Hepatitis C Overview
24 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What immunization is recommended for all patients with chronic HCV infection?

  • Human Papillomavirus vaccine
  • Pneumococcal vaccine
  • Hepatitis A and B vaccines (correct)
  • Influenza vaccine
  • What condition is NOT accelerated in progression of liver disease among children with chronic HCV infection?

  • Iron overload
  • Childhood cancer
  • Asthma (correct)
  • HIV
  • Which monitoring is essential for children with chronic HCV infection?

  • Regular ECG examinations
  • Monitoring of blood glucose levels
  • Sequential monitoring of serum alanine transaminase concentrations (correct)
  • Sequential monitoring of serum creatinine levels
  • What therapy is contraindicated for postexposure prophylaxis against HCV infection due to lack of clinical efficacy?

    <p>Immune globulin (D)</p> Signup and view all the answers

    Which factor increases liver-related morbidity and mortality in patients with chronic HCV infection?

    <p>Advancing age (C)</p> Signup and view all the answers

    What is NOT considered an adverse effect of traditional therapies for HCV?

    <p>Severe dehydration (B)</p> Signup and view all the answers

    Which statement regarding breastfeeding is true for mothers infected with HCV?

    <p>HCV transmission by breastfeeding has not been documented. (D)</p> Signup and view all the answers

    What is recommended for the management of pediatric patients with HCV infection?

    <p>Close monitoring and following published guidelines (B)</p> Signup and view all the answers

    What is the primary reason highly sensitive quantitative assays have replaced qualitative assays for measuring HCV RNA?

    <p>Quantitative assays provide information on drug treatment regimens. (C)</p> Signup and view all the answers

    What proportion of the general population in the United States is estimated to have chronic HCV infection?

    <p>1.3% (C)</p> Signup and view all the answers

    Why is HCV genotyping important in treatment protocols?

    <p>To determine which antiviral agents should be used. (D)</p> Signup and view all the answers

    What is the recommended age for serologic testing for HCV in perinatally infected infants?

    <p>18 months (D)</p> Signup and view all the answers

    Which group is most likely to experience acute HCV cases according to reported data?

    <p>Young nonurban white individuals (B)</p> Signup and view all the answers

    What should be done if a perinatally HCV-exposed infant is not followed until 18 months of age?

    <p>Consider performing quantitative RNA tests as early as 1 to 2 months. (C)</p> Signup and view all the answers

    Which method is primarily responsible for HCV transmission among children?

    <p>Maternal-fetal transmission (B)</p> Signup and view all the answers

    What should patients diagnosed with HCV infection be referred for?

    <p>Clinical monitoring and potential enrollment in clinical trials. (B)</p> Signup and view all the answers

    What is the estimated risk of HCV infection after blood transfusion in the United States?

    <p>1 in 2 million units (A)</p> Signup and view all the answers

    According to seroprevalence data, which region has the highest prevalence of chronic HCV infection worldwide?

    <p>Northern Africa (D)</p> Signup and view all the answers

    Which of the following is a disadvantage of traditional therapies such as interferon-based treatments?

    <p>They can have significant adverse reactions. (D)</p> Signup and view all the answers

    What is the current standard of care therapy for adults with HCV?

    <p>Interferon-free direct-acting antiviral drug regimens. (D)</p> Signup and view all the answers

    What is the most notable preventive measure to reduce the risk of HCV transmission during blood transfusions?

    <p>All of the above (D)</p> Signup and view all the answers

    Which demographic in the United States has seen a substantial increase in HCV infection rates?

    <p>Non-urban young white individuals (B)</p> Signup and view all the answers

    What should be done if the initial quantitative HCV RNA result is negative for an infant?

    <p>Serologic testing should be performed at 18 months. (B)</p> Signup and view all the answers

    What factor is often related to the prevalence of HCV among various populations?

    <p>Risk factors associated with behavior (B)</p> Signup and view all the answers

    Flashcards

    HCV RNA detection

    Measuring the presence or amount of Hepatitis C virus RNA in a sample.

    Quantitative HCV RNA assays

    Assays that measure the concentration of HCV RNA.

    HCV genotyping

    Identifying the specific type (genotype) of HCV.

    Treatment regimens for HCV

    Strategies used to treat Hepatitis C infection.

    Signup and view all the flashcards

    Perinatal HCV infection

    HCV infection acquired during childbirth.

    Signup and view all the flashcards

    Serologic testing (HCV)

    Blood test for antibodies against HCV.

    Signup and view all the flashcards

    Direct-acting antivirals (DAAs)

    Drugs that specifically target HCV.

    Signup and view all the flashcards

    HCV infection monitoring

    Tracking a patient's HCV infection for treatment and monitoring.

    Signup and view all the flashcards

    HCV infection in children

    Chronic HCV infection in children can progress faster if they have other health conditions like HIV, cancer, iron overload, or thalassemia.

    Signup and view all the flashcards

    HCV and Liver Disease

    Chronic HCV infection significantly increases the risk of liver damage, cirrhosis, and liver cancer, especially with age.

    Signup and view all the flashcards

    Hepatitis A&B vaccination

    Patients with chronic HCV infection should get vaccinated for hepatitis A and B, due to a high risk of severe hepatitis.

