Hepatic Cirrhosis and Lactulose Therapy
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Questions and Answers

What is the primary reason for using lactulose in the treatment of hepatic encephalopathy?

  • To directly reduce the levels of bilirubin in the blood
  • To favor the conversion of ammonia to ammonium, which is ionic and cannot cross back into the systemic circulation (correct)
  • To reduce the production of organic acids in the gut
  • To increase the pH of the colon and promote the growth of urease-producing bacteria
  • What is the typical dosage regimen for lactulose in the treatment of hepatic encephalopathy?

  • 550 mg orally twice a day, for chronic therapy
  • 25 ml orally every 8 to 12 hours, titrated to produce one to two soft stools per day
  • 25 ml orally every 1 to 2 hours, until catharsis begins, then decreased to 15 to 45 mL orally every 8 to 12 hours (correct)
  • 15 to 45 mL orally every 1 to 2 hours, until catharsis begins
  • What is the mechanism of action of rifaximin in the treatment of hepatic encephalopathy?

  • It directly reduces the levels of ammonia in the blood
  • It increases the production of urease-producing bacteria in the gut
  • It stimulates the metabolism of ammonia in the liver
  • It inhibits the activity of urease-producing bacteria in the gut (correct)
  • What is the potential benefit of zinc supplementation in patients with hepatic encephalopathy?

    <p>It acts as a co-factor for NH3 metabolism</p> Signup and view all the answers

    What is the indication for using flumazenil in the treatment of hepatic encephalopathy?

    <p>Refractory encephalopathic patients</p> Signup and view all the answers

    What is the underlying diagnosis of the patient described in the case?

    <p>Hepatic cirrhosis</p> Signup and view all the answers

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