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Questions and Answers
Which of the following indicates immunity due to resolved Hepatitis B infection?
Which of the following indicates immunity due to resolved Hepatitis B infection?
- HBsAg positive, anti-HBc IgM positive, anti-HBs negative
- HBsAg positive, HBV DNA detectable, anti-HBs negative
- HBsAg negative, anti-HBc IgG positive, anti-HBs negative
- HBsAg negative, anti-HBc IgG positive, anti-HBs positive (correct)
Which serologic marker is positive during the window period of Hepatitis B infection?
Which serologic marker is positive during the window period of Hepatitis B infection?
- HBV DNA
- Anti-HBs
- Anti-HBc IgM (correct)
- HBsAg
What is the most likely diagnosis for a 45-year-old man who has been HBsAg positive for 7 months with anti-HBc IgG positive and anti-HBs negative?
What is the most likely diagnosis for a 45-year-old man who has been HBsAg positive for 7 months with anti-HBc IgG positive and anti-HBs negative?
- Chronic Hepatitis B infection (correct)
- Resolved Hepatitis B infection
- Immunization
- Acute Hepatitis B infection
What does the presence of anti-HBs positive and anti-HBc negative indicate in a healthy individual?
What does the presence of anti-HBs positive and anti-HBc negative indicate in a healthy individual?
Which of the following statements about anti-HBc IgM is true?
Which of the following statements about anti-HBc IgM is true?
What does the presence of HBsAg in a patient’s serology indicate?
What does the presence of HBsAg in a patient’s serology indicate?
How can immunity from vaccination be differentiated from natural immunity?
How can immunity from vaccination be differentiated from natural immunity?
Which serologic marker persists for life and serves as evidence of past Hepatitis B infection?
Which serologic marker persists for life and serves as evidence of past Hepatitis B infection?
Flashcards
Resolved Hepatitis B infection markers
Resolved Hepatitis B infection markers
An infection that was cured and no longer active; indicated by negative HBsAg, positive anti-HBc IgG, and positive anti-HBs.
Hepatitis B window period marker
Hepatitis B window period marker
The time when HBsAg is undetectable, but anti-HBc IgM is present, as the body is fighting the virus.
Chronic Hepatitis B infection markers
Chronic Hepatitis B infection markers
A long-lasting Hepatitis B infection; indicated by positive HBsAg, positive anti-HBc IgG, and negative anti-HBs.
Vaccination immunity marker
Vaccination immunity marker
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Anti-HBc IgM meaning
Anti-HBc IgM meaning
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HBsAg presence meaning
HBsAg presence meaning
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Differentiating vaccination and natural immunity
Differentiating vaccination and natural immunity
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Acute Hepatitis B infection markers
Acute Hepatitis B infection markers
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Study Notes
Hepatitis B Serology Markers
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HBsAg (Hepatitis B surface antigen): Indicates active infection. Its presence signifies the virus is replicating.
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Anti-HBs (Antibody to Hepatitis B surface antigen): Indicates immunity, either from vaccination or recovery from infection. It's a marker of resolved infection or vaccination.
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Anti-HBc (Antibody to Hepatitis B core antigen): Indicates past or present infection. Anti-HBc IgM is the first to appear during acute infection. Anti-HBc IgG persists for life after infection and is a marker of past infection.
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Anti-HBc IgM: An essential marker to identify acute Hepatitis B infection. It appears early, before or alongside HBsAg.
Key Stages and Markers
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Acute infection: Characterized by the presence of HBsAg, Anti-HBc IgM, and absence of anti-HBs. Anti-HBc IgM appears early.
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Window period: A crucial period during infection where HBsAg is absent, but Anti-HBc IgM and eventually Anti-HBc IgG are present. HBV DNA may also be detectable.
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Chronic infection: Persistent HBsAg for at least 6 months suggests chronic infection. This is often associated with Anti-HBc IgG and absence of anti-HBs.
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Resolved infection: Marked by a negative HBsAg test and presence of Anti-HBs antibody, indicating recovery. Anti-HBc IgG will be positive, showing a past infection.
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Immunity from vaccination: Indicated by a positive anti-HBs test and absence of Anti-HBc.
Differentiating Immunity
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Natural immunity (from infection): Characterized by positive Anti-HBc (both IgM and IgG) and positive anti-HBs.
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Vaccination-acquired immunity: Recognized by a positive Anti-HBs result with a negative Anti-HBc.
Example Scenario Interpretations (based on the provided questions)
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A positive HBsAg, positive Anti-HBc IgG, negative anti-HBs indicates a likely chronic infection.
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A negative HBsAg, positive Anti-HBc IgM, negative anti-HBs suggests an acute infection.
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A positive Anti-HBs and negative Anti-HBc signifies immunity likely due to vaccination.
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A positive Anti-HBc IgG indicates past infection or chronic infection.
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