    Signup and view all the flashcards

    Monitoring Children with HCV

    Children with HCV should be closely monitored, including tracking alanine transaminase (ALT) levels, to detect and manage possible liver disease progression.

    Signup and view all the flashcards

    HCV in Adults

    Chronic HCV infection increases the risk of liver complications (cirrhosis and liver cancer) in adults as they age.

    Signup and view all the flashcards

    HCV and Other Conditions

    Co-occurring infections, alcohol use, and specific medications (like acetaminophen or antiretrovirals) can worsen HCV-related liver disease in patients.

    Signup and view all the flashcards

    HCV Guidelines

    Evidence-based guidelines for screening, treatment, and managing HCV infection are available online.

    Signup and view all the flashcards

    Breastfeeding with HCV

    Mothers with HCV infection can breastfeed safely. Transmission through breastfeeding is not documented.

    Signup and view all the flashcards

    HCV infection prevalence in US

    Estimated at 1.3% of general population, equating to 3.5 million with chronic infection.

    Signup and view all the flashcards

    HCV transmission in adults

    Injection drug use or blood products before 1992 are most common risk factors.

    Signup and view all the flashcards

    HCV transmission in children

    Maternal-fetal transmission is the most common route.

    Signup and view all the flashcards

    HCV risk from blood transfusion (US)

    Extremely low, estimated at less than 1 case per 2 million units.

    Signup and view all the flashcards

    HCV and injection drug use

    A significant risk factor, as approximately 60% of reported acute cases are linked to injection drug users.

    Signup and view all the flashcards

    High HCV prevalence regions

    Concentrated in northern Africa, the Middle East, and parts of Asia.

    Signup and view all the flashcards

    HCV infection route

    Primarily through percutaneous (parenteral) exposures to infected blood.

    Signup and view all the flashcards

    HCV in young people

    Mostly found in white, nonurban, young people with a history of injection drug use and opioid use.

    Signup and view all the flashcards

    Study Notes

    Hepatitis C

    • Hepatitis C virus (HCV) infection signs and symptoms are similar to other hepatitis types
    • Acute HCV is often mild and asymptomatic
    • Jaundice occurs in less than 20% of patients
    • Serum alanine transaminase levels are usually less pronounced than in hepatitis B
    • Up to 80% of children experience persistent HCV infection, often without symptoms
    • Chronic HCV infection and cirrhosis are less common in children than adults
    • Liver failure due to HCV is a leading cause of liver transplants in adults
    • HCV is a single-stranded, positive-sense RNA virus in the Flaviviridae family
    • At least 7 genotypes and more than 50 subtypes of HCV exist
    • Genotype 1a is prevalent in the United States
    • HCV transmission primarily occurs through percutaneous exposure to infected blood
    • Injection drug use and blood transfusions before 1992 are common risk factors for adults
    • Maternal-fetal transmission is a common route for children
    • Antibody testing and nucleic acid amplification tests (NAAT) are used for diagnosis
    • HCV RNA can be detected 1-2 weeks after exposure
    • 97% sensitivity and >99% specificity for third-generation immunoassays
    • Testing for HCV RNA is recommended as follow up for serologic results
    • HCV RNA tests can be used to monitor treatment response
    • Many current therapies are oral, once-daily, and effective
    • Treatment generally aims for a sustained virologic response (cure)
    • HCV infection increases risk of cirrhosis and liver cancer (HCC) with increasing age
    • Other conditions (e.g., HIV, cancer, iron overload) can increase HCV disease progression rates
    • Immunoprophylaxis is not recommended for HCV
    • Breastfeeding is safe for HCV-infected mothers
    • Children with HCV infection should not be excluded from child care
    • HCV testing is recommended for high-risk individuals (e.g., injection drug use history individuals born between 1945-1965) and those with symptoms/risk factors
    • Pregnant women should be tested due to potential for transmission
    • Children born to HCV-positive mothers may develop HCV, increasing with higher HCV RNA levels in the mother
    • Appropriate testing time for infants is after maternal antibody levels have subsided (~18 months).

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Hepatitis C PDF - Red Book 2018

    Description

    This quiz covers the key aspects of Hepatitis C infection, including its symptoms, transmission routes, and prevalence among different age groups. Learn about the characteristics of the Hepatitis C virus, including its genotypes and the impact on liver health. Test your knowledge on this important infectious disease.

    More Like This

    Hepatitis E Overview
    5 questions

    Hepatitis E Overview

    Darling talent avatar
    Darling talent
    Hepatitis B Virus Overview
    40 questions

    Hepatitis B Virus Overview

    EndorsedOrangeTree avatar
    EndorsedOrangeTree
    Liver Disease and Hepatitis Overview
    48 questions

    Liver Disease and Hepatitis Overview

    FastestGrowingWilliamsite5240 avatar
    FastestGrowingWilliamsite5240
    Hepatitis Overview Quiz
    24 questions

    Hepatitis Overview Quiz

    HardierNovaculite9063 avatar
    HardierNovaculite9063
    Use Quizgecko on...
    Browser
    Browser