant melanoma with a Breslow depth of invasion measuring 0.8mm, what is the safety margin of excision (in mm)?
If a patient presents with scaly plaques on hands and feet, and has a history of Bazex syndrome, what associated neoplasm should be considered?
If a patient presents with scaly plaques on hands and feet, and has a history of Bazex syndrome, what associated neoplasm should be considered?
Which biologic drug targets the MEK pathway in the treatment of melanoma?
Which biologic drug targets the MEK pathway in the treatment of melanoma?
In a case of melanoma with spread to LN, what is the first-line biologic treatment?
In a case of melanoma with spread to LN, what is the first-line biologic treatment?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
What is the mechanism of action of Vismodegib?
What is the mechanism of action of Vismodegib?
What is the mechanism of action of Bleomycin for intralesional therapy?
What is the mechanism of action of Bleomycin for intralesional therapy?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
The protein product of the gene PTCH1 is which of the following? (Gorlin syndrome)
The protein product of the gene PTCH1 is which of the following? (Gorlin syndrome)
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
What is the next step in the management of a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
What is the next step in the management of a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
What is the next step in the management of iatrogenic Kaposi without systemic affection in a patient on azathioprine and prednisolone?
What is the next step in the management of iatrogenic Kaposi without systemic affection in a patient on azathioprine and prednisolone?
In a patient with a highly progressive scalp tumor, what is the most appropriate treatment?
In a patient with a highly progressive scalp tumor, what is the most appropriate treatment?
In a male patient with a mass in his face showing vimentin positive, S100 negative, and CD 68 positive spindle-shaped cells, what type of tumor is most likely present?
In a male patient with a mass in his face showing vimentin positive, S100 negative, and CD 68 positive spindle-shaped cells, what type of tumor is most likely present?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
In a case of Kaposi and HHV8 positivity, what would be the most appropriate treatment?
In a case of Kaposi and HHV8 positivity, what would be the most appropriate treatment?
Which chromosome is associated with cylindroma?
Which chromosome is associated with cylindroma?
What treatment would be most appropriate for a single lesion of cutaneous B-cell lymphoma?
What treatment would be most appropriate for a single lesion of cutaneous B-cell lymphoma?
In a case of a tumor on the nose resembling keratoacanthoma or sebaceous carcinoma, which gene mutation is most likely present?
In a case of a tumor on the nose resembling keratoacanthoma or sebaceous carcinoma, which gene mutation is most likely present?
What is the next investigation needed for Langerhans cell histiocytosis?
What is the next investigation needed for Langerhans cell histiocytosis?
What protein inhibits the BCl2 apoptosis inhibitor, leading to cell death?
What protein inhibits the BCl2 apoptosis inhibitor, leading to cell death?
In the histopathology of spindle cells in a storiform pattern, which genetic abnormality is associated?
In the histopathology of spindle cells in a storiform pattern, which genetic abnormality is associated?
What is the target of Ipilimumab in the treatment of melanoma?
What is the target of Ipilimumab in the treatment of melanoma?
What is the most common benign tumor arising from nevus sebaceous?
What is the most common benign tumor arising from nevus sebaceous?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
What is the next investigation for an ulcerated melanoma with a Breslow depth of 0.85?
What is the next investigation for an ulcerated melanoma with a Breslow depth of 0.85?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
Which gene defect is associated with Birt-Hogg-Dube syndrome?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is present in H/E of porokeratosis?
What is present in H/E of porokeratosis?
In the treatment of melanoma, what is the target of Imatinib and Nilotinib?
In the treatment of melanoma, what is the target of Imatinib and Nilotinib?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
What is the next step for a brown lesion on the back that has been present for 6 weeks?
What is the next step for a brown lesion on the back that has been present for 6 weeks?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
What is the target of Vemurafenib and its alternative if not chosen?
What is the target of Vemurafenib and its alternative if not chosen?
In the treatment of melanoma, what is the first-line biologic treatment for patients with metastasis involving less than 5 organs?
In the treatment of melanoma, what is the first-line biologic treatment for patients with metastasis involving less than 5 organs?
What is the target of Cobimetinib and its alternative if not chosen?
