Podcast
Questions and Answers
What does a positive IgM anti-HAV result indicate?
What does a positive IgM anti-HAV result indicate?
What does a positive result for anti-HBs without HBsAg suggest?
What does a positive result for anti-HBs without HBsAg suggest?
How long can it take for HBsAg to appear in the serum after initial infection?
How long can it take for HBsAg to appear in the serum after initial infection?
What does the presence of anti-HBc indicate?
What does the presence of anti-HBc indicate?
Signup and view all the answers
When is the IgG anti-HAV typically detectable after symptoms begin?
When is the IgG anti-HAV typically detectable after symptoms begin?
Signup and view all the answers
What does HBsAg seroconversion indicate?
What does HBsAg seroconversion indicate?
Signup and view all the answers
What is a characteristic of IgM anti-HBc?
What is a characteristic of IgM anti-HBc?
Signup and view all the answers
What does a positive HAV IgM suggest when interpreted with clinical symptoms?
What does a positive HAV IgM suggest when interpreted with clinical symptoms?
Signup and view all the answers
Study Notes
Hepatitis Serology
- Hepatitis A Serology
- IgM anti-HAV test: Detects IgM antibodies produced during initial hepatitis A infection, usually detectable 2 weeks after symptom onset.
- IgG anti-HAV test: Detects IgG antibodies that develop later in the infection and persist for life, providing long-term immunity and indicating past infection.
- A positive IgM result might indicate a recent infection, needing consideration for clinical symptoms and exposure history.
- A positive IgG result confirms immunity to hepatitis A.
Hepatitis B Serology
- Hepatitis B Surface Antigen (HBsAg): Protein on the surface of HBV, the first detectable marker of infection, which sometimes takes up to 100 days to appear in the blood.
- HBsAg seroconversion: The development of antibodies against HBsAg (anti-HBs), signifying clearance of HBsAg and the resolution of the infection.
- Persistent HBsAg for more than six months signifies chronic active infection.
- Anti-HBs: The antibody produced by the body in response to HBsAg. A positive anti-HBs result without HBsAg signifies either a previous infection or successful vaccination for hepatitis B. Anti-HBs persists for life and signifies immunity to hepatitis B.
- Antibody to Hepatitis B core antigen (anti-HBc), IgM & IgG
- Appears during the onset of symptoms in acute hepatitis B and persists for life.
- Detecting anti-HBc indicates a previous or current hepatitis B infection.
- IgM anti-HBc appears during the initial infection, and its presence indicates recent infection within the last six months.
- Over time, IgM anti-HBc is replaced by IgG anti-HBc
- Anti-HBc, therefore, is seen in individuals with resolved infections or chronic hepatitis B.
Hepatitis C Serology
- Anti-HCV: Indicates either a past or current HCV infection.
- A negative Anti-HCV test result: Suggests no prior or current HCV infection.
- A positive Anti-HCV test result: Suggests a current infection, or past infection.
- HCV RNA: Indicates the presence of HCV in the blood.
- A negative HCV RNA test result: Suggests no current HCV infection.
- A positive HCV RNA test result: Identifies a current infection and viral replication.
Summary Table (Hepatitis B)
| Condition | HBsAg | Anti-HBs | Anti-HBc |
|---|---|---|---|
| Susceptible | Negative | Negative | Negative |
| Vaccinated | Negative | Positive | Negative |
| Past Infection | Negative | Positive | Positive |
| Acute Infection | Positive | Negative | IgM Positive |
| Chronic Infection | Positive | Negative | IgG Positive |
Summary Table (Hepatitis C)
| Condition | Anti-HCV | HCV RNA |
|---|---|---|
| Nonreactive | Negative | Negative |
| Current Infection | Positive | Positive |
| Past Infection | Positive | Negative |
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Explore the key aspects of hepatitis serology including tests for Hepatitis A and Hepatitis B. Understand the significance of IgM and IgG antibodies, as well as the markers for Hepatitis B infection. This quiz will help reinforce your knowledge of serological markers and their implications in clinical settings.
