Hemophilia Clinical Features and Bleeding Manifestations
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Questions and Answers

What is the most common bleeding manifestation of severe hemophilia?

  • Recurrent hemarthrosis (correct)
  • Hematuria
  • Recurrent hematomas
  • Intracranial hemorrhage

At what age does acquired Hemophilia A typically occur?

  • In pregnant or postpartum women
  • Predominantly in older adults (median age: 60 years) (correct)
  • In people with underlying malignancies
  • In childhood or early adulthood

What is a common complication of muscle hematomas?

  • Erythema
  • Fixed positioning
  • Synovial thickening
  • Compartment syndromes (correct)

What is the name of the assay used to confirm the diagnosis of acquired Hemophilia A?

<p>Bethesda assay (A)</p> Signup and view all the answers

In what percentage of patients with acquired Hemophilia A is an underlying disease associated?

<p>50% (D)</p> Signup and view all the answers

What is a common symptom of acute hemarthrosis?

<p>Local pain, swelling, and erythema (D)</p> Signup and view all the answers

Which factor is produced in endothelial cells?

<p>Factor VIII (B)</p> Signup and view all the answers

What is the most common disorder of coagulation among the given options?

<p>Hemorrhagic diathesis of liver disease (A)</p> Signup and view all the answers

Which of the following is produced in the bone marrow?

<p>Factor XIII A-subunit (C)</p> Signup and view all the answers

What is affected first in a patient with liver disease?

<p>Factor VII (D)</p> Signup and view all the answers

What is the most common bleeding disorder?

<p>Von Willebrand disease (C)</p> Signup and view all the answers

What are the most common disorders of coagulation?

<p>Hemorrhagic diathesis of liver disease, DIC, and vitamin K deficiency (A)</p> Signup and view all the answers

What is the inheritance pattern of Factor VIII deficiency?

<p>Autosomal recessive (C)</p> Signup and view all the answers

What is the treatment for inherited coagulation disorders?

<p>Factor replacement therapy (A)</p> Signup and view all the answers

Which clotting factor deficiency is inherited as an autosomal dominant trait?

<p>Factor V deficiency (B)</p> Signup and view all the answers

What is the most common bleeding manifestation seen in severe hemophilia?

<p>Joint bleeding (A)</p> Signup and view all the answers

Which of the following is NOT a coagulation factor?

<p>Vitamin K (B)</p> Signup and view all the answers

What is the composition of Cryoprecipitate?

<p>Factor VIII, VWF, Fibrinogen, Factor XIII (D)</p> Signup and view all the answers

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