Hepatitis B Complications Quiz
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Questions and Answers

What is the most common route of transmission for Hepatitis A virus?

  • Respiratory droplets
  • Fecal-oral route (correct)
  • Sexual contact
  • Blood transfusion

What changes are seen in liver cells due to Hepatitis A virus infection?

  • Minimal structural changes (correct)
  • Hepatocellular hypertrophy
  • Kupffer cell activation
  • Portal vein thrombosis

Which symptom is NOT commonly associated with Hepatitis A infection?

  • Dark yellow urine
  • Jaundice
  • Rash on the skin (correct)
  • Loss of appetite

What makes Hepatitis B virus highly infectious compared to HIV?

<p>High resistance to extreme conditions (A)</p> Signup and view all the answers

Which antigen is present on the envelope of Hepatitis B virus?

<p>Hepatitis B surface antigen (HBsAg) (C)</p> Signup and view all the answers

How long can chronic Hepatitis B infection last?

<p>&gt; 6 months (C)</p> Signup and view all the answers

Which condition may require a liver transplant to sustain life?

<p>Liver failure (C)</p> Signup and view all the answers

Which virus is the most common cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma?

<p>Hepatitis C Virus (HCV) (C)</p> Signup and view all the answers

What possible pathogenic mechanisms can lead to Hepatocellular Carcinoma as discussed in the text?

<p>Integration of viral RNA into host genome (A)</p> Signup and view all the answers

What factors contribute to the risk of liver cancer in individuals with chronic hepatitis B?

<p>Necrosis of hepatocytes (C)</p> Signup and view all the answers

Which viral infection can lead to chromosomal deletions and rearrangements in host DNA?

<p>Hepatitis B Virus (HBV) (D)</p> Signup and view all the answers

Which type of virus is HCV based on its genetic material and structure?

<p>Single-stranded RNA virus (B)</p> Signup and view all the answers

What is a significant complication of HBV disease?

<p>Hepatocellular carcinoma (B)</p> Signup and view all the answers

Which stage of the Hepatitis B Virus life cycle represents the incubation period?

<p>Immune tolerance (C)</p> Signup and view all the answers

Which phase is characterized by the identification of HBeAg in the sera and a decline in HBV DNA levels?

<p>Immune active/immune clearance (A)</p> Signup and view all the answers

What type of cells kill infected hepatocytes through the action of perforins and granzymes?

<p>Natural killer cells (D)</p> Signup and view all the answers

Which cytokines released by damaged liver cells can trigger prostaglandins in the brain?

<p>IL1, IL6 &amp; TNF-a (A)</p> Signup and view all the answers

What influences the development of the five stages in the Hepatitis B Virus life cycle?

<p>Age, sex, immunosuppression, &amp; coinfection (C)</p> Signup and view all the answers

What is a possible mechanism contributing to chronic Hepatitis C infection?

<p>Insulin resistance (D)</p> Signup and view all the answers

Why does chronic hepatitis C persist in the liver for more than 6 months?

<p>Inadequate immune response (D)</p> Signup and view all the answers

What is one similarity between Hepatitis C and HIV in terms of immune evasion?

<p>Both viruses generate CTL escape mutants (C)</p> Signup and view all the answers

What can develop after decades of Hepatitis C infection and makes liver function difficult?

<p>Liver cirrhosis (B)</p> Signup and view all the answers

How does Hepatitis C escape the immune system's detection?

<p>Changes through mutation to generate CTL escape mutants (D)</p> Signup and view all the answers

What is a possible consequence of advanced cirrhosis caused by chronic Hepatitis C infection?

<p>Liver cancer development (B)</p> Signup and view all the answers

What is one of the features of cirrhosis mentioned in the text?

<p>Nodular tissue growth (C)</p> Signup and view all the answers

Which of the following factors can lead to portal hypertension in cirrhosis?

<p>Distortion of blood vessels obstructing flow (C)</p> Signup and view all the answers

What may occur due to increased pressure in the portal vein in cirrhosis?

<p>Esophageal varices development (D)</p> Signup and view all the answers

What condition may result from the rupture of esophageal varices in cirrhosis?

<p>Blood leakage into the upper GI tract (B)</p> Signup and view all the answers

How do toxins contribute to Hepatic Encephalopathy in cirrhosis?

<p>Toxins build up in blood due to liver damage (A)</p> Signup and view all the answers

What happens to the reticulin network in cirrhosis as per the text?

<p>It collapses due to liver cell death (A)</p> Signup and view all the answers

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