Hepatic Encephalopathy Experiment Overview

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Questions and Answers

What is the primary hypothesis being tested in the hepatic encephalopathy experiment?

  • Increased liver size results from ammonia exposure.
  • Liver regeneration occurs after ammonia administration.
  • Liver injury causes elevated blood acidity levels.
  • Ammonia intoxication leads to hepatic encephalopathy. (correct)

Why is the rabbit fixed in a supine position without anesthesia during the experiment?

  • To prevent movement during the anesthesia process.
  • To maintain consciousness for observation of changes. (correct)
  • To reduce stress levels in the animal.
  • To avoid complications during the surgery.

What is the purpose of ligating blood vessels surrounding the liver during the surgery?

  • To simulate liver injury effectively. (correct)
  • To promote liver regeneration.
  • To enhance blood flow to the liver.
  • To prevent excessive blood loss during the procedure.

Which step in the procedure involves ensuring the catheter is directed toward the intestines?

<p>Duodenum surgery. (A)</p> Signup and view all the answers

What is the purpose of administering compound ammonium chloride every 5 minutes?

<p>To gradually increase blood ammonia levels. (A)</p> Signup and view all the answers

Which of the following best describes the significance of making an 8 cm midline incision?

<p>To provide adequate access to the liver and surrounding structures. (D)</p> Signup and view all the answers

What method is used to confirm the rabbit's responsiveness during the observation phase?

<p>Assessing corneal reflex. (B)</p> Signup and view all the answers

What initial action is taken to prepare the rabbit before surgery?

<p>Weighing the rabbit. (B)</p> Signup and view all the answers

Flashcards

Ammonia intoxication hypothesis

A hypothesis suggesting liver injury leading to increased blood ammonia causes ammonia toxicity, resulting in hepatic encephalopathy.

Liver ligation

A surgical procedure that simulates liver injury by tying off blood vessels surrounding the liver.

Ammonia salt injection

A procedure involving injecting ammonia salt into the intestine to mimic increased ammonia levels.

Procaine local anesthesia

A technique to reduce pain during the incision procedure.

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Falciform ligament

A thin transparent membrane separating the liver from the diaphragm.

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Duodenum

A part of the small intestine located immediately after the stomach.

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Physical examination

The observation of a rabbit's physical responses, evaluating aspects like reflexes, respiratory rate, and irritability.

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Compound ammonium chloride

A compound administered through intubation to increase ammonia levels in the blood.

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Study Notes

Hepatic Encephalopathy Experiment

  • Hypothesis: Liver injury is caused by increased blood ammonia.
  • Experiment Method: Ammonia toxicity hypothesis. Aimed to simulate liver injury through two operations:
    • Ligation of the liver.
    • Injection of ammonia salt into the intestinal tract.
  • Anesthesia: Rabbits are not given general anesthesia as changes in consciousness from normal state to hepatic encephalopathy aren't observed as the rabbit is under general anesthesia.
  • Preparation: Fix the rabbit in a supine position.
  • Procedure:
    • Shear hair from the upper abdomen.
    • Administer local anesthesia (procaine).
    • Incise (8cm) through the skin, subcutaneous tissue to reach linea alba.
    • Cut open abdominal muscles along the linea alba.
    • Expose the liver,
    • Cut the falciform ligament and expose liver.
    • Ligate the blood vessels of the liver (surgical steps to complete liver surgery).
    • Find the duodenum, create a hole in it, and insert a catheter.
  • Hemostatic forceps or thread can be used.
    • Observe the rabbit's overall condition.
    • Observe corneal reflection and blink speed.
    • Observe normal breathing frequency and irritability response.
    • Inject 5ml/5 minutes of compound ammonium chloride through intubation.
  • Observation: Constantly monitor response.
    • Corneal reflex.
    • Irritability.
  • Results/Symptoms:
    • If the experiment is successful, the rabbit will exhibit changes: arms and legs becoming straight, belly drumming, complete disappearance of corneal reflex, and the duration of this state is approximately 10 seconds.
    • Additional abnormal symptoms could include hyperventilation (rapid breathing), and high levels of irritability.

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