What is the target of Cobimetinib and its alternative if not chosen?
Which gene mutation is most likely present in a case of a tumor on the nose resembling keratoacanthoma or sebaceous carcinoma?
Which gene mutation is most likely present in a case of a tumor on the nose resembling keratoacanthoma or sebaceous carcinoma?
Which biologic drug is used for treating melanoma with PD-1 negative?
Which biologic drug is used for treating melanoma with PD-1 negative?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
What is the most appropriate treatment for a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
What is the most appropriate treatment for a patient with iatrogenic Kaposi and no systemic affection while on azathioprine & prednisolone?
A patient has a scalp tumor that appears to be keratoacanthoma. What would be the better treatment option between injection of Bleomycin or MTX?
A patient has a scalp tumor that appears to be keratoacanthoma. What would be the better treatment option between injection of Bleomycin or MTX?
In a case of a highly progressive tumor in the scalp, what would be the most likely diagnosis?
In a case of a highly progressive tumor in the scalp, what would be the most likely diagnosis?
A 40-year-old female presents with a generalized purpuric eruption all over her body and a sole ulcer. What is the most appropriate treatment option?
A 40-year-old female presents with a generalized purpuric eruption all over her body and a sole ulcer. What is the most appropriate treatment option?
A small girl has a small yellow nodule on her scalp, what is another site where this type of lesion might occur?
A small girl has a small yellow nodule on her scalp, what is another site where this type of lesion might occur?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
What is the commonest malignancy transformation associated with lymphomatoid papulosis?
In a case of Sezary syndrome, how long should the patient take contraception?
In a case of Sezary syndrome, how long should the patient take contraception?
What is the mechanism of action of P53?
What is the mechanism of action of P53?
What DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
What DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
What is the best treatment for a patient with mycosis fungoides, patch stage for 3 years?
What is the best treatment for a patient with mycosis fungoides, patch stage for 3 years?
What is the next investigation needed for Langerhans cell histiocytosis?
What is the next investigation needed for Langerhans cell histiocytosis?
What is the next investigation needed for a patient with Langerhans cell histiocytosis?
What is the next investigation needed for a patient with Langerhans cell histiocytosis?
In a case of melanoma with spread to bilateral lymph nodes, what is the second-line biologic treatment?
In a case of melanoma with spread to bilateral lymph nodes, what is the second-line biologic treatment?
In the context of Muir-Torre syndrome (Lynch syndrome), what DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
In the context of Muir-Torre syndrome (Lynch syndrome), what DNA repair gene is missing in the presence of a lesion formed of basaloid cells and sebaceous gland on the nose?
What is the most common benign tumor arising from nevus sebaceous?
What is the most common benign tumor arising from nevus sebaceous?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
Which drug is used as a second-line treatment for melanoma in patients with metastasis involving less than 5 organs?
What is the target of Vismodegib?
What is the target of Vismodegib?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
What is the target of Imatinib and Nilotinib in the treatment of melanoma?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
What is present in H/E of keratoacanthoma?
What is present in H/E of keratoacanthoma?
In patients with widespread porokeratosis, what is the treatment?
In patients with widespread porokeratosis, what is the treatment?
What is the mechanism of action of Vismodegib?
What is the mechanism of action of Vismodegib?
The protein product of the gene PTCH1, associated with Gorlin Syndrome, is:
The protein product of the gene PTCH1, associated with Gorlin Syndrome, is:
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the association of a skin-colored solitary nodule under the eye in a child with Von Kossa stain positive?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
What is the target of Pembrolizumab and Nivolumab in the treatment of melanoma?
In a patient with a mass in his face showing vimentin positive, S100 negative, and CD 68 positive spindle-shaped cells, what type of tumor is most likely present?
In a patient with a mass in his face showing vimentin positive, S100 negative, and CD 68 positive spindle-shaped cells, what type of tumor is most likely present?
What is the association of keratoacanthoma with intralesional therapy?
What is the association of keratoacanthoma with intralesional therapy?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
In patients with metastasis involving less than 5 organs, what is the first-line biologic treatment for melanoma?
What is the next investigation needed for Langerhans cell histiocytosis?
What is the next investigation needed for Langerhans cell histiocytosis?
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