Hemophilia Clinical Features and Bleeding Manifestations

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What is the most common bleeding manifestation of severe hemophilia?

Recurrent hemarthrosis (correct)

Hematuria

Recurrent hematomas

Intracranial hemorrhage

At what age does acquired Hemophilia A typically occur?

In pregnant or postpartum women

Predominantly in older adults (median age: 60 years) (correct)

In people with underlying malignancies

In childhood or early adulthood

What is a common complication of muscle hematomas?

Erythema

Fixed positioning

Synovial thickening

Compartment syndromes (correct)

What is the name of the assay used to confirm the diagnosis of acquired Hemophilia A?

Bethesda assay Signup and view all the answers

In what percentage of patients with acquired Hemophilia A is an underlying disease associated?

50% Signup and view all the answers

What is a common symptom of acute hemarthrosis?

Local pain, swelling, and erythema Signup and view all the answers

Which factor is produced in endothelial cells?

Factor VIII Signup and view all the answers

What is the most common disorder of coagulation among the given options?

Hemorrhagic diathesis of liver disease Signup and view all the answers

Which of the following is produced in the bone marrow?

Factor XIII A-subunit Signup and view all the answers

What is affected first in a patient with liver disease?

Factor VII Signup and view all the answers

What is the most common bleeding disorder?

Von Willebrand disease Signup and view all the answers

What are the most common disorders of coagulation?

Hemorrhagic diathesis of liver disease, DIC, and vitamin K deficiency Signup and view all the answers

What is the inheritance pattern of Factor VIII deficiency?

Autosomal recessive Signup and view all the answers

What is the treatment for inherited coagulation disorders?

Factor replacement therapy Signup and view all the answers

Which clotting factor deficiency is inherited as an autosomal dominant trait?

Factor V deficiency Signup and view all the answers

What is the most common bleeding manifestation seen in severe hemophilia?

Joint bleeding Signup and view all the answers

Which of the following is NOT a coagulation factor?

Vitamin K Signup and view all the answers

What is the composition of Cryoprecipitate?

Factor VIII, VWF, Fibrinogen, Factor XIII Signup and view all the answers