Podcast
Questions and Answers
What is the primary function of vasoconstriction in the process of hemostasis?
What is the primary function of vasoconstriction in the process of hemostasis?
Which disorder is characterized by a defect in collagen in the vessel wall?
Which disorder is characterized by a defect in collagen in the vessel wall?
What is the commonest inherited bleeding disorder involving platelets?
What is the commonest inherited bleeding disorder involving platelets?
Which factor deficiency is associated with secondary hemostasis disorders?
Which factor deficiency is associated with secondary hemostasis disorders?
Signup and view all the answers
Which anticoagulant drug directly inhibits thrombin?
Which anticoagulant drug directly inhibits thrombin?
Signup and view all the answers
What do normal endothelial cells express that inhibits platelet aggregation and promotes fibrinolysis?
What do normal endothelial cells express that inhibits platelet aggregation and promotes fibrinolysis?
Signup and view all the answers
In the process of hemostasis, what do platelets adhere to after injury?
In the process of hemostasis, what do platelets adhere to after injury?
Signup and view all the answers
What is the role of secreted granule contents in platelet aggregation?
What is the role of secreted granule contents in platelet aggregation?
Signup and view all the answers
Which factor is responsible for generating cross-linked fibrin and activating other coagulation factors?
Which factor is responsible for generating cross-linked fibrin and activating other coagulation factors?
Signup and view all the answers
What is the most common origin of pulmonary embolism?
What is the most common origin of pulmonary embolism?
Signup and view all the answers
What is the impact of a saddle embolus on the body?
What is the impact of a saddle embolus on the body?
Signup and view all the answers
What is the dominant histologic characteristic of infarction morphology?
What is the dominant histologic characteristic of infarction morphology?
Signup and view all the answers
What percentage of systemic emboli arise from intracardiac mural thrombi?
What percentage of systemic emboli arise from intracardiac mural thrombi?
Signup and view all the answers
From which part of the organ does the periphery of an infarct originate?
From which part of the organ does the periphery of an infarct originate?
Signup and view all the answers
What is the mortality rate associated with deep vein thrombosis (DVT)?
What is the mortality rate associated with deep vein thrombosis (DVT)?
Signup and view all the answers
What is the mortality rate associated with sepsis and shock?
What is the mortality rate associated with sepsis and shock?
Signup and view all the answers
Which of the following is NOT a focus of management in the treatment of sepsis?
Which of the following is NOT a focus of management in the treatment of sepsis?
Signup and view all the answers
What does a body temperature exceeding 38°C indicate in the context of SIRS?
What does a body temperature exceeding 38°C indicate in the context of SIRS?
Signup and view all the answers
What is the effect of hypoxic ischemic encephalopathy on brain regions?
What is the effect of hypoxic ischemic encephalopathy on brain regions?
Signup and view all the answers
Which population group is most commonly impacted by septic emboli?
Which population group is most commonly impacted by septic emboli?
Signup and view all the answers
What is the preferred timing for administering blood cultures in sepsis management?
What is the preferred timing for administering blood cultures in sepsis management?
Signup and view all the answers
Which physiological change in pregnancy can mimic SIRS criteria?
Which physiological change in pregnancy can mimic SIRS criteria?
Signup and view all the answers
In the context of cognitive impairment related to sepsis, which of the following is common?
In the context of cognitive impairment related to sepsis, which of the following is common?
Signup and view all the answers
'Pre-existing organ dysfunction/disease' is classified as which type of comorbidity in the context of sepsis?
'Pre-existing organ dysfunction/disease' is classified as which type of comorbidity in the context of sepsis?
Signup and view all the answers
What is the role of thrombin in platelet aggregation?
What is the role of thrombin in platelet aggregation?
Signup and view all the answers
Which condition is characterized by Abnormal blood flow, endothelial dysfunction, and hypercoagulability?
Which condition is characterized by Abnormal blood flow, endothelial dysfunction, and hypercoagulability?
Signup and view all the answers
What is the morphological characteristic of gross infarcts?
What is the morphological characteristic of gross infarcts?
Signup and view all the answers
What is the primary source of systemic emboli in the body?
What is the primary source of systemic emboli in the body?
Signup and view all the answers
Which type of embolus causes acute right heart failure and sudden death?
Which type of embolus causes acute right heart failure and sudden death?
Signup and view all the answers
In which time frame does a visible inflammatory response occur in infarction morphology?
In which time frame does a visible inflammatory response occur in infarction morphology?
Signup and view all the answers
What is the most common cause of pulmonary embolism?
What is the most common cause of pulmonary embolism?
Signup and view all the answers
Which type of PE causes pulmonary hemorrhage or pulmonary infarction?
Which type of PE causes pulmonary hemorrhage or pulmonary infarction?
Signup and view all the answers
What is the impact of hypoxic ischemic encephalopathy on brain regions?
What is the impact of hypoxic ischemic encephalopathy on brain regions?
Signup and view all the answers
Which step in the process of hemostasis involves the activation of clotting cascade and the generation of fibrin clot formation?
Which step in the process of hemostasis involves the activation of clotting cascade and the generation of fibrin clot formation?
Signup and view all the answers
Which inherited bleeding disorder is characterized by a defect in coagulation factor VIII or IX?
Which inherited bleeding disorder is characterized by a defect in coagulation factor VIII or IX?
Signup and view all the answers
Which type of Von Willebrand disease is characterized by the absence or severe reduction in Von Willebrand factor (VWF)?
Which type of Von Willebrand disease is characterized by the absence or severe reduction in Von Willebrand factor (VWF)?
Signup and view all the answers
Which drug acts as an indirect inhibitor of gamma carboxylation of vitamin K clotting factors?
Which drug acts as an indirect inhibitor of gamma carboxylation of vitamin K clotting factors?
Signup and view all the answers
What is the primary function of endothelial cells during the process of hemostasis?
What is the primary function of endothelial cells during the process of hemostasis?
Signup and view all the answers
Which disorder is characterized by a deficiency in platelets leading to abnormal primary hemostasis?
Which disorder is characterized by a deficiency in platelets leading to abnormal primary hemostasis?
Signup and view all the answers
What is the mechanism of action of direct thrombin inhibitors like Dabigatran?
What is the mechanism of action of direct thrombin inhibitors like Dabigatran?
Signup and view all the answers
Which step in hemostasis involves platelets adhering to the extracellular matrix (ECM) to protect it after injury?
Which step in hemostasis involves platelets adhering to the extracellular matrix (ECM) to protect it after injury?
Signup and view all the answers
Which anticoagulant drug is classified as a thrombin inhibitor with a short half-life?
Which anticoagulant drug is classified as a thrombin inhibitor with a short half-life?
Signup and view all the answers
What is the initial management approach recommended in the first hour of sepsis?
What is the initial management approach recommended in the first hour of sepsis?
Signup and view all the answers
Which of the following conditions results in a vasogenic oedema that can become cytotoxic if cells are damaged?
Which of the following conditions results in a vasogenic oedema that can become cytotoxic if cells are damaged?
Signup and view all the answers
What is a common cause of maternal mortality in pregnancy?
What is a common cause of maternal mortality in pregnancy?
Signup and view all the answers
In the context of sepsis management, what is advised after administering blood cultures and blood work?
In the context of sepsis management, what is advised after administering blood cultures and blood work?
Signup and view all the answers
Which factor contributes to the characteristic red neurons observed in brain damage during sepsis?
Which factor contributes to the characteristic red neurons observed in brain damage during sepsis?
Signup and view all the answers
What is a key feature of general comorbidities associated with sepsis?
What is a key feature of general comorbidities associated with sepsis?
Signup and view all the answers
