Podcast
Questions and Answers
Which of the following indicates immunity due to resolved Hepatitis B infection?
Which of the following indicates immunity due to resolved Hepatitis B infection?
Which serologic marker is positive during the window period of Hepatitis B infection?
Which serologic marker is positive during the window period of Hepatitis B infection?
What is the most likely diagnosis for a 45-year-old man who has been HBsAg positive for 7 months with anti-HBc IgG positive and anti-HBs negative?
What is the most likely diagnosis for a 45-year-old man who has been HBsAg positive for 7 months with anti-HBc IgG positive and anti-HBs negative?
What does the presence of anti-HBs positive and anti-HBc negative indicate in a healthy individual?
What does the presence of anti-HBs positive and anti-HBc negative indicate in a healthy individual?
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Which of the following statements about anti-HBc IgM is true?
Which of the following statements about anti-HBc IgM is true?
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What does the presence of HBsAg in a patient’s serology indicate?
What does the presence of HBsAg in a patient’s serology indicate?
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How can immunity from vaccination be differentiated from natural immunity?
How can immunity from vaccination be differentiated from natural immunity?
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Which serologic marker persists for life and serves as evidence of past Hepatitis B infection?
Which serologic marker persists for life and serves as evidence of past Hepatitis B infection?
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Study Notes
Hepatitis B Serology Markers
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HBsAg (Hepatitis B surface antigen): Indicates active infection. Its presence signifies the virus is replicating.
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Anti-HBs (Antibody to Hepatitis B surface antigen): Indicates immunity, either from vaccination or recovery from infection. It's a marker of resolved infection or vaccination.
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Anti-HBc (Antibody to Hepatitis B core antigen): Indicates past or present infection. Anti-HBc IgM is the first to appear during acute infection. Anti-HBc IgG persists for life after infection and is a marker of past infection.
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Anti-HBc IgM: An essential marker to identify acute Hepatitis B infection. It appears early, before or alongside HBsAg.
Key Stages and Markers
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Acute infection: Characterized by the presence of HBsAg, Anti-HBc IgM, and absence of anti-HBs. Anti-HBc IgM appears early.
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Window period: A crucial period during infection where HBsAg is absent, but Anti-HBc IgM and eventually Anti-HBc IgG are present. HBV DNA may also be detectable.
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Chronic infection: Persistent HBsAg for at least 6 months suggests chronic infection. This is often associated with Anti-HBc IgG and absence of anti-HBs.
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Resolved infection: Marked by a negative HBsAg test and presence of Anti-HBs antibody, indicating recovery. Anti-HBc IgG will be positive, showing a past infection.
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Immunity from vaccination: Indicated by a positive anti-HBs test and absence of Anti-HBc.
Differentiating Immunity
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Natural immunity (from infection): Characterized by positive Anti-HBc (both IgM and IgG) and positive anti-HBs.
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Vaccination-acquired immunity: Recognized by a positive Anti-HBs result with a negative Anti-HBc.
Example Scenario Interpretations (based on the provided questions)
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A positive HBsAg, positive Anti-HBc IgG, negative anti-HBs indicates a likely chronic infection.
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A negative HBsAg, positive Anti-HBc IgM, negative anti-HBs suggests an acute infection.
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A positive Anti-HBs and negative Anti-HBc signifies immunity likely due to vaccination.
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A positive Anti-HBc IgG indicates past infection or chronic infection.
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Description
Test your knowledge of Hepatitis B serology markers and their significance. This quiz covers the different antibodies and antigens, their roles in infection stages, and what they indicate about a person's health status. Perfect for students studying virology or medicine.
