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Questions and Answers
What is the primary function of vasoconstriction in the process of hemostasis?
What is the primary function of vasoconstriction in the process of hemostasis?
- To increase blood flow
- To activate the clotting cascade
- To promote platelet plug formation
- To reduce blood flow (correct)
Which disorder is characterized by a defect in collagen in the vessel wall?
Which disorder is characterized by a defect in collagen in the vessel wall?
- Glanzmann's thrombasthenia
- Von Willebrand disease
- Ehlers Danlos syndrome (correct)
- Hemophilia
What is the commonest inherited bleeding disorder involving platelets?
What is the commonest inherited bleeding disorder involving platelets?
- Hemophilia
- Ehlers Danlos syndrome
- Von Willebrand disease
- Glanzmann's thrombasthenia (correct)
Which factor deficiency is associated with secondary hemostasis disorders?
Which factor deficiency is associated with secondary hemostasis disorders?
Which anticoagulant drug directly inhibits thrombin?
Which anticoagulant drug directly inhibits thrombin?
What do normal endothelial cells express that inhibits platelet aggregation and promotes fibrinolysis?
What do normal endothelial cells express that inhibits platelet aggregation and promotes fibrinolysis?
In the process of hemostasis, what do platelets adhere to after injury?
In the process of hemostasis, what do platelets adhere to after injury?
What is the role of secreted granule contents in platelet aggregation?
What is the role of secreted granule contents in platelet aggregation?
Which factor is responsible for generating cross-linked fibrin and activating other coagulation factors?
Which factor is responsible for generating cross-linked fibrin and activating other coagulation factors?
What is the most common origin of pulmonary embolism?
What is the most common origin of pulmonary embolism?
What is the impact of a saddle embolus on the body?
What is the impact of a saddle embolus on the body?
What is the dominant histologic characteristic of infarction morphology?
What is the dominant histologic characteristic of infarction morphology?
What percentage of systemic emboli arise from intracardiac mural thrombi?
What percentage of systemic emboli arise from intracardiac mural thrombi?
From which part of the organ does the periphery of an infarct originate?
From which part of the organ does the periphery of an infarct originate?
What is the mortality rate associated with deep vein thrombosis (DVT)?
What is the mortality rate associated with deep vein thrombosis (DVT)?
What is the mortality rate associated with sepsis and shock?
What is the mortality rate associated with sepsis and shock?
Which of the following is NOT a focus of management in the treatment of sepsis?
Which of the following is NOT a focus of management in the treatment of sepsis?
What does a body temperature exceeding 38°C indicate in the context of SIRS?
What does a body temperature exceeding 38°C indicate in the context of SIRS?
What is the effect of hypoxic ischemic encephalopathy on brain regions?
What is the effect of hypoxic ischemic encephalopathy on brain regions?
Which population group is most commonly impacted by septic emboli?
Which population group is most commonly impacted by septic emboli?
What is the preferred timing for administering blood cultures in sepsis management?
What is the preferred timing for administering blood cultures in sepsis management?
Which physiological change in pregnancy can mimic SIRS criteria?
Which physiological change in pregnancy can mimic SIRS criteria?
In the context of cognitive impairment related to sepsis, which of the following is common?
In the context of cognitive impairment related to sepsis, which of the following is common?
'Pre-existing organ dysfunction/disease' is classified as which type of comorbidity in the context of sepsis?
'Pre-existing organ dysfunction/disease' is classified as which type of comorbidity in the context of sepsis?
What is the role of thrombin in platelet aggregation?
What is the role of thrombin in platelet aggregation?
Which condition is characterized by Abnormal blood flow, endothelial dysfunction, and hypercoagulability?
Which condition is characterized by Abnormal blood flow, endothelial dysfunction, and hypercoagulability?
What is the morphological characteristic of gross infarcts?
What is the morphological characteristic of gross infarcts?
What is the primary source of systemic emboli in the body?
What is the primary source of systemic emboli in the body?
Which type of embolus causes acute right heart failure and sudden death?
Which type of embolus causes acute right heart failure and sudden death?
In which time frame does a visible inflammatory response occur in infarction morphology?
In which time frame does a visible inflammatory response occur in infarction morphology?
What is the most common cause of pulmonary embolism?
What is the most common cause of pulmonary embolism?
Which type of PE causes pulmonary hemorrhage or pulmonary infarction?
Which type of PE causes pulmonary hemorrhage or pulmonary infarction?
What is the impact of hypoxic ischemic encephalopathy on brain regions?
What is the impact of hypoxic ischemic encephalopathy on brain regions?
Which step in the process of hemostasis involves the activation of clotting cascade and the generation of fibrin clot formation?
Which step in the process of hemostasis involves the activation of clotting cascade and the generation of fibrin clot formation?
Which inherited bleeding disorder is characterized by a defect in coagulation factor VIII or IX?
Which inherited bleeding disorder is characterized by a defect in coagulation factor VIII or IX?
Which type of Von Willebrand disease is characterized by the absence or severe reduction in Von Willebrand factor (VWF)?
Which type of Von Willebrand disease is characterized by the absence or severe reduction in Von Willebrand factor (VWF)?
Which drug acts as an indirect inhibitor of gamma carboxylation of vitamin K clotting factors?
Which drug acts as an indirect inhibitor of gamma carboxylation of vitamin K clotting factors?
What is the primary function of endothelial cells during the process of hemostasis?
What is the primary function of endothelial cells during the process of hemostasis?
Which disorder is characterized by a deficiency in platelets leading to abnormal primary hemostasis?
Which disorder is characterized by a deficiency in platelets leading to abnormal primary hemostasis?
What is the mechanism of action of direct thrombin inhibitors like Dabigatran?
What is the mechanism of action of direct thrombin inhibitors like Dabigatran?
Which step in hemostasis involves platelets adhering to the extracellular matrix (ECM) to protect it after injury?
Which step in hemostasis involves platelets adhering to the extracellular matrix (ECM) to protect it after injury?
Which anticoagulant drug is classified as a thrombin inhibitor with a short half-life?
Which anticoagulant drug is classified as a thrombin inhibitor with a short half-life?
What is the initial management approach recommended in the first hour of sepsis?
What is the initial management approach recommended in the first hour of sepsis?
Which of the following conditions results in a vasogenic oedema that can become cytotoxic if cells are damaged?
Which of the following conditions results in a vasogenic oedema that can become cytotoxic if cells are damaged?
What is a common cause of maternal mortality in pregnancy?
What is a common cause of maternal mortality in pregnancy?
In the context of sepsis management, what is advised after administering blood cultures and blood work?
In the context of sepsis management, what is advised after administering blood cultures and blood work?
Which factor contributes to the characteristic red neurons observed in brain damage during sepsis?
Which factor contributes to the characteristic red neurons observed in brain damage during sepsis?
What is a key feature of general comorbidities associated with sepsis?
What is a key feature of general comorbidities associated with sepsis?
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